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Development of small molecule drugs targeting immune checkpoints

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Cancer Biology & Medicine 2024年第5期21卷 382-399页

作者： Luoyi Chen Xinchen zhao Xiaowei Liu Yujie Ouyang Chuan Xu ying shi Department of Oncology Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610054China Institute for Breast Health Medicine State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Acupuncture and Massage College Chengdu University of Traditional Chinese MedicineChengdu 611137China

Immune checkpoint inhibitors(ICIs)are used to relieve and refuel anti-tumor immunity by blocking the interaction,transcription,and translation of co-inhibitory immune checkpoints or degrading co-inhibitory immune *** of small molecule drugs or biological materials,especially antibody-based ICIs,are actively being studied and antibodies are currently widely ***,such as anti-tumor efficacy,poor membrane permeability,and unneglected tolerance issues of antibody-based ICIs,remain evident but are thought to be overcome by small molecule *** structural studies have broadened the scope of candidate immune checkpoint molecules,as well as innovative chemical *** way of comparison,small molecule drug-based ICIs represent superior oral bioavailability and favorable pharmacokinetic *** ongoing clinical trials are exploring the synergetic effect of ICIs and other therapeutic strategies based on multiple ICI functions,including immune regulation,anti-angiogenesis,and cell cycle *** this review we summarized the current progression of small molecule ICIs and the mechanism underlying immune checkpoint proteins,which will lay the foundation for further exploration.

关键词： Immune checkpoints small molecule drugs programmed death protein 1 CD47 signal-regulatory proteinα

Visual and portable detection of metronidazole realized by metal-organic framework flexible sensor and smartphone scanning

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Chinese Chemical Letters 2024年第10期35卷 526-530页

作者： Xiangshuai Li Jian zhao Li Luo Zhuohao Jiao ying shi Shengli Hou Bin zhao Department of Chemistry Key Laboratory of Advanced Energy Materials Chemistry Renewable Energy Conversion and Storage Center (RECAST) Nankai University

Metronidazole （MNZ） is a type of antibiotic that can help people and animals cure bacterial in fections,however,abuse of MNZ has posed a threat to human ***,portable and vi sual detection of MNZ is meaningful for food safety and rational administration of drugs,bu full of ***,a porous three-dimensional Tb-based metal-organic framework (MOF{（CH3）2NH2·[Tb5（TDA）8（H2O）2]·6DMF·2C2H5OH}_n（TDA-Tb） with good solvent and p H stabilities was pre pared,and the framework possesses one-dimensional channels with a diameter of 12 A along the c-axis Experiment results suggest that the synthesized TDA-Tb can selectively and sensitively detect MNZ in water,and the limit of detection （LOD） is as low as 4.1×10-7mol/***,a flexible sensor TDA Tb-M was also constructed by incorporating TDA-Tb into membrane materials for convenient *** the TDA-Tb-M firstly realized portable and visual detection of MNZ through smartphone scanning,which may inspire more probes with wide application ranges.

关键词： Antibiotic Lanthanide Luminescence Metal-organic framework Sensor

Effect of perioperative chemotherapy on resection of isolated pulmonary metastases from colorectal cancer:A single center experience

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3457-3470页

作者： zhao Gao Xuan Jin ying-Chao Wu shi-Jie Zhang shi-Kai Wu Xin Wang Department of Medical Oncology Peking University First HospitalBeijing 10000China Department of General Surgery Peking University First HospitalBeijing 10000China Department of Thoracic Surgery Peking University First HospitalBeijing 10000China

BACKGROUND Numerous studies have assessed surgical resection as a standard treatment option for patients with colorectal cancer(CRC)and resectable pulmonary metastases(PM).However,the role of perioperative chemotherapy after complete resection of isolated PM from patients with CRC patients remains *** hypothesize that perioperative chemotherapy does not provide significant survival benefits for patients undergoing resection of PM from *** To determine whether perioperative chemotherapy affects survival after radical resection of isolated PM from *** We retrospectively collected demographic,clinical,and pathologic data on patients who underwent radical surgery for isolated PM from *** survival(CSS)and disease-free survival were calculated using Kaplan-Meier ***-group differences were compared using the log-rank *** multivariate analysis,Cox regression was utilized when *** This study included 120 patients with a median age of 61.6 *** 5-year CSS rate was 78.2%,with 36.7% experiencing *** resection for isolated PM resulted in a 5-year CSS rate of 50.0% for second *** chemotherapy(P=0.079)did not enhance survival *** associated with improved survival included fewer metastatic lesions[hazard ratio(HR):2.51,P=0.045],longer disease-free intervals(HR:0.35,P=0.016),and wedge lung resections(HR:0.42,P=0.035).Multiple PM predicted higher recurrence risk(HR:2.22,P=0.022).The log-rank test showed no significant difference in CSS between single and repeated metastasectomy(P=0.92).CONCLUSION Perioperative chemotherapy shows no survival benefit post-PM resection in ***-free intervals and fewer metastatic lesions predict better *** metastasectomy is warranted for eligible patients.

关键词： Pulmonary metastasis Colorectal cancer Perioperative chemotherapy Survival Repeated pulmonary metastasectomy

General Mean-Field BDSDEs with Continuous and Stochastic Linear Growth Coefficients

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Journal of Systems Science & Complexity 2024年第5期37卷 1887-1906页

作者： WANG Jinghan shi Yufeng zhao Nana Institute for Financial Studies Shandong University Zhiyuan School of Liberal Arts Beijing Institute of Petrochemical Technology

In this paper, the authors study a class of general mean-field BDSDEs whose coefficients satisfy some stochastic conditions. Specifically, the authors prove the existence and uniqueness theorem of solution under stochastic Lipschitz condition and obtain the related comparison theorem. Besides,the authors further relax the conditions and deduce the existence theorem of solutions under stochastic linear growth and continuous conditions, and the authors also prove the associated comparison ***, an asset pricing problem is discussed, which demonstrates the application of the general mean-field BDSDEs in finance.

关键词： Backward doubly stochastic differential equations comparison theorem mean-field stochastic conditions Wasserstein metric

The effects of in ovo feeding of selenized glucose on liver selenium concentration and antioxidant capacity in neonatal broilers

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Chinese Chemical Letters 2024年第6期35卷 312-315页

作者： Jiahui Li Qiao shi ying Xue Mingde Zheng Long Liu Tuoyu Geng Daoqing Gong Minmeng zhao Jiangsu Key Laboratory of Animal genetic Breeding and Molecular Design College of Animal Science and TechnologyYangzhou UniversityYangzhou 225009China Joint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China Yangzhou UniversityYangzhou 225009China

Selenium is an essential trace element for humans and *** the active center of selenoproteins,the addition of selenium is beneficial to enhance the antioxidant ***,the high cost limits the application of organic Se in agriculture animal *** glucose(SeGlu)is a newly invented organoselenium material with good stability,low toxicity and low *** assay found that SeGlu was able to increase selenium deposition in liver of newborn broilers,and enhance the antioxidant capacity of liver by elevating the activities of antioxidant enzymes such as total superoxide dismutase and glutathione *** paper as the first example clarifying the mechanism of SeGlu to enhance the antioxidant ability of chicks,shows that SeGlu can be used as an organic selenium enrichment additive for early nutrition of *** a cross-discipline study involving chemistry,biology and agriculture animal science,the work may be beneficial for studies in related fields and prompt the development of the selenium science.

关键词： Selenized glucose In ovo feeding Antioxidant capacity Selenium Broiler

Role of texture before rolling: a research based on texture and magnetic properties of 4.5 wt.% Si non-oriented electrical steel

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Journal of Iron and Steel Research International 2024年第8期31卷 1973-1986页

作者： Yu-fan Wang Guo-qing Zu shi-cheng Sun ying Han Wei-wei Zhu Hui Wu Yu zhao Xu Ran Key Laboratory of Advanced Structural Materials of Ministry of Education Changchun University of TechnologyChangchun 130012JilinChina CRRC Changchun Railway Vehicles Co. Ltd.Changchun 130000JilinChina School of Metallurgy Northeastern UniversityShenyang 110819LiaoningChina School of Mechanical MaterialsMechatronic and Biomedical EngineeringUniversity of WollongongWollongongNSW 2522Australia

The evolution of microstructure,texture,and magnetic properties with random texture,near-copper texture,weak near-cube texture,and strong λ fiber(/ND(normal direction))before rolling of non-oriented electrical steel was *** recrystallized hot bands with different textures but similar grain sizes were prepared by pre-annealing at low-temperature and high-temperature normalization *** was observed that the final annealed products exhibited similar recrystallized *** contrast,the final annealed product with more 2 fiber before rolling exhibited a stronger cube *** the fiber before rolling becoming stronger,the proportion of(111)deformed matrices became larger,which could be observed in the early recrystallization *** overwhelmingly dominant 2 orientation nuclei are formed in the(111)deformed matrix and become the dominant ***,the best magnetic properties are obtained in the products with strong 2 fiber before rolling,corresponding to the strong cube texture and low anisotropyparameter.

关键词： Texture before rolling Non-oriented electrical steel-Nucleation Grain growth Magnetic property

Well-dispersed Sb particles embedded on N-doped carbon nanofibers toward high-performance Li-ion battery

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Rare Metals 2024年第7期43卷 2994-3006页

作者： ying Li Yi-Han zhao Lu-Lu zhao Peng-Fei Wang ying Xie Ting-Feng Yi School of Materials Science and Engineering Northeastern UniversityShenyang 110819China Key Laboratory of Dielectric and Electrolyte Functional Material Hebei Province School of Resources and MaterialsNortheastern University at QinhuangdaoQinhuangdao 066004China Key Laboratory of Functional Inorganic Material Chemistry Ministry of EducationSchool of Chemistry and Materials ScienceHeilongjiang UniversityHarbin 150080China

The alloy-type material Sb is widely used in the anode materials of lithium-ion batteries(LIBs)due to its high theoretical specific ***,its serious volume expansion problem during alloying/dealloying of Li~+limits its practical *** this work,C-Sb composite was constructed as anode material of LIBs by electrospinning route for the first time,Sb was introduced into the polyacrylonitrile-based hard carbon and coal tar pitch-based soft carbon composite amorphous carbon fiber with a diameter of 300-600 nm,which realized high cycling *** C-Sb-2(the mass ratio of polyacrylonitrile to Sb source is 1:2)electrode displayed charge capacities of 1098.5,930.3,841.7,753.5,643.9 and 545.8 mAh·g^(-1)at 0.1,0.2,0.3,0.5,1 and 2 A·g^(-1),*** when the current density returned to 0.1 A·g^(-1),the charge capacity was 939.3 mAh·g^(-1),revealing good stability and *** introduction of Sb into the amorphous carbon improved its conductivity and addressed the volume expansion issue of high specific capacity Sb during charge/***-situ XRD analysis confirmed the high reversibility of the C-Sb-2 during charging and *** functional theory(DFT)calculations revealed the gradual enhancement of the interface interaction between Sb_(x)Li_(y) and amorphous carbon(AMC)with increasing lithium content,contributing to the anchoring of alloy nanoparticles on the AMC surface and buffering the volume change of the ***,the gradual lithiation of Sb facilitated the electron transfer from Sb_(x)Li_(y) to *** findings hold promise for designing lithium storage materials with exceptional performance,highlighting the potential of C-Sb composites as anode materials for efficient next-generation lithium storage.

关键词： Li-ion battery Metallic Sb Carbon Electrospinning Cycling stability

Study on Catalytic Behavior of Iron-based Catalyst with IITP as Electron Donor in the Polymerization of Butadiene

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Chinese Journal of Polymer Science 2024年第5期42卷 612-619,I0007页

作者： shi-Liang Xu ying-Nan zhao Yao Yu Qi Yang Li-Hua Na Heng Liu Chun-Yu Zhang Xue-Quan Zhang Key Laboratory of Advanced Rubber Material Ministry of EducationSchool of Polymer Science and EngineeringQingdao University of Science&TechnologyQingdao266042China Shandong Provincial College Laboratory of Rubber Material and Engineering School of Polymer Science and EngineeringQingdao University of Science&TechnologyQingdao266042China Key Lab of Rubber-Plastics Ministry of Education/Shandong Provincial Key Lab of Rubber-plasticsSchool of Polymer Science and EngineeringQingdao University of Science&TechnologyQingdao266042China

In this study,a novel iron-based catalyst system,Fe(acac)3/(isocyanoimino)triptenylphosphorane(IITP)/AlR3,was employed for the synthesis of syndiotactic 1,2-polybutadiene in *** catalyst system exhibits remarkably high catalytic activity,achieving a polymerization activity of 762 kgpolymer·molcatalyst^(-1)·h^(-1)at 50℃with a[BD]/[Fe]molar ratio of ***,living polymerization characteristic were observed during the investigation of the polymerization kinetics of 1,3-butadiene *** characteristics were well demonstrated by a narrow molecular weight distribution(PDI≈2.0)of the resulting polybutadiene and a linear relationship between-ln(1-c)and polymerization time as well as number average molecular weight and polymer *** resultant polymer showed a 1,2-selectivity of approximately 76%and stereoregularity ranging from 62%to 73%(rrrr).Additionally,through kinetic studies on polymerization reaction,an apparent activation energy Ea value of this catalytic system was calculated to be 84.98 kJ·mol^(-1),which suggests that high polymerization temperature favors efficient polymerization.

关键词： Iron catalyst Syndiotactic 1,2-polybutadiene Elastomers Donor Selectivity

Three-dimensional limit variation analysis on the ultimate pullout capacity of the anchor cables based on the Hoek-Brown failure criterion

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Journal of Mountain Science 2024年第3期21卷 1036-1047页

作者： ZUO shi zhao Lianheng HU shihong College of Civil Engineering Changsha UniversityChangsha 410022China Hunan Provincial Key Laboratory for Disaster Prevention and Mitigation of Rail Transit Engineering Structure Key Laboratory of Heavy-Haul Railway Engineering StructureMinistry of EducationCentral South UniversityChangsha 410075China College of Civil Engineering Central South UniversityChangsha 410075China

Only simplified two-dimensional model and a single failure mode are adopted to calculate the ultimate pullout capacity(UPC)of anchor cables in most previous *** study focuses on a more comprehensive combination failure mode that consists of bond failure of an anchorage body and failure of an anchored rock *** three-dimensional ultimate pullout capacity of the anchor cables is calculated based on the Hoek-Brown failure criterion and variation analysis *** numerical solution for the curvilinear function in fracture plane is obtained based on the finite difference theory,which more accurately reflects the failure state of the anchor cable,as opposed to that being assumed in *** results reveal that relying solely on a single failure mode for UPC calculations has limitations,as changes in parameter values not only directly impact the UPC value but also can alter the failure model and thus the calculation method.

关键词： Anchor cable Ultimate pullout capacity(UPC) Failure model Variation analysis Hoek-Brown failure criterion