检索结果-南通市图书馆

Research progress of small-molecule natural medicines for the treatment of ischemic stroke

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2025年第1期23卷 21-30页

作者： Kui Liu ling Wang Tao Pang State Key Laboratory of Natural Medicines New Drug Screening and Pharmacodynamics Evaluation Center China Pharmaceutical University

Stroke is the second leading cause of disability and mortality worldwide, imposing a substantial socioeconomic burden on individuals and healthcare systems. Annually, approximately 14 million people experience stroke, with ischemic stroke comprising nearly 85% of cases, of which 10% to 20% involve large vessel occlusions. Currently, recombinant tissue plasminogen activator(tPA) remains the only approved pharmacological intervention. However, its utility is limited due to a narrow therapeutic window and low recanalization rates, making it applicable to only a minority of patients. Therefore, there is an urgent need for novel therapeutic strategies, including pharmacological advancements and combinatory ***-molecule natural medicines, particularly those derived from traditional Chinese herbs,have demonstrated significant therapeutic potential in ischemic stroke management. These compounds exert multiple neuroprotective effects, such as antioxidation, anti-inflammatory action, and inhibition of apoptosis, all of which are critical in mitigating stroke-induced cerebral damage. This review comprehensively examines the pathophysiology of acute ischemic stroke(AIS) and highlights the recent progress in the development of small-molecule natural medicines as promising therapeutic agents for cerebral ischemic stroke.

关键词： Antioxidants Ischemic stroke Natural medicines Neuroinflammation. Small molecule

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中国文化价值下的基于问题的学习法分析

华北电力大学学报（社会科学版） 2015年第5期 129-131页

作者：施应玲孟雅儒华北电力大学经济与管理学院北京102206

基于问题的学习法(PBL)在加拿大麦克马斯特大学成功实施后,便在美国、欧洲等世界其它国家的医学课程上被广泛使用,后又将此学习法拓展到其它的非医学领域。不同文化价值体系会影响学习主体和教学主体的行为吗?PBL在一个非西方的文化环... 详细信息

基于问题的学习法(PBL)在加拿大麦克马斯特大学成功实施后,便在美国、欧洲等世界其它国家的医学课程上被广泛使用,后又将此学习法拓展到其它的非医学领域。不同文化价值体系会影响学习主体和教学主体的行为吗?PBL在一个非西方的文化环境中实施会产生与西方类似的学习过程吗?会取得其预期效果吗?本文描述了在中国实施PBL的成效及其形式上的变化、教师在PBL中的角色变化和中国文化价值观对PBL的团队学习效果的影响。

关键词： PBL 融合教学法中国文化价值

LEGF-DST:LLMs-Enhanced Graph-Fusion Dual-Stream Transformer for Fine-Grained Chinese Malicious SMS Detection

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2025年第2期82卷 1901-1924页

作者： Xin Tong Jingya Wang ying Yang Tian Peng Hanming Zhai Guangming ling School of Information and Cybersecurity People’s Public Security University of ChinaBeijing100038China Cyber Investigation Technology Research and Development Center The Third Research Institute of the Ministry of Public SecurityShanghai201204China Department of Cybersecurity Defense Beijing Police CollegeBeijing102202China School of Computer Science Henan Institute of EngineeringZhengzhou451191China

With the widespread use of SMS(Short Message Service),the proliferation of malicious SMS has emerged as a pressing societal *** deep learning-based text classifiers offer promise,they often exhibit suboptimal performance in fine-grained detection tasks,primarily due to imbalanced datasets and insufficient model representation *** address this challenge,this paper proposes an LLMs-enhanced graph fusion dual-stream Transformer model for fine-grained Chinese malicious SMS *** the data processing stage,Large Language Models(LLMs)are employed for data augmentation,mitigating dataset *** the data input stage,both word-level and character-level features are utilized as model inputs,enhancing the richness of features and preventing information loss.A dual-stream Transformer serves as the backbone network in the learning representation stage,complemented by a graph-based feature fusion *** the output stage,both supervised classification cross-entropy loss and supervised contrastive learning loss are used as multi-task optimization objectives,further enhancing the model’s feature *** results demonstrate that the proposed method significantly outperforms baselines on a publicly available Chinese malicious SMS dataset.

关键词： Transformers malicious SMS multi-task learning large language models

Phase-matching enhanced quantum phase and amplitude estimation of a two-level system in a squeezed reservoir

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics B 2025年第1期34卷 257-263页

作者： Yan-ling Li Cai-Hong Liao Xing Xiao School of Information Engineering Jiangxi University of Science and TechnologyGanzhou 341000China College of Physics and Electronic Information Gannan Normal UniversityGanzhou 341000China

Squeezed reservoir engineering is a powerful technique in quantum information that combines the features of squeezing and reservoir engineering to create and stabilize non-classical quantum states. In this paper, we focus on the previously neglected aspect of the impact of the squeezing phase on the precision of quantum phase and amplitude estimation based on a simple model of a two-level system(TLS) interacting with a squeezed reservoir. We derive the optimal squeezed phase-matching conditions for phase φ and amplitude θ parameters, which are crucial for enhancing the precision of quantum parameter estimation. The robustness of the squeezing-enhanced quantum Fisher information against departures from these conditions is examined, demonstrating that minor deviations from phase-matching can still result in remarkable precision of estimation. Additionally, we provide a geometric interpretation of the squeezed phase-matching conditions from the classical motion of a TLS on the Bloch sphere. Our research contributes to a deeper understanding of the operational requirements for employing squeezed reservoir engineering to advance quantum parameter estimation.

关键词： quantum parameter estimation squeezed reservoir phase-matching conditions quantum Fisher information

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu ling-Jie Zhu Xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

Engineering nanoparticle structure at synergistic Ru-Na interface for integrated CO_(2)capture and hydrogenation

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 779-791页

作者： Hanzi Liu ling Cen Xinlin Xie Lei Liu Zhao Sun Zhiqiang Sun Hunan Engineering Research Center of Clean and Low-Carbon Energy Technology School of Energy Science and EngineeringCentral South UniversityChangsha 410083HunanChina

The development of dual functional material for cyclic CO_(2)capture and hydrogenation is of great significance for converting diluted CO_(2)into valuable fuels,but suffers from kinetic limitation and deactivation of adsorbent and ***,we engineered a series of RuNa/γ-Al_(2)O_(3)materials,varying the size of ruthenium from single atoms to clusters/*** coordination environment and structure sensitivity of ruthenium were quantitatively investigated at atomic *** findings reveal that the reduced Ru nanoparticles,approximately 7.1 nm in diameter with a Ru-Ru coordination number of 5.9,exhibit high methane formation activity and selectivity at 340°*** Ru-Na interfacial sites facilitate CO_(2)migration through a deoxygenation pathway,involving carbonate dissociation,carbonyl formation,and ***-situ experiments and theoretical calculations show that stable carbonyl intermediates on metallic Ru nanoparticles facilitate heterolytic C–O scission and C–H bonding,significantly lowering the energy barrier for activating stored CO_(2).

关键词： CO_(2)capture Hydrogenation Ru-Na interface Dual functional material Reaction mechanism

Solid-state synthesis of mesoporous metals via mechanochemical coordination self-assembly

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2025年第2期68卷 492-498页

作者： Hailong Xiong Chunyu Qi Lantian Xue ling Zhang Hanyu Liu Zhen-An Qiao State Key Laboratory of Inorganic Synthesis and Preparative Chemistry Jilin UniversityChangchun 130012China State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012China State Key Laboratory of Superhard Materials College of PhysicsJilin UniversityChangchun 130012China Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China

Mesoporous metals with large surface area,high pore volume,and uniform pore structure hold excellent advantages for various ***,the state-of-the-art synthesis methods are still limited to wet chemistry,which requires excessive solvents and a time-consuming drying ***,we report a facile and general mechanochemical coordination self-assembly strategy to prepare mesoporous metals(e.g.,Rh,Ru,Ir,Pt,Pd,Ag,Co,and Ni)with remarkable porous properties by using metal chlorides and cationic polymer *** with the wet chemistry process,this method proceeds without solvents and does not need complicated experimental conditions and long synthetic periods,which not only greatly reduces the consumption of cost and energy and environmental pollution,but also improves the synthesis efficiency and yield of target *** believe the developed approach will provide a general pathway for the scalable preparation of advanced porous materials.

关键词： mechanochemistry self-assembly mesoporous materials mesoporous metals electrocatalysis

Adaptive VDI Session Placement via User Logoff Prediction

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Machine Intelligence Research 2025年第1期22卷 189-200页

作者： Wenping Fan Puhui Meng Yu Tian Min-ling Zhang Yao Zhang School of Computer Science and Engineering Southeast UniversityNanjing210096China VMware Information Technology(China)Limited Beijing100190China Key Laboratory of Computer Network and Information Integration(Southeast University) Ministry of EducationNanjing210096China

After the global pandemic,DaaS(desktop as a service)has become the first choice of many companies’remote working *** the desktops are usually deployed in the public cloud when using DaaS,customers are more cost-sensitive which boosts the requirement of proactive power *** researches in this area focus on virtual desktop infrastructure(VDI)session logon behavior modeling,but for the remote desktop service host(RDSH)-shared desktop pools,logoff optimization is also *** systems place sessions by round-robin or in a pre-defined order without considering their logoff ***,these approaches usually suffer from the situation that few left sessions prevent RDSH servers from being powered-off which introduces cost *** this paper,we propose session placement via adaptive user logoff prediction(SODA),an innovative compound model towards proactive RDSH session ***,an ensemble machine learning model that can predict session logoff time is combined with a statistical session placement bucket model to place RDSH sessions with similar logoff time in a more centralized manner on RDSH ***,the infrastructure cost-saving can be improved by reducing the resource waste introduced by those RDSH hosts with very few hanging sessions left for a long *** on real RDSH pool data demonstrate the effectiveness of the proposed proactive session placement approach against existing static placement techniques.

关键词： Virtual desktop infrastructure(VDI)resource management remote desktop service logoff prediction adaptive modeling session placement

Fluorine-functionalized zirconium-organic cages for efficient photocatalytic oxidation of thioanisole

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2025年第1期36卷 632-636页

作者： Jia-Ru Li Ning Li Li-ling He Jun He School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhou 510006China School of Chemistry South China Normal UniversityGuangzhou 510006China

Zirconium-based metal-organic cages(Zr-MOCs)typically exhibit high stability,but their structural and application reports are scarce due to stringent crystallization *** have successfully fluorinated the classical Zr-MOCs(ZrT-3)for the first time,obtaining the fluorinated MOCs(ZrT-3-F).Notably,ZrT-3-F not only inherits the high stability of its parent structure,but also acts as a catalyst for the effective oxidation of benzyl thioether for the first *** reaction can reach a conversion rate of 99%in 6 h,and the selectivity reaches 95%,which far exceeds the non-fluorinated *** work proves that the specific functionalization of the classical Zr-MOCs can further expand their application potential,such as catalysis.

关键词： Ultraviolet light Fluorine Zirconium-based metal-organic cages Sulfide oxidation Multiphase photocatalysis