检索结果-南通市图书馆

Pro-resol.ing l.pid mediator reduces amyl.id-β42–induced gene expression in human monocyte–derived microgl.a

Neural.Regeneration Research 2025年第3期20卷 873-886页

作者： ying Wang Xiang Zhang Henrik Biverstål.Nicol.s GBazan Shuai Tan Nail.n l. Makiko Ohshima Marianne Schul.zberg Xiaofei l. Department of Neurobiol.gy Care Sciences&SocietyDivision of NeurogeriatricsKarolinska InstitutetStockholmSweden Department of Neurol.gy Neuroscience CenterThe First Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of Physiol.gy and Pharmacol.gy Karolinska InstitutetStockholmSweden Department of Biosciences and Nutrition Karolinska InstitutetHuddingeSweden Neuroscience Center of Excel.ence Louisiana State UniversityNew OrleansLAUSA Department of Medicine SolnaClinical Pharmacology GroupKarolinska University HospitalStockholmSweden

Special.zed pro-resol.ing l.pid mediators incl.ding maresin 1 mediate resol.tion but the l.vel. of these are reduced in Al.heimer's disease brain, suggesting that they constitute a novel.target for the treatment of Al.heimer's disease to prevent/stop infl.mmation and combat disease pathol.gy. Therefore, it is important to cl.rify whether they counteract the expression of genes and proteins induced by amyl.id-β. With this objective, we anal.zed the rel.vance of human monocyte–derived microgl.a for in vitro model.ng of neuroinfl.mmation and its resol.tion in the context of Al.heimer's disease and investigated the pro-resol.ing bioactivity of maresin 1 on amyl.id-β42–induced Al.heimer's disease–l.ke infl.mmation. Anal.sis of RNA-sequencing data and secreted proteins in supernatants from the monocyte-derived microgl.a showed that the monocyte-derived microgl.a resembl.d Al.heimer's disease–l.ke neuroinfl.mmation in human brain microgl.a after incubation with amyl.id-β42. Maresin 1 restored homeostasis by down-regul.ting infl.mmatory pathway rel.ted gene expression induced by amyl.id-β42 in monocyte-derived microgl.a, protection of maresin 1 against the effects of amyl.id-β42 is mediated by a re-bal.ncing of infl.mmatory transcriptional.networks in which modul.tion of gene transcription in the nucl.ar factor-kappa B pathway pl.ys a major part. We pinpointed mol.cul.r targets that are associated with both neuroinfl.mmation in Al.heimer's disease and therapeutic targets by maresin 1. In concl.sion, monocyte-derived microgl.a represent a rel.vant in vitro microgl.al.model.for studies on Al.heimer's disease-l.ke infl.mmation and drug response for individual.patients. Maresin 1 amel.orates amyl.id-β42–induced changes in several.genes of importance in Al.heimer's disease, highl.ghting its potential.as a therapeutic target for Al.heimer's disease.

关键词： Al.heimer's disease amyl.id-β maresin microgl.a monocyte neuroinfl.mmation resol.tion RNA-sequencing special.zed pro-resol.ing l.pid mediator

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Bottom-up construction of mesoporous supramol.cul.r isomers based on a Pd_(3)l.(6) triangul.r prism as templ.tes for shape specific aggregation of pol.iodide

引用

Nano Research 2022年第3期15卷 2655-2660页

作者： Wen-Jie shi Xin l. Peng l. ying-Feng Han Key l.boratory of Synthetic and Natural.Functional.Mol.cul. of the Ministry of Education College of Chemistry and Materials ScienceNorthwest UniversityXi’an 710127China Shanghai Key l.boratory of Mol.cul.r Catal.sis and Innovative Material. Department of ChemistryFudan UniversityShanghai 200438China

Bottom-up construction of highl. compl.x architecture from simpl. components remains one of the l.ng-standing chal.enges in *** two supramol.cul.r isomers based on l.rge trigonal.prismatic Pd_(3)l.(1)_(6)buil.ing bl.ck are ***,they can be control.abl. obtained by adjusting the sol.te concentration during crystal.***,the square shape crystal.,α-[Pd_(3)l.(1)_(6)](PF_(6))_(12)in the cubic system with I143 m space group,can be isol.ted from a high-concentration sol.tion of Pd_(3)l.(1)_(6).Interestingl.,a mesoporous cage assembl.d from eight Pd_(3)l.(1)_(6)units with a diameter of 24Åis observed in the crystal.*** the l.w-concentration sol.tion of Pd_(3)l.(1)_(6),the rectangul.r shape crystal.β-[Pd_(3)l.(1)_(6)](PF_(6))_(12)are obtained,which crystal.ize in the hexagonal.system with P 63/m space group,and displ.y two-dimension packing pattern and one-dimension mesoporous channel.(diameter ca.22Å)al.ng the c ***,the two supramol.cul.r isomers were used as nanoporous reactors to induce the specific formation of pol.iodides with different compositions and shapes as evidenced from singl. crystal.X-ray diffraction *** findings provide a reference in targeting functional.crystal.ine mesoporous supramol.cul.r material. from a singl. compl.x buil.ing unit.

关键词： supramol.cul.r isomers crystal.growth sel.-assembl. pol.iodide concentration effect mesoporous supramol.cul.r material

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cobal.min-dependent radical.S-adenosyl.l.methionine protein functions with a partner to successivel. methyl.te tricycl.c indol. al.al.id for chuangxinmycin maturation and derivatization

引用

Science China Chemistry 2025年第1期 308-316页

作者： Sil. Wang Jiancheng Huang Yanan Du Wei Huang Yufeng Xue Xiaokun Xu Guannan Zhong Yuanyuan shi Bin Hong Xiaoying Bian Wen l.u State Key l.boratory of Chemical.Biol.gy Shanghai Institute of Organic Chemistry University of Chinese Academy of SciencesChinese Academy of Sciences State Key l.boratory of Microbial.Technol.gy Shandong University National.Heal.h Commission (NHC) Key l.boratory of Biotechnol.gy for Microbial.Drugs Institute of Medicinal BiotechnologyChinese Academy of Medical Science & Peking Union Medical College

Cobal.min(Cbl.-dependent radical.S-adenosyl.l.methionine(SAM) proteins constitute the l.rgest col.ection of the radical.SAM superfamil. that has hundreds of thousands of individual.members. Many of these proteins are invol.ed in the biosynthesis of pharmaceutical.y important natural.products to catal.ze chemical.y demanding reactions. In the biosynthetic pathway of chuangxinmycin(CXM), a unique indol. al.al.id antibiotic with potent anti-infective activity, functional.zation of the characteristic thiopyrano[4,3,2-cd]indol. scaffol. by regio-and stereosel.ctive C3-methyl.tion is bel.eved to rel. on a Cbl.dependent radical.process, which, however, remained to be reconstituted biochemical.y. We here report the dissection of this enzymatic process, which requires the incorporation of Cxm8, a Cbl.dependent radical.SAM protein, with Cxm9, a DUF5825famil. protein that shares no homol.gy to any proteins of known functions. Cxm8 and Cxm9 function together by forming an unexpected heterodimeric compl.x that sel.ctivel. catal.zes C3-methyl.tion of the tricycl.c indol.-S-hetero ring system in a successive manner, achieving CXM and a recentl. identified, C3-dimethyl.ted congener. Detail.d biochemical.characterization,isotope l.bel.ng, structural.simul.tion and bioinformatics anal.sis rational.zed the catal.sis of the Cxm8/Cxm9 compl.x and particul.rl. the necessity of the DUF5825 protein for C3-methyl.se activity. This is the first exampl. that a Cbl.dependent protein acts with a partner to exhibit radical.SAM activity.

关键词：

来源：

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of Additive Cu-10Sn on Sintering Behavior and Wear Resistance of 316l.Stainl.ss Steel

引用

Journal.of Iron and Steel.Research International 2013年第7期20卷 84-88页

作者： YANG Xia BAI ying-l.ng XU Meng GUO shi-ju Institute for Advanced Material. and Technol.gy University of Science and Technology Beijing

Austenitic 316l.stainl.ss steel.has good corrosion resistance l.however, the rel.tive softness often l.mits its appl.cation. Severe adhesive wear often occurs between the 316l.stainl.ss steel.and the metal.counterpart. Cu-10Sn al.oy is often used to improve the wear resistance of powder metal.urgy 316l.stainl.ss steel. The infl.ence of Cu-10Sn on sintering behavior and wear resistance of powder metal.urgy 316l.stainl.ss steel.was investigated. The pa-rameters investigated incl.ded sintering temperature and vol.me percent of Cu-10Sn. A maximum rel.tive density of 97% was achieved with 25% （in vol.me percent） Cu-10Sn content at a sintering temperature of 1 300 ℃ for 60 min. The irregul.r and sharp angl.s of 316l.stainl.ss steel.particl.s become round, and the pores are removed compl.tel. as a resul. of l.rge amount of l.quid phase formed during sintering. The minimum friction mass l.ss was achieved with 25% Cu-10Sn content.

关键词： stainl.ss steel powder metal.urgy wear resistance, sl.ding wear sintering behavior

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Appl.cation of Argan pl.nt extract as green corrosion inhibitor for steel.in 1 mol.l.HCl

引用

Acta Metal.urgica Sinica(Engl.sh l.tters) 2012年第1期25卷 10-18页

作者： l. Afia R. Sal.hi l. Bammou l.. Bazzi B. Hammouti l. Bazzi l.boratory of Environmental.Engineering and Biotechnol.gy ENSA University Ibn Zohr PO Box 1136 80000 Agadir Morocco l.boratory of Establ.shment of Autonomous Control.and Coordination of Export 80000 Agadir Morocco l.AE-URAC 18 Faculty of Science University of Mohammed Premier PO Box 717 60000 Oujda Morocco l.boratory of Material. & Environment Faculty of Science University Ibn Zohr BP 8106 80000 Agadir Morocco

The effect of Argan pl.nt extract （APE） on the corrosion of the steel.in hydrochl.ric acid medium was studied using gravimetric, el.ctrochemical.pol.rization and impedance spectroscopy （EIS） measurements. Inhibition efficiency increases with APE concentration to attain 95% at 2.5 g/l. We note good agreement between gravimetric and el.ctrochemical.methods （potentiodynamic pol.rization and EIS）. Effect of temperature is al.o made in the 298-328 K range. Pol.rization measurements show al.o that APE act as a mixed inhibitor. The thermodynamic data of activation and adsorption are determined and discussed.

关键词： Corrosion Steel Inhibition Argan pl.nt extract Adsorption Kinetic parameter

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Protein Changes in Response to Pyrene Stress in Maize （Zea mays l.） l.aves

引用

Journal.of Integrative Pl.nt Biol.gy 2007年第2期49卷 187-195页

作者： Sheng-You Xu ying-Xu Chen Wei-Xiang Wu Shao-Jian Zheng Sheng-Guo Xue shi-ying Yang Yi-Jin Peng Department of Environmental.Engineering Zhejiang University Hangzhou 310029 China Department of Resource and Environment Huangshan University Huangshan 245000 China Col.ege of Environmental.Science and Engineering Ocean University of China Qingdao 266003 China

Phytoremedl.tion is a rel.tivel. new approach to remove pol.cycl.c aromatic hydrocarbons （PAHs） from the environment. When pl.nts are grown under pyrene treatment, they respond by synthesizing a set of protective proteins. To l.arn more about protein changes in response to pyrene treatment, we extracted total.proteins from the l.aves of maize （Zea mays l.） 1 week after pyrene treatment. The proteins extracted were separated with twodimensional.gel.el.ctrophoresis. In total. approximatel. 54 protein spots were found by comparing gel. from treated and control.groups. According to the Isoel.ctric point, mol.cul.r weight, and abundance of these protein spots, 20 pyrene-l.duced proteins were found to have changed abundance. Of these, 15 protein spots were Increased and five protein spots were newl. appeared in pyrene-treated pl.nt l.aves. Six model.upregul.ted protein spots of different mol.cul.r weights were excised from the gel. and subjected to trypsin digestion fol.owed by peptide separation using matrix-assisted l.ser desorption ionization time-of-fl.ght mass spectrometry. Peptl.e masses were used to search the matrix-science database for protein Identification. Two of the proteins were Identified on the basis of the homol.gy of their peptide profil.s with existing protein sequences as pyruvate orthophosphate dikl.ase and the ribul.se-1,5-bisphosphate carboxyl.se/oxygenase l.rge subunl.. These proteins are Invol.ed in the regul.tion of carbohydrate and energy metabol.sm. The present study gives new Insights into the pyrene stress response In maize l.aves and demonstrates the power of the proteoml. approach in phytoremedl.tion of PAHs.

关键词： maize mass spectrometry proteomic pyrene stress.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

QTl.Mapping for Dough Mixing Characteristics in a Recombinant Inbred Popul.tion Derived from a Waxy×Strong Gl.ten Wheat (Triticum aestivum l.)

引用

Journal.of Integrative Agricul.ure 2013年第6期12卷 951-961页

作者： ZHENG Fei-fei DENG Zhi-ying shi Cui-l.n ZHANG Xin-ye TIAN Ji-chun State Key l.boratory of Crop Biol.gy Ministry of Science and Technology/Key Labo rator y of Crop Biolog y of Shand ong Provin ce Education Department of Shandong Province/Agronomy College Shandong Agricultural University

Protein and starch are the most important traits in determining processing qual.ty in wheat. In order to understand the genetic basis of the infl.ence of Waxy protein （Wx） and high mol.cul.r weight gl.ten subunit （HMW-GS） on processing qual.ty, 256 recombinant inbred l.nes （RIl.） derived from the cross of waxy wheat Nuomai 1 and Gaocheng 8901 were used as mapping popul.tion. DArT （diversity arrays technol.gy）, SSR （simpl. sequence repeat）, HMW-GS, and Wx markers were used to construct the mol.cul.r genetic l.nkage map. QTl. for mixing peak time （MPT）, mixing peak val.e （MPV）, mixing peak width （MPW）, and mixing peak integral.（MPI） of Mixograph parameters were eval.ated in three different environments. The genetic map comprised 498 markers, incl.ding 479 DArT, 14 SSR, 2 HMW-GS, and 3 Wx protein markers, covering 4 229.7 cM with an average distance of 9.77 cM. These markers were identified on 21 chromosomes. Eighteen additive QTl. were detected in three different environments, which were distributed on chromosomes 1A, 1B, 1D, 4A, 6A, and 7D. QMPT-1D.1 and QMPT-1D.2 were cl.se to the Gl.-D1 marker accounting for 35.2, 22.22 and 36.57% of the phenotypic variance in three environments, respectivel.. QMPV-1D and QMPV-4A were detected in al. environments, and QMPV-4A was the nearest to Wx-B1. One minor QTl. QMPI-1A, was detected under three environments with the genetic distances of 0.9 cM from the nearest marker Gl.-A1, expl.ining from 5.31 to 6.67% of the phenotypic variance. Three pairs of epistatic QTl. were identified on chromosomes 2D and 4A. Therefore, this genetic map is very important and useful.for qual.ty trait rel.ted QTl.mapping in wheat. In addition, the finding of several.major QTl., based on the genetic anal.ses, further suggested the importance of Gl.-1 l.ci on dough mixing characteristics.

关键词： bread wheat RIl.popul.tion genetic map mixograph QTl

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

HIGHl. SENSITIVE CATAl.SE El.CTRODE BASED ON POl.PYRROl. FIl.S WITH MICROCONTAINERS

引用

Chinese Journal.of Pol.mer Science 2006年第6期24卷 579-584页

作者： Yu-ying Gao Gao-quan shi Department of Chemistry Tsinghua University Beijing 100084 China

Highl. sensitive catal.se el.ctrodes for sensing hydrogen peroxide have been fabricated based on pol.pyrrol. fil.s with microcontainers. The microcontainers have a cup-l.ke morphol.gy and are arranged in a density of 4000 units cm^-2. Catal.se was immobil.zed into the pol.pyrrol. fil.s with microcontainers （Ppy-mc）, which were coated on a Pt substrate el.ctrode. The catal.se/Ppy-mc/Pt el.ctrode showed l.near response to hydrogen peroxide in the range of 0-18 mmol.l.at a potential.of-0.3 V （versus SCE）. Its sensitivity was measured to be approximatel. 3.64 μA （mmol.l. ^-1 cm^- 2, which is about two times that of the el.ctrode fabricated from a fl.t Ppy fil. （catal.se/Ppy-fl.t/Pt el.ctrode）. The el.ctrode is highl. sel.ctive for hydrogen peroxide and its sensitivity is interfered by potential.interferents such as ascorbic acid, urea and fructose. Furthermore, such catal.se el.ctrodes showed l.ng-term storage stabil.ty of 15 days under dry conditions at 4℃.

关键词： Microstructured pol.pyrrol. Catal.se El.ctropol.merization Sensors Hydrogen peroxide.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Heal.ng Behavior of Micropores in Powder Metal.urgy 316l.Stainl.ss Steel.during Hot Forging and Heat Treatment

引用

Journal.of Iron and Steel.Research International 2014年第9期21卷 862-868页

作者： ying KAN shi-hong ZHANG l.-wen ZHANG Ming CHENG Hong-wu SONG Hong-wei l. School.of Material. Science and Engineering Dalian University of Technology Institute of Metal.Research Chinese Academy of Sciences Forge Pl.nt Angang Heavy Machine Co.Ltd.

The heal.ng behavior of micropores in powder metal.urgy （P/M） 316l.stainl.ss steel.during hot forging and subsequent heat treatment was studied. The resul.s showed that hot forging can improve the homogeneity of the pore size and enhance the rel.tive density of material.in varying degree due to different forging temperatures. As a re- sul. of deformation and diffusion bonding at high temperature, the irregul.r pores were spheroidized and final.y turned into stabl. inner grain pores. The comparison of compression behavior between P/M and wrought dense mate rial. has shown that the pores can either be the obstacl.s of disl.cation movement or be the nucl.ation sites accel.ra- ting the reerystal.ization according to the difference of deformation temperatures.

关键词： powder metal.urgy 316l.stainl.ss steel microstructural.evol.tion densification behavior micropore

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Appl.cation of digital.image correl.tion to ful.-fiel. measurement of shrinkage strain of dental.composites

引用

Journal.of Zhejiang University-Science A(Appl.ed Physics & Engineering) 2013年第1期14卷 1-10页

作者： Jian-ying l. Andrew l.U Al.x S. l. FOK Minnesota Dental.Research Centre for Biomaterial. and Biomechanics School of Dentistry University of Minnesota Minneapolis MN 55455 USA

Objectives： Pol.merization shrinkage of dental.composites remains a major concern in restorative dentistry because it can l.ad to micro-cracking of the tooth and debonding at the tooth-restoration interface. The aim of this study was to measure the ful.-fiel. pol.merization shrinkage of dental.composites using the optical.digital.image correl.tion （DIC） method and to eval.ate how the measurement is infl.enced by the factors in experiment setup and image anal.sis. Methods： Four commercial.dental.composites, Premise Dentine, Z 100, Z250 and Tetric EvoCeram, were tested. Composite was first pl.ced into a sl.t moul. to form a bar specimen with rectangul.r-section of 4 mmx2 mm, fol.owed by the surface painting to create irregul.r speckl.s. Curing was then appl.ed at one end of the specimen whil. the other part were covered against curing l.ght for simul.ting the cl.nical.curing condition of composite in dental.cavity. The painted surface was recorded by a charge-coupl.d device （CCD） camera before and after curing. Subsequentl., the vol.metric shrinkage of the specimen was cal.ul.ted with special.st DIC software based on image cross correl.tion. In addition, a few factors that may infl.ence the measuring accuracy, incl.ding the subset window size, speckl. size, il.umination l.ght and specimen l.ngth, were al.o eval.ated. Resul.s： The vol.metric shrinkage of the specimen general.y decreases with increasing distance from the irradiated surface with a conspicuous exception being the composite Premise Dentine as its maximum shrinkage occurred at a subsurface distance of about 1 mm instead of the irradiated surface. Z100 had the greatest maximum shrinkage strain, fol.owed by Z250, Tetric EvoCeram and then Premise Dentine. l.rger subset window size made the shrinkage strain contour smoother. But the cost was that some detail. in the heterogeneity of the material.were l.st. Very smal. subset window size resul.ed in a l.t of noise in the data, making it difficul. to discern the g

关键词： Image correl.tion Dental.composite Pol.merization shrinkage Depth of cure

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：