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Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss

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Neural Regeneration Research 2025年第10期20卷 3025-3039页

作者： Jia Fang Zhuangzhuang Li Pengjun Wang Xiaoxu zhang Song Mao Yini Li Dongzhen Yu Xiaoyan Li Yazhi Xing Haibo shi Shankai Yin Department of Otolaryngology Head and Neck Surgery Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineOtolaryngology Institute of Shanghai Jiao Tong UniversityShanghai Key Laboratory of Sleep Disordered BreathingShanghaiChina Department of Otorhinolaryngology-Head and Neck Surgery Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial ***,their use leads to irreversible hearing damage by causing apoptosis of hair cells as their direct *** addition,the hearing damage caused by aminoglycosides involves damage of spiral ganglion neurons upon *** investigate the mechanisms underlying spiral ganglion neuron degeneration induced by aminoglycosides,we used a C57BL/6J mouse model treated with *** found that the mice exhibited auditory deficits following the acute loss of outer hair *** ganglion neurons displayed hallmarks of pyroptosis and exhibited progressive degeneration over *** profiling of these neurons showed significant upregulation of genes associated with inflammation and immune response,particularly those related to the NLRP3 *** of the canonical pyroptotic pathway in spiral ganglion neurons was observed,accompanied by infiltration of macrophages and the release of proinflammatory *** intervention targeting NLRP3 using Mcc950 and genetic intervention using NLRP3 knockout ameliorated spiral ganglion neuron degeneration in the injury *** findings suggest that NLRP3 inflammasome-mediated pyroptosis plays a role in aminoglycoside-induced spiral ganglion neuron *** of this pathway may offer a potential therapeutic strategy for treating sensorineural hearing loss by reducing spiral ganglion neuron degeneration.

关键词： degeneration hearing loss macrophages Mcc950 neuroinflammation NLRP3 inflammasome ototoxicity pyroptosis sensorineural hearing loss spiral ganglion neuron

BIOLOGICAL INVASION PROBLEM WITH FREE BOUNDARY NONLOCAL DIFFUSION EQUATION

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数学杂志 2025年第1期45卷 48-56页

作者： HE Yu-rong zhang Ya-rong School of Science Xi'an University of Architecture and TechnologyXi'an 710055China Xi'an Special Equipment Inspection Institute Xi'an 710065China School of Power and Energy Northwestern Polytechnical UniversityXi'an 710072China

In order to better describe the phenomenon of biological invasion,this paper introduces a free boundary model of biological ***,the right free boundary is added to the equation with logistic ***,the existence and uniqueness of local solutions are proved by the Sobolev embedding theorem and the comparison ***,according to the relevant research data and contents of red fire ants,the diffusion area and nest number of red fire ants were simulated without external *** paper mainly simulates the early diffusion process of red fire *** the early diffusion stage,red fire ants grow slowly and then spread over a large area after reaching a certain number.

关键词： Free boundary biological invasion differential equation

Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

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Neural Regeneration Research 2025年第9期20卷 2520-2537页

作者： Chonglin Su Taiqi Huang Meiyu zhang Yanyu zhang Yan Zeng Xingxing Chen Brain Science and Advanced Technology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplasticity stress

Multipartite Entanglement of a Tetrahedron Lattice

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Communications in Theoretical Physics 2006年第5X期46卷 863-872页

作者： zhang rong ZHU shi-Qun HAO Xiang School of Physical Science and Technology Suzhou University Suzhou 215006 China

Three-dimensional Heisenberg model in the form of a tetrahedron lattice is investigated. The concurrence and multipartite entanglement are calculated through 2-concurrence C and 4-concurrence C4. The concurrence C and multipartite entanglement G4 depend on different coupling strengths Ji and are decreased when the temperature T is increased. For a symmetric tetrahedron lattice, the concurrence C is symmetric about J1 when J~ is negative while the multipartite entanglement G4 is symmetric about J1 when J2 〈 2. For a regular tetrahedron lattice, the concurrence G of ground state is 1/3 for ferromagnetic case while G = 0 for antiferromagnetic ***. However, there is no multipartitc entanglement since C4=0 in a regular tetrahedron lattice. The external magnetic field 13 can increase the maximum value of the concurrence GB and induce two or three peaks in Cn. There is a peak in the multipartite entanglement G4 B when G4B is varied as a function of the temperature T. This peak is mainly induced by the magnetic field B.

关键词： multipartite entanglement concurrence three dimensions tetrahedron lattice

广东省南岭国家级自然保护区的野生动物及管理对策

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韶关学院学报 2001年第12期22卷 88-91页

作者：李石洲容长才广东南岭国家级自然保护区乳阳管理站广东韶关512727

广东南岭国家级自然保护区脊椎动物有 4 15种 ,其中列入国家重点保护的就有 5 7种 ,对南岭野生动物的保护现状作了分析研究 ,并对存在问题提出了保护对策 .

关键词：南岭保护区野生动物保护管理

Catalyst-Free Growth of Nanographene Films on Various Substrates

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Nano Research 2011年第3期4卷 315-321页

作者： Lianchang zhang Zhiwen shi Yi Wang rong Yang Dongxia shi Guangyu zhang Nanoscale Physics and Device Lab Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of Sciences Beijing 100190 China Surface Physics Lab Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of Sciences Beijing 100190 China

We have developed a new method to grow uniform graphene films directly on various substrates, such as insulators, semiconductors, and even metals, without using any catalyst. The growth was carried out using a remote plasma enhancement chemical vapor deposition （r-PECVD） system at relatively low temperatures, enabling the deposition of graphene films up to 4-inch wafer scale. Scanning tunneling microscopy （STM） confirmed that the films are made up of nanocrystalline graphene particles of tens of nanometers in lateral size. The growth mechanism for the nanographene is analogous to that for diamond grown by PECVD methods, in spite of sp2 carbon atoms being formed in the case of graphene rather than sp3 carbon atoms as in diamond. This growth approach is simple, low-cost, and scalable, and might have potential applications in fields such as thin film resistors, gas sensors, electrode materials, and transparent conductive films.

关键词： Nanographene catalyst-free plasma enhancement chemical vapor deposition (PECVD) transparent and conductive film

Surrogate-assisted differential evolution using manifold learning-based sampling for highdimensional expensive constrained optimization problems

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Chinese Journal of Aeronautics 2024年第7期37卷 252-270页

作者： Teng LONG Nianhui YE rong CHEN Renhe shi Baoshou zhang School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China Key Laboratory of Dynamics and Control of Flight Vehicle of Ministry of Education Beijing 100081China China Academy of Launch Vehicle Technology Beijing 100076China

To address the challenges of high-dimensional constrained optimization problems with expensive simulation models,a Surrogate-Assisted Differential Evolution using Manifold Learning-based Sampling(SADE-MLS)is *** SADE-MLS,differential evolution operators are executed to generate numerous high-dimensional candidate *** alleviate the curse of dimensionality,a Manifold Learning-based Sampling(MLS)mechanism is developed to explore the high-dimensional design space *** MLS,the intrinsic dimensionality of the candidate points is determined by a maximum likelihood ***,the candidate points are mapped into a low-dimensional space using the dimensionality reduction technique,which can avoid significant information loss during dimensionality ***,Kriging surrogates are constructed in the low-dimensional space to predict the responses of the mapped candidate *** candidate points with high constrained expected improvement values are selected for global ***,the local search process assisted by radial basis function and differential evolution is performed to exploit the design space *** numerical benchmarks are tested to compare SADE-MLS with other ***,SADE-MLS is successfully applied to a solid rocket motor multidisciplinary optimization problem and a re-entry vehicle aerodynamic optimization problem,with the total impulse and lift to drag ratio being increased by 32.7%and 35.5%,*** optimization results demonstrate the practicality and effectiveness of the proposed method in real engineering practices.

关键词： Surrogate-assisted differential evolution Dimensionality reduction Solid rocket motor Re-entry vehicle Expensive constrained optimization

浅议以概念为中心的教学法——第二语言学习者语义表征特点及其对大学英语词汇教学的启迪

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西南交通大学学报（社会科学版） 2002年第1期3卷 80-84页

作者：杨世蓉张文鹏西南交通大学外国语学院四川成都610031

本文从语言系统的运作出发 ,将语义的理解与概念的形成结合起来 ,联系学习者的第二语言习得和双语语义表征的特点 ,对大学英语的词汇教学进行探讨 ,提出了以概念为中心的词汇教学思路。

关键词：词汇教学大学英语语义表征第二语言学习者第二语言习得语词语言系统概念中心教学法

Integrating lipidomics and gut microbiota to study the anti-hyperlipidemia effect of Sargentodoxae Caulis extract

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Traditional Medicine Research 2025年第1期10卷 1-11页

作者： Xiao-Xiao zhang Li Jia Xiu-Jun Zhan Charity Ngina Qing-Rui zhang Xiao-Ge Li Qi-Bao Jiang shi Bai Miao-Miao Jiang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjin 301617China Haihe Laboratory of Modern Chinese Medicine Tianjin 301617China School of Medicine Taizhou UniversityTaizhou 318000China.

Background:Sargentodoxae Caulis(SC)is the vine stem of Sargentodoxa Cuneata(Oliv.)Rehd.&*** in ***,and it in traditional Chinese medicine has been known for promoting blood circulation and removing blood stasis as recorded in the ancient book“Illustrated Classics of Materia Medica”.It has been used effectively to treat blood stasis too in modern clinical ***,the anti-hyperlipidemia effect of SC is not fully *** paper aims at exploring the use of SC stems to improve the balance of blood lipids in the body,and its new role in treating ***:The effects of SC extract on hyperlipidemia were explored by combining lipidomics and gut ***,we explored the potential mechanism of SC in treating hyperlipidemia by pathway ***:The results showed that the stem extract of SC could restore the physiological and biochemical indices of hyperlipidemia in mice,as well as repair the morphological and structural damage to *** to the Model group,the SC extract significantly reduced the liver index,epididymal fat index,and Lee’s *** also significantly decreased serum levels of total cholesterol,triglycerides,low-density lipoprotein cholesterol,peroxisome proliferator-activated receptor gamma(PPAR-γ),D-lactate,and free fatty acids,while significantly increasing the relative content of peroxisome proliferator-activated receptor alpha(PPAR-α).These changes were statistically ***-targeted lipidomics,based on LC-MS,were utilized to investigate the lipid metabolism characteristics in serum,liver,and epididymal fat of the *** was observed that,compared to the blank group,the Model group exhibited significant changes primarily in glycerol lipids and *** treatment group also displayed alterations in these lipids.A total of 38,81,and 27 differential lipids were identified in serum,liver,and epididymal fat samples,*** these,14 common differenti

关键词： hyperlipidemia Sargentodoxae Caulis lipidomics intestinal flora