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Longitudinal observation of intraocular pressure variations with acute altitude changes

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World Journal of Clinical Cases 2019年第20期7卷 3226-3236页

作者： Yuan Xie Yun-Xiao Sun Ying Han Di-Ya Yang Yi-Quan Yang Kai Cao Shu-Ning Li Xue Li Xin-Xin Lu shi-zheng wu Ning-Li Wang Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology and Visual Sciences Key LaboratoryBeijing 100730China Beijing Institute of Ophthalmology Beijing Tongren HospitalCapital Medical UniversityBeijing 100005China Department of Ophthalmology University of CaliforniaSan FranciscoCA 94143United States Department of Laboratory Medicine Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Departments of Neurology the Qinghai Provincial People's HospitalXining 810007Qinghai ProvinceChina

BACKGROUND Higher intraocular pressure(IOP)is a major risk factor for developing glaucoma,and the leading cause of irreversible blindness *** altitude(HA)may be involved in IOP,but the reported results were *** to HA directly by plane from low altitude regions is an acute,effortless ***,the effects of such exposure to different altitudes on IOP have rarely been *** To investigate changes in IOP after rapid effortless exposure to HA in stages and compare it with systemic *** Fifty-eight healthy subjects(116 eyes)were divided into three groups:17 lowaltitude(LA)residents[44 m above sea level(ASL)],22 HA residents(2261 m ASL)and 19 very HA(VHA)residents(3750 m ASL).The LA group flew to HA *** days later,they flew with the HA group to VHA where both groups stayed for 2 ***,the LA group flew back to HA and stayed for 1 d before flying back to 44 ***,oxygen saturation(SpO2)and pulse rate were *** linear mixed model was used to compare repeated *** IOP in the LA group significantly decreased from 18.41±2.40 mmHg at 44 m to 13.60±3.68 mmHg at 2261 m ASL(P<0.001),and then to 11.85±2.48 mmHg at 3750 m ASL(P=0.036 compared to IOP at 2261 m ASL)and partially recovered to 13.47±2.57 mmHg upon return to 44 *** in the LA group at HA and VHA was comparable to that in the local residents(12.2±2.4 mmHg for HA,11.5±1.8 mmHg for VHA).IOP was positively associated with SpO2 while negatively associated with pulse *** IOP in the LA group gradually reduced as altitude elevated in stages and became comparable to IOP in local *** may be associated with IOP,which deserves further study.

关键词： Intraocular pressure High altitude Hypoxia Glaucoma Lowlanders Erythrocyte

Experience of the national-level old Chinese medicine expert wu zhengshi on syndrome differentiation and treatment of anaphylactoid purpura

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TMR Clinical Research 2020年第1期3卷 10-17页

作者： Qiang Su Zhuo-Feng Liu Teng zheng Yun Lu Ru Wang Yuan-Wei Gan Jiang Liang zheng-shi wu Guizhou University of Traditional Chinese Medicine Guiyang 550002China Department of Rheumatology and Hematology the First Affiliated Hospitai of Guizhou University of Traditional Chinese MedicineGuiyang 550002China The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine Guiyang 550002China Guiyang Maternal and Child Care Hospital Guiyang 550002China.

This paper introduced and summarized the experience of the national-level old Chinese medicine expert wu zhengshi on syndrome differentiation and treatment of anaphylactoid *** zhengshi believes that blood-heat is the main cause of anaphylactoid *** Qi is weak,the human body is attacked by external heat,resulting in the damage of the blood system,which lead to the anaphylactoid *** blood is thermalized poison,which enters the vessel quickly and forces the blood to overflow the vessel,which develops for the *** to the ancient book of Chinese medicine Jie Wei Yuan Sou(1550 C.E.),wu zhengshi put forward the treatment of relieving blood detoxification,heat and cooling blood,which achieved significant curative effects.

关键词： Anaphylactoid purpura Blood-heat Experience of famous doctors wu zhengshi

Electric Potential in a Dielectric Sphere Head Produced by a Time-Harmonic Equivalent Current Dipole

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Journal of Electronic Science and Technology of China 2007年第3期5卷 268-271页

作者： Xiao-Yong Duan shi-zheng Peng Long-wu Li Xiao-Chun Liu Rong Xin with Laboratory for Photoelectric Technology and Application and School of Science Guizhou University Guiyang 550025 China

A time-harmonic equivalent current dipole model is proposed to simulate EEG source which deals with the problem concerning the capacitance effect. The expressions of potentials in both homogeneous infinite dielectric medium and dielectric sphere on the electroquasistatic condition are presented. The potential in a 3-layer inhomogeneous spherical head is computed by using this model. The influences on potential produced by time-harmonic character and permittivity are discussed. The results show that potentials in dielectric sphere are affected by frequency and permittivity.

关键词： Electroquasistatic frequency permittivity time-harmonic equivalent current dipole timeharmonic factor.

一种具有回热功能的呼吸鼻式新风装置实验与研究

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北京理工大学学报 2018年第2期38卷 160-164页

作者：王秋实郑宏飞伍纲北京理工大学机械与车辆学院北京100081

为提高室内空气品质和节约建筑能耗,文中设计了一种具有回热功能的呼吸鼻式新风装置.它利用在通风道中设置储热体的方法,将废气中的部分有效热能保存下来,并利用新风送回室内,从而减小建筑能耗.介绍了装置的工作原理和性能测试方法,并... 详细信息

为提高室内空气品质和节约建筑能耗,文中设计了一种具有回热功能的呼吸鼻式新风装置.它利用在通风道中设置储热体的方法,将废气中的部分有效热能保存下来,并利用新风送回室内,从而减小建筑能耗.介绍了装置的工作原理和性能测试方法,并在模拟房间内,分别对冬季供热和夏季供冷两种情况下该呼吸鼻的储热体温度变化规律、换热效率和节能量进行了实验测试.实验结果表明,本装置每小时换风量达到60m^3,冬季可节省新风热负荷约280 W,夏季节约新风冷负荷270 W,装置的热回收效率可达80%.

关键词：呼吸鼻回热式新风装置储能

Identifying the dynamic behaviors in complete reconstruction of Co-based complex precatalysts during electrocatalytic oxygen evolution

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Journal of Energy Chemistry 2025年第1期100卷 226-233页

作者： Jingfang Zhang Danyang wu Linke Cai Youluan Lu Fanpeng Cheng Lijuan shi Qun Yi Yao Liu Yi Huang Key Laboratory of Green Chemical Engineering Process of Ministry of Education Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of Education Hubei Key Laboratory of Novel Reactor and Green Chemical Technology School of Chemical Engineering & Pharmacy Wuhan Institute of Technology Key Laboratory of Pesticide & Chemical Biology of Ministry of Education Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction of Ministry of Education College of Chemistry Central China Normal University College of Materials Science and Engineering Fuzhou University

Transition metal-based nanomaterials have emerged as promising electrocatalysts for oxygen evolution reaction（OER）. Considerable research efforts have shown that self-reconstruction occurs on these nanomaterials under operating conditions of OER process. However, most of them undergo incomplete reconstruction with limited thickness of reconstruction layer, leading to low component utilization and arduous exploration of real catalytic mechanism. Herein, we identify the dynamic behaviors in complete reconstruction of Co-based complexes during OER. The hollow phytic acid（PA） cross-linked CoFe-based complex nanoboxes with porous nanowalls are designed because of their good electrolyte penetration and mass transport ability, in favor of the fast and complete reconstruction. A series of experiment characterizations demonstrate that the reconstruction process includes the fast substitution of PA by OH-to form Co（Fe）(OH)xand subsequent potential-driven oxidation to Co（Fe）OOH. The obtained CoFeOOH delivers a low overpotential of 290 mV at a current density of 10 mA cm-2and a long-term *** experiment results together with theory calculations reveal that the Fe incorporation can result in the electron rearrangement of reconstructed CoFeOOH and optimization of their electronic structure,accounting for the enhanced OER activity. The work provides new insights into complete reconstruction of metal-based complexes during OER and offers guidelines for rational design of high-performance electrocatalysts.

关键词： Complete reconstruction Co-based complex Precatalysts Oxygen evolution reaction

Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis

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Neural Regeneration Research 2025年第4期20卷 1103-1123页

作者： Xiahong Tang Nan zheng Qingming Lin Yan You zheng Gong Yangping Zhuang Jiali wu Yu Wang Hanlin Huang Jun Ke Feng Chen Shengli Clinical Medical College of Fujian Medical University Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Emergency Fujian Provincial HospitalFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Emergency Medicine FuzhouFujian ProvinceChina The Second Department of Intensive Care Unit Fujian Provincial Hospital South BranchFuzhouFujian ProvinceChina

Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resuscitation neurological *** preconditioning has been shown to improve migration and survival of bone marrow–derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest,but the specific mechanisms by which hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect against brain injury after cardiac arrest are *** this end,we established an in vitro co-culture model of bone marrow–derived mesenchymal stem cells and oxygen–glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis,possibly through inhibition of the MAPK and nuclear factor κB ***,we transplanted hypoxia-preconditioned bone marrow–derived mesenchymal stem cells into the lateral ventricle after the return of spontaneous circulation in an 8-minute cardiac arrest rat model induced by *** results showed that hypoxia-preconditioned bone marrow–derived mesenchymal stem cells significantly reduced cardiac arrest–induced neuronal pyroptosis,oxidative stress,and mitochondrial damage,whereas knockdown of the liver isoform of phosphofructokinase in bone marrow–derived mesenchymal stem cells inhibited these *** conclude,hypoxia-preconditioned bone marrow–derived mesenchymal stem cells offer a promising therapeutic approach for neuronal injury following cardiac arrest,and their beneficial effects are potentially associated with increased expression of the liver isoform of phosphofructokinase following hypoxic preconditioning.

关键词： bone marrow–derived mesenchymal stem cells cardiac arrest cardiac resuscitation hypoxic preconditioning liver isoform of phosphofructokinase mitochondria neuroinflammation oxidative stress pyroptosis reactive oxygen species

Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis

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World Journal of Clinical Oncology 2025年第1期16卷 10-24页

作者： Yang-zheng Lan zheng wu Wen-Jia Chen Xin-Ning Yu Hua-Tao wu Jing Liu Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including *** six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX *** or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular *** to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor *** the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic ***,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular *** conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关键词： Sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis Therapeutics

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智能精密播种机的优化设计

农机化研究 2025年第1期47卷 114-119页

作者：吴政内蒙古机电职业技术学院呼和浩特010070

智能精密播种机是一种自动化的农业设备,可大幅提高种植效率、减少种植成本。但是,目前智能精密播种机依赖高精度的传感器、控制系统和算法来实现准确的种子投放和深度控制,需要较高的技术要求和技术支持,且对于一些不规则形状的种子或... 详细信息

智能精密播种机是一种自动化的农业设备,可大幅提高种植效率、减少种植成本。但是,目前智能精密播种机依赖高精度的传感器、控制系统和算法来实现准确的种子投放和深度控制,需要较高的技术要求和技术支持,且对于一些不规则形状的种子或大粒小种的种子,适应性较差。为此,提出了一种智能精密播种机优化方案,并使用高精度传感器和控制系统实现多功能播种,控制种子的投放量和调整播种深度,使用节能设备模块化设计和使用易于更换的部件、数据分析功能和简单易用的用户界面。最后,通过田间试验进行功能性试验,结果表明:经过优化后的智能精密播种机播种变异系数≤5%,满足播种农艺要求,可以实现准确的种子投放和深度控制,避免种植密度不均匀和深度不一致等问题,从而提高种植效率和作物品质。

关键词：智能精密播种机优化设计精度多功能性种植效率

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Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao De-En Xu Ming-Lei wu Ji-Chuan Liu Zi-Ling shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response