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Strategic insights into the cultivation of pancreatic cancer organoids from endoscopic ultrasonography-guided biopsy tissue

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World Journal of Gastroenterology 2024年第42期30卷 4532-4543页

作者： Jia-Li Yang Jun-Feng Zhang Jian-You Gu Mei Gao Ming-You Zheng shi-xiang guo Tao Zhang Institute of Hepatopancreatobiliary Surgery Chongqing General HospitalChongqing UniversityChongqing 401147China

BACKGROUND The frequent suboptimal efficacy of endoscopic ultrasound-guided fine-needle biopsy(EUS-FNB)to culture pancreatic cancer(PC)organoids(PCOs)poses a major challenge in the advancement of personalized medicine for advanced *** To explore how to obtain appropriate puncture tissues from EUS-FNB and optimize the strategy for efficiently constructing PCOs,providing an efficient tool for the advancement of personalized *** Patients who underwent EUS-FNB for the diagnosis of PC tissue were prospectively *** refined the endoscopic biopsy procedures and organoid cultivation *** tissue specimens verified by on-site pathological assessment were cultured in a semi-suspended medium in a microfluidic *** assessed differences in PCOs cultured beyond and below five generations examining patient demographics,specimen and organoid attributes,and the sensitivity of organoids to a panel of clinical drugs through cell viability *** In this study,16 patients with PC were recruited,one sample was excluded because onsite cytopathology showed no tumor *** organoid generation occurred in 93.3%(14 of 15)of the EUS-FNB specimens,with 60%(9 of 15)sustaining over five *** these patients,those with a history of diabetes,familial cancer,or larger tumors exhibited enhanced PCO *** key factors influencing longterm PCOs expansion included initial needle sample quality(P=0.005),rapid initiation of organoid culture postisolation(P≤0.001),and high organoid activity(P=0.031).Drug sensitivity analysis revealed a partial response in two patients following therapeutic intervention and surgery and stable disease in four patients,indicating a moderate correlation between organoid response and clinical *** Optimal initial needle sampling,rapid and precise biopsy sample processing,process isolated samples as soon as possible,and sufficient cellular material are crucial for successful cultiv

关键词： Endoscopic ultrasound-guided fine-needle biopsy Pancreatic cancer organoid Puncture technique Cultivation optimization strategy Drug screening

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横程动态约束的预测-校正再入制导方法

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宇航学报 2020年第4期41卷 429-437页

作者：张科石国祥王佩西北工业大学航天学院西安710072 空间电子信息技术研究院西安710100

针对大升阻比飞行器再入滑翔制导问题,基于预测-校正制导法,提出一种横程动态约束的侧向制导策略。利用再入过程中横程与剩余航程的近似线性关系,设计边界约束动态变化的横程走廊控制倾侧角反转。对大气密度和飞行器气动参数扰动引起的... 详细信息

针对大升阻比飞行器再入滑翔制导问题,基于预测-校正制导法,提出一种横程动态约束的侧向制导策略。利用再入过程中横程与剩余航程的近似线性关系,设计边界约束动态变化的横程走廊控制倾侧角反转。对大气密度和飞行器气动参数扰动引起的预测模型不确定性进行在线参数估计。以CAV-L高超声速飞行器为研究对象,进行再入制导仿真。结果表明,对不同航程的再入任务该制导法均能精确引导飞行器飞向目标,侧向制导倾侧角反转时机分布合理,反转次数少。Monte Carlo仿真校验了横程动态约束制导法对再入状态误差和过程扰动具有良好的自适应性和鲁棒性。

关键词：再入制导高超声速飞行器预测-校正制导侧向制导横程约束

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论旅游产业整合

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旅游科学 2005年第2期19卷 14-18页

作者：史国祥上海师范大学旅游学院上海200234

我国旅游产业的发展已陷入阶段性瓶颈,平均利润率下降,大多数单体企业经营困难重重。根据国际旅游产业的发展轨迹,突破阶段性瓶颈制约的必由之路在于产业整合。事实上,我国旅游产业整合正在遵循产业发展的内在要求而展开。但是这一展开... 详细信息

我国旅游产业的发展已陷入阶段性瓶颈,平均利润率下降,大多数单体企业经营困难重重。根据国际旅游产业的发展轨迹,突破阶段性瓶颈制约的必由之路在于产业整合。事实上,我国旅游产业整合正在遵循产业发展的内在要求而展开。但是这一展开过程又受到了政府提拉和外来挤压的合力影响,无法以完整的自然方式展开。所以,我国旅游产业的整合方式,只能是从低端产业整合走向高端产业整合,从空缺填补走向成熟领域的竞争,从借鉴到拓展。

关键词：旅游产业产业整合

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总方差方法在光纤陀螺随机误差分析中的应用

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光电工程 2012年第1期39卷 62-67,87页

作者：石国祥陈坚叶军王林第二炮兵工程学院西安710025 第二炮兵驻孝感地区军事代表室湖北孝感432100

总方差方法被引入到光纤陀螺随机误差特性分析当中,有效克服了传统Allan方差法在长相关时间上计算易出现"崩溃"的问题。但用它直接分析光纤陀螺随机噪声存在算法偏差,不能真实反映角度随机游走噪声、量化噪声和指数相关噪声方差值,因此... 详细信息

总方差方法被引入到光纤陀螺随机误差特性分析当中,有效克服了传统Allan方差法在长相关时间上计算易出现"崩溃"的问题。但用它直接分析光纤陀螺随机噪声存在算法偏差,不能真实反映角度随机游走噪声、量化噪声和指数相关噪声方差值,因此在算法上对总方差提出改进,使其适用于光纤陀螺噪声分析。对模拟的各项随机噪声进行仿真计算,验证改进后总方差方法可有效辨识噪声类型和水平。对光纤陀螺实测数据方差分析表明改进的总方差方法在平均因子较大的情况下可提高估计置信度,方差值稳定性好,比Allan方差法能更精确地分析出噪声项系数。

关键词：光纤陀螺 Allan方差总方差功率谱密度

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Multiple Tin Compounds Modified Carbon Fibers to Construct Heterogeneous Interfaces for Corrosion Prevention and Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第1期17卷 507-527页

作者： Zhiqiang guo Di Lan Zirui Jia Zhenguo Gao Xuetao shi Mukun He Hua guo Guanglei Wu Pengfei Yin College of Science Sichuan Agricultural UniversityYa’an 625014People’s Republic of China School of Materials Science and Engineering Hubei University of Automotive TechnologyShiyan 442002People’s Republic of China Institute of Materials for Energy and Environment State Key Laboratory of Bio‑Fibers and Eco‑TextilesCollege of Materials Science and EngineeringQingdao UniversityQingdao 266071People’s Republic of China Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’anShaanxi 710072People’s Republic of China

Currently,the demand for electromagnetic wave(EMW)absorbing materials with specific functions and capable of withstanding harsh environments is becoming increasingly ***-component interface engineering is considered an effective means to achieve high-efficiency EMW ***,interface modulation engineering has not been fully discussed and has great potential in the field of EMW *** this study,multi-component tin compound fiber composites based on carbon fiber(CF)substrate were prepared by electrospinning,hydrothermal synthesis,and high-temperature thermal *** utilizing the different properties of different substances,rich heterogeneous interfaces are *** effectively promotes charge transfer and enhances interfacial polarization and conduction *** prepared SnS/SnS_(2)/SnO_(2)/CF composites with abundant heterogeneous interfaces have and exhibit excellent EMW absorption properties at a loading of 50 wt%in epoxy *** minimum reflection loss(RL)is−46.74 dB and the maximum effective absorption bandwidth is 5.28 ***,SnS/SnS_(2)/SnO_(2)/CF epoxy composite coatings exhibited long-term corrosion resistance on Q235 steel ***,this study provides an effective strategy for the design of high-efficiency EMW absorbing materials in complex and harsh environments.

关键词： Electrostatic spinning Component regulation Heterogeneous interfaces Electromagnetic wave absorption Corrosion protection

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Mechanical Properties of Asphalt Pavement Structure in Highway Tunnel

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Journal of Shanghai Jiaotong university(Science) 2008年第2期13卷 206-210页

作者：石春香郭忠印 Shanghai Institute of Technology Tongji University

A linear full 3D finite element method (FEM) was performed in order to present the key design parameters of highway tunnel asphalt pavement under double-wheel load on rectangular loaded area considering horizontal contact stress induced by the acceleration/deceleration of *** key design parameters are the maximum horizontal tensile stresses at the surface of the asphalt layer,the maximum horizontal tensile stresses at the bottom of the asphalt layer and the maximum vertical shear stresses at the surface of the as- phalt layer were *** influencing factors such as double-wheel weight;asphalt layer thickness;base course stiffness modulus and thickness;and the contact conditions among the structure layers on these key design parameters were also examined separately to propose construction procedures of highway tunnel asphalt pavement.

关键词： tunnel asphalt pavement structure three-dimensional finite element method horizontal force horizontal tensile stress vertical shear stress

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Serum thymosin β4 levels in patients with hepatitis B virus-related liver failure

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World Journal of Gastroenterology 2010年第5期16卷 625-630页

作者： Tao Han,Ying Liu,Huan Liu,Zheng-Yan Zhu,Yan Li,shi-xiang Xiao,Zhen guo,Zhen-Gang Zhao,Department of Hepatology,Tianjin Institute of Hepatobiliary Disease,Tianjin Key Laboratory of Artificial Cells,Tianjin Third Central Hospital,Tianjin Medical University,83 Jintang Road,Tianjin 300170, China Department of Hepatology Tianjin Institute of Hepatobiliary Disease Tianjin Key Laboratory of Artificial Cells Tianjin Third Central Hospital Tianjin Medical University 83 Jintang Road Tianjin 300170 China. hantaomd@***

AIM:To investigate whether serum thymosinβ4 can provide diagnostic or prognostic information in liver failure patients caused by chronic hepatitis B virus(HBV) infection. METHODS:Serum thymosinβ4 levels were measured in 30 patients with acute-on-chronic liver failure(ACLF), 31 patients with chronic liver failure(CLF),30 patients with compensated liver cirrhosis(CR)and 32 patients with chronic hepatitis B and 30 healthy *** thymosinβ4 levels were measured by enzyme-linked immunosorbent assay and Child-Pugh and model for end-stage liver disease(MELD)scores were calculated for each patient on ***:Compared with healthy controls,serum thymosinβ4 levels in ACLF,CLF,CR and chronic hepatitis B patients were significantly lower,6.5047 (4.7879-10.5314)μg/mL vs 0.4632(0.2759-0.8768) μg/mL,0.6981(0.5209-1.2008)μg/mL,1.8053 (0.8110-2.3397)μg/mL,3.7803(1.8570-6.4722)μg/mL, respectively(Pship between thymosinβ4 levels and albumin, choline esterase,and platelet(Pship with alanine aminotransferase(P=0.020), aspartate aminotransferase,total bilirubin,international normalized ratio of prothrombin time,and Child-Pugh and MELD scores(P<0.001).Of the 61 liver failure patients,the thymosinβ4 levels of non-survivors were significantly lower than that of survivors(P=0.007). Receiver operating characteristics analysis identified a thymosinβ4 cutoff level of 0.5708μg/mL for predicting poor prognosis in all liver failure *** serial thymosinβ4 values were observed in 13 liver failure *** initial values were observed in the *** greater improvement in thymosinβ4 value was found in those who recovered from the disease. CONCLUSION:Serum thymosinβ4 can be used as an

关键词： Thymosinβ4 Liver failure Serum Hepatitis B virus Biochemistry

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一种改进的强跟踪滤波算法的推导及仿真验证

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现代防御技术 2012年第2期40卷 87-90页

作者：叶军陈坚石国祥第二炮兵工程大学陕西西安710025

针对一般强跟踪滤波算法(STEKF)在光纤陀螺动态输出滤波过程中存在跟踪效果不好的缺陷,分析推导一种新的强跟踪滤波算法(ISTEKF),使其能够克服原先算法存在的缺陷,并利用光纤陀螺动态输出数据进行仿真验证,滤波结果表明ISTEKF算法能够... 详细信息

针对一般强跟踪滤波算法(STEKF)在光纤陀螺动态输出滤波过程中存在跟踪效果不好的缺陷,分析推导一种新的强跟踪滤波算法(ISTEKF),使其能够克服原先算法存在的缺陷,并利用光纤陀螺动态输出数据进行仿真验证,滤波结果表明ISTEKF算法能够达到很好的跟踪效果,且具有较强的自适应能力。

关键词：改进的强跟踪滤波器渐消因子光纤陀螺滤波

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Low‑Temperature Oxidation Induced Phase Evolution with Gradient Magnetic Heterointerfaces for Superior Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第1期17卷 191-204页

作者： Zizhuang He Lingzi shi Ran Sun Lianfei Ding Mukun He Jiaming Li Hua guo Tiande Gao Panbo Liu School of Chemistry and Chemical Engineering Northwestern Polytechnical UniversityXi’an 710129People’s Republic of China School of Marine Science and Technology Northwestern Polytechnical UniversityXi’an 710072People’s Republic of China

Gradient magnetic heterointerfaces have injected infinite vitality in optimizing impedance matching,adjusting dielectric/magnetic resonance and promoting electromagnetic(EM)wave absorption,but still exist a significant challenging in regulating local phase ***,accordion-shaped Co/Co_(3)O_(4)@N-doped carbon nanosheets(Co/Co_(3)O_(4)@NC)with gradient magnetic heterointerfaces have been fabricated via the cooperative high-temperature carbonization and lowtemperature oxidation *** results indicate that the surface epitaxial growth of crystal Co_(3)O_(4) domains on local Co nanoparticles realizes the adjustment of magnetic-heteroatomic components,which are beneficial for optimizing impedance matching and interfacial ***,gradient magnetic heterointerfaces simultaneously realize magnetic coupling,and long-range magnetic ***,the synthesized Co/Co_(3)O_(4)@NC absorbents display the strong electromagnetic wave attenuation capability of−53.5 dB at a thickness of 3.0 mm with an effective absorption bandwidth of 5.36 GHz,both are superior to those of single magnetic domains embedded in carbon *** design concept provides us an inspiration in optimizing interfacial polarization,regulating magnetic coupling and promoting electromagnetic wave absorption.

关键词： Magnetic heterointerfaces Phase evolution Interfacial polarization Magnetic coupling Electromagnetic wave absorption

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沥青路面水损坏形成机理与防止对策

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山西建筑 2009年第22期35卷 298-299页

作者：史果香山西省公路局阳泉分局

结合工作实践,论述了高等级公路沥青路面水损坏的特点、危害、影响因素,解析了沥青路面水损坏形成机理,提出了沥青路面水损坏的防治措施,从而减少或避免沥青路面水损坏造成的损失。

关键词：沥青路面水损坏防治措施

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