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Transepithelial transport of nanoparticles in oral drug delivery:From the perspective of surface and holistic property modulation

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Acta Pharmaceutica Sinica B 2024年第9期14卷 3876-3900页

作者： Yaxian Zheng shiqin Luo Min Xu Qin He Jiang Xie Jiawei Wu Yuan Huang Department of Pharmacy the Third People’s Hospital of Chengduthe Affiliated Hospital of Southwest Jiaotong UniversityCollege of MedicineSouthwest Jiaotong UniversityChengdu 610031China Department of Pharmacy Personalized Drug Therapy Key Laboratory of Sichuan ProvinceSichuan Academy of Medical Sciences&Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610072China Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610041China

Despite the promising prospects of nanoparticles in oral drug delivery,the process of oral administration involves a complex transportation pathway that includes cellular uptake,intracellular trafficking,and exocytosis by intestinal epithelial cells,which are necessary steps for nanoparticles to enter the bloodstream and exert therapeutic *** researchers have identified several crucial factors that regulate the interaction between nanoparticles and intestinal epithelial cells,including surface properties such as ligand modification,surface charge,hydrophilicity/hydrophobicity,intestinal protein corona formation,as well as holistic properties like particle size,shape,and *** these properties is essential for enhancing transepithelial transport efficiency and designing effective oral drug delivery ***,this review provides a comprehensive overview of the surface and holistic properties that influence the transepithelial transport of nanoparticles,elucidating the underlying principles governing their impact on transepithelial *** review also outlines the chosen of parameters to be considered for the subsequent design of oral drug delivery systems.

关键词： Oral delivery Nanoparticles Intestinal epithelial cells Surface property Holistic property Transepithelial transport

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Amitriptyline inhibits NLRP3 inflammasome activation via the ASM/CE pathway in a cell model of NAFLD

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BIOCELL 2024年第5期48卷 759-769页

作者： QIN LIU CHUNYAN NIU QIANG ZHANG shiqin SUN YUE CHEN YONGQIANG SHI Shengli Clinical Medical College Fujian Medical UniversityFuzhou350001China Department of Gastroenterology Nanjing Lishui People’s HospitalZhongda Hospital Lishui BranchSoutheast UniversityNanjing211200China Department of Gastroenterology Yancheng Third People’s Hospital(The Yancheng School of Clinical Medicine of Nanjing Medical University)Yancheng224000China Administrative Department of Teaching and Scientific Research Nanjing Lishui People’s HospitalZhongda Hospital Lishui BranchSoutheast UniversityNanjing211200China

Background:Nonalcoholic fatty liver disease(NAFLD)is a global health concern with the acid sphingomyelinase(ASM)/ceramide(CE)pathway and the NOD-like receptor family,pyrin domain-containing protein 3(NLRP3)inflammasome identified as pivotal players in lipid disorders and *** study explores the interaction mechanism between the ASM/CE pathway and NLRP3 in NAFLD cell models,aiming to understand the impact of amitriptyline(Ami),an ASM inhibitor,on lipid deposition and hepatocyte injury by regulating the ASM/CE-NLRP3 ***:HepG2 and HL-7702 cells were exposed to free fatty acids(FFAs)to establish the NAFLD *** cells were divided into 5 groups:control group,model group,Ami group,tumor necrosis factoralpha(TNF-α)group,and Ami+TNF-α*** lipid droplets were visualized using Oil Red O staining,and Western blot analysis quantified ASM,NLRP3,and caspase 1 protein *** linked immunosorbent assay(ELISA)was measured CE and ASM levels,while qRT-PCR assessed mRNA *** apoptotic rate was evaluated by flow cytometry(FCM).Results:Following FFAs incubation,significant increases in ASM and CE levels were observed in HepG2 and HL-7702 cells,accompanied by elevated expression of NLRP3,and caspase 1,and IL-1β.TNF-αtreatment further amplified these *** demonstrated a reduction in lipid deposition,suppressed ASM/CE pathway activation,downregulated NLRP3 and caspase 1 expression,and improved ***,MCC950,a selective inhibitor of the NLRP3,mitigated NLRP3,caspase 1,and IL-1βexpression,alleviating lipid deposition and apoptosis in the NAFLD cell ***:The ASM/CE-NLRP3 pathway in NAFLD cells promotes hepatocyte steatosis,inflammation,and cell *** emerges as a promising therapeutic agent by inhibiting the ASM/CE-NLRP3 pathway,underscoring its potential as a key target for NAFLD treatment.

关键词： Nonalcoholic fatty liver disease Hepatocyte Amitriptyline ASM/CE pathway NLRP3 Nonalcoholic steatohepatitis

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Research on the Reform of"Separation of Three Rights"for Rural Homesteads in Juancheng County,Shandong Province

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Asian Agricultural Research 2024年第7期16卷 12-18页

作者： Jianglin MU shiqin YANG Institute of Land Resources and Sustainable Development Yunnan University of Finance and EconomicsKunming 650221China

In order to realize rural revitalization in an all-round way and promote the sustainable and healthy development of the economy and society,China is committed to deepening the pace of building a new countryside with Chinese *** reform of the"Separation of Three Rights"of rural homesteads is a key measure,which aims to activate rural resources,enhance the vitality of rural economic development,and then promote the overall process of rural *** study selects Juancheng County,Heze City,Shandong Province as a typical *** an in-depth analysis of the relevant policy orientation of the national homestead reform and the specific practice of local promotion work,it systematically sorts out the registration of homestead rights,transfer of use rights and relevant policy measures adopted in paid use,qualification conversion,policy publicity and system *** in-depth research on the system reform practice of the"Separation of Three Rights"of homesteads in Juancheng County,this paper reveals the main problems existing in the current reform,including the lack of clear policy support for the mechanism of paid use of homesteads,difficulties in the process of identifying qualification rights and challenges,the imperfection of the transfer mechanism of use rights,and the lack or lag of relevant policies.A series of problem-oriented policy suggestions are put forward,including establishing and improving the system of paid use of rural homesteads,improving the income distribution mechanism,promoting the innovation of the mortgage guarantee system for the right to use homesteads,and optimizing the homestead qualification certification *** suggestions aim to provide a useful reference for the Juancheng County Government in promoting the reform of"Separation of Three Rights"of homesteads,and then promote the rational allocation and efficient utilization of rural homestead resources.

关键词： Rural homesteads "Separation of Three Rights" Rural revitalization Juancheng County

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Analysis of Regional Difference of Agricultural Land Productivity in Heilongjiang Province

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Asian Agricultural Research 2024年第8期16卷 9-13,16页

作者： Linlin CAO Jinrong YANG shiqin YANG Institute of Land&Resources and Sustainable Development Yunnan University of Finance and EconomicsKunming 650221China

The sustenance of humanity is contingent upon the production of *** foundation of this production is agriculture,which in turn is dependent upon the cultivation of the *** a fundamental element of agricultural advancement,the rational development and utilization of land play a pivotal role in the process of rural *** land productivity serves as a principal indicator of the efficacy of land utilization and the extent of agricultural ***,there is a paucity of research examining the productivity of agricultural land,particularly a lack of specialized research on large agricultural *** light of the aforementioned considerations,this paper presents a comprehensive examination of agricultural land productivity and its regional variations in Heilongjiang Province in 2022,with the aid of pertinent statistical *** findings of the analysis indicate that among the prefecture-level cities,Daqing and Suihua exhibit the highest levels of agricultural land ***,Zhaodong City,Zhaozhou,Qinggang,Wangkui,and Lanxi counties exhibit high levels of agricultural land productivity within their respective prefecture-level *** are notable disparities in agricultural land productivity across various regions,including Yichun,Heihe,Harbin,Daqing,Hegang,and *** contrast,other regions demonstrate a more balanced spatial *** order to facilitate the prosperous development of the agricultural industry in Heilongjiang Province,it is essential to optimize the spatial planning of the land,to investigate the potential for agricultural development in each region,to establish effective collaboration between resources and industries,and to create a development synergy that will collectively advance rural revitalization.

关键词： Agricultural land Productivity Regional difference Heilongjiang Province

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Advances in Pharmacological Effects of Stevioside

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Journal of Clinical and Nursing Research 2024年第6期8卷 100-104页

作者： shiqin Fu Yanling Huang Yiting Xie Jing Zhang Jiangxi University of Chinese Medicine Nanchang 330004Jiangxi ProvinceChina

Stevioside is a low-calorie high-power sweetener with a variety of positive pharmacological *** the growing attention to health,stevia leaf has garnered widespread interest at home and *** article reviews the main pharmacological effects of stevioside and their mechanisms,in order to provide references for the research on the edible and medicinal value of stevioside.

关键词： Stevioside Pharmacological effect Safety

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结合网络药理学和分子对接技术分析绞股蓝皂苷在肥胖小鼠中的微生态调节机制

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中国微生态学杂志 2024年第8期36卷 907-914,921页

作者：谢诗琴邓娜湖南中医药大学中医学院湖南长沙410208

目的采用网络药理学和分子对接技术并结合体内实验探讨绞股蓝皂苷(Gyp)对高脂饮食小鼠肠道黏膜菌群及体重的影响,探析Gyp干预肥胖小鼠的微生态机制。方法18只SPF级小鼠按照随机数表法分为6只正常组(C组)和12只造模组,造模组给与高脂饲... 详细信息

目的采用网络药理学和分子对接技术并结合体内实验探讨绞股蓝皂苷(Gyp)对高脂饮食小鼠肠道黏膜菌群及体重的影响,探析Gyp干预肥胖小鼠的微生态机制。方法18只SPF级小鼠按照随机数表法分为6只正常组(C组)和12只造模组,造模组给与高脂饲料喂养,C组给与普通饲料喂养,持续12周。造模结束后,按照随机数表法将造模组分为6只模型组(M组)和6只Gyp组。Gyp组小鼠每日灌胃Gyp溶液,300 g/kg,2次/天,连续4周,同期灌胃C组和M组等量无菌水。收集小鼠小肠黏膜,利用16S rRNA高通量测序技术分析小鼠小肠黏膜菌群特征。同时结合网络药理学和分子对接技术预测绞股蓝治疗肥胖的潜在机制。结果网络药理学结果显示,绞股蓝可以调节90个与肥胖生成相关的靶点。这些靶点的PPI网络分析、GO和KEGG富集分析结果主要与代谢和炎症反应相关。分子对接验证结果显示,gypenosideⅩⅩⅤⅢ_qt作为绞股蓝的主要活性成分,与核心靶点蛋白TP53、TNF、AKT1的结合具有较强的亲和力。体重变化率结果显示,Gyp干预后,与M组相比,Gyp组小鼠体重增长趋缓。测序结果显示,造模改变了小肠黏膜菌群的α多样性和β多样性;Gyp干预后,与M组相比,Gyp组弧菌属相对丰度升高(t=6.662,P<0.001),uncultured bacterium f Lachnospiraceae相对丰度下降(t=2.850,P=0.017)。LEfSe分析结果显示,葡萄球菌属和弧菌属为Gyp组的优势菌属。相关性分析结果显示,uncultured bacterium f Muribaculaceae(r=0.733,P=0.020)、乳杆菌属(r=0.746,P=0.017)、韦荣球菌属(r=0.709,P=0.027)、脱硫弧菌属(r=0.758,P=0.015)、Candidatus Saccharimonas(r=0.721,P=0.023)、Lachnospiraceae NK4A136 group(r=0.794,P=0.008)、Ruminococcaceae UCG 014(r=0.733,P=0.020)、uncultured bacterium f Lachnospiraceae(r=0.830,P=0.005)与小鼠体重变化率呈显著正相关;葡萄球菌属(r=-0.721,P=0.023)和弧菌属(r=-0.649,P=0.049)与Gyp干预后的小鼠体重变化率呈显著负相关。结论绞股蓝通过多靶点、多通路作用于肥胖,其中TP53、AKT1、TNF、JUN为核心靶点。Gyp改变了肠道菌群的群落结构,增加了黏膜菌群的丰富度和多样性,减缓了肥胖小鼠体重的增长。

关键词：绞股蓝皂苷高脂饮食肥胖网络药理学分子对接肠道菌群

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考虑物性变化及壳体传热的新型板壳式换热器板程流动传热数值模拟

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化工进展 2024年第4期43卷 1676-1689页

作者：孙超艾诗钦刘月婵哈尔滨理工大学测控技术与通信工程学院黑龙江哈尔滨150080 哈尔滨工程大学动力工程及工程热物理博士后科研流动站黑龙江哈尔滨150001

板壳式换热器以优越的换热性能和耐温耐压性在化工生产等领域有着广阔的应用前景。本文采用可实现k⁃ε湍流模型结合增强壁面函数,对一种新型板壳式换热器板程流动与传热特性进行数值模拟研究,讨论了介质物性变化及壳体传热的影响,并与... 详细信息

板壳式换热器以优越的换热性能和耐温耐压性在化工生产等领域有着广阔的应用前景。本文采用可实现k⁃ε湍流模型结合增强壁面函数,对一种新型板壳式换热器板程流动与传热特性进行数值模拟研究,讨论了介质物性变化及壳体传热的影响,并与已有实验进行验证。重点分析了不同波纹高度在不同入口流速下的流动传热特性,基于场协同理论揭示了速度场与温度场及压强场协同分布规律。结果表明:流动传热计算不能忽略流体介质物性变化及壳体传热的影响;增大波纹高度流态由曲折流向十字交叉流转变,板间流体分布趋于均匀,换热性能增大;沿沟槽形成连续的涡结构,在触点周围形成具有周期性和中心对称的高剪切涡量集中区,垂直于流动方向场协同呈现周期性变化,波纹高度越高周期性越明显;在波纹核心流域内因流动与热流相似,其协同程度变差。

关键词：板壳式换热器波纹高度三场协同流动传热数值模拟

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单纯心尖肥厚型心肌病进展为中部梗阻并室壁瘤形成1例

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中华心血管病杂志 2024年第1期52卷 79-81页

作者：喻诗琴杨凯赵世华中国医学科学院、北京协和医学院、国家心血管病中心、阜外医院磁共振科北京100037

该文报道1例青年男性患者因体检心电图异常就诊,进一步磁共振检查诊断为心尖肥厚型心肌病,在无心血管系统相关症状的情况下进展为中部梗阻并室壁瘤形成。本文通过心脏磁共振成像展示了心尖肥厚型心肌病进展形成室壁瘤的形态、功能及组... 详细信息

该文报道1例青年男性患者因体检心电图异常就诊,进一步磁共振检查诊断为心尖肥厚型心肌病,在无心血管系统相关症状的情况下进展为中部梗阻并室壁瘤形成。本文通过心脏磁共振成像展示了心尖肥厚型心肌病进展形成室壁瘤的形态、功能及组织学变化,其中腺苷负荷状态下心肌灌注缺损揭示了冠状动脉血流储备减低、劳力性心肌缺血可能是室壁瘤形成原因之一。心脏磁共振在心尖肥厚型心肌病的随访复查中具有重要价值。

关键词：心肌病,肥厚性心尖肥厚型心肌病室壁瘤

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基于原位冷冻界面聚合法的纱线传感器制备及其应变传感性能

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纺织学报 2024年第1期45卷 74-82页

作者：艾靓雯卢东星廖师琴王清清生态纺织教育部重点实验室(江南大学) 江苏无锡214122 江西服装学院江西省现代服装工程技术研究中心江西南昌330201

为解决传统传感器柔性差、制备成本高等问题,以涤纶包氨纶纱为基材,通过聚多巴胺修饰和聚吡咯的原位冷冻界面聚合制备了具有快速响应、稳定的电力学性能和循环耐用传感性能的柔性纱线应变传感器。利用扫描电子显微镜、X射线能谱分析仪... 详细信息

为解决传统传感器柔性差、制备成本高等问题,以涤纶包氨纶纱为基材,通过聚多巴胺修饰和聚吡咯的原位冷冻界面聚合制备了具有快速响应、稳定的电力学性能和循环耐用传感性能的柔性纱线应变传感器。利用扫描电子显微镜、X射线能谱分析仪、傅里叶红外光谱仪对导电纱的微观形貌和化学结构进行表征,探究了不同拉伸应变下导电纱的电阻变化性能。结果显示:在吡咯单体与三氯化铁的量比为1的最佳配比下,在不同的拉伸范围、拉伸速度下,纱线传感器电阻变化稳定,拉伸形变小于6%时,灵敏度达4.039;在10%应变下,响应时间为166.67 ms;此外,纱线循环拉伸1000次后仍具有优异的稳定性。导电纱可通过编织、针织或刺绣等方式与织物相结合,实时监测人体关节活动,广泛应用于人体运动识别和远程医疗服务等领域。

关键词：聚多巴胺聚吡咯涤纶包氯纶弹性纱导电性能原位冷冻界面聚合法纱线应变传感器

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“在场”到“难忘”:偏惯常环境下旅游体验的记忆形成与反馈机制

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旅游学刊 2024年第1期39卷 62-78页

作者：张士琴石穆沙中山大学旅游学院广东珠海519082 中山大学旅游休闲与社会发展研究中心广东广州510275

体验经济时代,提供难忘的旅游体验成为目的地的核心竞争力,旅游体验作为旅游研究的重要领域得到广泛重视。然而,现有研究在空间上强调非惯常环境下的旅游体验,时间上侧重在场体验,对偏惯常环境下的难忘体验缺乏关注。因此,该研究以游客... 详细信息

体验经济时代,提供难忘的旅游体验成为目的地的核心竞争力,旅游体验作为旅游研究的重要领域得到广泛重视。然而,现有研究在空间上强调非惯常环境下的旅游体验,时间上侧重在场体验,对偏惯常环境下的难忘体验缺乏关注。因此,该研究以游客在城市绿道这一偏惯常环境下的旅游休闲活动为情境,通过在场和归家后的历时分析,旨在洞悉从“在场”到“难忘”这一体验记忆的形成过程与反馈机制。通过对5个城市绿道中的55名受访者进行两阶段考察,采用主题分析和系统动力分析,研究发现,游客在场体验以“存在性自我”为核心,且随时间推移其在场体验细节会消减,而彼时感知和感觉到的体验则抽象为情感性欣赏、满足和认同长期保存,成为记忆中的难忘体验。同时,研究提出了“在场感知-阈限自我-情感记忆-情感连接-行为动机”的体验记忆形成和促进重游的正反馈机制,与重游下体验阈限突破的负反馈机制构成体验记忆形成的S形曲线模型,对旅游体验、体验记忆以及目的地体验设计具有一定的理论和实践意义。

关键词：难忘旅游体验体验记忆在场体验偏惯常环境系统动力分析

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