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Bionic peptide scaffold in situ polarization and recruitment of M2 macrophages to promote peripheral nerve regeneration

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Bioactive Materials 2023年第12期30卷 85-97页

作者： Pengxiang Yang Yong Peng Xiu Dai Jing Jie Deling Kong Xiaosong gu Yumin Yang Key Laboratory of Neuroregeneration of jiangsu Province and Ministry of Education Co-Innovation Center of NeuroregenerationNMPA Key Laboratory for Researchand Evaluation of Tissue Engineering Technology ProductsNantong University226001NantongPR China Institute of Cancer Prevention and Treatment Heilongjiang Academy of Medical ScienceHarbin Medical University150081HarbinPR China Department of Clinical Laboratory The Second Affiliated Hospital of Nantong University226001NantongPR China State Key Laboratory of Medicinal Chemical Biology College of Life SciencesNankai UniversityTianjin300071PR China

Tissue regeneration requires exogenous and endogenous signals,and there is increasing evidence that the exogenous microenvironment may play an even more dominant role in the complex process of coordinated multiple *** short-distance peripheral nerve showed a spontaneous regenerative phenomenon,which was initiated by the guiding role of ***,it cannot sufficiently restore long-distance nerve injury by *** on this principle,we firstly constructed a proinflammatory model to prove that abnormal M2 expression reduce the guidance and repair effect of long-distance ***,a bionic peptide hydrogel scaffold based on self-assembly was developed to envelop M2-derived regenerative cytokines and extracellular vesicles(EVs).The cytokines and EVs were quantified to mimic the guidance and regenerative microenvironment in a direct and mild *** bionic scaffold promoted M2 transformation in situ and led to proliferation and migration of Schwann cells,neuron growth and motor function ***,the peptide scaffold combined with CX3CL1 recruited more blood-derived M2 macrophages to promote long-distance nerve recon***,we systematically confirmed the important role of M2 in regulating and restoring the injury peripheral *** bionic peptide hydrogel scaffold mimicked and remodeled the local environment for M2 transformation and recruitment,favoring long-distance peripheral nerve *** can help to explicate regulative effect of M2 may be a cause not just a consequence in nerve repair and tissue integration,which facilitating the development of pro-regenerative biomaterials.

关键词： Bionic peptide scaffolds Peripheral nerve regeneration Macrophages Conditional media Immune microenvironment

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Jellyfish Tentacle‑Inspired Hydrogel Microfibers Implanted with Discrete Structural Color Microsphere Tactile Sensing Units

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Advanced Fiber Materials 2022年第5期4卷 1209-1218页

作者： Jiahui guo Han Zhang Hui Zhang Hanxu Chen Zhuxiao gu Dagan Zhang Yuanjin Zhao Department of Rheumatology and Immunology Nanjing Drum Tower HospitalSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325001ZhejiangChina Institute for Stem Cell and Regeneration Chinese Academy of ScienceBeijing 100101China

Tactile sensors with distinctive ability to imitate skins have attracted considerable attention from researches for applications in a variety of sensing ***,inspired by the tentacles of jellyfish,biomimetic hydrogel microfibers were fabricated to be implanted with discrete structural color microsphere units for spatial tactile *** employing a microfluidic spinning technology,the generated microfibers were with high microsphere encapsulation features and controllable morphologies because of the density match of microspheres and the pre-hydrogel *** addition,benefitting from the easy manipulation of the microfluidics,microfibers implanted with different structural color microspheres could also be *** was demonstrated that the resultant microfibers would show synchronous shifts of photonic bandgaps as well as structural color when a local force like pressure or tension was applied to the microsphere *** on the localization of finger bending experiments,the practical values of the bioinspired microfibers have also been proved as spatial tactile ***,it is believed that the proposed bioinspired hydrogel microfibers are greatly significant in diverse sensing application fields.

关键词： Bioinspired Microfluidics Microfiber Structural color Tactile sensor

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Cross-Sectional Online Survey on Depression and Anxiety Among the Population Infected or Non-Infected with COVID-19——China,December 2022

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China CDC weekly 2023年第11期5卷 235-240页

作者： Tingting Qin Xingming Li Mingyu gu Yao Wang Yutong Yang Xinyuan Bai Kun Qiao School of Public Health Capital Medical UniversityBeijingChina

Summary What is already known about this topic?The psychological impact of the large-scale infection of the population resulting from the end of lockdown measures in China during the coronavirus disease 2019(COVID-19)pandemic is *** is added by this report?Among all participants,55.7%had depression symptoms,with a significant difference between the infected and non-infected groups,and 30.1%had *** who were young,unvaccinated,had lower incomes,and experienced chronic diseases were more likely to experience negative *** are the implications for public health practice?Government officials should take into account the effect of policies on public sentiment during similar public health events and implement tailored community interventions to address any negative sentiment.

关键词： Infect likely Population

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Rapid and non-destructive detection method for water status and water distribution of rice seeds with different vigor

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International Journal of Agricultural and Biological Engineering 2021年第2期14卷 231-238页

作者： Ping Song Ghiseok Kim Peng Song Tao Yang Xia Yue Ying gu College of Information and Electrical Engineering Shenyang Agricultural UniversityShenyang 110866China Liaoning Engineering Research Centre for Information Technology in Agricultural Shenyang Agricultural UniversityShenyang 110866China Department of Biosystems&Biomaterials Science and Engineering College of Agriculture&Life SciencesSeoul National UniversitySeoul 08826Korea College of Plant Science&Technology Huazhong Agricultural UniversityWuhan 430070China School of Information and Intelligence Engineering University of SanyaSanyaHainan 572022China Academician Workstation of guoliang Chen University of SanyaSanyaHainan 572022China

In this study,newly harvested and aged rice seeds were analyzed to determine their aging process,identify the difference between artificially and naturally aged seeds,and develop a rapid,accurate,and non-destructive detection method for water status and water distribution of rice seed with different *** this end,an artificially accelerated aging test was conducted on the newly harvested rice ***,low-field nuclear magnetic resonance(LF-NMR)technology was applied to test the new(Shennong No.9816,2018),old(Shennong No.9816,2017),and artificially aged seeds(Shennong No.9816,2018).A standard germination test was conducted for three types of ***,the differences of water status and distribution between rice seeds of different vigor were analyzed based on the standard germination test results and wave spectrometry information collected using *** results indicated that new seeds,old seeds,and the artificially accelerated aging rice seeds all exhibited two water phases,and the vigor of rice seeds after the artificial accelerated aging test was lower than that of new *** were significant differences between the frequencies of bound water at the time of the peak and the time at the end of the peak for the three types of *** two times showed an increasing trend for rice seeds with poor vigor,indicating that the ability of the water in the rice seeds having poor vigor to combine with other substances was *** were significant differences between the distributions of free water peak end time for the three types of *** the rice seeds with poor vigor exhibited a decreasing trend at this time,indicating that the freedom of free water inside the rice seed samples with poor vigor was *** total water content of the artificially aged seeds and the aged seeds was higher than that of the new seeds,but the free water content increased from artificially aged seeds to new seeds to aged *** indicates that LF-NMR technol

关键词： low-field nuclear magnetic resonance rice seed water status detection water distribution detection seed vigor

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超声引导胸椎旁神经阻滞对食管癌手术患者应激反应的影响

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临床麻醉学杂志 2015年第1期31卷 18-21页

作者：辜晓岚何建华顾连兵江苏省肿瘤医院麻醉科南京市210009

目的观察超声引导胸椎旁神经阻滞对食管癌手术患者循环及应激反应的影响。方法择期食管癌开胸手术患者40例,随机均分为胸椎旁神经阻滞复合全麻组（A组）和单纯全麻组（B组）。两组全麻方法相同,A组于全麻诱导前行超声引导下胸椎旁神经阻... 详细信息

目的观察超声引导胸椎旁神经阻滞对食管癌手术患者循环及应激反应的影响。方法择期食管癌开胸手术患者40例,随机均分为胸椎旁神经阻滞复合全麻组（A组）和单纯全麻组（B组）。两组全麻方法相同,A组于全麻诱导前行超声引导下胸椎旁神经阻滞,术后两组均采用患者静脉自控镇痛（PCIA）。记录患者全麻药物用量及麻醉前（T1）、诱导前（T2）、气管插管即刻（T3）、手术2h（T4）、术毕（T5）、术后1h（T6）、4h（T7）、8h（T8）、24h（T9）、48h（T10）的SBP、DBP、HR、SpO2,记录T6～T10时疼痛VAS评分、Ramsay镇静评分,并于T1、T4、T5、T9时抽血检测血糖、肾上腺素（E）、去甲肾上腺素（NE）、多巴胺（DA）浓度。结果 A组患者术中丙泊酚用量、瑞芬太尼用量明显少于B组（P〈0.05）。两组患者术中血流动力学平稳,术后A组T6～T9安静时和活动时的疼痛VAS评分均明显低于B组（P〈0.05）,Ramsay镇静评分差异无统计学意义。两组T9时血糖、NE均明显高于T1、T4、T5时,T4、T5时E均明显低于T1、T9时,B组T9时DA明显高于T1、T4、T5时（P〈0.05）,B组T9时血糖、NE、E、DA均明显高于A组（P〈0.05）。结论超声引导胸椎旁神经阻滞复合全麻用于食管癌手术安全有效,较单纯全麻能更好地抑制应激反应,减少全麻药物的使用。

关键词：胸椎旁神经阻滞超声引导应激反应

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求解约束规划的一个非线性Lagrange函数

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数学进展 2007年第6期36卷 749-760页

作者：顾剑任咏红大连理工大学应用数学系大连辽宁116024

本文提出了一个求解不等式约束优化问题的非线性Lagrange函数,并构造了基于该函数的对偶算法.证明了当参数σ小于某一阈值σ_0时,由算法生成的原始-对偶点列是局部收敛的,并给出了原始-对偶解的误差估计.此外,建立了基于该函数的对偶理... 详细信息

本文提出了一个求解不等式约束优化问题的非线性Lagrange函数,并构造了基于该函数的对偶算法.证明了当参数σ小于某一阈值σ_0时,由算法生成的原始-对偶点列是局部收敛的,并给出了原始-对偶解的误差估计.此外,建立了基于该函数的对偶理论.最后给出了算法的数值结果.

关键词：非线性Lagrange函数对偶算法对偶函数鞍点

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Numerical study of shoreline changes by emergency beach nourishment project at the Middle Beach of Beidaihe, China

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Acta Oceanologica Sinica 2012年第1期31卷 125-133页

作者： ZHANG Yu HE Lulu KUANG Cuiping PAN Yi gu Jie YANG Yanxiong ZHANG Jiabo College of Geoscience and Surveying Engineering China University of Mining and TechnologyBeijing 100083China Department of Hydraulic Engineering College of Civil EngineeringTongji UniversityShanghai 200092China College of Marine Science Shanghai Ocean UniversityShanghai 201306China Qinhuangdao Mineral Resource and Hydrogeological Brigade Hebei Geological Prospecting BureauQinhuangdao 066003China

Beach nourishment is a common coastal management strategy used to protect beach from erosion along the sandy coastlines. This method has been successfully applied to an emergency project at the West Beach of Beidaihe in the summer of 2008 and the full West Beach nourishment project in 2009-2010, which is the direct base of this study. Some basic information about the emergency engineering area at the Middle Beach is firstly described. The shoreline change of this area, including the analysis of beach width in five monitoring profiles in the bathing places of Middle Beach, is then discussed. After that a numerical modal based on one-line theory is established and the numerical results agree well with the measured shorelines, which indicates that the model is appropriate and is qualified to predict the shoreline change of the Middle Beach. With the same model and parameters, long-term performance of the project is predicted, and the result shows that without follow-up nourishment and project, the bathing places can remain suitable for bathing for about 10 a. It is suggested to nourish the beach in time and carry out the beach nourishment project for the full Middle Beach in Beidaihe.

关键词： one-line model numerical model shoreline change beach nourishmentl Middle Beach in Beidaihe

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Clinical and microbiological characteristics of patients with biliary disease

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World Journal of Gastroenterology 2020年第14期26卷 1638-1646页

作者： Xue-Xiang gu Meng-Pei Zhang Yan-Feng Zhao guang-Ming Huang Department of Gastroenterology The Affiliated Huaian No.1 People's Hospital of Nanjing Medical UniversityHuaian 223001Jiangsu ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011Jiangsu ProvinceChina Center of Laboratory Medicine The Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011Jiangsu ProvinceChina

BACKGROUND Biliary diseases are common digestive system disorders which may combine with biliary tract infection such as cholecystitis or ***,rapid identification of the bacteria and their antibiotic susceptibility profiles are crucial for reducing the mortality of patients with biliary tract *** To identify bacterial species and antibiotic susceptibility for antibacterial therapy and analyze bile cultivation risk factors for increasing detection *** This retrospective study was conducted from July 2008 to July *** total,1339 bile samples which were collected during therapeutic endoscopic retrograde cholangiopan-creatography or percutaneous transhepatic cholangiodrainage or other biliary surgeries or biliary drainage were obtained to characterize pathogen spectra,antibiotic susceptibility,and clinical *** data including age,sex,comorbidities,clinical symptoms,protopathies,and history of biliary tract diseases and surgeries were collated from hospital medical *** identification and initial drug susceptibility were further identified by biochemical characterization using the VITEK 2 Compact *** Positive microbiological findings were observed in 738 *** most frequently encountered strains were gram-negative bacteria(74.94%),including Escherichia coli(37.78%),Pseudomonas aeruginosa(8.96%),and Klebsiella pneumoniae(10.29%).Bile bacteria were largely sensitive to carbapenems,piperacillin/tazobactam,and ***-negative strains had low susceptibility to ceftriaxone,quinolones and *** the same microorganisms were present in patients with malignant and benign *** number of samples with Klebsiella pneumoniae in the bile culture were significantly different between patients with malignant and benign diseases(55 vs 30;P=0.019).Age(P<0.001),fever(P<0.001),history of biliary tract diseases and surgeries(both P<0.001),benign disease(P=0.002),and the comorbidity chronic re

关键词： Microorganism Antibiotic susceptibility Bile culture Biliary diseases Retrospective study Detection rate

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活性炭上化学气相沉积法生长纳米碳纤维

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无机化学学报 2009年第8期25卷 1342-1348页

作者：谷建宇李开喜刘越中国科学院山西煤碳化学研究所太原030021 中国科学院研究生院北京100049

利用流化床技术,以天然气为碳源,负载于活性炭上的纳米镍粒子为催化剂,在750℃下采用化学气相沉积法制备了气相生长纳米碳纤维(VGCNFs)/活性炭(AC)复合物。通过对样品进行XRD、激光拉曼光谱、扫描电镜和氮吸附检测,发现VGCNFs生长在活... 详细信息

利用流化床技术,以天然气为碳源,负载于活性炭上的纳米镍粒子为催化剂,在750℃下采用化学气相沉积法制备了气相生长纳米碳纤维(VGCNFs)/活性炭(AC)复合物。通过对样品进行XRD、激光拉曼光谱、扫描电镜和氮吸附检测,发现VGCNFs生长在活性炭的各个侧面上,以顶部生长模式为主,纤维的直径在40～120nm之间,由于粗糙的纤维表面和石墨片层的翘曲而缺陷较多。VGCNFs/AC复合物与原料活性炭相比,BET比表面积从2367m2.g-1降到了1474m2.g-1。实验结果表明,以溶胶凝胶法负载催化剂,利用化学气相沉积法在流化床上可以制备具有大比表面积和高性能的VGCNFs/AC复合物。

关键词：化学气相沉积活性炭纳米碳纤维溶胶凝胶法

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Performance analysis of amplify-and-forward relaying with hybrid-ARQ in Rayleigh fading channels

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The Journal of China Universities of Posts and Telecommunications 2009年第6期16卷 32-37页

作者： ZHENG Kan HU Li-jie gu Da-qing WANG Hai-la WANG Wen-bo Wireless Signal Processing and Network Lab Key Laboratory of Universal Wireless Communication Ministry of Education Beijing University of Posts and Telecommunications Beijing 100876 China Orange R&D (Beijing) Beijing 100080 China

Hybrid automatic repeat request（HARQ） is a well-known technique for improving system throughput and link performance of wireless communication systems,including cooperative communication *** amplify-and-forward（AF） relaying method is one of the most attractive cooperative diversity schemes because of its low *** this article,the end-to-end performance in terms of block error rate（BLER） and normalized throughput of AF relaying with HARQ transmission under the Rayleigh fading channel is *** results validate the proposed analysis and demonstrate the gain of HARQ schemes in AF relaying *** analytical method can be extended to the systems with other HARQ protocols and other cooperative relaying schemes.

关键词： cooperative diversity AF HARQ BLER

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