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Identifying the dynamic behaviors in complete reconstruction of Co-based complex precatalysts during electrocatalytic oxygen evolution

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Journal of Energy Chemistry 2025年第1期100卷 226-233页

作者： Jingfang Zhang Danyang Wu Linke Cai Youluan lu Fanpeng Cheng Lijuan shi Qun Yi Yao Liu Yi Huang Key Laboratory of Green Chemical Engineering Process of Ministry of Education Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of Education Hubei Key Laboratory of Novel Reactor and Green Chemical Technology School of Chemical Engineering & Pharmacy Wuhan Institute of Technology Key Laboratory of Pesticide & Chemical Biology of Ministry of Education Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction of Ministry of Education College of Chemistry Central China Normal University College of Materials Science and Engineering Fuzhou University

Transition metal-based nanomaterials have emerged as promising electrocatalysts for oxygen evolution reaction（OER）. Considerable research efforts have shown that self-reconstruction occurs on these nanomaterials under operating conditions of OER process. However, most of them undergo incomplete reconstruction with limited thickness of reconstruction layer, leading to low component utilization and arduous exploration of real catalytic mechanism. Herein, we identify the dynamic behaviors in complete reconstruction of Co-based complexes during OER. The hollow phytic acid（PA） cross-linked CoFe-based complex nanoboxes with porous nanowalls are designed because of their good electrolyte penetration and mass transport ability, in favor of the fast and complete reconstruction. A series of experiment characterizations demonstrate that the reconstruction process includes the fast substitution of PA by OH-to form Co（Fe）(OH)xand subsequent potential-driven oxidation to Co（Fe）OOH. The obtained CoFeOOH delivers a low overpotential of 290 mV at a current density of 10 mA cm-2and a long-term *** experiment results together with theory calculations reveal that the Fe incorporation can result in the electron rearrangement of reconstructed CoFeOOH and optimization of their electronic structure,accounting for the enhanced OER activity. The work provides new insights into complete reconstruction of metal-based complexes during OER and offers guidelines for rational design of high-performance electrocatalysts.

关键词： Complete reconstruction Co-based complex Precatalysts Oxygen evolution reaction

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高职院校学生工匠精神培育的现状与对策

职业技术教育 2017年第34期38卷 27-31页

作者：张宏涂玮石莉陆英昆山开放大学南京师范大学南京晓庄学院旅游与社会管理学院

培育高职院校学生工匠精神是提升学生职业素养、服务地方经济建设的有效途径。通过对高职院校学生、高职院校教师、用人合作企业三方分别开展问卷调查,了解学生对工匠精神内涵的掌握情况、工匠精神促进学生职业生涯发展的作用、高职院... 详细信息

培育高职院校学生工匠精神是提升学生职业素养、服务地方经济建设的有效途径。通过对高职院校学生、高职院校教师、用人合作企业三方分别开展问卷调查,了解学生对工匠精神内涵的掌握情况、工匠精神促进学生职业生涯发展的作用、高职院校学生接受工匠精神培育后发生的变化、高职院校学生工匠精神培育工作面临的主要问题,并针对问题提出以下对策:积极宣传工匠精神,增加学生对工匠精神内涵的深入了解;培育学生工匠精神,促进学生职业生涯规划与发展;制定相应的激励考核机制,提高学生工匠精神培育效果;采取相应措施解决高职院校学生工匠精神培育工作中存在的主要困难。

关键词：高职院校学生工匠精神培育职业生涯发展

Storage time affects the level and diagnostic efficacy of plasma biomarkers for neurodegenerative diseases

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Neural Regeneration Research 2025年第8期20卷 2373-2381页

作者： Lifang Zhao Mingkai Zhang Qimeng Li Xuemin Wang Jie lu ying Han Yanning Cai Department of Clinical Biobank Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Geriatric Medical Research Center BeijingChina Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Radiology and Nuclear Medicine Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics BeijingChina Key Laboratory of Neurodegenerative diseases Ministry of EducationBeijingChina School of Biomedical Engineering Hainan UniversityHaikouHainan ProvinceChina Center of Alzheimer’s Disease Beijing Institute for Brain DisordersBeijingChina National Clinical Research Center for Geriatric Diseases BeijingChina Institute of Biomedical Engineering Shenzhen Bay LaboratoryGaoke Innovation CenterShenzhenGuangdong ProvinceChina Department of Neurobiology Xuanwu HospitalCapital Medical UniversityBeijingChina

Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative ***,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°*** aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large *** samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on Cognitive Decline *** samples were stored at-80°C for up to 6 years before being used in this *** results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage ***,the level of total tau showed a negative correlation with sample storage ***,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage *** was not observed in individuals with cognitive ***,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage ***,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's ***,in cohort studies,it is important to consider the impact of storage time on the overall results.

关键词： Alzheimer’s disease amyloid-β diagnostic ability glial fibrillary acidic protein neurodegeneration neurofilament light chain plasma biomarkers single molecule array storage time tau

High Fe‑Loading Single‑Atom Catalyst Boosts ROS Production by Density Effect for Efficient Antibacterial Therapy

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Nano-Micro Letters 2025年第2期17卷 187-203页

作者： Si Chen Fang Huang Lijie Mao Zhimin Zhang Han Lin Qixin Yan Xiangyu lu Jianlin shi Department of Cardiology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200092People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China Shanghai Frontiers Science Center of Nanocatalytic Medicine School of MedicineTongji UniversityShanghai 200092People’s Republic of China

The current single-atom catalysts(SACs)for medicine still suffer from the limited active site ***,we develop a synthetic method capable of increasing both the metal loading and mass-specific activity of SACs by exchanging zinc with *** constructed iron SACs(h^(3)-FNC)with a high metal loading of 6.27 wt%and an optimized adjacent Fe distance of~4 A exhibit excellent oxidase-like catalytic performance without significant activity decay after being stored for six months and promising antibacterial ***,a“density effect”has been found at a high-enough metal doping amount,at which individual active sites become close enough to interact with each other and alter the electronic structure,resulting in significantly boosted intrinsic activity of single-atomic iron sites in h^(3)-FNCs by 2.3 times compared to low-and medium-loading ***,the overall catalytic activity of h^(3)-FNC is highly improved,with mass activity and metal mass-specific activity that are,respectively,66 and 315 times higher than those of commercial Pt/*** addition,h^(3)-FNCs demonstrate efficiently enhanced capability in catalyzing oxygen reduction into superoxide anion(O_(2)·^(−))and glutathione(GSH)*** in vitro and in vivo assays demonstrate the superior antibacterial efficacy of h^(3)-FNCs in promoting wound *** work presents an intriguing activity-enhancement effect in catalysts and exhibits impressive therapeutic efficacy in combating bacterial infections.

关键词： Nanocatalytic medicine Single-atom catalysts Reactive oxygen species(ROS) High metal loading Oxidase catalysis

低氧训练通过HIF-1α-miR-122-5p-SREBP-1c调节肥胖大鼠肝脏脂代谢的机制研究

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中国体育科技 2018年第3期54卷 60-67页

作者：荆文李传芬冯连世路瑛丽山东师范大学体育学院山东济南250014 济南军区总医院神经内科山东济南250031 国家体育总局体育科学研究所北京100061

目的:探讨低氧训练对肥胖大鼠肝脏中mi R-122-5p及其上下游调节因子在转录水平表达的影响,并在细胞中验证mi R-122-5p的表达对下游脂代谢相关基因的调节。方法:雄性SD大鼠经10周高脂饮食诱导建立肥胖大鼠模型,适应性训练后随机分为常氧... 详细信息

目的:探讨低氧训练对肥胖大鼠肝脏中mi R-122-5p及其上下游调节因子在转录水平表达的影响,并在细胞中验证mi R-122-5p的表达对下游脂代谢相关基因的调节。方法:雄性SD大鼠经10周高脂饮食诱导建立肥胖大鼠模型,适应性训练后随机分为常氧安静组(N组)和低氧训练组(H组)。4周后测量体重、体脂、血清脂类含量,利用实时荧光定量PCR检测肝脏中mi R-122-5p及上下游调节因子转录水平的相对表达。将大鼠正常肝细胞BRL-3A分为未转染组(C组)、过表达mi R-122-5p组(Up组)、抑制表达mi R-122-5p组(Down组)和空载体组(Nc组),慢病毒转染建立稳定转染细胞系,利用实时荧光定量PCR检测mi R-122-5p及下游脂代谢调节因子转录水平的相对表达。结果:与N组相比,H组大鼠体重、体脂显著降低(P<0.01),血清脂类含量显著改善(P<0.05或P<0.01),肝脏mi R-122-5p及C/EBPα、SREBP-1c、FASN、ACC1 m RNA的相对表达水平显著降低(P<0.05或P<0.01),HIF-1α、CPT1A m RNA的相对表达水平显著升高(P<0.05或P<0.01)。在BRL-3A细胞中过表达或抑制表达mi R-122-5p,导致SREBP-1c、FASN、ACC1 m RNA相对表达水平显著升高或降低(P<0.05或P<0.01),CPT1A m RNA的相对表达水平显著降低或升高(P<0.05或P<0.01)。结论:低氧训练可能通过HIF-1α-mi R-122-5p-SREBP-1c途径调节肥胖大鼠肝脏脂代谢,低氧训练诱导HIF-1α的表达升高,依次下调C/EBPα和mi R-122-5p的表达,进而通过升高SREBP-1c、FASN、ACC1和降低CPT1A的表达,抑制肝脏中脂肪酸的合成,促进脂肪酸的氧化,改善肝脏脂类的代谢。

关键词：低氧训练 miR-122-5p 肥胖肝脏脂代谢

Understanding the local structure and thermophysical behavior of Mg-La liquid alloys via machine learning potential

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 439-449页

作者： Jia Zhao Taixi Feng Guimin lu National Engineering Research Center for Integrated Utilization of Salt Lake Resource East China University of Science and TechnologyShanghai 200237China Joint International Laboratory for Potassium and Lithium Strategic Resources East China University of Science and TechnologyShanghai 200237China

The local structure and thermophysical behavior of Mg-La liquid alloys were in-depth understood using deep potential molecular dynamic(DPMD) simulation driven via machine learning to promote the development of Mg-La alloys. The robustness of the trained deep potential(DP) model was thoroughly evaluated through several aspects, including root-mean-square errors(RMSEs), energy and force data, and structural information comparison results;the results indicate the carefully trained DP model is reliable. The component and temperature dependence of the local structure in the Mg-La liquid alloy was analyzed. The effect of Mg content in the system on the first coordination shell of the atomic pairs is the same as that of temperature. The pre-peak demonstrated in the structure factor indicates the presence of a medium-range ordered structure in the Mg-La liquid alloy, which is particularly pronounced in the 80at% Mg system and disappears at elevated temperatures. The density, self-diffusion coefficient, and shear viscosity for the Mg-La liquid alloy were predicted via DPMD simulation, the evolution patterns with Mg content and temperature were subsequently discussed, and a database was established accordingly. Finally, the mixing enthalpy and elemental activity of the Mg-La liquid alloy at 1200 K were reliably evaluated,which provides new guidance for related studies.

关键词： magnesium-lanthanum liquid alloys local structure macroscopic properties thermodynamic behavior deep potential mo-lecular dynamic simulation

肾炎康复片联合西医常规治疗糖尿病肾病的药物经济学研究

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中国新药杂志 2017年第20期26卷 2491-2496页

作者：官海静韩晟王雅楠李成明郑丽英史录文北京大学药学院北京100191 北京大学中国卫生经济研究中心北京100871 北京大学医药管理国际研究中心北京100191 北京大学软件与微电子学院北京102600

目的:对肾炎康复片治疗糖尿病肾病的短期和长期经济性进行评价。方法:基于支付方角度,采用循证药物经济学评价方法,分析肾炎康复片联合西医常规治疗相比单用西医常规治疗的成本效果。在短期分析中,效果(血清肌酐、尿素氮、24 h蛋白尿定... 详细信息

目的:对肾炎康复片治疗糖尿病肾病的短期和长期经济性进行评价。方法:基于支付方角度,采用循证药物经济学评价方法,分析肾炎康复片联合西医常规治疗相比单用西医常规治疗的成本效果。在短期分析中,效果(血清肌酐、尿素氮、24 h蛋白尿定量)来源于现有的临床文献,成本数据基于药品中标价和DDD计算得到。在长期分析中,Markov模型参数来源于现有临床、经济学文献和离散事件仿真模拟,循环周期为1个月,模拟患者终身的直接医疗费用和质量调整生命年。采用单因素敏感性分析和概率敏感性分析评价结果的稳健性。结果:短期经济性分析显示,与西医常规治疗相比,肾炎康复片联合常规治疗的费用更高,效果更好,由于缺乏标准阈值,不能判断其经济性。长期经济性分析显示,肾炎康复片联合常规治疗组的终身费用为43.27万元,质量调整生命年为4.91 QALYs;常规治疗组的终身费用为41.22万元,质量调整生命年为4.44 QALYs。两组的增量成本-效用比为43 341元,小于2016年中国人均GDP 53 980元,说明肾炎康复片联合西医常规治疗具有经济性。敏感性分析表明了结果的稳健性。结论:从长期来看,与单纯西医常规治疗相比,肾炎康复片联合常规治疗组治疗糖尿病肾病具有经济性。

关键词：糖尿病肾病肾炎康复片药物经济学评价 Markov模型

负责任的社会科学数据治理的内涵、特征与层次

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现代情报 2025年第1期45卷 124-134页

作者：王英卢国强湖北大学历史文化学院湖北武汉430062 吉林大学商学与管理学院吉林长春130012

[目的/意义]“十四五”国家哲学社会科学发展规划的背景下,负责任的数据治理成为促进社会科学数据开放共享、推进社会科学研究与创新的重要驱动力,亟须探索负责任的社会科学数据治理的基础理论。[方法/过程]运用主题分析法,探寻负责任... 详细信息

[目的/意义]“十四五”国家哲学社会科学发展规划的背景下,负责任的数据治理成为促进社会科学数据开放共享、推进社会科学研究与创新的重要驱动力,亟须探索负责任的社会科学数据治理的基础理论。[方法/过程]运用主题分析法,探寻负责任的数据治理的概念要素及维度,按照国际标准ISO704:2009的概念关系,结合社会科学数据的特性,阐释负责任的社会科学数据治理的内涵及其与相关概念的关系、特征、层次与内容,旨在构建一个较为全面且系统的概念体系。[结果/结论]负责任的社会科学数据治理是多元主体在现有的数据治理环境之下,运用相应的治理机制和手段,将负责任的研究与创新的理念和原则融入社会科学数据全生命周期,以确保所有涉及社会科学数据的流程和成果的责任性的过程,具有责任性、反思性、前瞻性、开放性和工具性特征,可划分为战略层、数据层和活动层。

关键词：社会科学数据负责任的数据治理数据治理

Protein-based functional hydrogel improves cutaneous nerve repair and diabetic wound healing

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Nano Research 2025年第1期18卷 586-596页

作者： Hanzhi lu Mingrui Cui Yi Wang Xinran Du Xinyi Zhou Yuhan Fang Xiaoyan Gao ying Peng Jianyong Zhu Guang Yang Fulun Li Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine College of Biological Science and Medical EngineeringDonghua UniversityShanghai 201620China Clinical Laboratory Medicine Center Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China

Cutaneous nerve regeneration in diabetic wounds remains a challenge for current clinical ***,a natural protein-based functional hydrogel is developed using keratin as the sole matrix,and protocatechuic aldehyde(PA)and zinc ions as the building blocks through dual-dynamic crosslinking reactions of thiol-aldehyde addition and catecholzinc ions *** unique structural design endows the hydrogel with excellent injectability,skin adhesion,self-healing and antibacterial ability,and *** addition,this hydrogel acts as a drug carrier for the loading and sustained release of phellopterin(PP),a natural compound extracted from traditional Chinese medicine Angelica *** findings demonstrate that the PP-loaded hydrogel promotes cutaneous nerve regeneration,angiogenesis and tissue remodeling in the full-thickness wounds in both db/db and streptozotocin-induced C57BL/6 diabetic mice,notably by the synergistic effect of zinc ions and PP,showing a great potential in diabetic wound therapy.

关键词： functional hydrogel cutaneous nerve regeneration dynamic crosslinking diabetic wounds