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Abnormally expressed circular RNAs as novel non-invasive biomarkers for hepatocellular carcinoma: A meta-analysis

World Journal of Gastrointestinal Oncology 2019年第10期11卷 909-924页

作者： Ya-Lin Jiang Meng-Meng Shang shi-zhen dong Yong-Chao Chang Department of Clinical Laboratory The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and TechnologyLuoyang 471003Henan ProvinceChina Department of Clinical Laboratory The Family Planning Guidance Station of Luanchuan CountyLuoyang 471500Henan ProvinceChina

BACKGROUND Circular RNAs(circRNAs)are a newly discovered class of endogenous noncoding RNAs that may have roles in cancer genesis and *** the recent literature,dysregulated circRNAs have been extensively investigated in hepatocellular carcinoma(HCC).Whether or not circRNAs are of clinical value for the management of HCC has not been *** To meta-analyze the diagnostic and prognostic value of abnormally expressed circRNAs in *** Eligible studies were sourced from PubMed,EMBASE,and CNKI online *** on patients’clinical characteristics,including diagnostic efficacy and overall survival,were *** diagnostic and prognostic parameters were respectively synthesized using the bivariate meta-analysis model and multivariate Cox hazard regression analysis based on Stata *** trim and fill method was adopted to assess the possible effects from publication *** A total of 21 eligible studies were *** pooled sensitivity,specificity,and area under the curve of abnormally expressed circRNAs in distinguishing HCC from non-cancer controls were 0.78(95%CI:0.69–0.85),0.80(95%CI:0.74–0.86),and 0.86,*** analyses showed that the downregulated circRNA expression signature correlated perfectly with HCC survival[hazard ratio(HR)=0.42,95%CI:0.19–0.91,P=0.028;I2=92.7%,P=0.000],whereas the HCC cases with high circRNA levels had significantly poorer prognoses than those of patients with low circRNA levels(HR=2.22,95%CI:1.50–3.30,P=0.000;I2=91%,P=0.000).Moreover,abnormally expressed circRNAs were intimately associated with tumor size,differentiation grade,microvascular invasion,metastasis,TNM stage,and serum alpha fetal protein level in patients with *** analysis based on sample type,control source,and expression status also yielded robust *** Abnormally expressed circRNA signatures show immense potential as novel non-invasive biomarker(s)for HCC diagnosis and prognosis.

关键词： CircRNA Hepatocellular carcinoma Diagnosis Prognosis Meta-analysis

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Cardiac arrest after graft reperfusion during liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2006年第2期5卷 185-189页

作者： Xue-Yin shi, zhen-dong Xu, Hai-Tao Xu, Jin-Jin Jiang and Gang Liu Department of Anesthesiology, Changzheng Hospital, Second Military Medical University,Shanghai 200003 , China Department of Anesthesiology Changzheng Hospital Second Military Medical University Shanghai 200003 China. btxzd123@***

BACKGROUND: Cardiac arrest ( CA) during orthotopic liver transplantation (OLT) is rare but it threatens the lives of patients. The cause of perioperitive CA is not fully understood. We reported the occurrence of CA in 5 patients after unclamping of the vena cava and investigated the relationship between CA and associated variables. METHODS: Five patients with CA after graft reperfusion during OLT in our unit from November 1996 to September 2003 were retrospectively reviewed. Analyzed data included donor and recipient demographic data, and recipient operative and postoperative events. RESULTS: Five (2.1%) of 240 patients undergoing OLT experienced CA 5 minutes after graft reperfusion. Two patients died of resuscitation failure. Hyperkalemia and metabolic acidosis after revascularization were observed in some patients. The five patients had hypothermia and hypocalce-mia, and one had pulmonary embolism. CONCLUSIONS: CA is one of the syndromes after reperfusion. Many factors such as hyperkalemia, acidosis or pulmonary embolism combined with hypothermia and hy-pocalcemia during the operation seem to contribute to the occurrence of CA.

关键词： liver transplantation cardiac arrest postreperfusion syndrome electrolyte

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干冰表面处理技术在系统级封装的应用

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表面技术 2017年第3期46卷 177-183页

作者：隋春飞蔡坚石振东清华大学微电子所微纳电子系北京100083 北京亦庄国际投资发展有限公司北京100083

目的电子元器件表面材料的质量是影响电磁屏蔽镀层和封装材料表面结合力的主要因素,封装元件在切割分离过程中侧壁表面粘附的Cu杂质对屏蔽膜的质量有不利影响。为了提高电子封装体的表面质量,提出一种可应用于高精密电子加工领域的新型... 详细信息

目的电子元器件表面材料的质量是影响电磁屏蔽镀层和封装材料表面结合力的主要因素,封装元件在切割分离过程中侧壁表面粘附的Cu杂质对屏蔽膜的质量有不利影响。为了提高电子封装体的表面质量,提出一种可应用于高精密电子加工领域的新型表面技术——干冰处理技术。方法通过实验设计深入研究干冰技术的关键参量(喷射压力、喷射角度和清洗速度)对电子材料表面杂质去除的影响规律,分析了干冰处理封装材料表面的作用机理,对比了干冰作用与传统去离子水处理所获得的电磁屏蔽膜质量。结果作用机理为干冰的物理冲击和微爆破产生的冲击力将粘附到侧壁上的杂质剥离而去除,实验得到最优作用条件,即在喷射压力为0.2~0.4 MPa,作用速度为40~50 mm/s,喷射角度为40?~70?时,封装元件PCB侧壁表面质量明显改善,表面PCB区域铜杂质的含量由30%降至2%,阻焊层破损率可控,且有效地提高了电磁屏蔽镀层结合力的等级。结论干冰技术工艺操作简单,作业效率高,且在最优工艺参数下无其他不良产生,可作为未来电子元器件制造领域表面处理的技术支撑。

关键词：电子元器件表面质量干冰清洁粗糙度电磁屏蔽镀层水洗

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停用阿托伐他汀对老年急性脑梗死患者颈动脉易损斑块及预后的影响研究

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中国全科医学 2017年第28期20卷 3509-3514页

作者：张艳影石振东沈阳医学院附属铁法煤业集团总医院神经内科辽宁省铁岭市112700 沈阳医学院附属铁法煤业集团总医院VIP病房辽宁省铁岭市112700

目的探讨停用阿托伐他汀对老年急性脑梗死(ACI)患者颈动脉易损斑块及预后的影响。方法选取2012年2月—2015年9月沈阳医学院附属铁法煤业集团总医院神经内科收治的老年ACI患者235例,入院后均行常规治疗,出院后嘱长期口服阿托伐他汀和阿... 详细信息

目的探讨停用阿托伐他汀对老年急性脑梗死(ACI)患者颈动脉易损斑块及预后的影响。方法选取2012年2月—2015年9月沈阳医学院附属铁法煤业集团总医院神经内科收治的老年ACI患者235例,入院后均行常规治疗,出院后嘱长期口服阿托伐他汀和阿司匹林。根据患者的服药依从性,以出院后长期口服阿托伐他汀和阿司匹林的患者为观察组(n=102);以出院1周后长期自行停用阿托伐他汀,仅应用阿司匹林和基础疾病治疗药物的患者为对照组(n=133)。分析并比较两组患者发病时及发病6、12个月时的血脂指标、颈动脉内-中膜厚度(IMT)、斑块面积、斑块指数以及发病12个月内的脑梗死复发率、不良反应发生率。结果两组患者总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)比较,差异有统计学意义(P0.05)。结论阿托伐他汀具有降脂、抗动脉粥样硬化作用,并能稳定颈动脉易损斑块,老年ACI患者盲目停用阿托伐他汀可增加脑梗死复发率。

关键词：脑梗死阿托伐他汀停药颈动脉易损斑块预后

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Expression of SNC73, a transcript of the immunoglobulin α-1 gene, in human epithelial carcinomas

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World Journal of Gastroenterology 2007年第16期13卷 2305-2311页

作者： Li-Yi Geng zheng-zhen shi Qi dong Xin-Han Cai Yan-Ming Zhang Wei Cao Jia-Ping Peng Yong-Ming Fang Lei zheng Shu zheng Cancer Institute Zhejiang University School of Medicine Hangzhou 310009 Zhejiang Province China

AIM： To investigate the expression of SNC73, a transcript of the immunoglobulin α-1 gene （IgA1-H chain）, in human epitheliα-derived tumor cells. METHODS： Total RNAs and cell lysates were prepared from five different human epithelial cell lines derived from lung, stomach, liver, skin, and breast, respectively. RT-PCR and immunoblot analysis of these five cell lines were done. Both RT-PCR and immunochemistry were used to detect the expression of SNC73 in these cell lines. We also examined the expression of SNC73 in normal epithelial cells of colon mucosa by in situ hybridization. RT-PCR and immunoblot analysis were used to determine whether the recombination activating gene1/2 （RAG1 and RAG2） is present. The expression of three immunoglobulin transcription factors, EBF, E2A and Pax5, and the heavy chain of IgA1 and two types of light chains of immunoglobulin （κ and λ） in the aforementioned cell lines were analyzed by RT-PCR and immunochemistry, respectively. All the RT-PCR products were analyzed by sequencing. RESULTS： The results of RT-PCR and immunochemistry showed that both mRNA and protein of SNC73 were expressed in five human epitheliα-derived cancer cell lines. These data were further confirmed in the normal epithelial cells of colon mucosa by in situ hybridization. Also, the heavy chain of IgA1 and κ light chain were detected in these cells, but no λ light chain was observed. Both RAG1 and RAG2 were expressed in these human epitheliα-derived cancer cell lines and the sequence was identical to that expressed in pre-B and pre-T cells. In addition to RAG1 and RAG2, the mRNA in one of the immunoglobulin transcription factors, EBF, was also detected in these cell lines, and Pax5 was only expressed in SW480 cells, but no expression of E2A was observed in all the five cell lines. CONCLUSION： Immunoglobulin A1 is originally expressed and V（D）J recombination machine is also present in non-lymphoid cells, suggesting that V（D）J recombination machine mediates the assembly

关键词： SNC73 Immunoglobulin A1 Epithelial cancer cells Recombination activating gene1/2 Immunoglobulin transcription factor

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Low-temperature chlorination roasting technology for the simultaneous recovery of valuable metals from spent LiCoO_(2)cathode material

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 80-91页

作者： Junjie shi Changle Hou Jingjing dong dong Chen Jianzhong Li Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China

With the continuous increase in the disposal volume of spent lithium-ion batteries(LIBs),properly recycling spent LIBs has become essential for the advancement of the circular *** study presents a systematic analysis of the chlorination roasting kinetics and proposes a new two-step chlorination roasting process that integrates thermodynamics for the recycling of LIB cathode *** activation energy for the chloride reaction was 88.41 kJ/mol according to thermogravimetric analysis–derivative thermogravimetry data obtained by using model-free,model-fitting,and Z(α)function(αis conversion rate).Results indicated that the reaction was dominated by the first-order(F1)model when the conversion rate was less than or equal to 0.5 and shifted to the second-order(F2)model when the conversion rate exceeded *** conditions were determined by thoroughly investigating the effects of roasting temperature,roasting time,and the mass ratio of NH_(4)Cl to LiCoO_(2).Under the optimal conditions,namely 400℃,20 min,and NH_(4)Cl/LiCoO_(2)mass ratio of 3:1,the leaching efficiency of Li and Co reached 99.43% and 99.05%,*** of the roasted products revealed that valuable metals in LiCoO_(2)transformed into CoCl_(2) and ***,the reaction mechanism was elucidated,providing insights for the establishment of a novel low-temperature chlorination roasting technology based on a crystal structure *** technology can guide the development of LIB recycling processes with low energy consumption,low secondary pollution,high recovery efficiency,and high added value.

关键词： spent lithium-ion battery thermodynamics chlorination roasting kinetics circular economy

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Prediction and optimization of flue pressure in sintering process based on SHAP

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 346-359页

作者： Mingyu Wang Jue Tang Mansheng Chu Quan shi zhen Zhang School of Metallurgy Northeastern UniversityShenyang 110819China Liaoning Low-Carbon Steelmaking Technology Engineering Research Center Northeastern UniversityShenyang 110819China Engineering Research Center of Frontier Technologies for Low-Carbon Steelmaking(Ministry of Education) Shenyang 110819China

Sinter is the core raw material for blast *** pressure,which is an important state parameter,affects sinter *** this paper,flue pressure prediction and optimization were studied based on the shapley additive explanation(SHAP)to predict the flue pressure and take targeted adjustment ***,the sintering process data were collected and processed.A flue pressure prediction model was then constructed after comparing different feature selection methods and model algorithms using SHAP+extremely random-ized trees(ET).The prediction accuracy of the model within the error range of±0.25 kPa was 92.63%.SHAP analysis was employed to improve the interpretability of the prediction *** effects of various sintering operation parameters on flue pressure,the relation-ship between the numerical range of key operation parameters and flue pressure,the effect of operation parameter combinations on flue pressure,and the prediction process of the flue pressure prediction model on a single sample were analyzed.A flue pressure optimization module was also constructed and analyzed when the prediction satisfied the judgment *** operating parameter combination was then *** flue pressure was increased by 5.87%during the verification process,achieving a good optimization effect.

关键词： sintering process flue pressure shapley additive explanation prediction optimization

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用弹性薄板广义变分原理解某些综合边界支承矩形板在均匀压力作用下的屈曲问题

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力学学报 1964年第1期 81-89页

作者：施振东北京航空学院

本文应用薄板广义变分原理处理了某些综合边界支承矩形板在两个垂直方向受均匀压力作用下的屈曲问题.先就两邻边固定,其余两邻边悬空的情况导出一般解答.接着讨论了十一种特殊边界组合,并对正方板算出数字给果.从Fourier级数只取两项和... 详细信息

本文应用薄板广义变分原理处理了某些综合边界支承矩形板在两个垂直方向受均匀压力作用下的屈曲问题.先就两邻边固定,其余两邻边悬空的情况导出一般解答.接着讨论了十一种特殊边界组合,并对正方板算出数字给果.从Fourier级数只取两项和三项的计算给果表明,本文的方法是有效的,收敛情况比较令人满意;在有些情况下相对误差小于0.3％或更小,在最不利的情况下最多也不超过6％.此外,很多情况还给出最小临界应力的下估值.

关键词：广义变分均匀压力边界矩形板弹性薄板屈曲问题

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Construction of a nano-hybrid biosensor for the enhanced methyl parathion determination based on a methyl parathion degrading enzyme

Construction of a nano-hybrid biosensor for the enhanced met...

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中国化学会第十五届全国有机分析及生物分析学术研讨会

作者： shi-zhen Chen,Ai-dong Zhang~* (Key Laboratory of Pesticide & Chemical Biology of Ministry of Education,Central China Normal University, Wuhan 430079)

＜正＞We present the design of a hybrid biosensor,specific for detection of methyl parathion（MP）,on the base of the AuNPs/MWNTs/SiNPs nanocomposite for the immobilization of methyl parathion degrading enzyme（MPD）.The enzyme MPD embedded in the matrix exhibited high affinity to it substrate,and thus a selective,sensitive,fast and cheap method for quantitative determination of methyl parathion was *** welldefined electrochemical redox peaks proportional to the concentrations of the corresponding MP were observed in the range of 0.001 to 5.0μg/mL,with a detection limit of 0.3 ng/*** proposed biosensor showed good precision and reproducibility,acceptable stability and accuracy in garlic sample analysis.

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Wafer-Scale Ag₂S-Based Memristive Crossbar Arrays with Ultra-Low Switching-Energies Reaching Biological Synapses

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NANO-MICRO LETTERS 2025年第1期17卷 1-12页

作者： Zhu, Yuan Nyberg, Tomas Nyholm, Leif Primetzhofer, Daniel shi, Xun Zhang, zhen Uppsala Univ Dept Elect Engn Div Solid State Elect S-75121 Uppsala Sweden Uppsala Univ Dept Chem Uppsala Sweden Uppsala Univ Dept Phys & Astron Uppsala Sweden Chinese Acad Sci Shanghai Inst Ceram State Key Lab High Performance Ceram & Superfine M Shanghai 200050 Peoples R China

Memristive crossbar arrays (MCAs) offer parallel data storage and processing for energy-efficient neuromorphic computing. However, most wafer-scale MCAs that are compatible with complementary metal-oxide-semiconductor (CMOS) technology still suffer from substantially larger energy consumption than biological synapses, due to the slow kinetics of forming conductive paths inside the memristive units. Here we report wafer-scale Ag2S-based MCAs realized using CMOS-compatible processes at temperatures below 160 degrees C. Ag2S electrolytes supply highly mobile Ag+ ions, and provide the Ag/Ag2S interface with low silver nucleation barrier to form silver filaments at low energy costs. By further enhancing Ag+ migration in Ag2S electrolytes via microstructure modulation, the integrated memristors exhibit a record low threshold of approximately - 0.1 V, and demonstrate ultra-low switching-energies reaching femtojoule values as observed in biological synapses. The low-temperature process also enables MCA integration on polyimide substrates for applications in flexible electronics. Moreover, the intrinsic nonidealities of the memristive units for deep learning can be compensated by employing an advanced training algorithm. An impressive accuracy of 92.6% in image recognition simulations is demonstrated with the MCAs after the compensation. The demonstrated MCAs provide a promising device option for neuromorphic computing with ultra-high energy-efficiency.

关键词： Wafer-scale Ag2S films Reactive sputter Silver nucleation Ag+ migration Energy-efficient neuromorphic computing

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