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Synthesis and characterization of conjugated polymer containing azobenzene and oxadiazole units

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Chinese Chemical Letters 2009年第2期20卷 235-237页

作者： yue Zhang shi Jun yu lu Wang Cong Li College of Chemistry and Chemical Engineering Liaoning Normal University Dalian 116029 China

A novel conjugated polymer containing azobenzene and oxadiazole units was synthesized through multi-step synthesis. The structures and properties of monomer and polymer were characterized and evaluated with IR, ^1H NMR, UV, TGA and GPC, respectively. Polymer with long side chain of alkoxy shows good solubility, thermal stability and photoisomerization property.

关键词： Oxadiazole Conjugated polymer Synthesis Characterization

Completely Non-Normal Toeplitz Operators

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Journal of Mathematical Research and Exposition 2011年第4期31卷 727-734页

作者： Yah yue shi yu Feng lu School of Mathematical Sciences Dalian University of Technology Liaoning 116024 P. R. China

In this paper, we show that the hyponormal Toeplitz operator Tφ with trigonometric polynomial symbol φ is either normal or completely non-normal. Moreover, if Tφ is non-normal, then Tφ has a dense set of cyclic ve... 详细信息

关键词： Toeplitz operator completely nononormal hyponormal cyclic.

Quantitative Determination of Glymphatic Flow Using Spectrophotofluorometry

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Neuroscience Bulletin 2020年第12期36卷 1524-1537页

作者： yu Zhang Jian Song Xu-Zhong He Jian Xiong Rong Xue Jia-Hao Ge shi-yu lu Die Hu Guo-Xing Zhang Guang-Yin Xu Lin-Hui Wang Department of Physiology and Neurobiology Medical College of Soochow UniversitySuzhou 215123China Institute of Medical Biotechnology Suzhou Vocational Health CollegeSuzhou 215009China Institute of Neuroscience Soochow UniversitySuzhou 215123China

Following intrathecal injection of fluorescent tracers,ex vivo imaging of brain vibratome slices has been widely used to study the glymphatic system in the rodent *** penetration into the brain is usually quantified by image-processing,even though this approach requires much time and manual ***,we illustrate a simple protocol for the quantitative determination of glymphatic activity using *** specific time-points following intracisternal or intrastriatal injection of fluorescent tracers,certain brain regions and the spinal cord were harvested and tracers were extracted from the *** intensity of tracers was analyzed spectrophotometrically and their concentrations were quantified from standard *** this approach,the regional and dynamic delivery of subarachnoid CSF tracers into the brain parenchyma was assessed,and the clearance of tracers from the brain was also ***,the impairment of glymphatic influx in the brains of old mice was confirmed using our *** method is more accurate and efficient than the imaging approach in terms of the quantitative determination of glymphatic activity,and this will be useful in preclinical studies.

关键词： Glymphatic system Cerebrospinal fluid Fluorescent tracer Spectrophotofluorometry

Profitable credit card business empirical analysis of factors

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Chinese Business Review 2009年第10期8卷 33-37,24页

作者： SHUAI Qing-hong shi yu-lu School of Economic Information Engineering Southwestern University of Finance and Economics Chengdu 610034 China

Since 1995, major domestic commercial banks are beginning to have a variety of credit cards issued. However, at present, China＇s relatively low profitability of the credit card business, it accounts for a smaller proportion of total bank income. By means of credit card revenue／cost structure analysis, the authors found spending and overdraft balances affecting credit card business, an important factor in profitability. At the same time, combined with a commercial bank＇s existing statistical data, using SPSS software correlation and regression analysis, the authors found that the key to improve the bank card revenue is to raise China＇s commercial banks, credit card revolving credit utilization, and expand the scale of overdraft balances.

关键词： credit card profit factor revenue/cost structure correlation

Metal-organic frameworks with dinuclear metal centers for synergistically boosting CO2 photoreduction

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Science China Chemistry 2025年第01期 201-208页

作者： Hui-Feng Wang Wen-Jie shi yu-Xin Yang Bao-Xia Dong Tong-Bu lu Di-Chang Zhong School of Chemistry and Chemical Engineering Yangzhou University Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology

Dinuclear metal synergistic catalysis （DMSC） has been proved powerful in boosting CO2reduction,while this has not been achieved in heterogeneous catalysts with long-range order *** this study,we,by introduction of metal catalytic centers into an indium-based metal-organic framework （MOF）,obtained a series of isostructural In-MOFs,including three MOFs with mononuclear metal catalytic center （M-In）,three MOFs with dinuclear homometallic catalytic centers （MM-In）,and three MOFs with dinuclear heterometallic catalytic centers (MM’-In,M/M’=Co（II）,Ni（II）,Zn（II）).It was found that all these MOFs can serve as catalysts for photochemical CO2reduction to *** with M-In,the catalytic activities of MM-In were obviously enhanced,and that of MM’-In was further significantly *** example,the CO yield of Co Zn-In reaches a record value of 12,700μmol g-1h-1,which is 4.0,8.1,9.4,and 18.6-fold higher than that of Co Co-In,Zn Zn-In,Co-In,and Zn-In,***,the catalytic activities of Co Ni-In and Ni Zn-In also show different fold increase than those of corresponding dinuclear homometallic and mononuclear metallic *** results of control experiments and theoretical calculation reveal that the higher catalytic activities of MM-In over M-In can be ascribed to the DMSC effect,and the higher catalytic activity of MM’-In over MM-In can be ascribed to the strengthened DMSC *** work reveals the relationship between DMSC effect and bimetal centers in CO2reduction,which provides new insights into the DMSC and paves a new way to design highly active catalysts for photochemical CO2reduction.

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肿瘤干细胞与肿瘤相关巨噬细胞的相互作用

生物化学与生物物理进展 2022年第6期49卷 1075-1084页

作者：师玉露杨胜富唐磊张继虹昆明理工大学医学院昆明650500

肿瘤微环境(tumor microenvironment,TME)不仅促进了肿瘤的早期形成和远处转移,而且随着肿瘤的进展,其自身也不断地发生变化。作为TME的重要组成部分,肿瘤相关巨噬细胞(tumor associated macrophages,TAMs)可通过分泌多种细胞因子激活IL... 详细信息

肿瘤微环境(tumor microenvironment,TME)不仅促进了肿瘤的早期形成和远处转移,而且随着肿瘤的进展,其自身也不断地发生变化。作为TME的重要组成部分,肿瘤相关巨噬细胞(tumor associated macrophages,TAMs)可通过分泌多种细胞因子激活IL-6/STAT3、TGF-β、Wnt/β-catenin等信号通路促进肿瘤干细胞(cancer stem cells,CSCs)的存活、自我更新和化疗耐药等。同时,CSCs也可通过分泌多种细胞因子和趋化因子等募集巨噬细胞,并将其诱导为TAMs重塑CSCs特定的生态位,维持CSCs表型并促进肿瘤进展。TAMs与CSCs的相互作用在促进肿瘤生长、转移及化疗耐药等方面发挥了重要作用。本文对TME中CSCs与TAMs相互作用的研究进行综述,并总结了以CSCs与TAMs相互作用为靶点在新型癌症治疗以及增强化疗效果等方面的重要潜力。

关键词：肿瘤微环境肿瘤干细胞肿瘤相关巨噬细胞相互作用

Identifying the dynamic behaviors in complete reconstruction of Co-based complex precatalysts during electrocatalytic oxygen evolution

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Journal of Energy Chemistry 2025年第1期100卷 226-233页

作者： Jingfang Zhang Danyang Wu Linke Cai Youluan lu Fanpeng Cheng Lijuan shi Qun Yi Yao Liu Yi Huang Key Laboratory of Green Chemical Engineering Process of Ministry of Education Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of Education Hubei Key Laboratory of Novel Reactor and Green Chemical Technology School of Chemical Engineering & Pharmacy Wuhan Institute of Technology Key Laboratory of Pesticide & Chemical Biology of Ministry of Education Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction of Ministry of Education College of Chemistry Central China Normal University College of Materials Science and Engineering Fuzhou University

Transition metal-based nanomaterials have emerged as promising electrocatalysts for oxygen evolution reaction（OER）. Considerable research efforts have shown that self-reconstruction occurs on these nanomaterials under operating conditions of OER process. However, most of them undergo incomplete reconstruction with limited thickness of reconstruction layer, leading to low component utilization and arduous exploration of real catalytic mechanism. Herein, we identify the dynamic behaviors in complete reconstruction of Co-based complexes during OER. The hollow phytic acid（PA） cross-linked CoFe-based complex nanoboxes with porous nanowalls are designed because of their good electrolyte penetration and mass transport ability, in favor of the fast and complete reconstruction. A series of experiment characterizations demonstrate that the reconstruction process includes the fast substitution of PA by OH-to form Co（Fe）(OH)xand subsequent potential-driven oxidation to Co（Fe）OOH. The obtained CoFeOOH delivers a low overpotential of 290 mV at a current density of 10 mA cm-2and a long-term *** experiment results together with theory calculations reveal that the Fe incorporation can result in the electron rearrangement of reconstructed CoFeOOH and optimization of their electronic structure,accounting for the enhanced OER activity. The work provides new insights into complete reconstruction of metal-based complexes during OER and offers guidelines for rational design of high-performance electrocatalysts.

关键词： Complete reconstruction Co-based complex Precatalysts Oxygen evolution reaction

LETM1对骨肉瘤细胞恶性生物学行为的作用及其机制

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解放军医学杂志 2024年第10期49卷 1163-1173页

作者：石雨鹭康权岳小涵罗庆重庆医科大学附属儿童医院/国家儿童健康与疾病临床医学研究中心/儿童发育疾病研究教育部重点实验室/儿科学重庆市重点实验室重庆400014 川北医学院附属医院儿科四川南充637000 重庆医科大学附属儿童医院普通外科创伤外科重庆400014

目的探讨亮氨酸拉链-EF-hand跨膜蛋白1(LETM1)对人骨肉瘤MG63及143B细胞增殖、迁移、凋亡、成骨分化及体内成瘤的作用及其机制。方法将骨肉瘤MG63及143B细胞分为空白对照组(未加入腺病毒感染)、阴性对照组(sh-NC组,用RNAi阴性对照病... 详细信息

目的探讨亮氨酸拉链-EF-hand跨膜蛋白1(LETM1)对人骨肉瘤MG63及143B细胞增殖、迁移、凋亡、成骨分化及体内成瘤的作用及其机制。方法将骨肉瘤MG63及143B细胞分为空白对照组(未加入腺病毒感染)、阴性对照组(sh-NC组,用RNAi阴性对照病毒感染)及LETM1敲低组(sh-LETM1组,用sh-LETM1腺病毒感染)。采用Western blotting检测各组LETM1蛋白在健康人成骨细胞hFOB1.19及骨肉瘤细胞中的表达水平,以验证腺病毒敲低效果;细胞克隆形成实验及CCK-8法检测细胞增殖情况;划痕愈合实验及Transwell实验检测细胞迁移情况;DAPI染色法及Annexin V-APC/7-AAD流式细胞术双染法检测细胞凋亡情况;碱性磷酸酶(ALP)染色及茜素红S染色检测细胞的早期及晚期成骨分化情况。将10只裸鼠分为sh-NC组(n=5,以RNAi阴性对照病毒感染的143B细胞注入裸鼠皮下)与sh-LETM1组(n=5,以sh-LETM1腺病毒感染的143B细胞注入裸鼠皮下),并采用裸鼠皮下成瘤实验检测各组细胞的体内成瘤能力。结果 Western blotting检测结果显示,LETM1蛋白在骨肉瘤MG63及143B细胞中的表达明显高于健康人成骨细胞hFOB1.19(P<0.05),sh-LETM1腺病毒感染MG63及143B细胞后明显降低了LETM1蛋白的表达。细胞克隆形成实验及CCK-8法检测结果显示,在MG63及143B骨肉瘤细胞中,sh-LETM1组较sh-NC组及空白对照组的克隆形成能力及增殖能力明显降低(P<0.01)。Wound-healing实验及Transwell实验结果显示,在MG63及143B骨肉瘤细胞中,sh-LETM1组较sh-NC组及空白对照组的细胞迁移率明显降低(P<0.01)。DAPI染色及流式细胞术结果显示,在MG63及143B骨肉瘤细胞中,sh-LETM1组较sh-NC组的细胞凋亡率明显增高(P<0.01)。ALP染色及茜素红S染色实验结果显示,在MG63及143B骨肉瘤细胞中,sh-LETM1组较sh-NC组及空白对照组染色区域及钙盐结节增多。裸鼠皮下成瘤实验结果显示,143B sh-LETM1组较143B sh-NC组细胞的皮下成瘤能力降低。结论 LETM1可促进MG63和143B骨肉瘤细胞的增殖、迁移及体内成瘤,其机制可能与抑制细胞凋亡及成骨分化有关。

关键词：骨肉瘤细胞亮氨酸拉链-EF-hand跨膜蛋白1 细胞增殖细胞迁移凋亡细胞分化

基于供应商经济生产批量的供应链订单分配问题

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上海交通大学学报 2011年第12期45卷 1747-1752页

作者：史玉雷陆志强上海交通大学机械与动力工程学院机械系统与振动国家重点实验室上海200240

针对一条由1个占主导地位的制造商和多个供应商组成的二级供应链,考虑供应商生产过程的衰退,建立了生产批量与产品质量之间的关系.综合考虑制造商的采购成本和售后期望损失成本,并根据供应商决策其经济生产批量时考虑因素的不同,建立2... 详细信息

针对一条由1个占主导地位的制造商和多个供应商组成的二级供应链,考虑供应商生产过程的衰退,建立了生产批量与产品质量之间的关系.综合考虑制造商的采购成本和售后期望损失成本,并根据供应商决策其经济生产批量时考虑因素的不同,建立2种订单分配模型.该模型的约束条件包括供应商产能约束和供应商关系维持约束.通过遗传算法得到2种模型的优化解,并对2种模型进行分析比较.最后,基于联合决策模型对单一供应商的定价策略变动进行了灵敏度分析.

关键词：经济生产批量产品质量订单分配遗传算法二级供应链