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Single-cell omics: experimental workflow, data analyses and applications

Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

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新型冠状病毒肺炎疫情期间我国民众居家健身意愿与参与情况调研报告

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北京体育大学学报 2020年第3期43卷 46-56页

作者：孙湛宁胡博然程琳琳石阳君冯文莱北京体育大学中国奥林匹克高等研究院北京100084 石家庄学院体育学院河北石家庄050035

新型冠状病毒肺炎疫情发生至今,我国民众的日常生活方式和健身方式已经发生明显变化。主要采用问卷调查法,对新型冠状病毒肺炎疫情期间我国民众居家健身意愿与参与情况进行调查,并由此判断我国民众健身方式走向,同时对相关体育产业的发... 详细信息

新型冠状病毒肺炎疫情发生至今,我国民众的日常生活方式和健身方式已经发生明显变化。主要采用问卷调查法,对新型冠状病毒肺炎疫情期间我国民众居家健身意愿与参与情况进行调查,并由此判断我国民众健身方式走向,同时对相关体育产业的发展提出建议。基于对2686份疫情期间民众居家健身行为的问卷调查,认为:1)新型冠状病毒肺炎疫情期间居家健身行为有益于当前体育人口维持存量并培养潜在体育人口;2)居家健身行为有助于确立以健康身体与健康心理为导向的体育观;3)健身资讯的网络化传播在疫情期间发挥重要作用,对民众具有健身活动日常化的启蒙性作用,也将影响未来体育产业的发展格局;4)疫情期间的居家健身活动有助于重塑家庭体育,而家庭体育是培养稳定体育人口的重要维度;5)居家健身是特殊时期、特定人群的主要健身方式,但在疫情结束之后会逐步扩展其在民众日常健身活动中的影响力;6)应避免居家健身行为的运动化方式,促进居家健身方法在疫情之后对特殊人群的应用。

关键词：新型冠状病毒肺炎疫情居家健身参与意愿参与行为

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Increase in the variability of terrestrial carbon uptake in response to enhanced future ENSO modulation

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 32-38页

作者： Younong Li Li Dan Jing Peng Qidong yang Fuqiang yang Key Laboratory of Regional Climate-Environment for Temperate East Asia Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina Key Laboratory of Atmospheric Environment and Processes in the Boundary Layer over the Low-Latitude Plateau Region Department of Atmospheric ScienceYunnan UniversityKunmingChina

El Niño-Southern Oscillation(ENSO)is a major driver of climate change in middle and low latitudes and thus strongly influences the terrestrial carbon cycle through land-air *** the ENSO modulation and carbon flux variability are projected to increase in the future,but their connection still needs further *** investigate the impact of future ENSO modulation on carbon flux variability,this study used 10 CMIP6 earth system models to analyze ENSO modulation and carbon flux variability in middle and low latitudes,and their relationship,under different scenarios simulated by CMIP6 *** results show a high consistency in the simulations,with both ENSO modulation and carbon flux variability showing an increasing trend in the *** higher the emissions scenario,especially SSP5-8.5 compared to SSP2-4.5,the greater the increase in *** flux variability in the middle and low latitudes under SSP2-4.5 increases by 30.9%compared to historical levels during 1951-2000,while under SSP5-8.5 it increases by 58.2%.Further analysis suggests that ENSO influences mid-and low-latitude carbon flux variability primarily through *** occurrence may potentially be attributed to the increased responsiveness of gross primary productivity towards regional temperature fluctuations,combined with the intensified influence of ENSO on land surface temperatures.

关键词： Carbon variability ENSO modulation CMIP6 models

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惰性气体输运过程中的扩散性质研究

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四川大学学报（工程科学版） 2002年第6期34卷 102-104页

作者：郭建军石建杨继先四川工业学院四川成都610039

系统计算了惰性气体及其二元混合体系在不同温度下的扩散性质 ,给出了计算结果 ,并与***等人所计算的最佳值进行了比较 ,结果符合较好 ,但本文的方法简单而且使用的势函数解析性好。这就进一步从宏观扩散性质的计算证明了Tang-toennies... 详细信息

系统计算了惰性气体及其二元混合体系在不同温度下的扩散性质 ,给出了计算结果 ,并与***等人所计算的最佳值进行了比较 ,结果符合较好 ,但本文的方法简单而且使用的势函数解析性好。这就进一步从宏观扩散性质的计算证明了Tang-toennies势的准确性。

关键词：惰性气体扩散性质二元混合体系扩散系数对应态原理 Tang-toennies势气体输运过程

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三元复合驱中乳化作用对提高采收率的影响

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石油学报 2003年第5期24卷 71-73页

作者：李世军杨振宇宋考平康万利大庆石油学院黑龙江大庆163318 大庆油田有限责任公司黑龙江大庆163453

评价了不同机械搅拌力、不同含水率条件下 ,碱、表面活性剂、聚合物溶液与原油间的乳化能力 ,研究了这种三元复合驱过程中形成的乳化液类型及其稳定性 ,给出了油水比、化学剂类型、浓度、外力及其综合作用对产生乳化的影响程度。分析了... 详细信息

评价了不同机械搅拌力、不同含水率条件下 ,碱、表面活性剂、聚合物溶液与原油间的乳化能力 ,研究了这种三元复合驱过程中形成的乳化液类型及其稳定性 ,给出了油水比、化学剂类型、浓度、外力及其综合作用对产生乳化的影响程度。分析了大庆油田三元复合驱矿场试验中采出液产生乳化的原因。室内物理模拟实验表明 ,三元复合驱过程中产生的原油乳化作用是提高驱油效率。

关键词：碱表面活性剂聚合物驱油体系乳化作用乳状液提高采收率

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High-temperature-tolerant flexible supercapacitors: Gel polymer electrolytes and electrode materials

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Journal of Energy Chemistry 2025年第1期100卷 426-457页

作者： Chong Peng Xinyi Huang Mingwei Zhao Shuling Liao Quanhong yang Nianjun yang Siyu Yu School of Chemistry & Chemical Engineering Southwest University Nanoyang Group Tianjin Key Laboratory of Advanced Carbon and Electrochemical Energy Storage School of Chemical Engineering and Technology and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Tianjin University Department of Chemistry & IMO-IMOMEC Hasselt University

The development of flexible supercapacitors(FSCs) capable of operating at high temperatures is crucial for expanding the application areas and operating conditions of supercapacitors. Gel polymer electrolytes and electrode materials stand as two key components that significantly impact the efficacy of hightemperature-tolerant FSCs(HT-FSCs). They should not only exhibit high electrochemical performance and excellent flexibility, but also withstand intense thermal stress. Considerable efforts have been devoted to enhancing their thermal stability while maintaining high electrochemical and mechanical performance. In this review, the fundamentals of HT-FSCs are outlined. A comprehensive overview of state-of-the-art progress and achievements in HT-FSCs, with a focus on thermally stable gel polymer electrolytes and electrode materials is provided. Finally, challenges and future perspectives regarding HT-FSCs are discussed, alongside strategies for elevating operational temperatures and *** review offers both theoretical foundations and practical guidelines for designing and manufacturing HT-FSCs, further promoting their widespread adoption across diverse fields.

关键词： Flexible supercapacitors High-temperature tolerance Gel polymer electrolytes Electrode materials

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基于Feistel结构的超轻量级分组密码算法(PFP)

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计算机科学 2017年第3期44卷 163-167页

作者：黄玉划代学俊时阳阳刘宁钟曾庆喜苏菲南京航空航天大学计算机科学与技术学院南京211106 苏州中科启慧软件技术有限公司苏州215500 南京航空航天大学能源与动力学院南京210016

面向无线终端资源受限环境对加密算法的应用需求,借鉴PRESENT算法的设计思想,采用Feistel结构,并修改扩散层的P置换,设计了一种超轻量级分组密码算法PFP。其硬件实现需要1355GE,优于PRESENT算法,满足资源极端受限环境的需求(2000GE以下... 详细信息

面向无线终端资源受限环境对加密算法的应用需求,借鉴PRESENT算法的设计思想,采用Feistel结构,并修改扩散层的P置换,设计了一种超轻量级分组密码算法PFP。其硬件实现需要1355GE,优于PRESENT算法,满足资源极端受限环境的需求(2000GE以下)。速度测试结果表明,PFP算法的软件实现效率约为PRESENT算法的1.5倍。依赖性测试、线性分析、差分分析、不可能差分分析和密钥编排攻击表明,PFP算法满足轻量级分组密码的安全需求。

关键词：轻量级分组密码 Feistel结构 PRESENT算法依赖性测试密码分析

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LAMELLAR STRUCTURE IN LONG RANGE ORDERED PHASE δ′-TiN_(0.5)

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中国有色金属学会会刊：英文版 1997年第3期7卷 8-14页

作者： yang, Caiying Du, jun shi, Likai General Research Inst for Nonferrous Metals Beijing China

ＬＡＭＥＬＬＡＲＳＴＲＵＣＴＵＲＥＩＮＬＯＮＧＲＡＮＧＥＯＲＤＥＲＥＤＰＨＡＳＥδ′ＴｉＮ０．５①ＹａｎｇＧａｉｙｉｎｇ，ＤｕＪｕｎ，ＳｈｉＬｉｋａｉＧｅｎｅｒａｌＲｅｓｅａｒｃｈＩｎｓｔｉｔｕｔｅｆｏｒＮｏｎｆ... 详细信息

ＬＡＭＥＬＬＡＲＳＴＲＵＣＴＵＲＥＩＮＬＯＮＧＲＡＮＧＥＯＲＤＥＲＥＤＰＨＡＳＥδ′ＴｉＮ０．５①ＹａｎｇＧａｉｙｉｎｇ，ＤｕＪｕｎ，ＳｈｉＬｉｋａｉＧｅｎｅｒａｌＲｅｓｅａｒｃｈＩｎｓｔｉｔｕｔｅｆｏｒＮｏｎｆｅｒｒｏｕｓＭｅｔａｌｓ，Ｂｅｉｊ...

关键词： lamellar structure δ′ TiN 0.5 long range ordering transformation

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Role of the Greenland Sea ice anomaly in the late-spring drought over Northwest China

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 1-5页

作者： yang Liu Huopo Chen Nansen-Zhu International Research Centre Institute of Atmospheric Physics Chinese Academy of SciencesBeijingChina Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University for Information Science and TechnologyNanjingChina

Drought across Northwest China in late spring has exerted a vital effect on the local climate and agricultural production,and has been alleviated during the past *** study explored the influence of the preceding Arctic sea ice on the May drought in Northwest China caused by the precipitation *** analysis indicated that when the Greenland Sea ice concentration is abnormally high during February to April,the dry conditions in Northwest China tend to be *** increase of sea ice in the Greenland Sea can excite a meridional circulation,which causes sea surface temperature(SST)anomalies in the North Atlantic via the sea-air interaction,manifested as significant warm SST anomalies over the south of Greenland and the subtropical North Atlantic,but negative SST anomalies over the west of the *** abnormal SST pattern maintains to May and triggers a zonal wave train from the North Atlantic through Scandinavia and Central Asia to Northwest China,leading to abnormal cyclones in Northwest ***,Northwest China experiences a more humid climate than usual.

关键词： Arctic sea ice Greenland Sea North Atlantic SST Drought Northwest China

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A surface engineering strategy for the stabilization of zinc metal anodes with montmorillonite layers toward long-life rechargeable aqueous zinc ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 94-105页

作者： Wenbo Wang Ruifeng Xu Xu Zhang Peiyu Wang Bao yang Bingjun yang Juan yang Kailimai Su Pengjun Ma Yanan Deng Xianfeng Fan Wanjun Chen Key Laboratory for Electronic Materials College of Electrical Engineering Northwest Minzu University Resource Chemistry and Energy Materials Research Center State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics Chinese Academy of Sciences University of Chinese Academy of Sciences Institute for Materials and Processes School of Engineering University of Edinburgh

Rechargeable aqueous zinc-ion batteries （AZIBs） exhibit appreciable potential in the domain of electrochemical energy ***,there are serious challenges for AZIBs,for instance zinc dendrite growth,hydrogen evolution reaction （HER）,and corrosion side ***,we propose a surface engineering modification strategy for coating the montmorillonite （MMT） layer onto the surface of the Zn anode to tackle these issues,thereby achieving high cycling stability for rechargeable *** results reveal that the MMT layer on the surface of the Zn anode is able to provide ordered zincophilic channels for zinc ions migration,facilitating the reaction kinetics of zinc *** functional theory（DFT） calculations and water contact angle （CA） tests prove that MMT@Zn anode exhibits superior adsorption capacity for Zn2+and better hydrophobicity than the bare Zn anode,thereby achieving excellent cycling ***,the MMT@Zn||MMT@Zn symmetric cell holds the stable cycling over 5600 h at 0.5 mA cm-2and 0.125 m A h cm-2,even exceeding 1800 h long cycling under harsh conditions of 5 m A cm-2and 1.25 m A h *** MMT@Zn||V2O5full cell reaches over 3000 cycles at 2 A g-1with excellent rate ***,this surface engineering modification strategy for enhancing the electrochemical performance of AZIBs represents a promising application.

关键词： Surface engineering strategy Montmorillonite layer Protection mechanism of Zn anode Cycling stability Aqueous zinc ion batteries

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