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Development and validation of a prediction model for microvascular invasion in hepatocellular carcinoma

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World Journal of Gastroenterology 2020年第14期26卷 1647-1659页

作者： Lin Wang Yue-Xinzi Jin Ya-Zhou Ji Yuan Mu shi-Chang Zhang shi-yang pan Department of Laboratory Medicine The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina National Key Clinical Department of Laboratory Medicine Jiangsu Province HospitalNanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina

BACKGROUND Microvascular invasion(MVI)is an important prognostic factor affecting early recurrence and overall survival in hepatocellular carcinoma(HCC)patients after hepatectomy and liver transplantation,but it can be determined only in surgical *** preoperative prediction of MVI is conducive to clinical *** To develop and validate a preoperative prediction model for MVI in patients with *** Data from 454 patients with HCC who underwent hepatectomy at the First Affiliated Hospital of Nanjing Medical University between May 2016 and October 2019 were retrospectively ***,the patients were nonrandomly split into a training cohort and a validation *** regression analysis was used to identify variables significantly associated with MVI that were then included in the *** evaluated the discrimination and calibration ability of the nomogram by using R *** MVI was confirmed in 209(46.0%)patients by a pathological *** logistic regression analysis identified four risk factors independently associated with MVI:Tumor size[odds ratio(OR)=1.195;95%confidence interval(CI):1.107–1.290;P400 ng/mL,OR=3.476;95%CI:1.950–6.195;P<0.001).The concordance index was 0.79(95%CI:0.74–0.84)and 0.81(95%CI:0.74–0.89)in the training and validation cohorts,*** calibration curves showed good agreement between the predicted risk by the nomogram and real *** We have developed and validated a preoperative prediction model for MVI in patients with *** model could aid physicians in clinical treatment decision making.

关键词： Microvascular invasion Nomogram Hepatocellular carcinoma Discrimination and calibration Neutrophils Early recurrence

Liquid biopsy for non-invasive assessment of liver injury in hepatitis B patients

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World Journal of Gastroenterology 2019年第29期25卷 3985-3995页

作者： Wen-Ying Xia Li Gao Er-Hei Dai Dan Chen Er-Fu Xie Li yang shi-Chang Zhang Bing-Feng Zhang Jian Xu shi-yang pan Department of Laboratory Medicine the First Affiliated Hospital of Nanjing Medical University Nanjing 210029 Jiangsu Province China Department of Laboratory Medicine the Fifth Hospital of Shijiazhuang Shijiazhuang 050021 Hebei Province China

BACKGROUND Hepatitis B is a major public health problem in China. Accurate liver injury assessment is essential for clinical evidence-based treatment. Liver biopsy is considered the gold standard method to stage liver disease, but it is not widely used in resource-limited settings. Therefore, non-invasive liquid biopsy tests are needed. AIM To assess liver injury in hepatitis B patients using quantified cell free DNA combined with other serum biomarker as a liquid biopsy-based method. METHODS A cohort of 663 subjects including 313 hepatitis B patients and 350 healthy controls were enrolled. Ultrasound-guided liver biopsies followed by histopathological assessments were performed for the 263 chronic hepatitis B patients to determine the degree of liver injury. Cell-free DNA was quantified using a novel duplex real-time polymerase chain reaction assay. RESULTS Compared with healthy controls, patients with hepatitis B virus (HBV) infection had significantly higher plasma DNA, serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), bilirubin, and HBV DNA levels (P<0.01). Serum ALT, AST, bilirubin, and plasma DNA levels of patients with markedsevere inflammation were significantly higher than those with mild-moderate inflammation (P<0.01). There was a statistically significant correlation between hepatocyte inflammation severity and serum bilirubin (R^2=0.673, P<0.01) or plasma DNA (R^2=0.597, P<0.01) levels. The areas under the curves of serum ALT, bilirubin, plasma DNA, and their combination to distinguish between patients with mild–moderate and marked-severe inflammation were 0.8059, 0.7910, 0.7921, and 0.9564, respectively. CONCLUSION The combination of plasma DNA, serum ALT, and bilirubin could be a candidate liquid biopsy for non-invasive assessment of liver injury in hepatitis B patients.

关键词： Liquid biopsy plasma DNA Hepatitis B Alanine aminotransferase Duplex real-time quantitative polymerase chain reaction

Response to the Lomagundi-Jatuli Event in the southwestern margin of the yangtze Plate:Evidence from the carbon and oxygen isotopes of the Paleoproterozoic Yongjingshao Formation

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China Geology 2023年第1期6卷 50-60页

作者： Jun-ping Liu Wei Yin shi-pan yang Jiang-tai Zhao Wen-tao Zeng Feng Tang shi-jun He Wei-ke Li School of Earth Sciences and Resources China University of GeosciencesBeijing 100083China Yunnan Institute of Geological Survey Kunming 650216China Key Laboratory of Sanjiang Metallogeny and Resources Exploration and Utilization MNRKunming 650051China Institute of Geology Chinese Academy of Geological SciencesBeijing 100037China The Second Geological Institute of China Metallurgical Geology Bureau Fuzhou 350108China

The Lomagundi-Jatuli Event(LJE)refers to the significant positive carbon isotope excursion in seawater constituents that occurred immediately after the increase in atmospheric oxygen content during the Paleoproterozoic(2.22-2.06 Ga).Theδ^(13)C values of 46 dolostone samples collected from the Paleoproterozoic Yongjingshao Formation varied in the range of 0.05‰-4.95‰(V-PDB;maximum:4.95‰)in this study,which may be related to the multicellular eukaryotes in the Liangshan Formation in the Yimen *** are much higher than theδ^(13)C values of marine carbonates(-1.16‰on average).Theδ^(13)C values of other formations in the Paleoproterozoic Yimen Group are *** notable positive carbon isotope anomalies of the Yongjingshao Formation indicate the response to the LJE at the southwestern margin of the yangtze Block,which is reported for the first ***,they are comparable to theδ^(13)C values of carbonates in the Dashiling Formation of the Hutuo Group in the Wutaishan area in the North China Craton,the Wuzhiling Formation of the Songshan Group in the Xiong'er area,Henan Province,and the Dashiqiao Formation of the Liaohe Group in the Guanmenshan area,Liaoning ***,it can be further concluded that the LJE is a global *** study reveals that LJE occurred in Central Yunnan at 2.15-2.10 Ga,lasting for about 50 *** macro-columnar,bean-shaped,and microfilament fossils and reticular ultramicrofossils of multicellular eukaryotes in this period were discovered in the Liangshan Formation of the Yimen *** are the direct cause for the LJE and are also the oldest paleontological fossils ever *** major events successively occurring in the early stage of the Earth include the Great Oxygenation Event(first occurrence),the global Superiortype banded iron formations(BIFs),the Huronian glaciation,the Great Oxygenation Event(second occurrence),the explosion of multicellular eukaryotes,the positive carbon isotope excursion,and the global a

关键词： Lomagundi-Jatuli Event Eucaryon Paleoproterozoic Bean-shaped fossil Micro-filament fossil Micro-columnar fossil Carbon and oxygen isotopes yangtze Plate Geological survey engineering China

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当前国产动画片现状分析

艺术百家 2016年第5期32卷 109-113,173页

作者：史可扬潘琳北京师范大学艺术与传媒学院北京1000875

国产动画片起点很高,20世纪也曾有过几次创作高潮,曾被誉为"中国动画学派"。但从20世纪90年代以来,随着外来动画片的强势入侵,国产动画片遇到发展瓶颈,出现主题与类型单一、低幼化现象突出、艺术水准不高、资源有待整合等问题,亟待改进。

关键词：影视艺术国产动画动画艺术创作影视作品成就问题

Plasma Vitamin D Levels And Vitamin D Receptor Polymorphisms Are Associated with Survival of Non-small Cell Lung Cancer

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Chinese Journal of Cancer Research 2011年第1期23卷 33-37页

作者： Yao Liu Wei Chen Zhi-bin Hu Lin Xu Yong-qian Shu shi-yang pan Jun-cheng Dai Guang-fu Jin Hong-xia Ma Hong-bing shen Department of Epidemiology and Biostatistics School of Public Heolth Nonjing Medical University Nanjing 210029 China Department of Thoracic Surgery Jiengsu Cancer Hospital Nanjing China Department of Oncology Jiangsu Key Discipline of Medicine the First Affiliated Hospital Nanjing Medical UniversityNanjing China Department of Laboratory Diagnosis the First Affiliated Hospital Nanjing Medical University Nanjing China Section of Clinical Epidemiology Jiangsu Key Lab of Cancer Biomarkers Prevention and Treatment Cancer Center Nanjing China

Objective：Vitamin D and its receptor（VDR） involve in multiple cellular processes and play an important role in the initiation and progression of *** we hypothesized that plasma vitamin D levels and single nucleotide polymorphisms（SNPs） in VDR may be of prognostic significance in non-small cell lung cancer（NSCLC）.Methods：We examined plasma 25-hydroxyvitamin D [25（OH）D] levels in 87 patients diagnosed with NSCLC using enzyme-linked immunosorbent assay（ELISA） and genotyped seven potentially functional SNPs in VDR in 568 NSCLC patients on Illumina Golden Gate ***：Patients with higher plasma 25（OH）D levels had worse survival than patients with lower ones（P for trend = 0.048）.The SNPs of rs1544410 and rs739837 were independently associated with NSCLC survival（adjusted HR = 1.61,95% CIs = 1.06-2.45 for rs739837 AA vs AC/CC and adjusted HR = 1.51,95% CIs = 1.06-2.16 for rs1544410 AG/AA vs GG）.A joint effect was observed between rs1544410 and rs739837 and the risk of death elevated as the number of unfavourable genotypes patients carried increased（P for trend = 0.003）.There were no significant associations between VDR polymorphisms and plasma 25（OH）D ***：Our findings indicate that plasma 25（OH）D levels and genetic variants of VDR may serve as prognostic markers for NSCLC in this Chinese population.

关键词： Vitamin D receptor polymorphisms Non-small cell lung cancer Chinese population Prognosis

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养殖鲟鱼肝硬化病的器官和组织病理学观察

大连海洋大学学报 2016年第6期31卷 623-629页

作者：杨仕豪潘连德郑串上海海洋大学省部共建水产种质资源发掘与利用教育部重点实验室上海201306

为了明确养殖鲟鱼Acipenser sinensis肝硬化的致病因素及诊治方法,在3批次现场采集病样(共计41尾)中,选取9尾具典型症状的患病鲟鱼,对其重要组织器官进行采样,制作石蜡切片,H-E染色,对自然发病的疑似肝硬化杂交鲟进行了病理解剖观察和... 详细信息

为了明确养殖鲟鱼Acipenser sinensis肝硬化的致病因素及诊治方法,在3批次现场采集病样(共计41尾)中,选取9尾具典型症状的患病鲟鱼,对其重要组织器官进行采样,制作石蜡切片,H-E染色,对自然发病的疑似肝硬化杂交鲟进行了病理解剖观察和组织病理学研究,并对其组织病理变化及发病机理进行了分析。结果表明:1、2、3、9号病样表现出明显肝组织病变,肝组织内出现弥漫性纤维增生等典型肝纤维化症状;脾充血,空泡变性、坏死;胃、肠充血,炎性细胞浸润,肠绒毛坏死甚至脱落;其他器官(鳃、心等)组织轻微淤血、炎症;结合各器官症状和组织病变及参考相关研究,确定本病例为鲟鱼肝病,具体诊断为鲟鱼肝硬化。研究表明,鲟鱼肝硬化的器官和组织病理学诊断特征为肝淤血和溃疡,肝腹水,肝血窦扩张、炎性细胞浸润、组织空泡化、组织纤维化。

关键词：鲟鱼肝硬化组织病理器官病理

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生物检材中氯敌鼠的LC-MS分析

分析测试学报 2004年第Z1期23卷 32-34页

作者：杨士云潘冠民北京市公安局法医检验鉴定中心北京100085

　　氯敌鼠(chlorophacinone)为第一代抗凝血杀鼠剂,主要是拮抗维生素K1的活性,阻碍凝血酶原的合成,损害微血管,降低血液凝固能力,因而造成皮下出血和内脏大量出血而引起死亡.中毒潜伏期3～5天,死亡高峰为4～6天.……

关键词： Chlorophacinone Biological HPLC-MS HPLC

Defect Engineering:Can it Mitigate Strong Coulomb Effect of Mg^(2+)in Cathode Materials for Rechargeable Magnesium Batteries?

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Nano-Micro Letters 2025年第1期17卷 135-159页

作者： Zhengqing Fan Ruimin Li Xin Zhang Wanyu Zhao Zhenghui pan Xiaowei yang School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China School of Chemistry and Chemical Engineering Taiyuan University of TechnologyTaiyuan 030024People’s Republic of China School of Materials Science and Engineering Tongji UniversityShanghai 201804People’s Republic of China

Rechargeable magnesium batteries(RMBs)have been considered a promising“post lithium-ion battery”system to meet the rapidly increasing demand of the emerging electric vehicle and grid energy storage ***,the sluggish diffusion kinetics of bivalent Mg^(2+)in the host material,related to the strong Coulomb effect between Mg^(2+)and host anion lattices,hinders their further development toward practical *** engineering,regarded as an effective strategy to break through the slow migration puzzle,has been validated in various cathode materials for *** this review,we first thoroughly understand the intrinsic mechanism of Mg^(2+)diffusion in cathode materials,from which the key factors affecting ion diffusion are further ***,the positive effects of purposely introduced defects,including vacancy and doping,and the corresponding strategies for introducing various defects are *** applications of defect engineering in cathode materials for RMBs with advanced electrochemical properties are also ***,the existing challenges and future perspectives of defect engineering in cathode materials for the overall high-performance RMBs are described.

关键词： Rechargeable magnesium battery Sluggish diffusion kinetic Defect engineering Cathode materials Ion migration

Deciphering the role of mtH2O2 in hepatic ischemia-reperfusion injury mechanisms with low-background super-resolution fluorogenic probe

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Science China Chemistry 2025年第01期 297-307页

作者： Bin Fang Limin Wang Haoqin Li Jiaxin Zhang yang Ding pan pan Li Bo Peng Hua Bai Lin Li Frontiers Science Center for Flexible Electronics Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials &Engineering Northwestern Polytechnical University Institute of Flexible Electronics (IFE Future Technologies) Xiamen University

Hepatic ischemia-reperfusion injury（HIRI） is characterized by mitochondrial dysfunction and oxidative stress. Monitoring mitochondrial hydrogen peroxide（mtH2O2） levels in real-time through super-resolution imaging is crucial for elucidating its distribution in live cells and its mechanism of action during HIRI. However, low-background fluorogenic probes have been overlooked in the context of super-resolution imaging. In this study, we developed a low-background fluorogenic probe（MitoWG） with the potential for super-resolution morphology-correlated mitochondrial identification to track the fluctuates of mtH2O2in HIRI. Activation of the desirable fluorescence properties of the probe by mtH2O2was confirmed using structural illumination microscopy（SIM）, enabling high-quality mitochondrial imaging with exceptional specificity and *** in mtH2O2levels were successfully observed in both cellular and rat models of HIRI. Furthermore, we associated the decline in mitochondrial redox homeostasis with accelerated mtH2O2production during HIRI, which triggered mitophagy deficiency and led to cell death. In conclusion, Mito-WG possesses excellent photophysical and low-background properties for SIM imaging, making it a promising tool for mtH2O2tracking in HIRI research and clinical diagnosis.

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