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Effects of Prandtl number in two-dimensional turbulent convection

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Chinese Physics B 2021年第9期30卷 290-296页

作者： Jian-Chao He Ming-Wei Fang Zhen-Yuan Gao shi-di huang Yun Bao School of Aeronautics and Astronautics Sun Yat-sen UniversityGuangzhou 510275China Center for Complex Flows and Soft Matter Research and Department of Mechanics and Aerospace Engineering Southern University of Science and TechnologyShenzhen 518055China Guangdong Provincial Key Laboratory of Turbulence Research and Applications Southern University of Science and TechnologyShenzhen 518055China

We report a numerical study of the Prandtl-number(Pr)effects in two-dimensional turbulent Rayleigh-Bénard *** simulations were conducted in a square box over the Pr range from 0.25 to 100 and over the Rayleigh number(Ra)range from 10^(7) to 10^(10).We find that both the strength and the stability of the large-scale flow decrease with the increasing of Pr,and the flow pattern becomes plume-dominated at high *** evolution in flow pattern is quantified by the Reynolds number(Re),with the Ra and the Pr scaling exponents varying from 0.54 to 0.67 and-0.87 to-0.93,*** is further found that the non-dimensional heat flux at small Ra diverges strongly for different Pr,but their difference becomes marginal as Ra *** the thermal boundary layer,the spatially averaged thicknesses for all the Pr numbers can be described byδθ~Ra^(-0.30) approximately,but the local values vary a lot for different Pr,which become more uniform with Pr increasing.

关键词： turbulent convection Prandtl number direct numerical simulations(DNS)

Longitudinal assessment of peripheral organ metabolism and the gut microbiota in an APP/PS1 transgenic mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2982-2997页

作者： Hongli Li Jianhua huang di Zhao Lemei Zhu Zheyu Zhang Min Yi Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina National Clinical Research Center for Metabolic diseases ChangshaHunan ProvinceChina Hunan Academy of Chinese Medicine ChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina

Alzheimer’s disease not only affects the brain,but also induces metabolic dysfunction in peripheral organs and alters the gut *** aim of this study was to investigate systemic changes that occur in Alzheimer’s disease,in particular the association between changes in peripheral organ metabolism,changes in gut microbial composition,and Alzheimer’s disease *** do this,we analyzed peripheral organ metabolism and the gut microbiota in amyloid precursor protein-presenilin 1(APP/PS1)transgenic and control mice at 3,6,9,and 12 months of ***-month-old APP/PS1 mice exhibited cognitive impairment,Alzheimer’s disease-related brain changes,distinctive metabolic disturbances in peripheral organs and fecal samples(as detected by untargeted metabolomics sequencing),and substantial changes in gut microbial composition compared with younger APP/PS1 ***,a strong correlation emerged between the gut microbiota and kidney metabolism in APP/PS1 *** findings suggest that alterations in peripheral organ metabolism and the gut microbiota are closely related to Alzheimer’s disease development,indicating potential new directions for therapeutic strategies.

关键词： Alzheimer’s disease APP/PS1 mice brain-kidney axis gut microbiota heart-brain axis liver-brain axis lung-brain axis microbiota-gut-brain axis peripheral organ metabolism spleen-brain axis

High Fe‑Loading Single‑Atom Catalyst Boosts ROS Production by Density Effect for Efficient Antibacterial Therapy

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Nano-Micro Letters 2025年第2期17卷 187-203页

作者： Si Chen Fang huang Lijie Mao Zhimin Zhang Han Lin Qixin Yan Xiangyu Lu Jianlin shi Department of Cardiology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200092People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China Shanghai Frontiers Science Center of Nanocatalytic Medicine School of MedicineTongji UniversityShanghai 200092People’s Republic of China

The current single-atom catalysts(SACs)for medicine still suffer from the limited active site ***,we develop a synthetic method capable of increasing both the metal loading and mass-specific activity of SACs by exchanging zinc with *** constructed iron SACs(h^(3)-FNC)with a high metal loading of 6.27 wt%and an optimized adjacent Fe distance of~4 A exhibit excellent oxidase-like catalytic performance without significant activity decay after being stored for six months and promising antibacterial ***,a“density effect”has been found at a high-enough metal doping amount,at which individual active sites become close enough to interact with each other and alter the electronic structure,resulting in significantly boosted intrinsic activity of single-atomic iron sites in h^(3)-FNCs by 2.3 times compared to low-and medium-loading ***,the overall catalytic activity of h^(3)-FNC is highly improved,with mass activity and metal mass-specific activity that are,respectively,66 and 315 times higher than those of commercial Pt/*** addition,h^(3)-FNCs demonstrate efficiently enhanced capability in catalyzing oxygen reduction into superoxide anion(O_(2)·^(−))and glutathione(GSH)*** in vitro and in vivo assays demonstrate the superior antibacterial efficacy of h^(3)-FNCs in promoting wound *** work presents an intriguing activity-enhancement effect in catalysts and exhibits impressive therapeutic efficacy in combating bacterial infections.

关键词： Nanocatalytic medicine Single-atom catalysts Reactive oxygen species(ROS) High metal loading Oxidase catalysis

Effects of Shenqi Xiangyi granules in advanced gastric cancer chemotherapy

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 169-175页

作者： Xiao-Jing shi Yu Song Xue-Xue Liang Ting Chen huang-Yu Hao Xue Han Ya-Nan Chen Department of Oncology Zhangjiagang First People's HospitalSuzhou 215600Jiangsu ProvinceChina

BACKGROUND Owing to the absence of specific symptoms in early-stage gastric cancer,most patients are diagnosed at intermediate or advanced *** a result,treatment often shifts from surgery to other therapies,with chemotherapy and targeted therapies being the primary options for advanced gastric cancer treatment.A total of 116 patients with advanced gastric cancer,admitted from January 2021 to December 2023,were selected and divided into two groups of 58 each using the random number table *** control group received FOLFOX4 chemothe-rapy(oxaliplatin+calcium+folinate+5-fluorouracil)combined with intravenous *** observation group received the same treatment as the control group,supplemented by oral administration of Senqi shiyiwei *** groups underwent treatment cycles of 3 weeks,with a minimum of two *** therapeutic efficacy,immune mechanisms,and treatment-related toxicity and side effects were compared between the *** objective remission rate in the observation group(55.17%)was higher than that of the control group(36.21%)(Pditionally,the incidence of leukopenia,nausea,and vomiting was lower in observed group(Pdifferences were observed in the incidence of other adverse reactions(P>0.05).CONCLUSION Adjuvant therapy with Shenqixian granules may enhance the efficacy of simudizumab combined with FOLFOX4 chemotherapy in advanced gastric cancer and the immune function by increasing immune cell counts,making it a valuable option in clinical treatment.

关键词： Sindilizumab FOLFOX4 chemotherapy Advanced gastric cancer Ginseng Qi Xiangyi granule Clinic treatment

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并联谐振型微细电火花线切割加工脉冲电源

上海交通大学学报 2005年第1期39卷 56-60页

作者：狄士春黄瑞宁于滨迟关心赵万生哈尔滨工业大学机械工程系哈尔滨150001

为了提高微细电火花线切割(WEDM)效率和表面质量,应用并联谐振电路原理,研究出新型的并联谐振型微细WEDM脉冲电源.该脉冲电源利用其辅助电路中谐振电感和谐振电容的高频振荡,在MOSFET管的两端获得零电压或零电流的开通关断条件,降低了... 详细信息

为了提高微细电火花线切割(WEDM)效率和表面质量,应用并联谐振电路原理,研究出新型的并联谐振型微细WEDM脉冲电源.该脉冲电源利用其辅助电路中谐振电感和谐振电容的高频振荡,在MOSFET管的两端获得零电压或零电流的开通关断条件,降低了开关器件的开关损耗,提高了开关频率,并且可以获得很窄脉冲宽度和很小的单个脉冲放电能量.与传统的脉冲电源相比,此脉冲电源提高了微细WEDM速度和表面质量,并且能切割出高质量的齿顶圆直径为0.3mm的微小齿轮.实验结果表明,这种高质的脉冲电源为改善微细WEDM整体性能、拓展加工领域提供了技术保证.

关键词：微细电火花线切割并联谐振脉冲电源

Efficient white-light-emitting lead-free halide double perovskites enabling full-spectrum pc-WLEDs

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Science China Materials 2025年第01期 305-306页

作者： Xiaoyong huang College of Physics and Optoelectronics Taiyuan University of Technology

With the rapid development of solid-state lighting, an important goal of phosphor-converted white light-emitting diodes (pc-WLEDs) is to provide a healthy and comfortable fullspectrum artificial light source with a co...

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发展银发经济的战略设计、焦点难点及路径优化

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新疆师范大学学报（哲学社会科学版） 2025年第2期46卷 59-69,F0002页

作者：黄石松胡清中国人民大学国家发展与战略研究院北京100872 中国人民大学老年学研究所北京100872

我国正处于由中度老龄化社会步入重度老龄化社会的进程,银发经济将逐步从“以政府为主导的事业发展”阶段转向“事业和产业协同发展”的新阶段。准确把握这一转型发展特征,适时调整工作重心和节奏,注重运用市场机制推进产业发展迫在眉... 详细信息

我国正处于由中度老龄化社会步入重度老龄化社会的进程,银发经济将逐步从“以政府为主导的事业发展”阶段转向“事业和产业协同发展”的新阶段。准确把握这一转型发展特征,适时调整工作重心和节奏,注重运用市场机制推进产业发展迫在眉睫。对银发产业进行业态划分是制定产业组织政策、产业管理政策、产业发展政策的前提和基础,文本尝试将我国银发产业划分为基础性产业、延伸性产业和战略性产业,并据此分析三类产业在发展中存在的焦点难点问题,按照分类精准施策原则,提出优化我国银发经济发展路径的政策建议。

关键词：银发经济老龄产业老龄事业战略设计业态划分

Quickly obtaining densely dispersed coherent particles in steel matrix and its related mechanical property

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 111-118页

作者： Xiaoxiao Wang Qingsong huang School of Chemical Engineering Sichuan UniversityChengdu 610065China

Densely distributed coherent nanoparticles(DCN)in steel matrix can enhance the work-hardening ability and ductility of steel *** the routes to this end can be generally classified into the liquid-solid route and the solid-solid ***,the formation of DCN structures in steel requires long processes and complex *** far,obtaining steel with coherent particle enhancement in a short time remains a bottleneck,and some necessary steps remain ***,we show a high-efficiency liquid-phase refining process reinforced by a dynamic magnetic ***-Y-Mn-O particles had an average size of around(3.53±1.21)nm and can be obtained in just around 180 *** small nanoparticles were coherent with the matrix,implying no accumulated dislocations between the particles and the steel *** findings have a potential application for improving material machining capacity,creep resistance,and radiation resistance.

关键词： ferritic steels coherent particles microstructure compression test work hardening

A novel flexible nerve guidance conduit promotes nerve regeneration while providing excellent mechanical properties

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Neural Regeneration Research 2025年第7期20卷 2084-2094页

作者： Tong Li Quhan Cheng Jingai Zhang Boxin Liu Yu shi Haoxue Wang Lijie huang Su Zhang Ruixin Zhang Song Wang Guangxu Lu Peifu Tang Zhongyang Liu Kai Wang Department of Orthopedics the Fourth Medical Center of Chinese PLA General HospitalBeijingChina Department of Training and Sports Medicine Characteristic Medical Center of Chinese People’s Armed Police ForceTianjinChina Medical School of Chinese PLA BeijingChina Key Laboratory of Bioactive Materials for the Ministry of Education College of Life SciencesNankai UniversityTianjinChina Department of Orthopedics Tianjin HospitalTianjinChina Department of Rehabilitation Medicine Er Quan Hospital of PAPWuxiJiangsu ProvinceChina

Autografting is the gold standard for surgical repair of nerve defects>5 mm in length;however,autografting is associated with potential complications at the nerve donor *** an alternative,nerve guidance conduits may be *** ideal conduit should be flexible,resistant to kinks and lumen collapse,and provide physical cues to guide nerve *** designed a novel flexible conduit using electrospinning technology to create fibers on the innermost surface of the nerve guidance conduit and employed melt spinning to align ***,we prepared disordered electrospun fibers outside the aligned fibers and helical melt-spun fibers on the outer wall of the electrospun fiber *** presence of aligned fibers on the inner surface can promote the extension of nerve cells along the *** helical melt-spun fibers on the outer surface can enhance resistance to kinking and compression and provide *** novel conduit promoted nerve regeneration and functional recovery in a rat sciatic nerve defect model,suggesting that it has potential for clinical use in human nerve injuries.

关键词： aligned fibers anti-kinking helical fibers nerve guidance conduit nerve regeneration peripheral nerve injury topological guidance