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Antibiotic resistance and molecular characterization of diarrheagenic Escherichia coli and non-typhoidal Salmonella strains isolated from infections in Southwest China

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Infectious Diseases of Poverty 2018年第1期7卷 512-522页

作者： Shun-Xian Zhang Yong-Ming Zhou li-Guang Tian Jia-Xu Chen Rita Tinoco-Torres Emmanuel Serrano shi-zhu li Shao-Hong Chen lin Ai Jun-Hu Chen Shang Xia Yan Lu Shan Lv Xue-Jiao Teng Wen Xu Wen-Peng Gu Si-Tang Gong Xiao-Nong Zhou Lan-Lan Geng Wei Hu Guangzhou Institute of Pediatrics Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou 510623People’s Republic of China Department of Gastroenterology Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou 510623People’s Republic of China Yunnan Provincial Center for Disease Control and Prevention Kunming 650022People’s Republic of China National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionShanghai 200025People’s Republic of China Chinese Center for Tropical Diseases Research WHO Collaborating Centre for Tropical DiseasesNational Center for International Research on Tropical DiseasesMinistry of Science and TechnologyKey Laboratory of Parasite and Vector BiologyMinistry of HealthShanghai 200025People’s Republic of China Department of Biology&CESAM University of Aveiro3810-193 AveiroPortugal Wildlife Ecology and Health group and Servei d’Ecopatologia de Fauna Salvatge(SEFaS) Departament de Medicina i Cirurgia AnimalsUniversitat Autònoma de Barcelona(UAB)BellaterraSpain Department of Microbiology and Microbial Engineering School of Life SciencesFudan UniversityShanghai 200433People’s Republic of China

Background:Bacterial diarrhea is one of the most common causes for medical consultations,mortality and morbidity in the *** Escherichia coli(DEC)and non-typhoidal Salmonella(NTS)are major intestinal pathogens in developing countries,and the indiscriminate use of antibiotics has greatly contributed to resistant ***,the aim of the present study is to identify the antimicrobial resistance patterns and the molecular characteristics of DEC and NTS in southwest,***:1121 diarrheal patients and 319 non-diarrheal subjects across all age groups were recruited from four sentinel hospitals from June 2014 to July 2015 in Kunming City,Yunnan *** stool specimen was collected to detect DEC and NTS with standard microbiological and molecular *** resistance testing was performed with the Kirby-Bauer disk diffusion method,and the standards for antimicrobial susceptibility testing complied with the Clinical and Laboratory Standards Institute(CLSI).Molecular characterization of strains was carried out using pulsed-field gel electrophoresis(PFGE).A structured questionnaire was used to record basic epidemiological data(***,age,residence,season,etc.).Data were analyzed using Chi-square or Fisher’s exact ***:DEC was detected in 127(11.33%)diarrhea cases and 9(2.82%)non-diarrheal cases(χ^(2)=20.69,Plin and Clavulafiate(AMC),Cephalothin(CEP),Gentamicin(GEN)and Sulfamethoxazole-Trimethoprim(SXT)of DEC isolated from diarrhea cases were higher than those of NTS isolated from diarrhea patients(37.01%vs 14.29%,χ^(2)=7.57,P=0.006;29.92%vs 11.

关键词： Enterobacterial infections Gastroenteritis Fingerprint typing Kunming Yunnan

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Low‑Temperature Oxidation Induced Phase Evolution with Gradient Magnetic Heterointerfaces for Superior Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第1期17卷 191-204页

作者： Zizhuang He lingzi shi Ran Sun lianfei Ding Mukun He Jiaming li Hua Guo Tiande Gao Panbo liu School of Chemistry and Chemical Engineering Northwestern Polytechnical UniversityXi’an 710129People’s Republic of China School of Marine Science and Technology Northwestern Polytechnical UniversityXi’an 710072People’s Republic of China

Gradient magnetic heterointerfaces have injected infinite vitality in optimizing impedance matching,adjusting dielectric/magnetic resonance and promoting electromagnetic(EM)wave absorption,but still exist a significant challenging in regulating local phase ***,accordion-shaped Co/Co_(3)O_(4)@N-doped carbon nanosheets(Co/Co_(3)O_(4)@NC)with gradient magnetic heterointerfaces have been fabricated via the cooperative high-temperature carbonization and lowtemperature oxidation *** results indicate that the surface epitaxial growth of crystal Co_(3)O_(4) domains on local Co nanoparticles realizes the adjustment of magnetic-heteroatomic components,which are beneficial for optimizing impedance matching and interfacial ***,gradient magnetic heterointerfaces simultaneously realize magnetic coupling,and long-range magnetic ***,the synthesized Co/Co_(3)O_(4)@NC absorbents display the strong electromagnetic wave attenuation capability of−53.5 dB at a thickness of 3.0 mm with an effective absorption bandwidth of 5.36 GHz,both are superior to those of single magnetic domains embedded in carbon *** design concept provides us an inspiration in optimizing interfacial polarization,regulating magnetic coupling and promoting electromagnetic wave absorption.

关键词： Magnetic heterointerfaces Phase evolution Interfacial polarization Magnetic coupling Electromagnetic wave absorption

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风电场抗台风备用电源并联电抗器参数的设计

可再生能源 2017年第9期35卷 1336-1340页

作者：史立勤许国东杨靖施亚强朱长江李旭锋浙江运达风电股份有限公司风力发电系统国家重点实验室浙江杭州310012 浙江龙源风力发电有限公司浙江杭州310008

针对风电场在抗台风模式下系统存在容性无功电流过大问题,提出了一种备用电源并联电抗器参数优化方法。文章分别通过两种方式对并联电抗器的参数值进行确定,首先通过理论计算得到一组计算值;然后建立风电场在抗台风模式下的Digsilent系... 详细信息

针对风电场在抗台风模式下系统存在容性无功电流过大问题,提出了一种备用电源并联电抗器参数优化方法。文章分别通过两种方式对并联电抗器的参数值进行确定,首先通过理论计算得到一组计算值;然后建立风电场在抗台风模式下的Digsilent系统模型,对其各种工况下进行仿真,观察仿真结果得到另一种仿真数值。比较验证表明,两者的误差很小,可为风电场抗台风模式下电力设备参数值的选取提供参考。

关键词：抗台风模式 Digsilent系统模型并联电抗器无功补偿

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(φ,ψ)凸函数的一个充要条件

首都师范大学学报（自然科学版） 2017年第4期38卷 4-7页

作者：时统业朱璟李鼎海军指挥学院信息系江苏南京211800

作为凸函数的推广,引入(φ,ψ)凸函数的概念.利用凸函数的Jensen不等式和(φ,ψ)凸函数的定义,建立了(φ,ψ)凸函数的Hermite-Hadamard型不等式.借助(φ,ψ)凸函数的Hermite-Hadamard型不等式给出(φ,ψ)凸函数的一个充要条件.

关键词： (φ,ψ)凸函数 Hermite-Hadamard型不等式充分必要条件

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膀胱癌盆腔淋巴结转移的影像学诊断

岭南现代临床外科 2017年第1期17卷 113-118,127页

作者：石思雅朱望舒李勇中山大学孙逸仙纪念医院放射科广州510120

膀胱癌是泌尿系统最常见的恶性肿瘤,易发生复发、转移。相对于淋巴结转移阴性的患者,淋巴结转移阳性的患者复发、转移概率更高,而且往往是致死性的。准确预测淋巴结转移与否对于患者治疗策略的选择具有重要指导意义。目前诊断淋巴结转... 详细信息

膀胱癌是泌尿系统最常见的恶性肿瘤,易发生复发、转移。相对于淋巴结转移阴性的患者,淋巴结转移阳性的患者复发、转移概率更高,而且往往是致死性的。准确预测淋巴结转移与否对于患者治疗策略的选择具有重要指导意义。目前诊断淋巴结转移的金标准为术后病理,术前主要依靠影像学,但是准确性不太理想。本文就膀胱癌盆腔淋巴结转移的影像学诊断方法,包括CT、MRI及PET/CT、SPECT/CT及前哨淋巴结显像等作一综述。

关键词：膀胱癌淋巴结转移影像学诊断

Towards a global One Health index: a potential assessment tool for One Health performance

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Infectious Diseases of Poverty 2022年第3期11卷 12-26页

作者： Xiao-Xi Zhang Jing-Shu liu Le-Fei Han Shang Xia shi-zhu li Odel Yli Kokouvi Kassegne Min li Kun Yin Qin-Qin Hu Le-Shan Xiu Yong-Zhang zhu liang-Yu Huang Xiang-Cheng Wang Yi Zhang Han-Qing Zhao Jing-Xian Yin Tian-Ge Jiang Qin li Si-Wei Fei Si-Yu Gu Fu-Min Chen Nan Zhou Zi-Le Cheng Yi Xie Hui-Min li Jin Chen Zhao-Yu Guo Jia-Xin Feng lin Ai Jing-Bo Xue Qian Ye liz Grant Jun-Xia Song Geoff Simm Jürg Utzinger Xiao-Kui Guo Xiao-Nong Zhou School of Global Health Chinese Center for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghaiPeople’s Republic of China One Health Center Shanghai Jiao Tong University-The University of EdinburghShanghaiPeople’s Republic of China National Institute of Parasitic Diseases at Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research) NHC Key Laboratory of Parasite and Vector BiologyWHO Collaborating Centre for Tropical DiseasesShanghaiPeople’s Republic of China Shanghai Legislative Research Institute ShanghaiPeople’s Republic of China zhuhai Branch ESPREBeijing Normal University Zhuhai CampusZhuhaiGuangdongPeople’s Republic of China Global Health Academy The University of EdinburghEdinburghUK Food and Agriculture Organization of the United Nations RomeItaly Global Academy of Agriculture and Food Systems The University of EdinburghEdinburghUK Swiss Tropical and Public Health Institute AllschwilSwitzerland University of Basel BaselSwitzerland

Background:A One Health approach has been increasingly mainstreamed by the international community, as it provides for holistic thinking in recognizing the close links and inter-dependence of the health of humans, animals and the environment. However, the dearth of real-world evidence has hampered application of a One Health approach in shaping policies and practice. This study proposes the development of a potential evaluation tool for One Health performance, in order to contribute to the scientific measurement of One Health approach and the identification of gaps where One Health capacity building is most urgently ***:We describe five steps towards a global One Health index (GOHI), including (i) framework formulation;(ii) indicator selection;(iii) database building;(iv) weight determination;and (v) GOHI scores calculation. A cell-like framework for GOHI is proposed, which comprises an external drivers index (EDI), an intrinsic drivers index (IDI) and a core drivers index (CDI). We construct the indicator scheme for GOHI based on this framework after multiple rounds of panel discussions with our expert advisory committee. A fuzzy analytical hierarchy process is adopted to determine the weights for each of the ***:The weighted indicator scheme of GOHI comprises three first-level indicators, 13 second-level indicators, and 57 third-level indicators. According to the pilot analysis based on the data from more than 200 countries/territories the GOHI scores overall are far from ideal (the highest score of 65.0 out of a maximum score of 100), and we found considerable variations among different countries/territories (31.8–65.0). The results from the pilot analysis are consistent with the results from a literature review, which suggests that a GOHI as a potential tool for the assessment of One Health performance might be ***:GOHI—subject to rigorous validation—would represent the world’s first evaluation tool that constructs the

关键词： Antimicrobial resistance Cell-like framework Climate change Food security Global One Health index(GOHI) Global performance assessment Governance Zoonotic diseases

The potential mechanism and clinical application value of remote ischemic conditioning in stroke

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Neural Regeneration Research 2025年第6期20卷 1613-1627页

作者： Yajun zhu Xiaoguo li Xingwei Lei liuyang Tang Daochen Wen Bo Zeng Xiaofeng Zhang Zichao Huang Zongduo Guo The First Affiliated Hospital of Chongqing Medical University ChongqingChina

Some studies have confirmed the neuroprotective effect of remote ischemic conditioning against stroke. Although numerous animal researches have shown that the neuroprotective effect of remote ischemic conditioning may be related to neuroinflammation, cellular immunity, apoptosis, and autophagy, the exact underlying molecular mechanisms are unclear. This review summarizes the current status of different types of remote ischemic conditioning methods in animal and clinical studies and analyzes their commonalities and differences in neuroprotective mechanisms and signaling pathways. Remote ischemic conditioning has emerged as a potential therapeutic approach for improving stroke-induced brain injury owing to its simplicity, non-invasiveness, safety, and patient tolerability. Different forms of remote ischemic conditioning exhibit distinct intervention patterns, timing, and application range. Mechanistically, remote ischemic conditioning can exert neuroprotective effects by activating the Notch1/phosphatidylinositol 3-kinase/Akt signaling pathway, improving cerebral perfusion, suppressing neuroinflammation, inhibiting cell apoptosis, activating autophagy, and promoting neural regeneration. While remote ischemic conditioning has shown potential in improving stroke outcomes, its full clinical translation has not yet been achieved.

关键词： Akt apoptosis autophagy cerebral perfusion cerebral vascular stenosis clinical transformation hemorrhagic stroke ischemic stroke neuroinflammation neuroprotection Notch1 PI3K remote ischemic conditioning stroke

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鼻咽癌差异表达基因PROL4特性分析

生物化学与生物物理进展 2003年第2期30卷 262-265页

作者：张必成周鸣周后德肖炳燚聂新民朱诗国李伟芳李小玲李桂源中南大学湘雅医学院肿瘤研究所长沙410078

在正常成人鼻咽与鼻咽癌活检组织之间进行抑制性消减杂交和微阵列 (microarray)杂交 ,获得了鼻咽癌差异表达基因PROL4的全长cDNA序列 ,其GenBank登录号为 :AF5 30 4 72 .该基因包含 5 6 7个核苷酸 ,其编码产物是由 134个氨基酸组成的富... 详细信息

在正常成人鼻咽与鼻咽癌活检组织之间进行抑制性消减杂交和微阵列 (microarray)杂交 ,获得了鼻咽癌差异表达基因PROL4的全长cDNA序列 ,其GenBank登录号为 :AF5 30 4 72 .该基因包含 5 6 7个核苷酸 ,其编码产物是由 134个氨基酸组成的富含脯氨酸蛋白 .采用RT PCR证实了PROL4基因在鼻咽癌细胞株HNE1和鼻咽癌活检组织中表达下调或缺失 (42 /48) .12种组织RNA印迹显示 :PROL4基因在人骨骼肌、胸腺和肺组织中表达 ,其转录本大小约为 0 6kb ,与所克隆的PROL4基因的cDNA大小一致 .进而通过肿瘤表达谱阵列(cancerprofilingarray)杂交检测了其在乳腺癌、子宫癌、结肠癌、胃癌、卵巢癌、肺癌、肾癌、直肠癌、甲状腺癌、子宫颈癌、前列腺癌、胰腺癌、小肠癌组织及其配对的正常组织的表达状况 .

关键词：鼻咽癌差异表达基因 PROL4 特性克隆基因表达

Ti含量对Ni-Ti镀层形貌及其电解析氢性能的影响

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材料科学与工程学报 2015年第3期33卷 386-390,454页

作者：刘秋平董虹星郑国渠朱施利浙江工业大学化学工程学院浙江杭州310014 杭州科技职业技术学院机电工程学院浙江杭州311402 浙江工业大学材料科学与工程学院浙江杭州310014 杭州钢铁集团技术中心浙江杭州310022

在Ni镀液中添加2g/L、4g/L的-400目的 Ti粉,获取Ni-7.8at%Ti、Ni-35at%Ti镀层,并对所制备的镀层进行了结构和析氢性能分析。结果表明:随着镀液中Ti粉的添加,镀层中Ti含量增加,镀层结构呈现多孔性,镀层的表面积得到大幅度提升。在25℃、6... 详细信息

在Ni镀液中添加2g/L、4g/L的-400目的 Ti粉,获取Ni-7.8at%Ti、Ni-35at%Ti镀层,并对所制备的镀层进行了结构和析氢性能分析。结果表明:随着镀液中Ti粉的添加,镀层中Ti含量增加,镀层结构呈现多孔性,镀层的表面积得到大幅度提升。在25℃、6mol/L的NaOH溶液中的电解析氢实验表明:Ni-Ti镀层电极比Ni镀层电极具有更好的析氢性能,且析氢性能随着Ni-Ti镀层中Ti含量的增加而增强;长时间浸泡之后的电解析氢表明Ni-Ti镀层电极在碱性溶液中有良好的稳定性。

关键词： Ni-Ti镀层析氢性能电沉积