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A Compact System of Capacitively Coupled Contactless Conductivity Detection Based on the Square Wave Excitation Signal for Capillary Electrophoresis

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Chinese Chemical Letters 2006年第9期17卷 1229-1232页

作者： Shui Feng ZHANG Li shi wang zhi DANG College of Environmental Science and Engineering South China University of Technology Guangzhou 510640

This paper reported a compact system of capacitively coupled contactless conductivity detection （C4D） based on the square wave excitation voltage for capillary electrophoresis, and it exhibited excellent sensitivity at the optimal frequency of 198 kHz. The feasibility and sensitivity of this detector was demonstrated by simultaneous detection of thirteen ions including alkali, alkaline earth and heavy metal ions. And the detection limits （S/N 3） were in the range of 0.2-1μmol/L for Mn^2＋, K^＋, Na^＋, Mg^2＋, Ca^2＋, Li^＋, Ba^2＋, and 7-25 μmol/L for Ni^2＋, Cu^2＋, Cd^2＋, Pb^2＋, Co^2＋, Zn^2＋.

关键词： Capillary electrophoresis square wave excitation signal contactless conductivitydetector metal ions.

A single-nucleus transcriptomic atlas of the dog hippocampus reveals the potential relationship between specific cell types and domestication

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National Science Review 2022年第11期9卷 108-120页

作者： Qi-Jun Zhou Xingyan Liu Longlong Zhang Rong wang Tingting Yin Xiaolu Li Guimei Li Yuqi He Zhaoli Ding Pengcheng Ma shi-zhi wang Bingyu Mao shihua Zhang Guo-Dong wang State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of Sciences NCMIS CEMS RCSDSAcademy of Mathematics and Systems ScienceChinese Academy of Sciences School of Mathematical Sciences University of Chinese Academy of Sciences Kunming College of Life Science University of Chinese Academy of Sciences College of Life Science University of Chinese Academy of Sciences Genomic Center of Biodiversity Kunming Institute of ZoologyChinese Academy of Sciences Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences Key Laboratory of Systems Health Science of Zhejiang Province School of Life ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences

The process of domestication has led to dramatic differences in behavioral traits between domestic dogs and gray wolves. Whole-genome research found that a class of putative positively selected genes were related to various aspects of learning and memory, such as long-term potentiation and long-term depression. In this study, we constructed a single-nucleus transcriptomic atlas of the dog hippocampus to illustrate its cell types, cell lineage and molecular features. Using the transcriptomes of 105 057 nuclei from the hippocampus of a Beagle dog, we identified 26 cell clusters and a putative trajectory of oligodendrocyte *** analysis revealed a significant convergence between dog differentially expressed genes(DEGs) and putative positively selected genes(PSGs). Forty putative PSGs were DEGs in glutamatergic neurons, especially in Cluster 14, which is related to the regulation of nervous system development. In summary, this study provides a blueprint to understand the cellular mechanism of dog domestication.

关键词： dog single-nucleus RNA sequencing hippocampus domestication

Behavioral evidence for the origin of Chinese Kunming dog

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Current Zoology 2021年第4期67卷 469-471页

作者： Jin-Xiu Li Qing-Guo Huang shi-zhi wang Qi-Jun Zhou Xu Gao Ya-Ping Zhang Guo-Dong wang State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunming650223China Kunming Police Dog Base of the Chinese Ministry of Public Security Kunming650204China Harbin Police Dog Training Centre Heilongjiang General Station of Exit and Entry Frontier InspectionHarbin150000China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunming650223China

As the only working dog independently developed and bred in China,Chinese Kunming dog(CKD)was approved as a new breed by the Chinese National Livestock and Poultry Genetics Commission in *** CKD is widely used by the Chinese army and police and has been exported to Singapore,Thailand,Vietnam,North Korea,and other more than 10 countries as working *** published studies of CKD have focused on coat color genetics(wang et al.2013)and reproduction performance(Wei et al.2018).The study by wang et al.(2013)pointed out that the breed of CKD was developed in the 1950s by hybridizing German shepherd dogs(GSDs)imported from the Soviet Union with Kunming indigenous village dogs.

关键词： behavior test Chinese Kunming dog origin

Detection and Recognition of Spray Code Numbers on Can Surfaces Based on OCR

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Computers, Materials & Continua 2025年第1期82卷 1109-1128页

作者： Hailong wang Junchao shi School of Computer Science Zhongyuan University of TechnologyZhengzhou450007China

A two-stage algorithm based on deep learning for the detection and recognition of can bottom spray codes and numbers is proposed to address the problems of small character areas and fast production line speeds in can bottom spray code number *** the coding number detection stage,Differentiable Binarization Network is used as the backbone network,combined with the Attention and Dilation Convolutions Path Aggregation Network feature fusion structure to enhance the model detection *** terms of text recognition,using the Scene Visual Text Recognition coding number recognition network for end-to-end training can alleviate the problem of coding recognition errors caused by image color distortion due to variations in lighting and background *** addition,model pruning and quantization are used to reduce the number ofmodel parameters to meet deployment requirements in resource-constrained environments.A comparative experiment was conducted using the dataset of tank bottom spray code numbers collected on-site,and a transfer experiment was conducted using the dataset of packaging box production *** experimental results show that the algorithm proposed in this study can effectively locate the coding of cans at different positions on the roller conveyor,and can accurately identify the coding numbers at high production line *** Hmean value of the coding number detection is 97.32%,and the accuracy of the coding number recognition is 98.21%.This verifies that the algorithm proposed in this paper has high accuracy in coding number detection and recognition.

关键词： Can coding recognition differentiable binarization network scene visual text recognition model pruning and quantification transport model

Genetic variations in the SMAD4 gene and gastric cancer susceptibility

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World Journal of Gastroenterology 2010年第44期16卷 5635-5641页

作者： Dong-Mei Wu Hai-Xia Zhu Qing-Hong Zhao zhi-Zhong Zhang shi-zhi wang Mei-Lin wang Zheng-Dong Zhang Wei-Da Gong Ming Tan Department of Molecular and Genetic Toxicology School of Public Health Cancer Center Nanjing Medical University Nanjing 210029 Jiangsu Province China Hai-Xia Zhu Core laboratory Nantong Tumor Hospital Nantong 226001 China Qing-Hong Zhao Department of General Surgery The Second Affiliated Hospital of Nanjing Medical University China Department of Surgery Yixing People’sHospitalYixing 214200Jiangsu ProvinceChina Department of General Surgery Institute of Cancer ResearchYangzhong People’s HospitalYangzhong 212200Jiangsu ProvinceChina

AIM:To explore the association between mothers against decapentaplegic homolog 4 (SMAD4) gene polymorphisms and gastric cancer ***:Five tagging single nucleotide polymor-phisms (tSNPs) in the SMAD4 gene were selected and genotyped in 322 gastric cancer cases and 351 cancerfree controls in a Chinese population by using the polymerase chain reactionrestriction fragment length polymorphism *** was used to examine SMAD4 protein expression in 10 normal gastric tissues adjacent to ***:In the single-locus analysis,two significantly decreased risk polymorphisms for gastric cancer were observed:the SNP3 rs17663887 TC genotype (adjusted odds ratio=0.38,95% confidence interval:0.21-0.71),compared with the wild-type TT genotype and the SNP5 rs12456284 GG genotype (0.31,0.16-0.60),and with the wild-type AA *** the combined analyses of these two tSNPs,the combined genotypes with 2-3 protective alleles (SNP3 C and SNP5 G allele) had a significantly decreased risk of gastric cancer (0.28,0.16-0.49) than those with 0-1 protective ***,individuals with 0-1 protective allele had significantly decreased SMAD4 protein expression levels in the norma tissues adjacent to tumors than those with 2-3 protective alleles (P=0.025).CONCLUSION:These results suggest that genetic variants in the SMAD4 gene play a protective role in gastric cancer in a Chinese population.

关键词： Mothers against decapentaplegic homolog 4 Genetic variation Gastric tumor Molecular epidemiology

The pivotal role of microglia in injury and the prognosis of subarachnoid hemorrhage

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Neural Regeneration Research 2025年第7期20卷 1829-1848页

作者： Wenjing Ning shi Lv Qian wang Yuzhen Xu Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina Department of Central Laboratory The Affiliated Taian City Central Hospital of Qingdao UniversityTaianShandong ProvinceChina

Subarachnoid hemorrhage leads to a series of pathological changes,including vascular spasm,cellular apoptosis,blood–brain barrier damage,cerebral edema,and white matter ***,which are the key immune cells in the central nervous system,maintain homeostasis in the neural environment,support neurons,mediate apoptosis,participate in immune regulation,and have neuroprotective *** evidence has shown that microglia play a pivotal role in the pathogenesis of subarachnoid hemorrhage and affect the process of injury and the prognosis of subarachnoid ***,microglia play certain neuroprotective roles in the recovery phase of subarachnoid *** approaches aimed at modulating microglia function are believed to attenuate subarachnoid hemorrhage *** provides new targets and ideas for the treatment of subarachnoid ***,an in-depth and comprehensive summary of the role of microglia after subarachnoid hemorrhage is still *** review describes the activation of microglia after subarachnoid hemorrhage and their roles in the pathological processes of vasospasm,neuroinflammation,neuronal apoptosis,blood–brain barrier disruption,cerebral edema,and cerebral white matter *** also discusses the neuroprotective roles of microglia during recovery from subarachnoid hemorrhage and therapeutic advances aimed at modulating microglial function after subarachnoid ***,microglia in subarachnoid hemorrhage are targeted with TLR inhibitors,nuclear factor-κB and STAT3 pathway inhibitors,glycine/tyrosine kinases,NLRP3 signaling pathway inhibitors,Gasdermin D inhibitors,vincristine receptorαreceptor agonists,ferroptosis inhibitors,genetic modification techniques,stem cell therapies,and traditional Chinese ***,most of these are still being evaluated at the laboratory *** clinical studies and data on subarachnoid hemorrhage are required to improve the treatment of subarachnoid hemor

关键词： apoptosis blood–brain barrier brain edema microglia neuroinflammation neuron neuroprotection subarachnoid hemorrhage vasoconstriction white matter injury

Effect of pyrite content on chalcopyrite flotation under different regrinding conditions

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 49-57页

作者： Zejun wang Qing shi Guofan Zhang Yuxuan Zhu Binbin Li School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China Key Laboratory of Hunan Province for Clean and Efficient Utilization of Strategic Calcium-containing Mineral Resources Central South UniversityChangsha 410083China

This study aimed to investigate the effect of varying pyrite(Py)content on copper(Cu)in the presence of different regrinding conditions,which were altered using different types of grinding media:iron,ceramic balls,and their mixture,followed by flotation in the cleaner *** flotation performance of rough Cu concentrate can be improved by changing the regrinding conditions based on the Py *** electron microscopy,X-ray spectrometry,ethylenediaminetetraacetic acid disodium salt extraction,and X-ray photoelectron spectroscopy studies illustrated that when the Py content was high,the use of iron media in regrinding promoted the generation of hydrophilic Fe OOH on the surface of Py and improved the Cu *** ceramic medium with a low Py content prevented excessive Fe OOH from covering the surface of chalcopyrite(Cpy).Electrochemical studies further showed that the galvanic corrosion current of Cpy-Py increased with the addition of Py and became stronger with the participation of iron media.

关键词： chalcopyrite regrinding media pyrite galvanic corrosion flotation

金融摩擦与新兴经济体特征对中国货币政策传导的影响

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当代财经 2017年第7期 58-70页

作者：陈师郑直王颖西南财经大学经济学院四川成都611130 西南财经大学经济与管理研究院四川成都611130

通过建立一个具备货币替代、金融加述器和负债美元化的中型开放经济动态随机一般均衡模型,利用中国宏观季度数据进行贝叶斯估计,结果表明:中国的货币政策及汇率制度可由一个有管理的浮动汇率制形式的货币政策规则加以经验描述,货币政策... 详细信息

通过建立一个具备货币替代、金融加述器和负债美元化的中型开放经济动态随机一般均衡模型,利用中国宏观季度数据进行贝叶斯估计,结果表明:中国的货币政策及汇率制度可由一个有管理的浮动汇率制形式的货币政策规则加以经验描述,货币政策的传导受到金融摩擦和新兴市场经济体特征因素的影响;并且,金融摩擦和新兴市场经济体特征会造成更为积极的货币政策干预,弱化货币政策在稳定经济方面的表现,并带来更大的福利损失。因此,应该探索一系列更为灵活的外汇政策,加快汇率市场化改革,逐步开放国内金融市场。

关键词：金融加速器货币替代负债美元化最优货币政策

Experimental study on bioeffects of canine myocardium by microbubble destruction via diversity of ultrasonic intension

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Experimental study on bioeffects of canine myocardium by mic...