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广东自贸试验区在线调解机制的构建——以跨境电子商务纠纷的快速解决为视角

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特区经济 2016年第9期 39-40页

作者：叶诗瑜游文婷暨南大学法学院广东广州510632

跨境电子商务的发展对于广东自贸试验区具有重要意义。在线调节机制具有低廉、高效、便捷的特点,是解决跨境电子商务纠纷的有效方式。广东自贸试验区可结合国内外实践经验和自身情况,构建在线调解纠纷解决机制以促进跨境电子商务纠纷的... 详细信息

跨境电子商务的发展对于广东自贸试验区具有重要意义。在线调节机制具有低廉、高效、便捷的特点,是解决跨境电子商务纠纷的有效方式。广东自贸试验区可结合国内外实践经验和自身情况,构建在线调解纠纷解决机制以促进跨境电子商务纠纷的快速解决。

关键词：广东自贸试验区在线调解跨境电子商务纠纷

上海崇明东滩堤内次生人工湿地鸟类冬春季生境选择的因子分析

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Zoological Research 2006年第2期27卷 144-150页

作者：葛振鸣王天厚周晓赵平施文彧华东师范大学生命科学学院上海市城市化生态过程与生态恢复重点实验室上海200062

2004年12月—2005年5月,对上海崇明东滩98海堤内200hm2次生人工湿地进行鸟类调查,在冬季统计到鸟类8目15科56种,以游、涉禽为主;在春季统计到鸟类10目19科55种,以涉禽为主。运用多元回归对鸟类种类数、数量、物种多样性、均匀性指数和... 详细信息

2004年12月—2005年5月,对上海崇明东滩98海堤内200hm2次生人工湿地进行鸟类调查,在冬季统计到鸟类8目15科56种,以游、涉禽为主;在春季统计到鸟类10目19科55种,以涉禽为主。运用多元回归对鸟类种类数、数量、物种多样性、均匀性指数和科属多样性等群落特征以及调查样点内水位、水面积、植被盖度、底栖动物密度、鱼类捕捞和人类干扰等环境因子进行鸟类生境选择分析。回归模型显示冬季鸟类种类数与植被盖度呈显著正相关,鸟类数量、物种多样性、科属多样性等群落特征与水位高低、水面积比例以及鱼类捕捞强度等有关,底栖动物密度影响鸟类均匀度和数量;春季鸟类数量与鱼塘的水面积呈正相关,而种类和数量与水位呈显著负相关,物种多样性和均匀性明显受水位、水面积和植被盖度影响,鸟类科属多样性与底栖动物密度呈显著相关,捕捞状况对春季鸟类群落影响不大。

关键词：崇明东滩次生人工湿地鸟类群落生境选择

三阴性乳腺癌组织长链非编码RNA-P21、microRNA-17-3p的表达及其临床意义

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中国现代医学杂志 2023年第5期33卷 16-22页

作者：刘凡施文瑜刘益飞王国华南通大学附属医院肿瘤化疗科江苏南通226001 南通大学附属医院病理科江苏南通226001 南通大学特种研究所江苏南通226001

目的探讨三阴性乳腺癌组织中长链非编码RNA-P21(LncRNA-P21)、microRNA-17-3p(miR-17-3p)的表达,分析其与三阴性乳腺癌患者的临床病理特征及预后的关系。方法选取2016年1月—2017年5月南通大学附属医院收治的106例三阴性乳腺癌患者经手... 详细信息

目的探讨三阴性乳腺癌组织中长链非编码RNA-P21(LncRNA-P21)、microRNA-17-3p(miR-17-3p)的表达,分析其与三阴性乳腺癌患者的临床病理特征及预后的关系。方法选取2016年1月—2017年5月南通大学附属医院收治的106例三阴性乳腺癌患者经手术切除的癌组织和癌旁组织(距离癌组织至少5 cm)标本,采用实时荧光定量聚合酶链反应检测癌组织、癌旁组织中LncRNA-P21和miR-17-3p的表达;收集患者的临床病理特征资料,分析LncRNA-P21、miR-17-3p表达与临床病理特征的关系;术后随访5年,采用Kaplan-Meier法绘制不同LncRNA-P21、miR-17-3p表达三阴性乳腺癌患者的生存曲线;Cox回归分析影响三阴性乳腺癌患者预后的因素。结果癌组织LncRNA-P21 mRNA相对表达量低于癌旁组织(P0.05)。三阴性乳腺癌组织中LncRNA-P21表达与miR-17-3p表达呈负相关(r=-0.570,P<0.05)。LncRNA-P21低表达组5年无病生存期(DFS)和总生存期(OS)生存率低于LncRNA-P21高表达组(P<0.05),miR-17-3p高表达组5年DFS、OS生存率低于miR-17-3p低表达组(P<0.05)。单因素Cox回归分析结果显示,分化程度、TNM分期、腋窝淋巴结转移、LncRNA-P21、miR-17-3p是三阴性乳腺癌患者预后的影响因素(P<0.05);多因素Cox风险比例回归分析结果显示,腋窝淋巴结转移、miR-17-3p是三阴性乳腺癌患者预后不良的危险因素(P<0.05),LncRNA-P21是保护因素(P<0.05)。结论三阴性乳腺癌组织LncRNA-P21表达下调,miR-17-3p表达上调,且与乳腺癌Ki-67≥30%、临床Ⅲ期、腋窝淋巴结转移及预后不良有关。

关键词：三阴性乳腺癌长链非编码RNA-P21 microRNA-17-3p 病理预后

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由幂级数产生的线性正算子

高等学校计算数学学报 1981年第2期 176-187页

作者：施咸亮余文熊杭州大学浙江师范学院

周知,对于[0,+∞)上连续的函数f(x)可以用线性正算子。和来逼近。它们分别称为Szasz-Mirakjan算子和Baskakov算子。对于[0,1)上的连续函数f(x)可以用线性正算子

关键词：线性正算子余文幂级数线性组合逆函数二止线性无关幕级数正整数定义施咸亮连续函数定理

Intelligent interaction system based on multimodal conformal triboelectric nanogenerator patch for disabled sports and life

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Science China Technological Sciences 2025年

作者： yuzhang wen Mengqi ZHANG Zhenning XIE Zida AN Bing LIU Fengxin SUN Tianming ZHAO Zuojun yu Fei WANG yupeng MAO Physical Education Department Northeastern University(Shenyang) Faculty of Robot Science and Engineering Northeastern University Criminal Investigation Police University of China State Key Laboratory of Robotics Shenyang Institute of Automation Chinese Academy of Sciences China Ice Sports College Beijing Sport University

Intelligent interaction technology based on advanced sensing units has become a research hotspot. In this paper, an intelligent interaction system (IIS) based on a multimodal conformal triboelectric nanogenerator patch (MCTP) is reported for sports monitoring and life promotion of the disabled. This IIS consists of a cloud-based smart sports recognition program and a smart life application. The porous micro-reinforced structure of polyurethane (PU) Sponge&Ecoflex, and the surface modification of PTFE by coating it with MXene endows the MCTP with excellent electrical properties. It shows good angle and force sensitivities of 1.1 V/°and 1.61 V/N, respectively, and has an ultra-fast response time of 15 ms, meeting the needs of human motion monitoring. The MCTP can also capture the mechanical energy, producing a maximum output power of 139μ*** with the commercial inertial measuring unit (IMU), the MCTP shows better consistency in human joint angle sensing. A precise analysis of wheelchair curling sports monitoring points is achieved by combining the MCTP and the human anatomy model. The cloud-based smart sports recognition program utilizes machine learning to achieve visual feedback on the three throwing technologies of draw, takeout and clearing. In addition, the developed smart life application uses a highsensitivity MCTP-sensor array design to achieve a variety of smart home interactions through simple finger touches. Overall,the IIS integrates the three major functions of smart sports sensing, energy capture, and smart home control, providing important application prospects in the fields of smart sports and human-computer interaction for the disabled.

关键词：

Association of Polymorphisms of IGF-1 and GHR with Reproductive Traits in wenchang Chicken

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Association of Polymorphisms of IGF-1 and GHR with Reproduct...

新疆阿克苏和吐鲁番地区硬蜱中3种立克次体检测及遗传进化分析

第十次全国畜禽遗传标记研讨会

作者： CHEN Kuan-wei,WU Xu,LI Hui-fang , TANG Qing-ping,GAO yu-shi, ZHU wen-qi (Institute of Poultry Science, Chinese academy of agriculture science, Yanghou 225003 College of Animal Science and Technology, Yangzhou 225009)

Alleles of physiological candidate genes for reproductive traits, insulin-like growth factor-1 (IGF-1) and growth hormone receptor (GHR) were assessed to determine the association with the total egg production (NE), average days of continual egg-laying (ADCE) and number of double-yolked eggs (DYE) in Chinese indigenous breed chicken (wenchang). PCR-RFLP method was used for genotypes identification. The frequency of restriction enzyme C1/ C2 alleles in the population was 0.53 (C1) and 0.47 (C2) for IGF-1. For GHR-Intron 2 was 0.06 and 0.94 for (A1) and (A2), respectively, while GHR-Intron5 was 0.20 (B1) and 0.80 (B2). IGF-1 polymorphism has an additive effect on egg production trait. The IGF-1 PstI C2C2 genotype had greater number eggs (300d) at 89.03 compared to 82.61 for PstI C1C1 (P<0,05) and (400d) at 137.84 compared to 127.82 for PstI C1C1 (P<0.05). The IGF-1 C2C2 genotype had longer ADCE at 3.38 compared to 2.96 and 2.78 for PstI C1C1 and C1C2 , respectively (P<0.05). GHR polymorphism has additive effect on number of double-yolked eggs (DYE), The GHR HindⅢ A1A1 genotype had greater DYE at 1.00 compared to 0.30 for HindⅢ A2A2 (P<0.05). The current research supports the effects of GHR and IGF-1 genes on reproductive traits of chickens.

关键词： Chicken IGF-1 GHR Reproduction SNP

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动物医学进展 2024年第7期45卷 42-47页

作者：温丽翠李才善周娜赵珊珊石文玉普浩刘诗语伍军巴音查汗新疆农业大学动物医学学院新疆乌鲁木齐830052

分析采自新疆阿克苏(SY)和吐鲁番(ADH)两地共132只蜱样本,研究蜱与其携带共生菌、病原三者之间的遗传进化关系。提取单个蜱总DNA,采用PCR方法对132份DNA样品进行无浆体16S rRNA基因扩增检测,挑选7份阳性样本基于COI基因进行分子生物学鉴... 详细信息

分析采自新疆阿克苏(SY)和吐鲁番(ADH)两地共132只蜱样本,研究蜱与其携带共生菌、病原三者之间的遗传进化关系。提取单个蜱总DNA,采用PCR方法对132份DNA样品进行无浆体16S rRNA基因扩增检测,挑选7份阳性样本基于COI基因进行分子生物学鉴定;使用MEGA X构建系统发育树,采用DNA SP V5.0软件统计两地蜱单倍型的数量,计算突变位点和核甘酸多样性。经PCR检测发现蜱无浆体总感染率为34.8%(46/132);测序结果发现SY1为图兰扇头蜱(46/132),携带斑点热立克次体,SY2、SY3及SY4为亚洲璃眼蜱,其中SY2、SY3携带*** sp.,SY4携带嗜吞噬细胞无浆体;ADH1、ADH2及ADH3为小亚璃眼蜱,ADH1携带绵羊无浆体,ADH2、ADH3携带*** sp.。构建系统发育树分析发现,ADH2、ADH3、SY2、SY3中鉴定出的Candidatus Midichloria mitochondrii sp.(*** sp.),与意大利株***同源性较高聚为一支,SY4中鉴定出的Anaplasma sp.与新疆株嗜吞噬细胞无浆体聚为一支,ADH1中鉴定的Anaplasma sp.与意大利株绵羊无浆体聚为一支;SY1与斑点热立克次体表现出较近的亲缘关系;单倍型结果分析显示,***单倍型数量为2,突变位点为4,核酸多样性为0.00408。***单倍型数量为3,突变位点为3,核酸多样性为0.00303,两个地区亚洲璃眼蜱和小亚璃眼蜱的基因流动性较低。研究从亚洲璃眼蜱和小亚璃眼蜱中均检测出*** sp.,可为后续蜱-蜱传疾病-共生菌三者之间的关系提供理论基础。

关键词：蜱传疾病共生菌进化分析

Lenalidomide regulates the CCL21/CCR7/ERK1/2 axis to inhibit migration and proliferation in diffuse large B-cell lymphoma

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Oncology Research 2025年第1期33卷 199-212页

作者： wen YANG BIN TANG DAN XU wenXIU YANG Department of Pathology Guizhou Medical UniversityThe Affiliated Hospital of Guizhou Medical UniversityGuiyang550004China

Background:The prognostic significance of the chemokine receptor CCR7 in diffuse large B-cell lymphoma(DLBCL)has been reported ***,the detailed mechanisms of CCR7 in DLBCL,particularly regarding its interaction with lenalidomide treatment,are not fully ***:Our study utilized bioinformatics approaches to identify hub genes in SU-DHL-2 cell lines treated with lenalidomide compared to control *** data and clinical information from 122 patients with DLBCL were analyzed to assess the correlation of CCR7 and p-ERK1/2 expression with the prognosis of ***,in vitro and in vivo experiments were conducted to clarify the role of CCR7 in the response of DLBCL to lenalidomide ***:Our bioinformatics analysis pinpointed CCR7 as a hub gene in the context of lenalidomide treatment in ***,31.14%and 36.0%(44/122)of DLBCL cases showed positive expression for CCR7 and ERK1/2 respectively,establishing them as independent prognostic factors for adverse outcomes in DLBCL via multivariate Cox regression ***,our studies demonstrated that the external application of the protein CCL21 promoted proliferation,migration,invasion,and activation of the ERK1/2 pathway in SU-DHL-2 and OCI-LY3 cell lines with high levels of CCR7 *** effect was mitigated by CCR7 silencing through siRNA,application of ERK inhibitors,or lenalidomide *** vivo experiments reinforced the efficacy of lenalidomide,significantly reducing tumor growth rate,tumor mass,serum total LDH levels,and expression of CCR7 and p-ERK1/2 in a SUDHL-2 xenograft model in nude mice(p<0.05).Conclusion:Our study clarifies the potential role of the CCL21/CCR7/ERK1/2 axis in the therapeutic effects of lenalidomide in DLBCL treatment.

关键词： CCR7 CCL21 ERK1/2 Lenalidomide Diffuse large B-cell lymphoma(DLBCL)

Experimental Study on Geometry Characteristics of Turbulent Premixed Flames for Natural Gas/Air Mixtures

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Journal of Thermal Science 2025年第1期34卷 268-282页

作者： ZHENG Weilin WANG Qijiao XIAO Huahua CHEN Xiaoxiao XIE Fan ZENG wen Liaoning Key Lab of Advanced Test Technology for Aerospace Propulsion System Shenyang Aerospace University State Key Laboratory of Fire Science University of science and Technology of China AVIC Shenyang Aircraft Design and Research Institute

In this study,focusing on the geometry characteristics of spherical expanding flame,the turbulent premixed flames of natural gas/air mixtures were investigated in a fan-stirred turbulent *** effects of initial temperature（T=300-400 K）,initial pressure（P=0.1-0.3 MPa）,turbulence intensity（u'=1.0-2.7 m/s）,oxygen volumetric percentage(φ（O2）=15%-21%) and carbon dioxide volumetric percentage(φ（CO2）=0-20%)were delved *** flame profile under the Cartesian coordinate system was derived from the schlieren images taken by the high-speed ***,from both macroscopic and microscopic perspectives,the influence of experimental conditions on the flame geometry characteristics was explored through flame front extraction,wavelet decomposition and network *** results demonstrate that for significant flame wrinkling,changes in species concentrations and turbulence intensity have more pronounced effects on the flame wrinkling *** wrinkling of the flame front maintains a certain degree of similarity,as evidenced by the locally concentrated distribution of the angles of the maximum fluctuation *** disturbance energy under large-scale（D6-D8） disturbances exhibits relatively high values with a similar trend,exerting a significant impact on the geometry characteristics of the flame *** peaks of correlation degree are scattered either with the decomposition scale or the development of flame radius,indicating no linear correlation between different detail ***,the probability distribution of node degrees in key wrinkled regions exhibits different trends with that of large-scale wrinkling and disturbance energy,especially with changes in initial *** occurs because the number of key wrinkles varies based on the perturbation's strength or the region's ***,an increase in the fluctuation frequency of the flame's local radius may not necessarily lead to an increase in the number of key folded regions.

关键词： fan-stirred turbulent combustor geometry characteristics large-scale wrinkling network topology wavelet decomposition