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A Cytotoxic Neolignan from Schisandra propinqua （Wall.） Baill.

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Journal of Integrative Plant Biology 2006年第12期48卷 1493-1497页

作者： Li-Jia Xu Feng Huang Si-Bao chen Lian-Niang Li shi-lin chen Pei-Gen Xiao Institute of Medicinal Plant Development Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100094 China State Key Laboratory of Chinese Medicine and Molecular Pharmacology Shenzhen 518057 China Department of Appfied Biology and Chemical Technology Hong Kong Polytechnic University Hong Kong SAR China Institute of Materia Medica Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100050 China

In the course of our study of bioactive natural products from Schisandra plants, we isolated a neolignan from an EtOAc extract of the stems of Schisandra propinqua （Wall.） Baill. The structure of the new com- pound was determined to be 4, 4-di （4-hydroxy-3-methoxyphenly）-2, 3-dimethylbutanol （compound 1） on the basis of 1H- and 13C-NMR spectra and 2D NMR methods. Eight known compounds, compounds 2-9, were also isolated and identified, of which compounds 3, 4, 6 and 9 were isolated for the first time from this plant. In addition, compounds 1-4 were evaluated for cytotoxicity by an 3-（4,5-dimethyl-2 thiazoyl）-2,5-diphenyl-2H- tetrazolium bromide （MTT） assay. Compound 1 showed significant potential cytotoxic ability in the bioassay.

关键词： cytotoxicity lignan Schisandra propinqua Schisandraceae

浓缩生长因子联合骨代品用于拔牙位点保存的研究进展

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北京口腔医学 2024年第1期32卷 74-76页

作者：蔺世晨李钧首都医科大学电力教学医院口腔科北京100073 首都医科大学口腔医学院种植科

牙齿拔除后剩余牙槽骨会发生不同程度的吸收,给后期的种植修复造成困难,临床上可以选择拔牙位点保存技术来维持剩余牙槽骨的骨量。目前常用的位点保存方法是将骨代用品植入拔牙窝并覆盖胶原膜,其费用较高,且近年来的研究显示其成骨效果... 详细信息

牙齿拔除后剩余牙槽骨会发生不同程度的吸收,给后期的种植修复造成困难,临床上可以选择拔牙位点保存技术来维持剩余牙槽骨的骨量。目前常用的位点保存方法是将骨代用品植入拔牙窝并覆盖胶原膜,其费用较高,且近年来的研究显示其成骨效果并不确切。浓缩生长因子(concentrated growth factors,CGF)是最新一代的自体血浆提取物,能够加快软硬组织愈合,提高成骨质量。本文从CGF在拔牙位点保存技术中的应用方面做一综述。

关键词：浓缩生长因子拔牙位点保存

Association between SHBG(TAAAA)n and AR(CAG)n polymorphisms and PCOS risk: A meta-analysis

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World Journal of Meta-Analysis 2015年第1期3卷 72-81页

作者： Jie-Wen Jin shi-lin chen Zhan-Tao Deng Center for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine Medical School of Nanjing University

AIM: To systematically assess the association between sex hormone-binding globulin(SHBG)(TAAAA)n and androgen receptor(AR)(CAG)n polymorphisms and polycystic ovarian syndrome(PCOS) risk.METHODS: We searched MEDlinE(PubM ed), EMBASE and Web of Science database from inception to May2014. To avoid missing any additional studies, we looked through all the references of relevant articles. Case-control studies concerning the(CAG)n variants in the AR gene or the(TAAAA)n polymorphism in the SHBG gene in PCOS patients were included. Five studies regarding the(TAAAA)n polymorphism in the SHBG gene and 14 studies regarding the(CAG)n polymorphism in the AR gene met our criteria. Odd ratio(OR) and weighted mean difference(WMD) were selected as the effect size measurements to evaluate the influence of the(TAAAA)n polymorphism and(CAG)n variants on PCOS risk. Begg's test was used for the evaluation of publication bias.RESULTS: With respect to the relationship between the(TAAAA)n polymorphism and PCOS risk, the statistical results showed that there was no significant difference between PCOS patients and controls in the alleles of TAAAA(S: OR = 0.91, 95%CI: 0.78-1.05; L: OR = 1.10, 95%CI: 0.95-1.27). Subgroup analyses of the combination of alleles indicated similar results(shortshort: OR = 0.87, 95%CI: 0.66-1.14; short-long: OR = 1.12, 95%CI: 0.86-1.46; long-long: OR = 1.03, 95%CI: 0.72-1.47). As for the relationship between the(CAG)n polymorphism and PCOS risk, we found no association between CAG repeat variants and PCOS risk(WDM = 0.03, 95%CI:-0.13-0.08). Subgroup analyses by race and diagnosis criteria indicated the same results(Asian: WMD =-0.03, 95%CI:-0.14-0.07; Caucasian: WMD =-0.02, 95%CI:-0.24-0.21; the criteria of Rotterdam: WMD = 0.01, 95%CI:-0.01-0.03). CONCLUSION: There is no association between(TAAAA)n polymorphism in SHBG gene,(CAG)n repeat variants in AR gene and PCOS.

关键词： Sex hormone-binding globulin TAAAA Androgen receptor CAG Polycystic ovarian syndrome

Integrated chemical and transcriptomic analyses unveils synthetic characteristics of different medicinal root parts of Angelica sinensis

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Chinese Herbal Medicines 2020年第1期12卷 19-28页

作者： Ran Xu Jiang Xu Yong-chang Li Yun-tao Dai Shao-peng Zhang Guang Wang Zhi-guo Liu lin-lin Dong shi-lin chen College of Biology and Pharmaceutical Engineering Wuhan Polytechnic UniversityWuhan 430000China Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Kansas City University of Medicine and Biosciences Joplin 64804USA

Objective:Why are different medicinal parts including heads,bodies and tails of Angelicae Sinensis Radix(ASR)distinct in pharmaceutical activities?Here we explored their discrepancy in chemical constituents and transcriptome.Methods:ASR were separated into three medicinal parts:heads(rootstocks with petiole traces of ASR),bodies(taproots of ASR)and tails(lateral roots of ASR),and chemical and transcriptomic analyses were conducted simultaneously.Results:High performance liquid chromatography(HPLC)fingerprint results showed that five widely used active ingredients(ferulic acid,senkyunolide H,senkyunolide A,n-butylphathlide,and ligustilide)were distributed unevenly in the three ASR medicinal parts.Partial least squares-discriminant analysis(PLS-DA)demonstrated that the heads can be differentiated from the two other root parts due to different amounts of the main components.However,the content of ferulic acid(a main quality marker)was significantly higher in tails than in the heads and bodies.The transcriptome analysis found that 25,062,10,148 and 29,504 unigenes were specifically expressed in the heads,bodies and tails,respectively.WGCNA analysis identified 17 co-expression modules,which were constructed from the 19,198 genes in the nine samples of ASR.Additionally,we identified 28 unigenes involved in two phenylpropanoid biosynthesis(PB)pathways about ferulic acid metabolism pathways,of which 17 unigenes(60.7%)in the PB pathway were highly expressed in the tails.The expression levels of PAL,C3 H,and CQT transcripts were significantly higher in the tails than in other root parts.RT-q PCR analysis confirmed that PAL,C3 H,and CQT genes were predominantly expressed in the tail parts,especially PAL,whose expression was more than doubled as compared with that in other root parts.Conclusion:Chemical and transcriptomic analyses revealed the distribution contents and pivotal transcripts of the ferulic acid biosynthesis-related pathways.The spatial gene expression pattern partially explained the discrepancy of integral medi

关键词： Angelicae Sinensis Radix biosynthesis comparative transcriptomics ferulic acid three medicinal root parts

NSNO:Neumann Series Neural Operator for Solving Helmholtz Equations in Inhomogeneous Medium

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Journal of Systems Science & Complexity 2024年第2期37卷 413-440页

作者： chen Fukai LIU Ziyang lin Guochang chen Junqing shi Zuoqiang Department of Mathematical Sciences Tsinghua UniversityBeijing 100084China Yau Mathematical Sciences Center Tsinghua UniversityBeijing 100084China Yanqi Lake Beijing Institute of Mathematical Sciences and Applications Beijing 101408China

In this paper,the authors propose Neumann series neural operator(NSNO)to learn the solution operator of Helmholtz equation from inhomogeneity coefficients and source terms to solutions.Helmholtz equation is a crucial partial differential equation(PDE)with applications in various scientific and engineering fields.However,efficient solver of Helmholtz equation is still a big challenge especially in the case of high wavenumber.Recently,deep learning has shown great potential in solving PDEs especially in learning solution operators.Inspired by Neumann series in Helmholtz equation,the authors design a novel network architecture in which U-Net is embedded inside to capture the multiscale feature.Extensive experiments show that the proposed NSNO significantly outperforms the state-of-the-art FNO with at least 60%lower relative L^(2)-error,especially in the large wavenumber case,and has 50%lower computational cost and less data requirement.Moreover,NSNO can be used as the surrogate model in inverse scattering problems.Numerical tests show that NSNO is able to give comparable results with traditional finite difference forward solver while the computational cost is reduced tremendously.

关键词： Helmholtz equation inverse problem neumann series neural network solution operator

The genome sequence of star fruit(Averrhoa carambola)

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Horticulture Research 2020年第1期7卷 1703-1712页

作者： Shasha Wu Wei Sun Zhichao Xu Junwen Zhai Xiaoping Li chengru Li Diyang Zhang Xiaoqian Wu Liming Shen Junhao chen Hui Ren Xiaoyu Dai Zhongwu Dai Yamei Zhao Lei chen Mengxia Cao Xinyu Xie Xuedie Liu Donghui Peng Jianwen Dong Yu-Yun Hsiao shi-lin chen Wen-Chieh Tsai Siren Lan Zhong-Jian Liu Key Laboratory of National Forestry and Grassland Administration for Orchid Conservation and Utilization at College of Landscape Architecture Fujian Agriculture and Forestry UniversityFuzhou 350002China Institute of Chinese Materia Medica Chinese Academy of China Medical SciencesBeijing 100700China Institute of Medicinal Plant Development Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China State Key Laboratory of Subtropical Silviculture Zhejiang A&F UniversityLin’anHangzhou 311300China Horticulture Research Institute Guangxi Academy of Agricultural SciencesNanning 530007China Orchid Research and Development Center National Cheng Kung UniversityTainan 701China Institute of Tropical Plant Sciences and Microbiology National Cheng Kung UniversityTainan City 701China

Oxalidaceae is one of the most important plant families in horticulture,and its key commercially relevant genus,Averrhoa,has diverse growth habits and fruit types.Here,we describe the assembly of a high-quality chromosomescale genome sequence for Averrhoa carambola(star fruit).Ks distribution analysis showed that A.carambola underwent a whole-genome triplication event,i.e.,the gamma event shared by most eudicots.Comparisons between A.carambola and other angiosperms also permitted the generation of Oxalidaceae gene annotations.We identified unique gene families and analyzed gene family expansion and contraction.This analysis revealed significant changes in MADS-box gene family content,which might be related to the cauliflory of A.carambola.In addition,we identified and analyzed a total of 204 nucleotide-binding site,leucine-rich repeat receptor(NLR)genes and 58 WRKY genes in the genome,which may be related to the defense response.Our results provide insights into the origin,evolution and diversification of star fruit.

关键词： sequence insight analysis

Immune checkpoint inhibitor-associated gastritis:Patterns and management

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World Journal of Gastroenterology 2024年第14期30卷 1941-1948页

作者： Jing lin Zhong-Qiao lin shi-cheng Zheng Yu chen Department of Medical Oncology Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhou 350000Fujian ProvinceChina Phase I Clinical Trial Ward Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhou 350000Fujian ProvinceChina School of Basic Medical Sciences Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina

Immune checkpoint inhibitors(ICIs)are widely used due to their effectiveness in treating various tumors.Immune-related adverse events(irAEs)are defined as adverse effects resulting from ICI treatment.Gastrointestinal irAEs are a common type of irAEs characterized by intestinal side effects,such as diarrhea and colitis,which may lead to the cessation of ICIs.Although irAE gastritis is rarely reported,it may lead to serious complications such as gastrorrhagia.Furthermore,irAE gastritis is often difficult to identify early due to its diverse symptoms.Although steroid hormones and immunosuppressants are commonly used to reverse irAEs,the best regimen and dosage for irAE gastritis remains uncertain.In addition,the risk of recurrence of irAE gastritis after the reuse of ICIs should be considered.In this editorial,strategies such as early identification,pathological diagnosis,mana-gement interventions,and immunotherapy rechallenge are discussed to enable clinicians to better manage irAE gastritis and improve the prognosis of these patients.

关键词： Immunotherapy Immune checkpoint inhibitor Immune-related adverse events Immune checkpoint inhibitor-related gastritis

Biosynthesis and Regulation of Active Compounds in Medicinal Model Plant Salvia miltiorrhiza

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Chinese Herbal Medicines 2016年第1期8卷 3-11页

作者： Zhi-chao Xu Ai-jia Ji Xin Zhang Jing-yuan Song shi-lin chen Institute of Medicinal Plant Development Chinese Academy of Medical Sciences Peking Union Medical College Institute of Chinese Materia Medica Chinese Academy of Chinese Medical Sciences

Natural products from plant secondary metabolits are a major source of clinical drugs and industrial chemicals. Salvia miltiorrhiza is one of the most important plants in traditional Chinese medicine. Its dried roots and rhizomes are highly valued for use in the treatment of vascular diseases and for their anti-oxidative activities. Furthermore, S. miltiorrhiza is described as a medicinal model plant mainly due to its biosynthesis of active compounds. Here, we reviewed the research on S. miltiorrhiza in genomics, transcriptomics, biosynthesis of tanshinones and phenolic acids, biotic and abiotic elicitors, and regulation of transcription factors. This will provide a solid foundation for new breeding and synthetic biology approaches to produce and study natural products.

关键词： omics phenolic acids Salvia mi/tiorrhiza synthetic biology tanshinones transcription factors

Effects of huoxiangzhengqi liquid on enteric mucosal immune responses in mice with Bacillus dysenteriae and Salmonella typhimurium induced diarrhea

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World Journal of Gastroenterology 2006年第45期12卷 7346-7349页

作者： Yin-Hui He Hong-Yan Zhao Zhen-Li Liu cheng Lu Xiao-Jian Luo Se-Qi lin Xing-Wen Qian shi-lin chen Ai-Ping Lu National Pharmaceutical Engineering Research Center Jiangxi University of Traditional Chinese Medicine Nanchang 33000 Jiangxi Province China Institute of Basic Research China Academy of Traditional Chinese Medicine Beijing 100700 China State Key Laboratory of Traditional Chinese Medicine and Molecular Pharmacology Shenzhen 518057 Guangdong Province China E-institute of Shanghai Municipal Education Commission Shanghai Traditional Chinese Medicine University Shanghai China

AIM: To explore effects of huoxiangzhengqi liquid (HXZQ) on enteric mucosal immune responses in mice with Bacillus dysenteriae and Salmonella typhimurium induced diarrhea (BSD). METHODS: BSD was induced in Balb/c mice by oral administration with Bacillus dysenteriae and Salmonella typhimurium. HXZQ was administrated from the day of diarrhea induction at dosages of 5.21 g/kg and 0.52 g/kg, respectively. The onset of diarrhea and lasting time were recorded. Peyer’s patches and peripheral lymphocytes were prepared for ? ow cytometry, and levels of TNF-α in peripheral blood and enteric tissue homogenates were determined with ELISA. Student’s t test was employed for statistics. RESULTS: Mice in BSD group started showing continuous diarrhea on the day of induction until the fourth day when they were sacrificed. Diarrhea in the mice of HXZQ high and low dose groups lasted for 36 and 54 h, respectively. There were more CD4+ and CD8+ cells in peripheral blood, fewer CD4+ cells in Peyer’s patches in BSD mice compared to normal mice. Fewer CD4+ and CD8+ cells was shown in the mice in HXZQ high groupcompared to BSD mice. In Peyer’s patch, there were more CD8+ cells in mice in HXZQ high and low dose groups and more CD4+ in mice in HXZQ high group. Higher levels of TNF-α in peripheral blood and intestinal tissue homogenates in BSD group were observed. Mice in HXZQ high group showed decreased levels of TNF-α in peripheral blood and enteric tissue homogenates. CONCLUSION: The immune regulation of CD4+ and CD8+ cells in Peyer’s patch and suppression of TNF-α levels in enteric homogenates may partially explain the effect of HXZQ on improvement of BSD.

关键词：痢疾腹泻肠溶性免疫系统