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Unraveling colorectal cancer prevention:The vitamin D-gut flora-immune system nexus

World Journal of Gastrointestinal Oncology 2024年第6期16卷 2394-2403页

作者： Zhi-Song Zhan Zu-Shun Zheng Jing shi Juan Chen Si-Yi Wu shi-yan zhang Department of Dentistry Fuding HospitalFujian University of Traditional Chinese MedicineFuding 355200Fujian ProvinceChina Department of Physical Examination Fuding HospitalFujian University of Traditional Chinese MedicineFuding 355200Fujian ProvinceChina Department of Anesthesiology Fuding HospitalFujian University of Traditional Chinese MedicineFuding 355200Fujian ProvinceChina Department of Clinical Laboratory Fuding HospitalFujian University of Traditional Chinese MedicineFuding 355200Fujian ProvinceChina Department of Surgery Fuding HospitalFujian University of Traditional Chinese MedicineFuding 355200Fujian ProvinceChina

Colorectal cancer(CRC)is one of the most common cancers diagnosed in the *** environmental and genetic factors play a major role in the pathogenesis of CRC,extensive research has suggested that vitamin D may play a pivotal role in the development of *** D,primarily obtained through sunlight exposure,dietary sources,and supplements,has long been recognized for its essential functions in maintaining health,including immune *** article delves into the intricate relationship between vitamin D,the immune system,gut flora,and the prevention of *** presents a synthesis of epidemiological data,experimental studies,and clinical trials,highlighting the mechanisms by which vitamin D influences immune cell function,cytokine production,and *** enhancing the immune system’s surveillance and antitumor activity,vitamin D may offer a promising avenue for CRC ***,this comprehensive review delves into the prospective clinical applications of vitamin D supplementation and delineates the forthcoming avenues of research in this dynamic ***,the paper tentatively outlines a spectrum of prophylactic impacts of vitamin D on CRC,emphasizing its significant potential in reducing CRC risk through shedding light on its mechanisms,encompassing antineoplastic mechanisms,influences on the immune system,and modulation of the gut microbiome.

关键词： Colorectal cancer Vitamin D Immune system Gut flora Immunomodulation Microbial dysbiosis Cancer prevention

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Exploring predictive markers for liver failure post-hepatectomy in hepatocellular carcinoma patients

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1482-1484页

作者： shi-yan zhang Xiong-Jian Ma Xue-Xia Zhu Na Cai Department of Clinical Laboratory Fuding HospitalFujian University of Traditional Chinese MedicineFuding 355200Fujian ProvinceChina

This letter to the editor addresses the study titled“Predictive value of NLR,Fib4,and APRI in the occurrence of liver failure after hepatectomy in patients with hepatocellular carcinoma”by Kuang et al in the World Journal of Gastrointestinal *** study acknowledges the comprehensive patient data analysis while suggesting that there is a need for further discussion on the clinical applicability of these markers across diverse patient *** letter recommends prospective studies for validation and considers the influence of confounding *** finding underscores the significance of this study in improving hepatocellular carcinoma management.

关键词： Neutrophil-to-lymphocyte ratio Hepatocellular carcinoma Liver failure Hepatectomy Letter to the Editor Commentary

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Enhancing predictive accuracy in hypertriglyceridemia-induced acute pancreatitis:Role of red cell distribution width and prospective studies

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World Journal of Clinical Cases 2024年第20期12卷 4452-4454页

作者： shi-yan zhang Department of Clinical Laboratory Fuding HospitalFujian University of Traditional Chinese MedicineFuding 355200Fujian ProvinceChina

This letter addresses the study titled“Red cell distribution width:A predictor of the severity of hypertriglyceridemia-induced acute pancreatitis”by Lv et al published in the World Journal of Experimental *** study offers a valuable analysis of red cell distribution width(RDW)as a predictive marker for persistent organ failure in patients with hypertriglyceridemia-induced acute *** study results suggest that RDW,combined with the Bedside Index for Severity in Acute Pancreatitis score,could enhance the predictive accuracy for severe *** investigation into the role of RDW in different severities of acute pancreatitis is ***,the need for large-scale and multicenter prospective studies to validate these findings is emphasized.

关键词： Red cell distribution width Hypertriglyceridemia-induced acute pancreatitis Persistent organ failure Predictive marker Letter to the Editor Commentary

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Integrating disulfidptosis-related long noncoding RNAs in colorectal cancer prognosis:A path to precision medicine

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World Journal of Clinical Oncology 2024年第5期15卷 664-666页

作者： shi-yan zhang Department of Clinical Laboratory Fuding HospitalFujian University of Traditional Chinese MedicineFuding 355200Fujian ProvinceChina

This commentary explores the burgeoning field of disulfidptosis-related long noncoding RNAs(lncRNAs)in the prognosis and therapeutic targeting of colorectal cancer(CRC).By evaluating recent research,including the pivotal study"Predicting colorectal cancer prognosis based on long noncoding RNAs of disulfidptosis genes"by Wang et al,this analysis underscores the critical role of lncRNAs in deciphering the molecular complexities of *** the innovative methodologies and significant findings,I discuss the implications for patient survival,therapeutic response,and the potential of lncRNAs as biomarkers for precision *** integration of bioinformatics,clinical databases,and molecular biology in these studies offers a promising avenue for advancing CRC treatment strategies and improving patient outcomes.

关键词： Colorectal cancer Disulfidptosis Long noncoding RNAs Prognosis Precision medicine

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Combined gastroscopic and laparoscopic resection of gastric metastatic adenosquamous carcinoma from lung: A case report

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 3065-3073页

作者： Yin Lin Yi-Long Wu Dong-Dong Zou Xiao-Long Luo shi-yan zhang Department of Gastroenterology Fuding HospitalFujian University of Traditional Chinese MedicineFuding 355200Fujian ProvinceChina Department of Proctology Fuding HospitalFujian University of Traditional Chinese MedicineFuding 355200Fujian ProvinceChina Department of Clinical Laboratory Fuding HospitalFujian University of Traditional Chinese MedicineFuding 355200Fujian ProvinceChina

BACKGROUND Primary lung cancer is the leading cause of cancer-related death *** metastatic sites include the brain,liver,bones,and adrenal ***,gastric metastases from lung cancer are *** case may be the first report of a combined gastroscopic and laparoscopic resection for gastric metasta-tic adenosquamous carcinoma(ASC).CASE SUMMARY We report a case of gastric metastasis from lung *** patient was a 61-year-old Han Chinese female who first attended our hospital complaining of a per-sistent cough,leading to the diagnosis of advanced-stage lung *** more than four years of chemotherapy,the patient began to experience epi-gastric *** was performed,and pathological examination of biopsy specimens confirmed that the gastric lesion was a metastasis from lung *** lesion was successfully resected by combined gastroscopy and *** examination of the resected gastric specimen revealed *** Gastric metastases from lung cancer are ***,histological and immunohistochemical staining are useful for diagnosing metastatic *** management may provide extended survival in appropriately selected patients.

关键词： Primary lung cancer Gastric metastasis Endoscopic submucosal dissection Laparoscopic surgery Adenosquamous carcinoma Case report

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Geochronological and geochemical constraints on the petrogenesis and geodynamic process of Hemler,Vlinder,and Il'ichev seamount lavas in NW Pacific

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Science China Earth Sciences 2024年第6期67卷 1856-1871页

作者： Xun WEI yan zhang Xuefa shi Hui zhang Key Laboratory of Marine Geology and Metallogeny First Institute of OceanographyMinistry of Natural ResourcesQingdao 266061China Laboratory for Marine Geology Qingdao Marine Science and Technology CenterQingdao 266237China Shandong Key Laboratory of Deep Sea Mineral Resources Development(Preparatory) Qingdao 266061China

Oceanic intraplate volcanoes with linear age progressions are usually accepted to be derived from melting of an upwelling mantle *** seamount groups in NW Pacific,however,show complex age-distance relationships that are difficult to explain using the classic“mantle plume hypothesis”,and thus their origins are *** this study,we present ^(40)Ar-^(39)Ar age,geochemical,and Sr-Nd-Pb-Hf isotopic data of lavas from Hemler,Vlinder,and Il’ichev seamounts in NW Pacific,to elucidate their petrogenesis and geodynamic *** lavas from Hemler,Vlinder,and Il’ichev seamounts are classified as alkali basalt,basanite/nephelinite,and *** with Mg O>8 wt.%exhibit high contents of CaO,FeO^(T),and TiO_(2),similar to the composition of melts formed from reaction between carbonated eclogite-derived melts and fertile *** lavas have elevated Zr/Hf ratios(40.6-45.2)and negative Zr and Hf anomalies,indicating the presence of a carbonate component in the mantle *** are enriched in incompatible trace elements and have enriched mantle 1(EM1)-like SrNd-Pb-Hf isotopic *** isotopic compositions of Vlinder,Il’ichev basanite,and Hemler lavas in this study are similar to the Rarotonga *** occurring at the same seamount,the Il’ichev alkali basalts display more depleted SrNd-Hf isotopic compositions compared to Il’ichev *** to plate tectonic reconstruction results,the ages of Hemler(100.1 Ma),Vlinder pre-(100.2 Ma)and post-shield(87.5 Ma),and Il’ichev(56.4 Ma)lavas clearly deviate from the Macdonald,Arago,Rarotonga,and Samoa hotspot tracks,indicating that they cannot directly originate from mantle *** propose that in the mid-Cretaceous,when the Pacific plate passed over Rarotonga hotspot,melting of Rarotonga plume formed the Vlinder(main-shield stage),Pako,and Ioah *** Rarotonga(and possibly Samoa)plume materials would have been dispersed into the surrounding asthenosphere by mantle conve

关键词： Mantle plume Magellan seamount trail Carbonated mantle component Hotspot Lithosphere extension

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Microwave synthesis of La_(1-x)Sr_xCo_(1-y)Fe_yO_3 cathode materials for solid oxide fuel cells

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Rare Metals 2010年第6期29卷 576-578页

作者： ZHAI Xiujing,shi Weixi,FU yan,and zhang Nan School of Materials & Metallurgy,Northeastern University,Shenyang 110004,China School of Materials & Metallurgy Northeastern University Shenyang China

La1-xSrxCo1-yFeyO3 cathode materials for solid oxide fuel cells were prepared by the microwave synthesis *** reaction mechanism was studied using a thermal analysis *** influences of microwave synthesis conditions were examined and the characteristics of the samples were determined by X-ray diffraction and scanning electron *** was found that the optimum conditions were the microwave power of 800 W and the reaction time of 40 *** with perosvkite-type crystal structure were *** samples consist of uniformly distributed internal particles and the particle size is less than 1 μm.

关键词： solid oxide fuel cells cathode materials microwave synthesis thermal analysis microstructure

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Clustering for Bivariate Functional Data

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 613-629页

作者： shi-yun CAO yan-qiu ZHOU yan-ling WAN Tao zhang School of Science Guangxi University of Science and TechnologyLiuzhou 545006China School of Marxism Guangxi University of Science and TechnologyLiuzhou 545006China Key Laboratory of Intelligent Information Processing and Graph Processing Guangxi University of Science and TechnologyLiuzhou 545006China

In this paper,we consider the clustering of bivariate functional data where each random surface consists of a set of curves recorded repeatedly for each *** k-centres surface clustering method based on marginal functional principal component analysis is proposed for the bivariate functional data,and a novel clustering criterion is presented where both the random surface and its partial derivative function in two directions are *** addition,we also consider two other clustering methods,k-centres surface clustering methods based on product functional principal component analysis or double functional principal component *** results indicate that the proposed methods have a nice performance in terms of both the correct classification rate and the adjusted rand *** approaches are further illustrated through empirical analysis of human mortality data.

关键词： bivariate functional data -centres surface clustering functional principal component analysis partial derivative function

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Chloride transport and its sensitivities to different boundary conditions in reclaimed soil solutions filled with fly ash

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Journal of Coal Science & Engineering(China) 2013年第2期19卷 249-255页

作者： Xiao-yang CHEN Jia-Ping yan shi-Wen zhang School of Earth and Environment Anhui University of Science and Technology Huainan 232001 China

Chloride ion transport in reclaimed soil solutions filled with fly ash （FA） was investigated by measuring the hydraulic parameters （i,e. water retention curves and hydraulic conductivity） of three substrates, namely GSL, GFA, and CFA. Similar simulations were carried out under certain weather conditions. The different boundary conditions of chloride transport were also discussed from FA texture, cover soil thickness, groundwater table level, and initial chloride concentration. Furthermore, the sensitivities of chloride ions to these effect factors were analyzed. The results show that the different top soil thickness and initial chloride concentration have no effect on salinity of topsoil solution in the monitoring points, but they can clearly change the chloride concentration of FA layers. The sensibilities from top soil thickness and initial chloride content are exceedingly weak to the salinity balance based on two dimensions of the time and concentration. While the different FA texture and groundwater table not only affect the salinity equilibrium process of the whole reclaimed soil profile, but also change its balance state. Generally, coarse FA particles and high groundwater table can defer the salinity balance process of the reclaimed soil solution, and they also increase the chloride concentration of FA layer solutions, and even topsoil ones.

关键词： chloride ion transport reclaimed soil fly ash boundary condition sensitivity

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Experimental and numerical analyses of the effect of fibre content on the close-in blast performance of a UHPFRC beam

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Defence Technology（防务技术） 2024年第1期31卷 242-261页

作者： Junbo yan Qiyue zhang yan Liu Yingliang Xu Zhenqing shi Fan Bai Fenglei Huang State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China Beijing Institute of Technology Chongqing Innovation Center Chongqing 401120China

Limited research has been conducted on the influences of fiber content on close-in blasting characteristics for ultrahigh-performance fiber-reinforced concrete(UHPFRC)*** paper aims to address this knowledge gap through experimental and mesoscale numerical *** were conducted on ten UHPFRC beams built with varying steel fiber volumetric fractions subjected to close-in explosive ***,this study considered other parameters,such as the longitudinal reinforcement type and *** the case of UHPFRC beams featuring normal-strength longitudinal reinforcement of diametersΦ12,Φ16,andΦ20,a reduction in maximum displacement by magnitudes of19.6%,19.5%,and 17.4%was observed,respectively,as the volumetric fractions of fiber increased from1.0%to 2.5%.In addition,increasing the longitudinal reinforcement ratio and using high-strength steel longitudinal reinforcement both significantly reduced the deformation characteristics and increase the blasting resistances of UHPFRC ***,the effects on the local crushing and spalling damage were not significant.A mesoscale finite element model,which considers the impacts of fiber parameters on UHPFRC beam behaviors,was also established and well correlated with the test ***,parametric analyses were further conducted to examine the impacts of the steel fiber content and length and the hybrid effects of various types of microfibers and steel fibers on the blasting performance of UHPFRC beams.

关键词： Blast performance Close-in blast Fiber content Mesoscale approach UHPFRC beams

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