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Quantitative modeling, optimization, and verification of ^(63)Nipowered betavoltaic cells based on three-dimensional ZnO nanorod arrays

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Nuclear Science and Techniques 2022年第11期33卷 101-112页

作者： Zan Ding Tong-Xin Jiang Ren-Rong Zheng Na Wang Li-Feng Zhang shi-chao liu Xin Li Hai-Sheng San Pen-Tung Sah Institute of Micro-Nano Science and Technology Xiamen UniversityXiamen 361005China Shenzhen Research Institute of Xiamen University Shenzhen 518000China China Institute of Atomic Energy Beijing 102413China Shanghai Institute of Space Power-Sources Shanghai 200245China

Betavoltaic cells(BCs)are promising self-generating power cells with long life and high power ***,the low energy conversion efficiency(ECE)has limitations in practical engineering *** semiconductors(WBGSs)with three-dimensional(3-D)nanostructures are ideal candidates for increasing the ECE of *** paper proposes hydrothermally grown ZnO nanorod arrays(ZNRAs)for ^(63)Ni-powered BCs.A quantitative model was established for simulation using the parameter values of the dark characteristics,which were obtained from the experimental measurements for a simulated BC based on a Ni-incorporated ZNRAs *** Carlo(MC)modeling and simulation were conducted to obtain the values of the β energy deposited in ZNRAs with different nanorod spacings and *** the simulation and optimization of the 3-D ZNRAs and 2-D ZnO bulk structures,the performance of the ^(63)Ni-powered BCs based on both structures was evaluated using a quantitative *** BCs based on the 3-D ZNRAs structure and 2-D ZnO bulk structure achieved a maximum ECE of 10.1%and 4.69%,respectively,which indicates the significant superiority of 3-D nanostructured WBGSs in increasing the ECE of BCs.

关键词： Betavoltaic cells Monte Carlo simulation ZnO nanorod arrays Quantitative model Performance evaluation

Research on Multimedia Transmission Controlled Scheduling Algorithm on Internet

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通讯和计算机（中英文版） 2010年第2期7卷 9-13页

作者： Zhongcheng Yu Qianzhu shi chao liu The college of Information Science and Engineering YanShan University QinHuang Dao 066004 China

Clinical Observation of Bevacizumab Combined with S-1 in the Treatment of Pretreated Advanced Esophageal Carcinoma

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Chinese Medical Sciences Journal 2016年第4期31卷 221-227页

作者： Ke-ke Nie Chuan-xin Geng Ling Zhang shi-chao liu Zhong-fa Zhang Rong Wang Xiao Zou You-xin Ji Department of Oncology Qingdao Cancer Hospital Department of Oncology Qingdao Central Hospital2nd Affiliated Hospital of Qingdao University

Objective To investigate the clinical effects and safety of bevacizumab combined with S-1 as the second-line treatment of recurrent and/or metastatic esophageal cancer after chemoradiation. Methods Patients with recurrent or metastatic esophageal cancer after chemoradiation were treated with bevacizumab and S-1. Bevacizumab was used by intravenous infusion, 7.5mg/kg body weight on day 1; S-1 was used by oral at 80mg/m^2·d on day 1-14, 21 days as a cycle of treatment and repeated until either progressive disease or intolerable toxicity occurred. Chest CT were performed and RECIST 1.1 was used for response evaluation. Kaplan-Meier method was used for survival analysis. Side effects were recorded and analyzed. Results Totally 78 patients were enrolled in the study, including 67 squamous cell carcinoma and 11 adenocarcinoma histologically. The overall response(CR+PR) rate was 22.4%(17/76) and disease control(CR+PR+SD) rate was 61.8%(47/76) respectively. The median follow-up time was 20 months(range from 9 to 44 months). The median progression-free survival(PFS) was 4.9 months(95% CI 4.4-5.5) and the median overall survival(OS) was 8.1 months(95% CI 7.6-9.2). The median PFS and OS of patients with metastasis diseases were 6.2 months(95% CI 3.3 to 6.3) and 8.5 months(95% CI 5.8 to 11.2), where PFS was longer than that of patients with local regional recurrence(median 5.0 months, 95% CI 3.0 to 5.5, P=0.017) and OS was longer than that of patients with regional disease and metastasis(median 8.0 months, 95% CI 4.6 to 9.5, P=0.010). The common adverse effects were mild to moderate neutropenia(84.2%), grade Ⅰ -Ⅱ hand and foot syndrome(51.3%), grade Ⅰ -Ⅱ nausea(48.7%), mild epistaxis(30.1%) and mild vomiting(14.5%). Esophageal bleeding occurred in 7.9% of patients. One patient(1.3%) died from massive bleeding which was caused by esophageal perforation. Conclusion Bevacizumab combined with S-1 was effective and safe for esophageal cancer patients who had recurrent or metastatic

关键词： anti-angiogenesis bevacizumab chemoradiation S-1 esophageal carcinoma

Sorafenib in Liver Function Impaired Advanced Hepatocellular Carcinoma

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Chinese Medical Sciences Journal 2014年第1期29卷 7-14页

作者： You-xin Ji Zhong-fa Zhang Ke-tao Lan Ke-ke Nie Chuan-xin Geng shi-chao liu Ling Zhang Xing-jun Zhuang Xiao Zou Lei Sun Zong-chun Zhang Department of Oncology Qingdao Central Hospital The Second Affiliated Hospital of Qingdao University Department of Radiotherapy Qingdao Cancer Hospital Department of Oncology PLA 401 Hospital

Objective To explore the efficacy and safty of sorafenib in Child-Pugh class B to class C hepatocellular carcinoma （HCC）. Methods In this three-center open-label study from November 2011 to May 2013, we randomly assigned 189 patients with advanced Child-Pugh class B or C HCC patients into two groups, one group with 95 patient to receive sorafenib （400 mga time, twice a day） and the other group with 94 patients to receive best supportive care. The primary end points were progression-free survival and overall survival. Results The median progression-free survival was 2.2 months and 1.9 months in the sorafenib group and best supportive care group respectively （Hazard ratio in the sorafenib group, 0.55; 95% confidence interval, 0.40-0.75; P=O.O02）. The median overall survival was 4.0 months and 3.5 months in the sorafenib group and best supportive care group respectively （Hazard ratio in the sorafenib group, 0.48; 95% confidence interval, 0.35-0.68; P〈0.001）. The main adverse effect of sorafenib was rash and ache of the skin （in 51.7% patients）. The incidences of severe rash, diarrhea, and dry skin were 5.6%, 5.6%, and 2.2% in the sorafenib group. One patient reached partial response in the sorafenib group. Conclusions Sorafenib is safe in patients with liver function impaired advanced HCC. It is effective in terms of progression-free survival and overall survival compared with best supportive care. Liver functions are the important predictive factors.

关键词： sorafenib hepatocullelar carcinoma best supportive care survival

Effect of non-isothermal aging on microstructure and properties of Al−5.87Zn−2.07Mg−2.42Cu alloys

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Transactions of Nonferrous Metals Society of China 2021年第10期31卷 2899-2908页

作者： Yao LI Guo-fu XU Xiao-yan PENG shi-chao liu Ying DENG Xiao-peng LIANG School of Materials Science and Engineering Central South UniversityChangsha 410083China Key Laboratory of Nonferrous Metal Materials Science and Engineering of Ministry of Education Central South UniversityChangsha 410083China

The evolution of microstructure and properties of Al−5.87Zn−2.07Mg−2.42Cu alloys during non-isothermal aging was *** mechanical properties of the alloy were tested by stretching at room *** results show that in the non-isothermal aging process,when the alloy is cooled to 140℃,the ultimate tensile strength of the alloy reaches a maximum value of 582 MPa and the elongation is 11.9%.The microstructure was tested through a transmission electron microscope,and the experimental results show that the GP zones andη'phases are the main strengthening *** the cooling stage,when the temperature dropped to 180℃,the GP zones were precipitated ***,the experimental results show that the main strengthening phase during non-isothermal aging isη'phases.

关键词： Al−Zn−Mg−Cu aluminum alloy non-isothermal aging η'phases mechanical properties

High temperature mechanical properties and microstructure of die forged Al-5.87Zn-2.07Mg-2.42Cu alloy

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Transactions of Nonferrous Metals Society of China 2020年第7期30卷 1771-1779页

作者： Yao LI Guo-fu XU Xiao-yan PENG shi-chao liu Yu-hai DOU Xiao-peng LIANG School of Materials Science and Engineering Central South UniversityChangsha 410083China Key Laboratory of Nonferrous Materials Science and Engineering Ministry of EducationChangsha 410083China Centre for Clean Environment and Energy Griffith UniversityGold CoastQLD 4222Australia

The high temperature mechanical properties(250 ℃) and microstructure of a die-forged Al-5.87 Zn-2.07 Mg-2.42 Cu alloy after T6 heat treatment were investigated. High temperature tensile tests show that as the temperature increases from room temperature to 250 ℃, the ultimate tensile strength of the alloy decreases from 638 to 304 MPa, and the elongation rises from 13.6% to 20.4%. Transmission electron microscopy(TEM) and electron backscattered diffraction(EBSD) were applied for microstructure characterization, which indicates that the increase of tensile temperature can lead to the coarsening of precipitates, drop of dislocation density, and increase of dynamic recovery. After tensile testing at 250 ℃, a sub-grain structure composed of a high fraction of small-angle grain boundary is formed.

关键词： Al-Zn-Mg-Cu alloy dynamic recovery high temperature mechanical properties microstructure

AZD9291-induced Acute Interstitial Lung Disease

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Chinese Medical Journal 2016年第12期129卷 1507-1508页

作者： Ke-Ke Nie Xiao Zou Chuan-Xin Geng Ling Zhang shi-chao liu Chun-Ling Zhang You-Xin Ji Department of Oncology Qingdao Central Hospital Second Affiliated Hospital of Qingdao University Qingdao Shandong 266042 China

To the Editor： A 32-year-old Chinese male patient with 1 week cough and dyspnea on exertion was presented to hospital. He was a metastatic lung adenocarcinoma patient with 3 years treatment history. In October 2012, the patient complained cough, short of breath, and thoracic computerized axial tomography scan （CAT-scan） revealed left lung hilum mass with the right lung multismall patches or opacities. Core needle biopsy on supraclavicular lymph nodes was performed and diagnosis of Stage IV （T3N3MIa） lung adenocarcinoma was made by radiologist, pathologist, and oncologist.

关键词：肺谷胱甘肽过氧化酶呼吸困难活组织检查针吸咳嗽淋巴结体层摄影术腺癌男(雄)性

Clinical effects of phospholipase D2 in attenuating acute pancreatitis

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World Journal of Gastroenterology 2025年第2期31卷 52-60页

作者： Jin-Wei Niu Guo-chao Zhang Wu Ning Hai-Bin liu Hua Yang chao-Feng Li Department of General Surgery China-Japan Friendship HospitalBeijing 100029China

BACKGROUND The objective of the current study was to elucidate the clinical mechanism through which phospholipase D2(PLD2)exerted a regulatory effect on neutrophil migra-tion,thereby alleviating the progression of acute *** To elucidate the clinical mechanism through which PLD2 exerted a regulatory effect on neutrophil migration,thereby alleviating the progression of acute *** The study involved 90 patients diagnosed with acute pancreatitis,admitted to our hospital between March 2020 and November 2022.A retrospective analysis was conducted,categorizing patients based on Ranson score severity into mild(n=25),moderate(n=30),and severe(n=35)*** data was collected for each *** blot analysis assessed PLD2 protein expression in patient ***-time reverse transcription polymerase chain reaction was used to evaluate the mRNA expression of chemokine receptors associated with neutrophil *** levels of inflammatory factors in patients were detected using enzyme-linked immunosorbent *** migration tests were conducted to compare migration of neutrophils across groups and analyze the influence of PLD2 on neutrophil *** Overall data analysis did not find significant differences between patient groups(P>0.05).The expression of PLD2 protein in the severe group was lower than that in the moderate and mild groups(P<0.05).The expression level of PLD2 in the moderate group was also lower than that in the mild group(P<0.05).The severity of acute pancreatitis is negatively correlated with PLD2 expression(r=-0.75,P=0.002).The mRNA levels of C-X-C chemokine receptor type 1,C-X-C chemokine receptor type 2,C-C chemokine receptor type 2,and C-C chemokine receptor type 5 in the severe group are significantly higher than those in the moderate and mild groups(P<0.05),and the expression levels in the moderate group are also higher than those in the mild group(P<0.05).The levels of C-reactive protein,tumo

关键词： Phospholipase D2 Neutrophil migration Acute pancreatitis Retrospective analysis Inflammatory response

预变形量对2050 Al−Li合金显微组织和力学性能的影响

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Transactions of Nonferrous Metals Society of China 2024年第6期34卷 1774-1788页

作者：李耀徐国富乔海光刘时超彭小燕中南大学材料科学与工程学院长沙410083 中南大学有色金属材料科学与工程教育部重点实验室长沙410083

研究经不同轧制预变形处理(0~20%)后2050 Al−Li合金T8时效状态的显微组织演变和力学性能。通过透射电子显微镜(TEM)和扫描电子显微镜(SEM)对其显微组织进行表征。结果表明:随着预变形量的增加,晶粒尺寸沿ND方向显著变小,晶内畸变增大。... 详细信息

研究经不同轧制预变形处理(0~20%)后2050 Al−Li合金T8时效状态的显微组织演变和力学性能。通过透射电子显微镜(TEM)和扫描电子显微镜(SEM)对其显微组织进行表征。结果表明:随着预变形量的增加,晶粒尺寸沿ND方向显著变小,晶内畸变增大。位错等的缠结为T1相的析出提供了大量的形核位点。这导致析出相数量增多,析出相之间的距离缩小,从而提高了对位错运动的阻碍作用和合金强度。当预变形量为16%时,T1相数量密度和合金强度最高(屈服强度和抗拉强度分别达到568和584 MPa,伸长率为8.6%);当预变形量进一步增加到20%时,由于位错缠结,原子扩散通道减少,T1相数量的减少最终导致合金强度降低。

关键词： 2050铝锂合金轧制预变形 T1相显微组织力学性能