检索结果-南通市图书馆

Circadian disturbance induces erectile dysfunction by impairing endothelial function

Asian Journal of Andrology 2024年第2期26卷 205-211页

作者： Tao Li Yi-Ting Jiang Xin-Zhu Qi Peng chen Jun-hao Zhang Fu Luo Jun Qiao Jiang Gu Guang-shi Du Qiang Wang Department of Urology Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004China Department of Urology Guizhou Provincial People's HospitalGuiyang 550002China Department of Otorhinolaryngology Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004China Guizhou Institute for Food and Drug Control Guiyang 550004China Department of Reproductive Center Guizhou Provincial People's HospitalGuiyang 550002China Translational Medicine Research Center of Guizhou Medical University Guiyang 550025China

In order to explore the impact of circadian disturbance on erectile function,we randomly divided 24 adult male rats into groups of control(light on at 8:00 *** off at 8:00 p.m.),dark/dark(DD;constant dark),light/light(LL;constant light),and shift dark/light(DL;light off at 8:00 *** on at 8:0o p.m.).Four weeks later,erectile function was measured and corpora cavernosa were harvested for *** maximum intracavernous pressure(mlcP)and mCP/mean arterial pressure(MAP)ratio in the DD,LL,and DL groups were significantly lower than that in the control *** LL and DL groups showed significantly attenuated endothelial nitric oxide synthase(eNOS),while DD,LL,and DL showed reduced neuronal nitric oxide synthase(nNOS)at both mRNA and protein *** production of nitric oxide(NO)and cyclic guanosinemonophosphate(cGMP)was inhibited by altered light/dark cycles to varying *** disturbance impaired endothelial function and contributed to erectile *** the core circadian elements,mRNA expression of circadian locomotor output cycles kaput(Clock)and brain/muscle aryl-hydrocarbon receptor nuclear translocator-like protein 1(Bmal1)was elevated in the DL group,but their protein expression was not significantly ***,LL,and DL increased period 1(Per1)and Per3 levels,while LL and DL increased PER1 *** significant difference was found for Per2levels,and PER2 and PER3 concentrations were not significantly ***,LL and DL significantly increased cryptochrome-1(CRY1)and CRY2 at both mRNA and protein *** altered light/dark rat model showed that circadian disturbance contributed to erectile dysfunction probably by impairing endothelial ***,the core circadian elements were detected in the corpora cavernosa,but these were ***,which circadian element regulates erectile function and how it works need further analysis.

关键词： circadian disturbance endothelial function erectile function light/dark cycle NO/cGMP

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Efficient conversion of acoustic vortex using extremely anisotropic metasurface

引用

Frontiers of physics 2024年第4期19卷 257-264页

作者： Zhanlei hao haojie chen Yuhang Yin cheng-Wei Qiu Shan Zhu Huanyang chen Institute of Electromagnetics and Acoustics and Department of Physics College of Physical Science and TechnologyXiamen UniversityXiamen 361005China Department of Electrical and Computer Engineering National University of Singapore4 Engineering Drive 3117583Singapore Department of Mechanical and Electrical Engineering Xiamen UniversityXiamen 361005China Pen-Tung Sah Institute of Micro-Nano Science and Technology Xiamen UniversityXiamen 361005China

Vortex wave and plane wave,as two most fundamental forms of wave propagation,are widely applied in various research ***,there is currently a lack of basic mechanism to enable arbitrary conversion between *** this paper,we propose a new paradigm of extremely anisotropic acoustic metasurface(AM)to achieve the efficient conversion from 2D vortex waves with arbitrary orbital angular momentum(OAM)to plane *** underlying physics of this conversion process is ensured by the symmetry shift of AM medium parameters and the directional compensation of ***,this novel phenomenon is further verified by analytical calculations,numerical demonstrations,and acoustic experiments,and the deflection angle and direction of the converted plane waves are qualitatively and quantitatively confirmed by a simple *** work provides new possibilities for arbitrary manipulation of acoustic vortex,and holds potential applications in acoustic communication and OAM-based devices.

关键词： efficient wave conversion vortex wave plane wave orbital angular momentum acoustic metasurface

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

High-resolution recognition of FOAM modes via an improved EfficientNet V2 based convolutional neural network

引用

Frontiers of physics 2024年第3期19卷 175-183页

作者： Youzhi shi Zuhai Ma Hongyu chen Yougang Ke Yu chen Xinxing Zhou International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology Institute of Microscale OptoelectronicsShenzhen UniversityShenzhen 518060China Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education Synergetic Innovation Center for Quantum Effects and ApplicationsSchool of Physics and ElectronicsHunan Normal UniversityChangsha 410081China Key Laboratory of Hunan Province on Information Photonics and Freespace Optical Communications School of Information Science and EngineeringHunan Institute of Science and TechnologyYueyang 414006China

Vortex beam with fractional orbital angular momentum (FOAM) is the excellent candidate for improving the capacity of free-space optical (FSO) communication system due to its infinite modes. Therefore, the recognition of FOAM modes with higher resolution is always of great concern. In this work, through an improved EfficientNetV2 based convolutional neural network (CNN), we experimentally achieve the implementation of the recognition of FOAM modes with a resolution as high as 0.001. To the best of our knowledge, it is the first time this high resolution has been achieved. Under the strong atmospheric turbulence (AT) (C_(n)^(2)=10^(-15)m^(-2/3)), the recognition accuracy of FOAM modes at 0.1 and 0.01 resolution with our model is up to 99.12% and 92.24% for a long transmission distance of 2000 m. Even for the resolution at 0.001, the recognition accuracy can still remain at 78.77%. This work provides an effective method for the recognition of FOAM modes, which may largely improve the channel capacity of the free-space optical communication.

关键词： OAM free-space optical communication deep learning convolutional neural network

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A target parameter estimation method via atom-reconstruction in radar mainlobe jamming

引用

Journal of Systems Engineering and Electronics 2024年第2期35卷 350-360页

作者： ZHOU Bilei LIU Weijian LI Rongfeng chen Hui ZHANG Liang DU Qinglei LI Binbin chen hao Air Force Early Warning Academy Wuhan 430019China Aerospace Nanhu Electronic Information Technology Co. Ltd.Jingzhou 434000China

Mainlobe jamming(MLJ)brings a big challenge for radar target detection,tracking,and *** suppression of MLJ is a hard task and an open problem in the electronic counter-counter measures(ECCM)*** parameters and target direction estimation is difficult in radar MLJ.A target parameter estimation method via atom-reconstruction in radar MLJ is proposed in this *** proposed method can suppress the MLJ and simultaneously provide high estimation accuracy of target range and ***,the eigen-projection matrix processing(EMP)algorithm is adopted to suppress the MLJ,and the target range is estimated effectively through the beamforming and pulse *** the target angle can be effectively estimated by the atom-reconstruction *** any prior knowledge,the MLJ can be canceled,and the angle estimation accuracy is well ***,the proposed method does not have strict requirement for radar array construction,and it can be applied for linear array and planar ***,the proposed method can effectively estimate the target azimuth and elevation simultaneously when the target azimuth(or elevation)equals to the jamming azimuth(or elevation),because the MLJ is suppressed in spatial plane dimension.

关键词： mainlobe jamming anti-jamming atom-reconstruction radar

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Arbitrary acoustic orbital angular momentum detection using dual-layer metasurfaces

引用

Science China(Physics,Mechanics & Astronomy) 2024年第6期67卷 106-112页

作者： Zhanlei hao haojie chen Yuhang Yin Shan Zhu Yadong Xu cheng-Wei Qiu Huanyang chen Department of Physics College of Physical Science and TechnologyXiamen UniversityXiamen 361005China Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore Department of Mechanical and Electrical Engineering Xiamen UniversityXiamen 361005China Pen-Tung Sah Institute of Micro-Nano Science and Technology Xiamen UniversityXiamen 361005China School of Physical Science and Technology and Jiangsu Key Laboratory of Thin Films Soochow UniversitySuzhou 215006China

Orbital angular momentum(OAM),with its unique physical properties and vast application prospects,has attracted widespread attention in various ***,the development of valid and practical acoustic OAM detection methods continues to be a challenging *** this paper,we propose a novel construction method of dual-layer metasurfaces to achieve a doubleconversion process for the waveform reshaping and differentiated focusing of two-dimensional vortex sources with different ***,by utilizing a concise formula,a one-to-one correspondence is established between the OAM of incident vortex waves and different imaging *** fundamental principle of this special conversion relationship is rigorously constrained by the directional compensation of phase and the material parameters of dual-layer metasurfaces with different quadratic phase *** importantly,the highly consistent results between numerical demonstrations and acoustic experiments further confirm the feasibility and effectiveness of the proposed OAM detection *** work provides a new perspective on the precise manipulation for the phase of vortex fields,holding potential applications in super-resolution imaging and the design of acoustic OAM-based devices.

关键词： arbitrary acoustic OAM detection vortex waves dual-layer metasurfaces waveform reshaping differentiated focusing acoustic experiments

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Remodel the perifollicular microenvironment via Minoxidil-loaded microneedle patch and cold atmospheric plasma for treating androgenetic alopecia

引用

Nano Research 2024年第7期17卷 6411-6419页

作者： hao chen Xianzhe Tang Yueye Huang chen chen Yuheng Yang Chaojie hao Wenqi Xie Tingjing Huang Xiaofeng cheng Qingnan Xu shicong Huang Zhi Ye Xucong Lin Zhaowei chen Zhitong chen MOE Key Laboratory for Analytical Science of Food Safety and Biology and New Cornerstone Science LaboratoryCollege of ChemistryFuzhou UniversityFuzhou 350108China Institute of Biomedical and Health Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Advanced Therapeutic Center National Innovation Center for Advanced Medical DevicesShenzhen 518000China Department of Chemistry University College LondonLondon WC1H 0AJUK Engineering Technology Research Center on Reagent and Instrument for Rapid Detection of Product Quality and Food Safety in Fujian Province College of ChemistryFuzhou UniversityFuzhou 350108China Key Laboratory of Biomedical Imaging Science and System Chinese Academy of SciencesShenzhen 518055China

Androgenetic alopecia(AGA)is a chronic and progressive form of hair loss characterized by vascular degeneration in the perifollicular microenvironment,leading to cell apoptosis and eventual loss of hair follicles(HFs).Traditional therapeutic formulations,such as Minoxidil(MXD)tincture,have limitations in reshaping the perifollicular microenvironment and exhibit limited ***,we report a multi-synergistic therapeutic platform for high-performance hair regeneration *** platform combines microneedle(MN)patches loaded with MXD-encapsulated nanostructured lipid carriers(MXD-NLC-MNs)and cold atmospheric plasma(CAP).The MNs’mechanical strength enables efficient transdermal delivery of MXD to the targeted dermal papilla cells,promoting cell ***,in collaboration with MXD,the mechanical stimulation exerted by MN application synergistically upregulates the expression of vascular endothelial growth factor,leading to ***,the transient microchannels in the skin created by MNs facilitate the transdermal delivery of CAPgenerated nitric oxide(NO)to the sites of HF lesions,whereby the synergistic interaction between MXD and NO boosts perifollicular ***,the perifollicular microenvironment can be effectively reshaped to accelerate hair regeneration in AGA murine *** multi-synergistic combination therapy strategy would hold great promise for effectively treating AGA and promoting hair regrowth.

关键词： nanomedicine androgenetic alopecia microneedle cold atmospheric plasma drug delivery

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Six types of spin solitons in three-component Bose-Einstein condensates

引用

Communications in Theoretical Physics 2024年第6期76卷 57-65页

作者： Yu-hao Wang Ling-Zheng Meng Li-chen Zhao School of Physics Northwest UniversityXi'an 710127China School of Science Xi'an Technological UniversityXi'an 710032China Peng Huanwu Center for Fundamental Theory Xi'an 710127China

Exact analytical solutions are good candidates for studying and explaining the dynamics of solitons in nonlinear *** further extend the region of existence of spin solitons in the nonlinearity coefficient space for the spin-1 Bose-Einstein *** types of spin soliton solutions can be obtained,and they exist in different *** analysis and numerical simulation results indicate that three types of spin solitons are stable against weak *** non-integrable properties of the model can induce shape oscillation and increase in speed after the collision between two spin *** results further enrich the soliton family for non-integrable models and can provide theoretical references for experimental studies.

关键词： Bose-Einstein condensate non-integrable spin soliton exact analytical solution

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Bacterial microcompartment-mimicking Pickering emulsion droplets for detoxification of chemical threats under sweet conditions

引用

Science China Chemistry 2024年第9期67卷 3039-3049页

作者： Xiao Xu Wenqi Xie Ting Wu chen chen Xiaoning chen Yuheng Yang hao Lian hao chen Xiaofeng cheng Zhitong chen Guojun chen Chaoqun Liu Lanlan chen Yu He Zhaowei chen Bernard P.Binks Huanghao Yang New Cornerstone Science Laboratory MOE Key Laboratory for Analytical Science of Food Safety and Biology College of ChemistryFuzhou University Institute of Biomedical and Health Engineering Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Department of Biomedical Engineering and the Rosalind & Morris Goodman Cancer Research Institute Mc Gill University School of Pharmacy Henan University Department of Chemistry University of Hull

Chemical warfare agents represent a severe threat to mankind and their efficient decontamination is a global necessity. However,traditional disposal strategies have limitations, including high energy consumption, use of aggressive reagents and generation of toxic byproducts. Here, inspired by the compartmentalized architecture and detoxification mechanism of bacterial microcompartments, we constructed oil-in-water Pickering emulsion droplets stabilized by hydrogen-bonded organic framework immobilized cascade enzymes for decontaminating mustard gas simulant(2-chloroethyl ethyl sulfide, CEES) under sweet conditions. Two exemplified droplet systems were developed with two-enzyme(glucose oxidase/chloroperoxidase) and threeenzyme(invertase/glucose oxidase/chloroperoxidase) cascades, both achieving over 6-fold enhancement in decontamination efficiency compared with free enzymes and >99% selectivity towards non-toxic sulfoxide. We found that the favored mass transfer of sugars and CEES from their respective phases to approach the cascade enzymes located at the droplet surface and the facilitated substrate channeling between proximally immobilized enzymes were key factors in augmenting the decontamination efficacy. More importantly, the robustness of immobilized enzymes enabled easy reproduction of both the droplet formation and detoxification performance over 10 cycles, following long-term storage and in far-field locations.

关键词： Pickering emulsion biomimetics chemical warfare agent bacterial microcompartment biocatalysis

来源：

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A novel algorithm for evaluating cement azimuthal density based on perturbation theory in horizontal well

引用

Petroleum Science 2024年第1期21卷 244-251页

作者： Ji-Lin Fan Feng Zhang Qian chen hao-chen Song Lu-Yu Zhong Yue-Xiang Dai National Key Laboratory of Deep Oil and Gas School of GeosciencesChina University of Petroleum(East China)Qingdao 266580ShandongChina China National Logging Corporation Xi'an 710076ShaanxiChina Sinopec Matrix Corporation Qingdao 266001ShandongChina

Cement density monitoring plays a vital role in evaluating the quality of cementing projects,which is of great significance to the development of oil and ***,the presence of inhomogeneous cement distribution and casing eccentricity in horizontal wells often complicates the accurate evaluation of cement azimuthal *** this regard,this paper proposes an algorithm to calculate the cement azimuthal density in horizontal wells using a multi-detector gamma-ray detection *** spatial dynamic response functions are simulated to obtain the influence of cement density on gamma-ray counts by the perturbation theory,and the contribution of cement density in six sectors to the gamma-ray recorded by different detectors is obtained by integrating the spatial dynamic response *** with the relationship between gamma-ray counts and cement density,a multi-parameter calculation equation system is established,and the regularized Newton iteration method is employed to invert casing eccentricity and cement azimuthal *** approach ensures the stability of the inversion process while simultaneously achieving an accuracy of 0.05 g/cm^(3) for the cement azimuthal *** accuracy level is ten times higher compared to density accuracy calculated using calibration ***,this algorithm enhances the accuracy of cement azimuthal density evaluation,provides valuable technical support for the monitoring of cement azimuthal density in the oil and gas industry.

关键词： Cement azimuthal density Perturbation theory Casing eccentricity Spatial dynamic response function Regularized Newton iteration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Quantitative method for calculating spatial release region for laser-guided bomb

引用

Journal of Systems Engineering and Electronics 2024年第4期35卷 1053-1062页

作者： YANG Ping XIAO Bing chen Xin hao Yuntao Air Force Early Warning Academy Wuhan 430019China Unit 93175 of the PLA Changchun 136000China

The laser-guided bomb(LGB)is an air-to-ground pre-cision-guided weapon that offers high hit rates,great power,and ease of *** are guided by semi-active laser ground-seek-ing technology,which means that atmospheric conditions can affect their *** spatial release region(SRR)of LGBs is difficult to calculate precisely,especially when there is a poor field of *** can result in a lower real hit *** increase the hit probability of LGBs in tough atmospheric situa-tions,a novel method for calculating the SRR has been *** method is based on the transmittance model of the 1.06μm laser in atmospheric species and the laser diffuse reflection model of the target surface to determine the capture target time of the laser ***,it calculates the boundary ballistic space starting position by ballistic model and gets the spatial scope of the spatial release *** method can determine the release region of LGBs based on flight test data such as instantaneous velocity,altitude,off-axis angle,and atmospheric *** more effectively employing aircraft release conditions,atmospheric visibility and other factors,the SRR calculation method can improve LGB hit probabi-lity by 9.2%.

关键词： laser-guided bombs(LGBs) hit probability atmo-spheric transmittance spatial release region(SRR)boundary ballistic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：