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考虑公平关切的自主减排低碳供应链决策研究

系统工程理论与实践 2016年第12期36卷 3079-3091页

作者：石松颜波石平华南理工大学经济与贸易学院广州510006 广东工业大学管理学院广州510520

在碳减排约束下,通过对低碳供应链进行建模,借助数值实验,运用博弈论的方法研究产品碳系数和制造商公平关切行为对低碳供应链定价策略、碳减排水平、供应链各方利润以及供应链整体利润的影响.研究结果表明:1)集中式决策模式下,产品碳减... 详细信息

在碳减排约束下,通过对低碳供应链进行建模,借助数值实验,运用博弈论的方法研究产品碳系数和制造商公平关切行为对低碳供应链定价策略、碳减排水平、供应链各方利润以及供应链整体利润的影响.研究结果表明:1)集中式决策模式下,产品碳减排水平和供应链整体利润要高于分散式决策.制造商客观存在的公平关切属性会进一步降低产品碳减排水平和供应链整体利润,且随着制造商公平关切程度的增大,供应链各方成员以及供应链整体利润均会减小,但制造商利润所占供应链总利润的份额却在不断增大;2)三种不同供应链决策模式下,低碳产品零售价格、碳减排水平和供应链利润均会随着碳系数的增大而增大;3)碳减排投资成本分担契约的实施能够促进低碳产品零售价格降低,销量增加,从而能够有效地提高低碳供应链的整体效率.

关键词：低碳供应链碳减排公平关切碳系数成本分担

Exit options sustain altruistic punishment and decrease the second-order free-riders, but it is not a panacea

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Science China(Information Sciences) 2025年第1期68卷 278-291页

作者： Chen SHEN Zhao song Lei shi Jun TANIMOTO Zhen WANG Faculty of Engineering Sciences Kyushu University School of Statistics and Mathematics Yunnan University of Finance and Economics School of Computing Engineering and Digital Technologies Teesside University School of Artificial Intelligence OPtics and Electro Nics (iOPEN) Northwestern Polytechnical University

Why do humans punish free riders at their own expense? This behavior represents an evolutionary puzzle in human societies. This study explores the role of exit strategies in fostering altruistic punishment within evolutionary game theory. We extend the traditional prisoner's dilemma model by incorporating exiters, players who opt out for a small payoff while nullifying their opponent's payoff, and altruistic punishers who cooperate and punish non-cooperators. Our findings indicate that in well-mixed populations, exiters destabilize defection but do not promote altruistic punishment. In social networks, however,exiters enable altruistic punishment via cyclic dominance among altruistic punishers, defectors, and exiters. Notably, this cyclic dominance is sensitive to exit payoffs; adjustments can lead to cyclic dominance of non-punishing cooperators, defectors, and exiters, or to a bi-stable state between these two types of cyclic dominance. These results highlight the nuanced impact of exiters on altruistic punishment, emphasizing the need for careful incentivization of exit behavior. While exiters can support altruistic punishment in networked populations, their effectiveness is not a panacea and is highly sensitive to exit payoffs, indicating limits to the voluntary participation mechanism.

关键词： evolutionary game theory altruistic punishment coexistence cyclic dominance bi-stable

Neuronal regulated cell death in aging-related neurodegenerative diseases:key pathways and therapeutic potentials

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Neural Regeneration Research 2025年第8期20卷 2245-2263页

作者： Run song shiyi Yin Jiannan Wu Junqiang yan Department of Neurology The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina Neuromolecular Biology Laboratory The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina

Regulated cell death(such as apoptosis,necroptosis,pyroptosis,autophagy,cuproptosis,ferroptosis,disulfidptosis)involves complex signaling pathways and molecular effectors,and has been proven to be an important regulatory mechanism for regulating neuronal aging and ***,excessive activation of regulated cell death may lead to the progression of aging-related *** review summarizes recent advances in the understanding of seven forms of regulated cell death in age-related ***,the newly identified ferroptosis and cuproptosis have been implicated in the risk of cognitive impairment and neurodegenerative *** forms of cell death exacerbate disease progression by promoting inflammation,oxidative stress,and pathological protein *** review also provides an overview of key signaling pathways and crosstalk mechanisms among these regulated cell death forms,with a focus on ferroptosis,cuproptosis,and *** instance,FDX1 directly induces cuproptosis by regulating copper ion valency and dihydrolipoamide S-acetyltransferase aggregation,while copper mediates glutathione peroxidase 4 degradation,enhancing ferroptosis ***,inhibiting the Xc-transport system to prevent ferroptosis can increase disulfide formation and shift the NADP^(+)/NADPH ratio,transitioning ferroptosis to *** insights help to uncover the potential connections among these novel regulated cell death forms and differentiate them from traditional regulated cell death *** conclusion,identifying key targets and their crosstalk points among various regulated cell death pathways may aid in developing specific biomarkers to reverse the aging clock and treat age-related neurodegenerative conditions.

关键词： apoptosis autophagy cuproptosis disulfidptosis ferroptosis necroptosis neurodegenerative disease neurological aging diseases PANoptosis pyroptosis

Eukaryotic translation initiation factor OseIF5A4 negatively regulates rice immunity against blast and bacterial blight diseases

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Crop Journal 2025年第1期13卷 79-91页

作者： Wang, Hui yan, Yuqing Bi, yan Li, Dayong song, Fengming National Key Laboratory for Rice Biology and Breeding Institute of Biotechnology Zhejiang University Zhejiang Hangzhou 310058 China Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insect Pests Institute of Biotechnology Zhejiang University Zhejiang Hangzhou 310058 China Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang Province Institute of Biotechnology Zhejiang University Zhejiang Hangzhou 310058 China

The RING-type E3 ligase OsBBI1 regulates rice resistance against Magnaporthe oryzae through modifying cell wall defenses. In this study, we report the function of an OsBBI1 substrate, eukaryotic translation initiation factor OseIF5A4, in rice immunity. OsBBI1 interacts with OseIF5A4 and other four members of the OseIF5A family. The RING domain in OsBBI1 and the eIF-5a domain in OseIF5A4 are critical for the OsBBI1-OseIF5A4 interaction. OsBBI1 ubiquitinates OseIF5A4 and mediates its degradation in vitro and in vivo. Moreover, the expression of OseIF5A4 was upregulated during early stage of compatible interaction but downregulated in incompatible interaction between rice and M. oryzae. Knockout of OseIF5A4 enhances rice immunity against M. oryzae and Xanthomonas oryzae pv. oryzae, boosts pattern-triggered immune responses, and strengthens pathogen-induced defense responses (e.g., expression of defense genes, accumulation of reactive oxygen species and reinforcement of cell wall). However, overexpression of OseIF5A4 attenuates rice immunity and immune responses. These results demonstrate that OseIF5A4, a substrate of the immunity-associated E3 ligase OsBBI1, negatively regulates rice immunity against M. oryzae and X. oryzae pv. oryzae through modulating pathogen-induced defense responses, highlighting the importance of the protein translational machinery in rice immunity. © 2025 Crop Science Society of China and Institute of Crop Science, CAAS

关键词： Magnaporthe oryzae OsBBI1 OseIF5A Rice immunity Xanthomonas oryzae pv. oryzae

Hierarchical porous carbon guided by constructing organic-inorganic interpenetrating polymer networks to facilitate performance of zinc hybrid supercapacitors

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Chinese Chemical Letters 2025年第1期36卷 561-567页

作者： Ting shi Ziyang song Yaokang Lv Dazhang Zhu Ling Miao Lihua Gan Mingxian Liu Shanghai Key Lab of Chemical Assessment and Sustainability School of Chemical Science and EngineeringTongji UniversityShanghai 200092China College of Chemical Engineering Zhejiang University of TechnologyHangzhou 310014China

Customized design of well-defined cathode structures with abundant adsorption sites and rapid diffusion dynamics,holds great promise in filling capacity gap of carbonaceous cathodes towards high-performance Zn-ion hybrid supercapacitors(ZHC).Herein,we fabricate a series of dynamics-oriented hierarchical porous carbons derived from the unique organic-inorganic interpenetrating polymer *** interpenetrating polymer networks are obtained through physically knitting polyferric chloride(PFC)network into the highly crosslinked resorcinol-formaldehyde(RF)*** of covalent bonding,physical interpenetrating force in such RF-PFC networks efficiently relieves the RF skeleton shrinkage upon ***,the in-situ PFC network sacrifices as a structure-directing agent to suppress the macrophase separation,and correspondingly 3D hierarchical porous structure with plentiful ion-diffusion channels(pore volume of 1.35 cm^(3)/g)is generated in the representative HPC_(4) via nanospace occupation and swelling *** removal of Fe fillers leaves behind a large accessible specific surface area of 1550 m^(2)/g for enhanced Zn-ion *** used as the cathode for ZHC,HPC_(4) demonstrates a remarkable electrochemical performance with a specific capacity of 215.1 mAh/g at 0.5 A/g and a high Zn^(2+)ion diffusion coefficient of 11.1×10^(-18)cm^(2)/*** ZHC device yields 117.0 Wh/kg energy output at a power density of 272.1 W/kg,coupled with good cycle lifespan(100,000 cycles@10 A/g).This work inspires innovative insights to accelerate Zn diffusion dynamics by structure elaboration towards high-capacity cathode materials.

关键词： Carbonaceous cathode Interpenetrating polymer networks Zinc-ion hybrid supercapacitors Specific capacity Energy/power density

Perspectives on the potential application of microRNAs in the diagnosis and treatment of triple-negative breast cancer

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Oncology and Translational Medicine 2025年第1期11卷 5-9页

作者： Yeqin Wu Haitao song Huifang shi Gangping Wang Department of Pathology the Fourth Affiliated Hospital of Zhejiang University School of MedicineInternational School of Medicine Zhejiang UniversityInternational Institutes of Medicine Zhejiang UniversityYiwuChina Department of Oncology the Rizhao People’s HospitalRizhaoChina Central Laboratory the Rizhao People’s HospitalRizhaoChina

Triple-negative breast cancer(TNBC)is currently the most heterogeneous and aggressive breast cancer *** has a high recurrence rate,poor clinical prospects,and lack of predictive markers and potential treatment *** microRNAs(miRNAs)are involved in various cellular processes in ***,variations in the miRNA levels in TNBC may act as a dependable indicator for predicting the effectiveness and specificity of ***,the application of miRNAs for breast cancer therapy is primarily in the preclinical stage,with a focus on identifying highly specific and sensitive miRNAs that could offer new possibilities for early diagnosis,clinical treat-ment,and prognostic monitoring of TNBC.

关键词： Triple-negative breast cancer miRNA oncomiRs Tumorigenesis Prognosis Chemotherapy resistance

Effects of aspirin on metastasis-associated gene expression detected by cDNA microarray

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Acta Pharmacologica Sinica 2004年第10期 87-93页

作者： Xue-qin GAO, Jin-xiang HAN, Hai-yan HUANG, shi yan, Chang-zheng song, Hai-nan HUANGKey Laboratory of Ministry of Health for Biotech-Drug, Shandong Medicinal Biotechnology Center, Shandong Academy of Medical Sciences, Ji-nan 250062, ChinaNow in Medical College of Shandong University, Ji-nan 250012, China.

AIM: To investigate the effect of aspirin on the metastasis-associated gene expression in 3AO ovarian cancer cells. METHODS: 3AO cells were treated with aspirin at the concentration of 1.2 mmol/L for 16 and 48 h, respectively. The total RNA was extracted with Trizol reagents and reverse transcribed with Superscript Ⅱand hybridized with cDNA microarray (containing oncogenes, tumor suppressor genes, signal transduction pathway molecules , adhesive molecules, growth factors and ESTs) fabricated in our lab. After normalization, the ratio of gene expression of aspirin treated to untreated 3AO cells being either 2 fold up higher or 0.5 fold down (lower) were defined as differential expression. Semi-quantitative RT-PCR was used to validate the microarray results. RESULTS: Among the 447 metastasis-associated genes, 4 genes were up-regulated and 14 genes were down-regulated in 3AO cells treated with aspirin for 16 h compared with untreated cells. While 24 genes were up-regulated and 10 genes were down-regulated

关键词： aspirin ovarian neoplasms gene expression neoplasm metastasis cDNA microarray

CMOS direct conversion X-ray detector coupled with fluorinated liquid

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Nuclear Science and Techniques 2025年第1期36卷 59-68页

作者： shi-Hua Liu Chao-song Gao Xin Zhang Xiang-Ming Sun Meng Wu Zhi-Hui Han Tong Wan Yong-Shuai Ge Key Laboratory of Quark&Lepton Physics(MOE) Central China Normal UniversityWuhan 430079China Guizhou Education University Guiyang 550018China Research Center for Medical Artificial Intelligence Chinese Academy of SciencesShenzhen Institutes of Advanced TechnologyShenzhen 518055China

X-ray detectors show potential applications in medical imaging,materials science,and nuclear *** achieve high detection efficiency and spatial resolution,many conventional semiconductor materials,such as amorphous selenium,cadmium telluride zinc,and perovskites,have been utilized in direct conversion X-ray ***,these semiconductor materials are susceptible to temperature-induced performance degradation,crystallization,delamination,uneven lattice growth,radiation damage,and high dark *** study explores a new approach by coupling an FC40 electronic fluorinated liquid with a specialized high-resolution and high-readout-speed complementary metal-oxide-semiconductor(CMOS)pixel array,specifically the Topmetal II−chip,to fabricate a direct conversion X-ray *** fluorinated liquid FC40(molecular formula:C_(21)F_(48)N_(2))is an electronic medium that is minimally affected by temperature and displays no issues with uniform *** exhibits a low dark current and minimal radiation damage and enables customizable thickness in X-ray *** addresses the limitations inherent in conventional semiconductor-based *** this study,simple X-ray detector imaging tests were conducted,demonstrating the excellent coupling capability between FC40 electronic fluorinated liquid and CMOS chips by the X-ray detector.A spatial resolution of 4.0 lp/mm was measured using a striped line par card,and a relatively clear image of a cockroach was displayed in the digital radiography imaging *** test results indicated the feasibility of fabricating an X-ray detector by combining FC40 electronic fluorinated liquid and CMOS *** to the absence of issues related to chip-material coupling,a high spatial resolution could be achieved by reducing the chip pixel *** method presents a new avenue for studies on novel liquid-based direct conversion X-ray detectors.

关键词： FC40 electronic fluorinated liquid CMOS pixel chip X-ray detector Spatial resolution

Stem-leaf saponins of Panax notoginseng attenuate experimental Parkinson's disease progression in mice by inhibiting microglia-mediated neuroinflammation via P2Y2R/PI3K/AKT/NFκB signaling pathway

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Chinese Journal of Natural Medicines 2025年第1期23卷 43-53页

作者： Hui Wu Chenyang Ni Yu Zhang Yingying song Longchan Liu Fei Huang Hailian shi Zhengtao Wang Xiaojun Wu Shanghai Key Laboratory of Compound Chinese Medicines The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines Institute of Chinese Materia Medica The MOE Innovation Centre for Basic Medicine Research on Qi-Blood TCM Theories Shanghai University of Traditional Chinese Medicine

Stem-leaf saponins from Panax notoginseng(SLSP) comprise numerous PPD-type saponins with diverse pharmacological properties; however, their role in Parkinson's disease(PD),characterized by microglia-mediated neuroinflammation, remains unclear. This study evaluated the effects of SLSP on suppressing microglia-driven neuroinflammation in experimental PD models, including the 1-methyl-4-phenylpyridinium(MPTP)-induced mouse model and lipopolysaccharide(LPS)-stimulated BV-2 microglia. Our findings revealed that SLSP mitigated behavioral impairments and excessive microglial activation in models of PD, including MPTP-treated mice. Additionally, SLSP inhibited the upregulation of inducible nitric oxide synthase(i NOS) and cyclooxygenase-2(COX2) and attenuated the phosphorylation of PI3K,protein kinase B(AKT), nuclear factor-κB(NFκB), and inhibitor of NFκB protein α(IκBα) both in vivo and in vitro. Moreover, SLSP suppressed the production of inflammatory markers such as interleukin(IL)-1β, IL-6, and tumor necrosis factor alpha(TNF-α) in LPS-stimulated BV-2cells. Notably, the P2Y2R agonist partially reversed the inhibitory effects of SLSP in LPStreated BV-2 cells. These results suggest that SLSP inhibit microglia-mediated neuroinflammation in experimental PD models, likely through the P2Y2R/PI3K/AKT/NFκB signaling pathway. These novel findings indicate that SLSP may offer therapeutic potential for PD by attenuating microglia-mediated neuroinflammation.

关键词： Microglia NFκB Neuroinflammation P2Y2 receptor Stem-leaf saponins of Panax Notoginseng