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Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss

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Neural Regeneration Research 2025年第10期20卷 3025-3039页

作者： Jia Fang Zhuangzhuang li Pengjun Wang Xiaoxu Zhang Song Mao Yini li Dongzhen Yu Xiaoyan li Yazhi Xing Haibo shi Shankai Yin Department of Otolaryngology Head and Neck Surgery Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineOtolaryngology Institute of Shanghai Jiao Tong UniversityShanghai Key Laboratory of Sleep Disordered BreathingShanghaiChina Department of Otorhinolaryngology-Head and Neck Surgery Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial ***,their use leads to irreversible hearing damage by causing apoptosis of hair cells as their direct *** addition,the hearing damage caused by aminoglycosides involves damage of spiral ganglion neurons upon *** investigate the mechanisms underlying spiral ganglion neuron degeneration induced by aminoglycosides,we used a C57BL/6J mouse model treated with *** found that the mice exhibited auditory deficits following the acute loss of outer hair *** ganglion neurons displayed hallmarks of pyroptosis and exhibited progressive degeneration over *** profiling of these neurons showed significant upregulation of genes associated with inflammation and immune response,particularly those related to the NLRP3 *** of the canonical pyroptotic pathway in spiral ganglion neurons was observed,accompanied by infiltration of macrophages and the release of proinflammatory *** intervention targeting NLRP3 using Mcc950 and genetic intervention using NLRP3 knockout ameliorated spiral ganglion neuron degeneration in the injury *** findings suggest that NLRP3 inflammasome-mediated pyroptosis plays a role in aminoglycoside-induced spiral ganglion neuron *** of this pathway may offer a potential therapeutic strategy for treating sensorineural hearing loss by reducing spiral ganglion neuron degeneration.

关键词： degeneration hearing loss macrophages Mcc950 neuroinflammation NLRP3 inflammasome ototoxicity pyroptosis sensorineural hearing loss spiral ganglion neuron

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New Functions of an Old Protein:the Maintenance Role of Vav1 in T Cells

New Functions of an Old Protein:the Maintenance Role of Vav1...

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2008年全国生物化学与分子生物学学术大会

作者： Jie Yin lin-lin Sun Ying-chi Zhang shi-yang li you-jia Cao (Department of Biochemistry and Molecular Biology,College of life Sciences,Nankai University,Tianjin,300071 P.R.China)

Vav1 is a guanine nucleotide exchange factor(GEF)which is expressed in hematopoietic cells and plays important roles in T cell development and ***1 consists of multiple structural domains so as to

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锰基正极材料容量衰减机理及抑制方法研究进展

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现代化工 2017年第10期37卷 29-33页

作者：耿彤彤张飞龙唐凤娟王鹏李世友李春雷兰州理工大学石油化工学院甘肃兰州730050

从锰溶解、相变、界面膜的形成等方面综述了锰基正极材料容量衰减机理研究进展,总结了引入添加剂、改变黏结剂含量等抑制容量衰减的方法,并对今后锰基正极材料容量衰减机理的研究工作进行了展望。

关键词：锰基正极材料容量衰减锰溶解界面抑制

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具备高效析氢催化效率的三维多孔氮化钒八面体催化剂（英文）

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电化学 2019年第5期25卷 579-588页

作者：尹灿付威威方玲游时利张慧娟王煜重庆大学输配电装备及系统安全与新技术国家重点实验室重庆大学化学化工学院

随着中国经济和社会的快速发展,能源需求和环境污染问题也日益渐长.发展和开发高效清洁的新能源燃料可以有效地缓解能源危机和环境污染.如今,研发高效、环境友好和低成本的催化剂仍是析氢反应的研究重点.在此项研究中,作者首先通过煅烧... 详细信息

随着中国经济和社会的快速发展,能源需求和环境污染问题也日益渐长.发展和开发高效清洁的新能源燃料可以有效地缓解能源危机和环境污染.如今,研发高效、环境友好和低成本的催化剂仍是析氢反应的研究重点.在此项研究中,作者首先通过煅烧处理方式制备了一种三维多孔的氮化钒八面体结构型的催化剂.该催化剂具备高效的析氢效率,包括较低的过电位94.0 mV(在-10 mA·cm-2时),塔菲尔斜率为54.6 mV·dec-1,以及在酸性条件80小时展现出的优良稳定性,该氮化钒的析氢催化效率优于许多报道过的氮化物,其优良的催化效率可以归因于它独一无二的自身性质和大量的活性位点.

关键词：氮化物(氮化钒) 多孔催化剂活性位点析氢反应

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Comparison Between Two Solutions Based on the Relationship of Load-deflection Character of a Large Deflection Rubber Circular Plate

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Journal of Shanghai Jiaotong university(Science) 2003年第1期8卷 67-70页

作者：段浩胡宗武杨赪石黎佑铭 School of Mechanical and Power Eng. Shanghai Jiaotong Univ.

The rubber circular plate is considered as a kind of membrane. Based on the character that there exists no bending moment inside a membrane, the geometric behavior of the rubber circular plate in expanding state was described with the aid of a group of mathematic method. The relationship between deflection and load was attained by means of calculating stress and strain inside the curved surface of rubber plate. Meantime, based on Hencky method, the relationship between deflection and load was attained and considered as the Hencky solution. The different results given rise by the two different resolving methods were compared. The deviation results from the Hencky method was discussed, and a kind of correcting method was put forward.

关键词： rubber circular plate large deflection load geometric character immediate numerical solution Hencky solution

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Single-cell omics: experimental workflow, data analyses and applications

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Science China life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan li Dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing Jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi liu Xiaohui Fan Chen li Chenfei Wang Tieliu shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of life Science Chinese Academy of Sciences Peking-Tsinghua Center for life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

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Low‑Temperature Oxidation Induced Phase Evolution with Gradient Magnetic Heterointerfaces for Superior Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第1期17卷 191-204页

作者： Zizhuang He lingzi shi Ran Sun lianfei Ding Mukun He Jiaming li Hua Guo Tiande Gao Panbo liu School of Chemistry and Chemical Engineering Northwestern Polytechnical UniversityXi’an 710129People’s Republic of China School of Marine Science and Technology Northwestern Polytechnical UniversityXi’an 710072People’s Republic of China

Gradient magnetic heterointerfaces have injected infinite vitality in optimizing impedance matching,adjusting dielectric/magnetic resonance and promoting electromagnetic(EM)wave absorption,but still exist a significant challenging in regulating local phase ***,accordion-shaped Co/Co_(3)O_(4)@N-doped carbon nanosheets(Co/Co_(3)O_(4)@NC)with gradient magnetic heterointerfaces have been fabricated via the cooperative high-temperature carbonization and lowtemperature oxidation *** results indicate that the surface epitaxial growth of crystal Co_(3)O_(4) domains on local Co nanoparticles realizes the adjustment of magnetic-heteroatomic components,which are beneficial for optimizing impedance matching and interfacial ***,gradient magnetic heterointerfaces simultaneously realize magnetic coupling,and long-range magnetic ***,the synthesized Co/Co_(3)O_(4)@NC absorbents display the strong electromagnetic wave attenuation capability of−53.5 dB at a thickness of 3.0 mm with an effective absorption bandwidth of 5.36 GHz,both are superior to those of single magnetic domains embedded in carbon *** design concept provides us an inspiration in optimizing interfacial polarization,regulating magnetic coupling and promoting electromagnetic wave absorption.

关键词： Magnetic heterointerfaces Phase evolution Interfacial polarization Magnetic coupling Electromagnetic wave absorption

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若干镍(Ⅱ)、铜(Ⅱ)的平面型配合物对丙烯氧化反应的催化作用

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无机化学学报 1987年第1期 104-108页

作者：施舒游效曾李培李大光南京大学配位化学研究所江西大学化学系进修教师

本文报道若干平面四方多酮配合物对丙烯氧化反应的催化作用。指出Ni(Ⅱ)平面四方配合物可以利用其轴向的配位空穴活化烯键。

关键词：催化丙烯丙酮气相色谱

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Hierarchical hollow microspheres assembled from carbon nanosheets integrated with molybdenum carbide nanoparticles for boosting microwave absorption properties

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Nano Research 2025年第1期18卷 10-20页

作者： Zongsheng Chen Yahui Wang Yi liu Zhigang li Xiangyin Lv liping liu Yajing Chang Jiaming shi Xiao Zhang State Key Laboratory of Pulsed Power Laser Technology School of Electronic EngineeringNational University of Defense TechnologyHefei 230037China Anhui Provincial Laboratory of Advanced Laser Technology School of Electronic EngineeringNational University of Defense TechnologyHefei 230037China Centre for Environmental and Energy Nanomaterials Anhui Key Laboratory of Nanomaterials and NanotechnologyCAS Centre for Excellence in NanoscienceInstitute of Solid State PhysicsHefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China

Hierarchical hollow structure has demonstrated potential for enhancing electromagnetic(EM)attenuation and improving impedance matching,garnering significant attention for ***,we have successfully implemented compositional and structural engineering to fabricate hollow Mo2C/C microspheres with controllable composition by coupling interaction between dopamine hydrochloride and ammonium *** the synergistic effect of composition and hollow structure,the strongest reflection loss intensity and broadest effective absorption of the optimized sample reach-70.2 dB and 6.2 GHz,*** formation of hollow heterogeneous structures not only favors impedance matching feature,but also generates considerable contribution to EM attenuation ***,radar cross-section simulation data indicate that hollow Mo2C/C microspheres with compositional optimization and heterogeneous structures have broad prospects for practical applications.

关键词： electromagnetic absorption Mo2C/C microwave absorption hollow structure

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氟性关节病的临床影像学研究

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国外医学（医学地理分册） 2003年第2期24卷 94-96页

作者：刘军富昭李维如史有利西安交通大学第一医院影像中心陕西西安710061 西安交通大学外语部陕西西安710061 子长县医院陕西子长717300

目的　探讨氟中毒性关节病的临床和影像学表现及其机理。　方法　报告氟中毒性关节病 1 8例 ,对其临床表现、X线片及磁共振检查进行分析。　结果　 1 8例患者有不同程度的氟骨症。临床主要症状为脊柱、四肢关节及其周围的肌肉疼痛 ,以... 详细信息

目的　探讨氟中毒性关节病的临床和影像学表现及其机理。　方法　报告氟中毒性关节病 1 8例 ,对其临床表现、X线片及磁共振检查进行分析。　结果　 1 8例患者有不同程度的氟骨症。临床主要症状为脊柱、四肢关节及其周围的肌肉疼痛 ,以腰腿痛明显 ,关节活动受限、功能障碍甚至关节强直 ,可有关节的畸形及脊柱的弯曲。氟中毒性关节病的主要影像学表现为 ,滑膜增厚 ,关节囊肿胀 ,关节腔积液 ,关节间隙增宽 ,关节软骨钙化 ,进而关节间隙变窄 ,骨性关节面侵蚀破坏、模糊不清或关节硬化 ,关节腔内游离体 ,关节边缘骨质增生 ,周围韧带钙化 ,关节囊钙化 ,甚至关节间隙模糊不清。

关键词：氟中毒性关节病临床表现病理学影像学检查

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