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A Single-institution Experience with Open Irreversible Electroporation for Locally Advanced Pancreatic Carcinoma

Chinese Medical Journal 2016年第24期129卷 2920-2925页

作者： Li Yan Yong-Liang Chen Ming Su Tian Liu Kai Xu Feng Liang Wan-Qing Gu shi-chun lu Department of Hepatobiliary Surgery Chinese PLA General Hospital Beijing 100853 China Department of General Surgery People's Hospital of Rizhao Rizhao Shandong 276800 China

Background： Locally advanced pancreatic carcinoma （LAPC） is characterized by poor prognosis despite recommended concurrent chemoradiotherapy. Irreversible electroporation （IRE） has emerged as a potential option for the management of unresectable pancreatic cancer. This study was conducted to evaluate the safety and short-term efficacy of open IRE for the treatment of LAPC. Methods： Retrospective data of 25 consecutive patients receiving IRE for T3 lesions from July 2015 to June 2016 at a single center were analyzed. The perioperative and long-term IRE-related complications were reviewed to evaluate the safety of the procedure. The tumor reduction and biological response were analyzed through computed tomography/magnetic resonance imaging; the serum level of CA19-9 was measured as a secondary endpoint to evaluate the short-term efficacy of IRE. Results： All patients were successfully treated; the median tumor size was 4.2 cm and the median IRE time was 36 min. Four intraoperative procedure-related complications were observed （16%）： two transient hypertensive episodes, one hypotension case, and one transient supraventricular tachycardia case. Nine postoperative complications were described, including three Grade A pancreatic fistulas, three delayed gastric emptying, one acute pancreatitis, one upper gastrointestinal hemorrhage, and one portal vein thrombosis. The overall rate of stable disease was 28%, 36% achieved partial response, and lower serum CA19-9 levels were recorded in all patients at discharge. Conclusions： IRE is feasible for the treatment of LAPC and is a reasonable intervention strategy owing to its combined attributes of safety and efficacy.

关键词： CA 19-9 Irreversible Electroporation Locally Advanced Pancreatic Carcinoma

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Anticoagulation therapy prevents portal-splenic vein thrombosis after splenectomy with gastroesophageal devascularization

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World Journal of Gastroenterology 2012年第26期18卷 3443-3450页

作者： Wei Lai shi-chun lu Guan-Yin Li Chuan-Yun Li Ju-Shan Wu Qing-Liang Guo Meng-Long Wang Ning Li Depart-ment of Hepatobiliary Surgery and You-An Liver Transplanta-tion Center Beijing You-An HospitalCapital Medical Univer-sityBeijing 100069China

AIM:To compare the incidence of early portal or splenic vein thrombosis(PSVT) in patients treated with irregular and regular anticoagulantion after splenectomy with gastroesophageal ***:We retrospectively analyzed 301 patients who underwent splenectomy with gastroesophageal devascularization for portal hypertension due to cirrhosis between April 2004 and July *** were categorized into group A with irregular anticoagulation and group B with regular anticoagulation,*** A(153 patients) received anticoagulant monotherapy for an undesignated time period or with aspirin or warfarin without low-molecular-weight heparin(LMWH) *** B(148 patients) received subcutaneous injection of LMWH routinely within the first 5 d after surgery,followed by oral warfarin and aspirin for one month *** target prothrombin time/international normalized ratio(PT/INR) was *** and PT/INR were *** Doppler imaging was performed to monitor PSVT as well as the effectiveness of thrombolytic ***:The patients' data were collected and analyzed *** the patients,94 developed early postoperative mural PSVT,including 63 patients in group A(63/153,41.17%) and 31 patients in group B(31/148,20.94%).There were 50(32.67%) patients in group A and 27(18.24%) in group B with mural PSVT in the main trunk of portal *** the administration of thrombolytic,anticoagulant and antiaggregation therapy,complete or partial thrombus dissolution achieved in 50(79.37%) in group A and 26(83.87%) in group ***:Regular anticoagulation therapy can reduce the incidence of PSVT in patients who undergo splenectomy with gastroesophageal devascularization,and regular anticoagulant therapy is safer and more effective than irregular anticoagulant *** and timely thrombolytic therapy is imperative and feasible for the prevention of PSVT.

关键词： Portal vein hypertension Splenectomy withgastroesophageal devascularization Portal or splenicvein thrombosis Anticoagulation regimen Thrombo-lyric therapy

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Design parameter optimization method for a prestressed steel structure driven by multi-factor coupling

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Frontiers of Structural and Civil Engineering 2024年第7期18卷 1066-1083页

作者： Guo-Liang shi Zhan-Sheng LIU De-chun lu Qing-Wen ZHANG Majid DEZHKAM Ze-Qiang WANG Faculty of Architecture Civil and Transportation EngineeringBeijing University of TechnologyBeijing 100124China The Key Laboratory of Urban Security and Disaster Engineering of the Ministry of Education Beijing University of TechnologyBeijing 100124China Beijing Building Construction Research Institute Co. Ltd.Beijing 100039China

To achieve efficient structural design,it is crucial to reduce the cost of materials while ensuring structural *** study proposes an optimization method for design parameters(DPs)in a prestressed steel structure driven by multi-factor *** accomplish this,a numerical proxy model of prestressed steel structures is established with integration of DPs and mechanical parameters(MPs).A data association-parameter analysis-optimization selection system is established.A correlation between DPs and MPs is established using a back propagation(BP)neural *** correlation provides samples for parameter analysis and optimization *** are used to characterize the safety of the *** on the safety grade analysis,the key DPs that affect the mechanical properties of the structure are obtained.A mapping function is created to match the MPs and the key *** optimal structural DPs are obtained by setting structural materials as the optimization objective and safety energy as the constraint *** theoretical model is applied to an 80-m-span gymnasium and verified with a scale test physical *** MPs obtained using the proposed method are in good agreement with the experimental *** with the traditional design method,the design cycle can be shortened by more than 90%.Driven by the optimal selection method,a saving of more than 20% can be achieved through reduction of structural material ***,the cross-sectional dimensions of radial cables have a substantial influence on vertical *** initial tension and cross-sectional size of the upper radial cable exhibit the most pronounced impact on the stress distribution in that *** initial tension and cross-sectional size of the lower radial cable hold the greatest sway over the stress distribution in that cable.

关键词： structure design association relationship performance analysis optimum selection experimental verification

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AGK2 pre-treatment protects against thioacetamide-induced acute liver failure via regulating the MFN2-PERK axis and ferroptosis signaling pathway

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 43-51页

作者： Qing-Qi Zhang Qian Chen Pan Cao chun-Xia shi lu-Yi Zhang lu-Wen Wang Zuo-Jiong Gong Department of Infectious Diseases Renmin Hospital of Wuhan UniversityWuhan 430060China

Background:Acute liver failure(ALF)is an unpredictable and life-threatening critical *** pathological characteristic of ALF is massive necrosis of hepatocytes and lots of inflammatory cells infiltration which may lead to multiple organ ***:Animals were divided into 3 groups,normal,thioacetamide(TAA,ALF model)and TAA+*** L02 cells were divided into 5 groups,normal,TAA,TAA+mitofusin 2(MFN2)-siRNA,TAA+AGK2,and TAA+AGK2+MFN2-siRNA *** liver histology was evaluated with hematoxylin and eosin staining,inositol-requiring enzyme 1(IRE1),activating transcription factor 6β(ATF6β),protein kinase R(PKR)-like endoplasmic reticulum kinase(PERK)and phosphorylated-PERK(p-PERK).C/EBP homologous protein(CHOP),reactive oxygen species(ROS),MFN2 and glutathione peroxidase 4(GPX4)were measured with Western blotting,and cell viability and liver chemistry were also *** endoplasmic reticulum membranes(MAMs)were measured by ***:The liver tissue in the ALF group had massive inflammatory cell infiltration and hepatocytes necrosis,which were reduced by AGK2 *** comparison to the normal group,apoptosis rate and levels of IRE1,ATF6β,p-PERK,CHOP,ROS and Fe2+in the TAA-induced ALF model group were significantly increased,which were decreased by AGK2 *** levels of MFN2 and GPX4 were decreased in TAA-induced mice compared with the normal group,which were enhanced by AGK2 *** with the TAA-induced L02 cell,apoptosis rate and levels of IRE1,ATF6β,p-PERK,CHOP,ROS and Fe2+were further increased and levels of MFN2 and GPX4 were decreased in the MFN2-siRNA ***2 pre-treatment decreased the apoptosis rate and levels of IRE1,ATF6β,p-PERK,CHOP,ROS and Fe2+and enhanced the protein expression of MFN2 and GPX4 in MFN2-siRNA treated L02 *** observation showed that level of MAMs was promoted in the AGK2 pre-treatment group when compared with the TAA-induced gr

关键词： SIRT2 inhibitor AGK2 Acute liver failure MFN2 Ferroptosis

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Comprehensive modeling strategy for thermomechanical tribological behavior analysis of railway vehicle disc brake system

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Friction 2024年第1期12卷 74-94页

作者： Jiabao YIN chun lu Jiliang MO School of Mechanical Engineering Southwest Jiaotong UniversityChengdu 610031China Technology and Equipment of Rail Transit Operation and Maintenance Key Laboratory of Sichuan Province Chengdu 610031China

A comprehensive modeling strategy for studying the thermomechanical tribological behaviors is proposed in this *** wear degradation considering the influence of temperature(T)is predicted by Archard wear model with the help of the UMESHMOTION subroutine and arbitrary Lagrangian–Eulerian(ALE)remeshing *** the proposed method,the thermomechanical tribological behaviors of railway vehicle disc brake system composed of forged steel brake disc and Cu-based powder metallurgy(PM)friction block are studied *** effectiveness of the proposed methodology is validated by experimental test on a self-designed scaled brake test bench from the perspectives of interface temperature,wear degradation,friction noise and vibration,and contact status *** work can provide an effective way for the investigation of thermomechanical tribological behaviors in the engineering field.

关键词： tribological behaviors thermomechanical field wear prediction finite element simulation disc brake system railway vehicle

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Usefulness of three-dimensional visualization technology in minimally invasive treatment for infected necrotizing pancreatitis

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World Journal of Gastroenterology 2018年第17期24卷 1911-1918页

作者： Peng-Fei Wang Zhi-Wei Liu Shou-Wang Cai Jun-Jun Su Lei He Jian Feng Xian-Lei Xin shi-chun lu Department of hepatobiliary Surgery PLA General hospital

AIM To explore the value of three-dimensional(3 D) visualization technology in the minimally invasive treatment for infected necrotizing pancreatitis(INP). METHODS Clinical data of 18 patients with INP, who were admitted to the PLA General Hospital in 2017, were retrospectively analyzed. Two-dimensional images of computed tomography were converted into 3 D images based on 3 D visualization technology. The size, number, shape and position of lesions and their relationship with major abdominal vasculature were well displayed. Also, percutaneous catheter drainage(PCD) number and puncture paths were designed through virtual surgery(percutaneous nephroscopic necrosectomy) based on the principle of maximum removal of infected necrosis *** Abdominal 3 D visualization images of all the patients were well reconstructed, and the optimal PCD puncture paths were well designed. Infected necrosis was conveniently removed in abundance using a nephroscope during the following surgery, and the median operation time was 102(102 ± 20.7) min. Only 1 patient underwent endoscopic necrosectomy because of residual necrosis. CONCluSION The 3 D visualization technology could optimize the PCD puncture paths, improving the drainage effect in patients with INP. Moreover, it significantly increased the efficiency of necrosectomy through the rigid nephroscope. As a result, it decreased operation times and improved the prognosis.

关键词： infected necrotizing pancreatitis threedimensional visualization percutaneous catheter drainage percutaneous nephroscopic necrosectomy

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A high-performance lithium anode based on N-doped composite graphene

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Rare Metals 2024年第3期43卷 1030-1036页

作者： Can Jiao Hao-Bo Sun Li Zhang Shang-Qian Zhao Guo-Yao Pang chun-Rong Zhao shi-Gang lu General Research Institute for Nonferrous Metals Beijing100088China China Automotive Battery Research Institute Co.Ltd Beijing101407China

Lithium(Li)metal is the most promising electrode for next-gene ration rechargeable *** order to push the commercialization of the lithium metal batteries,a kind of nitrogen(N)-doped composite graphene(NCG)adopted as the Li plating host was prepared to regulate Li metal nucleation and suppress dendrite ***,a new kind of sandwich-type composite lithium metal(STCL)electrode was developed to improve its *** STCL electrode can be used as convenient as a piece of Li foil but no dendrite *** a symmetric battery,the STCL electrode cycled for more than 4500 h with the overpotential of less than 40 *** due to the creative design,the STCL promises the Li-S battery with a prolonged cycling lifespan.

关键词： Lithium metal anode Lithiophilic N-doped composite graphene Sandwich-type composite lithium metal electrode

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Postoperative inflammation as a possible cause of portal vein thrombosis after irreversible electroporation for locally advanced pancreatic cancer

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World Journal of Gastroenterology 2017年第32期23卷 6003-6006页

作者： Jun-Jun Su Ming Su Kai Xu Peng-Fei Wang Li Yan shi-chun lu Wan-Qing Gu Yong-Liang Chen Division of Gastroenterological Surgery Department of Surgery Shanxi Provincial People’s Hospital Department of Hepatobiliary Surgery Chinese People’s Liberation Army General Hospital

Portal vein thrombosis(PVT) is a rare but serious postoperative complication associated with irreversible electroporation(IRE). We report a case of postoperative PVT in a 54-year-old woman who underwent IRE for locally advanced pancreatic cancer. Drain removal and discharge of the patient from the hospital were scheduled on postoperative day(POD) 7; however, a magnetic resonance imaging scan revealed the presence of PVT. We suspected postoperative inflammation in the pancreas as the main cause of PVT. However, the patient did not undergo any medical treatment because she did not have any clinical symptoms, and she was discharged on POD 8.

关键词： Irreversible electroporation Portal vein thrombosis Locally advanced pancreatic cancer Safety

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Navigating the safe operation of high-voltage cathodes:Challenges and strategies

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Nano Research 2024年第10期17卷 8694-8705页

作者： Yue Sun Changjian Zuo Yi-chun lu Electrochemical Energy and Interfaces Laboratory Department of Mechanical and Automation EngineeringThe Chinese University of Hong KongHong Kong 999077China

Lithium-ion batteries play a crucial role in storing energy for renewable sources and electric vehicles,yet face challenges related to insufficient energy *** the working-voltage of cathodes is promising to boost the energy density of batteries by increasing both the output voltage and capacity of cathode,which however could compromise life cycle and *** review provides a comprehensive summary of essential factors governing pathways of cathode-induced thermal runaway,including electrolyte decomposition,phase transitions,and crosstalk-induced *** and electrolyte modifications aimed at mitigating parasitic reactions and preventing crosstalk were also *** review concludes with insights into the future application of these strategies,providing a comprehensive perspective on the realization of high-energy and safe batteries.

关键词： battery safety high-voltage cathode lithium-ion battery thermal runaway

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Retrospective observation of therapeutic effects of adult auxiliary partial living donor liver transplantation on postpartum acute liver failure: A case report

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World Journal of Gastroenterology 2015年第9期21卷 2840-2847页

作者： Chuan-Yun Li Wei Lai shi-chun lu Department of Hepatobiliary Surgery and Liver Transplantation Center Beijing You-An HospitalCapital Medical University Department of Hepatobiliary Surgery the First People’s Hospital of Chengdu Institute and Hospital of Hepatobiliary Surgery Key Laboratory of Digital Hepatobiliary Surgery of Chinese PLAChinese PLA Medical SchoolChinese PLA General Hospital

We present a female patient with preterm labor, severe viral hepatitis B of acute phase, hepatic encephalopathy stage Ⅲ and *** delivery, the illness was exacerbated and the patient presented with clinical signs of vital organ dysfunctions such as acute respiratory distress syndrome, cerebral edema and hypoxemia that needed mechanical *** liver transplantation was recommended after multidisciplinary panel *** donor, her mother, consented to donate her right *** partial orthotopic living donor liver transplantion(APOLDLT) was *** operation, the patient was on triple medication of tacrolimus plus mofetil mycophenolate and prednisone for *** combination of antihepatitis B virus(HBV) immunoglobulin and entecavir was initiated for anti-HBV *** the patient and the donor recovered well without any *** patient was followed up *** liver function, clinical signs and symptoms improved *** now, the recipient has been living for more than 78 mo free of any *** APOLDLT is a life-saving modality for rescuing patients with high-risk acute liver failure following HBV infection without available donor and hence is recommended under standardized antiviral therapy coverage as stated above.

关键词： Auxiliary partial orthotopic living donor liver tr

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