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Inhibitory effect of antisense oligodeoxynucleotide to p44/p42 MAPK on angiotensin Ⅱ-induced hypertrophic response in cultured neonatal rat cardiac myocyte

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Acta Pharmacologica Sinica 2004年第1期 43-48页

作者： shi-qin zhang, Bo DING, Zhao-gui GUO, Yun-xia LILaboratory of Molecular Pharmacology, Xiang Ya School of Medicine, Central South University, Changsha,, 410078,China

AIM: To explore the inhibitory effect of antisense oligonucleotide (ODN) to mitogen activated protein kinase (MAPK) on cardiomyocyte hypertrophy induced by angiotensin Ⅱ (Ang Ⅱ). METHODS: A 17-mer phosphorothioate protected antisense ODN directed against the initiation of translation sites of the p42 and p44 MAPK isoforms by liposomal transfection was applied to inhibit the translation of p44/p42 MAPK mRNA. The sense and random ODNs to p44/p42MAPK were used as sequence controls. Neonatal cardiac myocytes were exposed to Ang Ⅱ (10 nmol/L) for 5 min and then harvested in lysis buffer for the measurement of the activity and the phosphorylated protein content of p44/p42MAPK that were tested by P-81 phosphocellulose filter paper method and Western blotting, respectively. The

关键词： mitogen-activated protein kinases antisense oligodeoxynucleotides angiotensin Ⅱ hypertrophy myocardium

The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

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Neural Regeneration Research 2025年第2期20卷 402-415页

作者： Xiaorong zhang Zhiying Chen Yinyi Xiong qin Zhou Ling-Qiang Zhu Dan Liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine Research Center JiujiangJiangxi ProvinceChina Center for Cognitive Science and Transdisciplinary Studies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia

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基于絮凝沉砂的立式砂仓面积最佳计算模式

东北大学学报（自然科学版） 2016年第10期37卷 1501-1506页

作者：王石张钦礼王新民李帅中南大学资源与安全工程学院湖南长沙410083

为探究全尾砂絮凝沉降条件下立式砂仓面积最佳计算模式,根据最理想沉砂条件和不同沉砂特点,从3种计算模式中确定出结果误差最小者.以某铅锌矿为例,进行细粒级全尾砂絮凝沉降试验,回归分析得到最佳沉砂条件下的沉降曲线,依此从3个角度分... 详细信息

为探究全尾砂絮凝沉降条件下立式砂仓面积最佳计算模式,根据最理想沉砂条件和不同沉砂特点,从3种计算模式中确定出结果误差最小者.以某铅锌矿为例,进行细粒级全尾砂絮凝沉降试验,回归分析得到最佳沉砂条件下的沉降曲线,依此从3个角度分析立式砂仓面积计算模式的可靠度.最佳絮凝条件:相对分子量为8×106的阴离子聚丙烯酰胺(APAM),入料砂浆体积分数为7.80%,对应的絮凝剂单耗为17.66 g·t-1.最佳立式砂仓面积为36.06 m2,托麦吉-菲契图解计算模式所得结果与其贴近度达97.04%.

关键词：全尾砂絮凝沉降立式砂仓面积回归分析计算模式

基于消费者感知的企业伦理行为与消费者响应分析

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商业研究 2017年第9期 40-46页

作者：蒋丽芹史敏张迪江南大学商学院江苏无锡214122

基于消费者感知的视角,本文运用统计分析软件SPSS18.0和AMOS20.0对收集到的数据进行检验,探讨顾客感知价值在企业伦理行为与消费者响应之间的中介作用,以及消费者信任的调节效应。研究结果表明:企业伦理行为的消费者关系伦理与回馈社会... 详细信息

基于消费者感知的视角,本文运用统计分析软件SPSS18.0和AMOS20.0对收集到的数据进行检验,探讨顾客感知价值在企业伦理行为与消费者响应之间的中介作用,以及消费者信任的调节效应。研究结果表明:企业伦理行为的消费者关系伦理与回馈社会对消费者情感响应、行为响应存在显著的正向影响,企业伦理行为的环境保护维度对消费者情感响应存在显著的正向影响,顾客感知价值在企业伦理行为与消费者响应之间起部分中介作用,消费者信任在消费者关系伦理、环境保护与消费者情感响应之间具有显著的正向调节作用。以上结论旨在为企业开展伦理活动、提高消费者对企业的感知价值以及增强消费者响应提供理论参考。

关键词：企业伦理行为消费者响应顾客感知价值消费者信任

EMBEDDED MANDARIN CONCATENATIVE SPEECH SYNTHESIS SYSTEM

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EMBEDDED MANDARIN CONCATENATIVE SPEECH SYNTHESIS SYSTEM

COMPARISONS AMONG FOUR STATISTICS BASED METHODS OF PROSODY STRUCTURE PREDICTION

第八届全国人机语音通讯学术会议

作者： Xijun Ma, qin shi, Wei zhang, Haiping Li, Weibin Zhu and Liqin Shen IBM China Research Lab

Most modern text-to-speech (TTS) systems are corpus based unit selection system, among them is IBM Phoenix system. This paper presents the work done to achieve a high quality embedded speech synthesis system by reducing the footprint of our server based system. The key technologies include the deep segment pre-selection, high quality speech CODEC with high compression ratio and simplified probability based prosody model to reduce computation complexity. Experiments show even with a dataset of a few megabytes, a high quality concatenative Mandarin speech synthesis system can be achieved.

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COMPARISONS AMONG FOUR STATISTICS BASED METHODS OF PROSODY S...

基于人力资本视角的江苏制造业比较优势重塑研究

第七届全国人机语音通讯学术会议（NCMMSC7）

作者： qin shi, Wei zhang, XiJun Ma, WeiBin Zhu, Ling Jin IBM China Research Lab, Beijing, P.R.China

Prosody structure prediction plays an important role in text-to-speech (ITS) conversion systems, ft is the must and prior step to parametric prosody prediction. Dynamic programming (DP) and decision tree (DT) are widely used for prosody structure prediction [1][2][3] but with well-known limitations. In this paper, two other new methods, combination of dynamic programming with decision tree and combination of decision tree with finite state machine (FSM), are proposed. Then, based on a manually labeled corpus, comprehensive comparisons among the four methods are done. It could be concluded from these experiments that combination of dynamic programming with decision tree method is the best choice for prosody word boundary prediction and combination of decision tree with FSM is the best candidate for prosody phrase boundary prediction.

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金陵科技学院学报（社会科学版） 2016年第4期30卷 20-25页

作者：洪世勤张骏金陵科技学院商学院江苏南京211169

人力资本是企业竞争优势的第一来源。随着江苏制造业低成本劳动力竞争优势逐步削减,江苏制造业迫切需要构建"走出去"的新优势,而人力资本是影响其"走出去"的关键因素。通过对江苏制造业的比较优势进行测度,分析江苏制造业及分行业的人... 详细信息

人力资本是企业竞争优势的第一来源。随着江苏制造业低成本劳动力竞争优势逐步削减,江苏制造业迫切需要构建"走出去"的新优势,而人力资本是影响其"走出去"的关键因素。通过对江苏制造业的比较优势进行测度,分析江苏制造业及分行业的人力资本需求,探讨江苏制造业人力资本优势重塑的基础,为江苏制造业"走出去"提供政策建议。

关键词：人力资本制造业比较优势重塑江苏

Effect of pyrite content on chalcopyrite flotation under different regrinding conditions

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 49-57页

作者： Zejun Wang qing shi Guofan zhang Yuxuan Zhu Binbin Li School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China Key Laboratory of Hunan Province for Clean and Efficient Utilization of Strategic Calcium-containing Mineral Resources Central South UniversityChangsha 410083China

This study aimed to investigate the effect of varying pyrite(Py)content on copper(Cu)in the presence of different regrinding conditions,which were altered using different types of grinding media:iron,ceramic balls,and their mixture,followed by flotation in the cleaner *** flotation performance of rough Cu concentrate can be improved by changing the regrinding conditions based on the Py *** electron microscopy,X-ray spectrometry,ethylenediaminetetraacetic acid disodium salt extraction,and X-ray photoelectron spectroscopy studies illustrated that when the Py content was high,the use of iron media in regrinding promoted the generation of hydrophilic Fe OOH on the surface of Py and improved the Cu *** ceramic medium with a low Py content prevented excessive Fe OOH from covering the surface of chalcopyrite(Cpy).Electrochemical studies further showed that the galvanic corrosion current of Cpy-Py increased with the addition of Py and became stronger with the participation of iron media.

关键词： chalcopyrite regrinding media pyrite galvanic corrosion flotation

Development of a nomogram for overall survival in patients with esophageal carcinoma:A prospective cohort study in China

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 158-168页

作者： shi-shi Yu Xi Zheng Xiao-Sheng Li Qian-Jie Xu Wei zhang Zhong-Li Liao Hai-Ke Lei Department of Gastroenterology Chongqing University Cancer HospitalChongqing 400030China Chongqing Cancer Multi-omics Big Data Application Engineering Research Center Chongqing University Cancer HospitalChongqing 400030China Department of Health Statistics School of Public HealthChongqing Medical UniversityChongqing 400016China

BACKGROUND Esophageal carcinoma(EC)presents a significant public health issue in China,with its prognosis impacted by myriad *** creation of a reliable prog-nostic model for the overall survival(OS)of EC patients promises to greatly advance the customization of treatment *** To create a more systematic and practical model that incorporates clinically significant indicators to support decision-making in clinical *** This study utilized data from a prospective longitudinal cohort of 3127 EC patients treated at Chongqing University Cancer Hospital between January 1,2018,and December 12,*** the least absolute shrinkage and selection operator regression alongside multivariate Cox regression analyses helped pinpoint pertinent variables for constructing the *** efficacy was assessed by concordance index(C-index),area under the receiver operating characteristic curve(AUC),calibration curves,and decision curve analysis(DCA).RESULTS Nine variables were determined to be significant predictors of OS in EC patients:Body mass index(BMI),Karnofsky performance status,TNM stage,surgery,radiotherapy,chemotherapy,immunotherapy,platelet-to-lymphocyte ratio,and albumin-to-globulin ratio(ALB/GLB).The model demonstrated a C-index of 0.715(95%CI:0.701-0.729)in the training cohort and 0.711(95%CI:0.689-0.732)in the validation *** the training cohort,AUCs for 1-year,3-year,and 5-year OS predictions were 0.773,0.787,and 0.750,respectively;in the validation cohort,they were 0.772,0.768,and 0.723,respectively,illustrating the model's *** curves and DCA verified the model's predictive accuracy and net *** A novel prognostic model for determining the OS of EC patients was successfully developed and validated to help clinicians in devising individualized treatment schemes for EC patients.

关键词： Esophageal carcinoma High-risk factors Prognosis Overall survival Prediction model