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Effect of Intravenous Administration of Liposomal Prostaglandin E1 on Microcirculation in Patients with ST Elevation Myocardial Infarction Undergoing Primary Percutaneous Intervention

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Chinese Medical Journal 2015年第9期128卷 1147-1150页

作者： Li-Ye Wei Xiang-Hua Fu Wei Li Xi-Le Bi shi-ru bai Kun Xing Yan-Bo Wang Department of Cardiology The First Hospital of Hebei Medical University Shijiazhuang Hebei 050000 China Department of Cardiology The Second Hospital of Hebei Medical University Shijiazhuang Hebei 050000 China

Background：Several studies have demonstrated that primary percutaneous coronary intervention （PCI） can result in reperfusion *** study aims to investigate the effectiveness of liposomal prostaglandin E l （Lipo-PGE1,Alprostadil,Beijing Tide Pharmaceutical Co.,Ltd.） for enhancing microcirculation in reperfusion *** addition,this study determined the optimal administration method for acute ST elevation myocardial infarction （STEMI） patients undergoing primary ***：Totally,68 patients with STEMI were randomly assigned to two groups：intravenous administration ofLipo-PGE 1 （Group A）,and no Lipo-PGE1 administration （Group B）.The corrected thrombolysis in myocardial infarction （TIMI） frame count （cTFC） and myocardial blush grade （MBG） were *** were followed up for 6 *** adverse cardiac events （MACE） were also ***：There was no significant difference in the baseline characteristics between the two *** cTFC parameter in Group A was significantly lower than Group B （18.06 ± 2.06 vs.25.31 ± 2.59,P ＜ 0.01）.The ratio of final MBG grade-3 was significantly higher （P ＜ 0.05） in Group A （87.9％） relative to Group B （65.7％）.There was no significant difference between the two groups in final TIMI-3 flow and *** were followed up for 6 months,and the occurrence of MACE in Group A was significantly lower than that in Group B （6.1％ vs.25.9％ respectively,P ＜ 0.05）.Conclusions：Myocardial microcirculation of reperfusion injury in patients with STEMI,after primary PCI,can be improved by administering Lipo-PGE1.

关键词： Intravenous Administration Liposomal Prostaglandin E l Primary Percutaneous Coronary Intervention ST Elevation Myocardial Infarction

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Influence of Puncture Site on Radial Artery Occlusion After Transradial Coronary Intervention

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Chinese Medical Journal 2016年第8期129卷 898-902页

作者： Xi-Le Bi Xiang-Hua Fu Xin-Shun Gu Yan-Bo Wang Wei Li Li-Ye Wei Yan-Ming Fan shi-ru bai Department of Cardiology The Second Hospital of Hebei Medical University Shijiazhuang Hebei 050000 China

Background：The risk of radial artery occlusion （RAO） needs particular attention in transradial intervention （TRI）.Therefore,reducing vascular occlusion has an important clinical *** aim of this study was to determine the appropriate puncture site during TRI through comparing the occurrence of RAO between the different puncture sites to reduce the occurrence of RAO after ***：We prospectively assessed the occurrence of RAO in 606 consecutive patients undergoing *** occlusion was evaluated with Doppler ultrasound in 2 days and 1 year after the *** factors for RAO were evaluated using a multivariate model ***：Of the 606 patients,the RAO occurred in 56 *** with TRI at 2-5 cm away from the radius styloid process,the odds ratio （OR） for occlusion risk at 0 cm and 1 cm were 9.65 （P =0.033） and 8.90 （P =0.040）,*** RAO occurred in the ratio of the arterial diameter to the sheath diameter ≤1 （OR =2.45,P =0.004）.Conclusion：Distal puncture sites （0-1 cm away from the radius styloid process） can lead to a higher rate of RAO.

关键词： Percutaneous Coronary Intervention Puncture Site Radial Artery Risk Factors

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Boosting bidirectional sulfur conversion enabled by introducing boron-doped atoms and phosphorus vacancies in Ni2P for lithium-sulfur batteries

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Journal of Energy Chemistry 2025年第1期100卷 760-769页

作者： Lin Peng Yu bai Hang Li Meixiu Qu Zhenhua Wang Kening Sun Advanced Research Institute of Multidisciplinary Science Beijing Institute of Technology Beijing Key Laboratory of Chemical Power Source and Green Catalysis School of Chemistry and Chemical Engineering Beijing Institute of Technology

Lithium-sulfur （Li-S） batteries have gained great attention due to the high theoretical energy density and low cost,yet their further commercialization has been obstructed by the notorious shuttle effect and sluggish redox ***,we supply a strategy to optimize the electron structure of Ni2P by concurrently introducing B-doped atoms and P vacancies in Ni2P （Vp-B-Ni2P）,thereby enhancing the bidirectional sulfur *** study indicates that the simultaneous introduction of B-doped atoms and P vacancies in Ni2P causes the redistribution of electron around Ni atoms,bringing about the upward shift of d-band center of Ni atoms and effective d-p orbital hybridization between Ni atoms and sulfur species,thus strengthening the chemical anchoring for lithium polysulfides （LiPSs） as well as expediting the bidirectional conversion kinetics of sulfur ***,theoretical calculations reveal that the incorporation of B-doped atoms and P vacancies in Ni2P selectively promotes Li2S dissolution and nucleation ***,the Li-S batteries with Vp-B-Ni2P-separators present outstanding rate ability of 777 m A h g-1at 5 C and high areal capacity of 8.03 mA h cm-2under E/S of 5μL mg-1and sulfur loading of 7.20 mg *** work elucidates that introducing heteroatom and vacancy in metal phosphide collaboratively regulates the electron structure to accelerate bidirectional sulfur conversion.

关键词： Lithium sulfur batteries

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大肠埃希菌质粒介导的blaNDM-1基因耐药及传播性研究

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中国感染控制杂志 2019年第6期18卷 505-510页

作者：文江雄邬小萍张伟刘洋朱滢石白茹胡大利向天新南昌大学第一附属医院感染科江西南昌330006 南昌大学第一附属医院呼吸科江西南昌330006 南昌大学第一附属医院检验科江西南昌330006

目的探讨某院携带blaNDM-1基因大肠埃希菌的流行现况及传播机制。方法收集2016年1-12月南昌大学某附属医院对碳青霉烯类抗生素不敏感的大肠埃希菌92株,对其进行blaNDM-1基因筛查,并对blaNDM-1基因阳性的大肠埃希菌进行其他常见碳青霉烯... 详细信息

目的探讨某院携带blaNDM-1基因大肠埃希菌的流行现况及传播机制。方法收集2016年1-12月南昌大学某附属医院对碳青霉烯类抗生素不敏感的大肠埃希菌92株,对其进行blaNDM-1基因筛查,并对blaNDM-1基因阳性的大肠埃希菌进行其他常见碳青霉烯酶基因检测。将blaNDM-1基因阳性的大肠埃希菌(供体菌)与大肠埃希菌J53(受体菌)进行接合试验,采用药敏试验及mCIM试验对接合子进行表型验证,提取供体菌及接合子的质粒采用Southern blot技术对blaNDM-1基因进行基因定位,并验证其水平转移的能力。结果在对碳青霉类抗生素不敏感的92株大肠埃希菌中发现2株携带blaNDM-1基因,携带率2.2%。此2株大肠埃希菌未发现同时携带其他常见碳青霉烯酶基因。接合试验及Southern blot发现此2株大肠埃希菌的blaNDM-1基因均位于菌株的质粒上,且有1株大肠埃希菌的blaNDM-1基因可以通过质粒向大肠埃希菌J53转移。药敏试验结果显示,此2株大肠埃希菌对临床使用的多种抗菌药物耐药,且接合子获得了与供体菌相似的药敏结果。mCIM试验表明,此2株大肠埃希菌及接合子均产NDM-1型碳青霉烯酶。结论该院存在携带blaNDM-1基因而产NDM-1型碳青霉烯酶的大肠埃希菌,携带blaNDM-1基因的大肠埃希菌对临床使用的大多数抗菌药物耐药,质粒可介导blaNDM-1基因的水平传播。

关键词：大肠埃希菌耐药 blaNDM-1基因质粒碳青霉烯酶

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Synergistic effect of bonding heterogeneity and phonon localization in introducing excellent thermoelectric properties in layered heteroanionic NdZnSbO material

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Journal of Energy Chemistry 2025年第1期100卷 259-272页

作者： Da Wan Shuwei Tang Shulin bai Xiaodong Li Peng Ai Wanrong Guo Tuo Zheng College of Materials Science and Engineering Liaoning Technical University Faculty of Chemistry Northeast Normal University

Layered rare-earth metal oxides, harnessing the dual properties of oxides and two-dimensional layered materials, exhibit remarkable thermal stability and quantum confinement effects. Therefore, this work adopts the first-principles calculation combined with the Boltzmann transport theory to predict the thermoelectric properties of NdZnSbO compound. The coexistence of weak interlayer van der Waals interactions, robust intralayer ionic bonding, and partial covalent bonding leads to remarkable bonding heterogeneity, which engenders pronounced phonon scattering and imposes constraints on thermal transport along the out-of-plane direction. The weakened chemical bonds induced by the antibonding states, together with the rattling-like behavior of the Zn atom, culminate in the profound anharmonicity in the layered NdZnSbO compound. The weakening bond and heavy element contribute to the softness of phonon modes, which significantly diminishes the phonon group velocity. The redistribution-dominated four-phonon scattering process spans a large optical gap, which effectively reduces the lattice thermal conductivity. The NdZnSbO compound exhibits direct semiconductor characteristic with a bandgap of 0.73 e V by adopting the Heyd-Scuseria-Ernzerhof(HSE06) functional in combination with spin–orbit coupling(SOC) effect. The multi-valley feature of NdZnSbO compound augur favorably for band degeneracy, thus amplifying the power factor. Consequently, an optimal figure-of-merit(ZT) of 3.40 at 900 K is achieved for the n-type NdZnSbO compound. The present study delves deeply insights into the origins for the low thermal conductivity of NdZnSbO compound and proposes an optimization scheme to enhance overall thermoelectric performance.

关键词： Bond strength (chemical)

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New exploration on pathogenesis and early diagnosis of gestational diabetes

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World Journal of Clinical Cases 2025年第1期13卷 1-5页

作者： Hua bai Department of Neurology The Third Affiliated Hospital of Guizhou Medical UniversityDuyun 558099Guizhou ProvinceChina

Gestational diabetes mellitus(GDM)refers to varying degrees of abnormal glucose metabolism that occur during pregnancy and excludes patients pre-viously diagnosed with *** is a unique among the four subtypes of diabetes classified by the international World Health Organization *** GDM patients constitute a small proportion of the total number of diabetes cases,the incidence of GDM has risen significantly over the past decade,posing substantial risk to pregnant women and ***,it warrants considerable *** pathogenesis of GDM is generally considered to resemble that of type II diabetes,though it may have distinct *** blood biochemical proteins in the context of GDM can help elucidate its pathogenesis,thereby facilitating more effective prevention and management *** article reviews this critical clinical issue to enhance the medical community's sufficient understanding of GDM.

关键词： Gestational diabetes mellitus Pathogenesis Proteomics RBP4 ANGPTL8

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2,2,6,6-四甲基-4-甲氧基哌啶氮氧自由基制备方法的改进

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当代化工 2002年第1期31卷 17-19页

作者：白丽丽郭燕文余从煊石白茹北京理工大学化工与材料学院北京100081

阐述了一种制备 4 -甲氧基 -2 ,2 ,6 ,6 -四甲基哌啶氮氧自由基的改进方法 :以四氢呋喃为溶剂 ,0℃时 ,在N2 的保护下和NaH的存在下 ,2 ,2 ,6 ,6 -四甲基 -4 -羟基哌啶氮氧自由基与MeI在室温反应 5h。分离混合物 ,得到粘稠状红色液体 ,... 详细信息

阐述了一种制备 4 -甲氧基 -2 ,2 ,6 ,6 -四甲基哌啶氮氧自由基的改进方法 :以四氢呋喃为溶剂 ,0℃时 ,在N2 的保护下和NaH的存在下 ,2 ,2 ,6 ,6 -四甲基 -4 -羟基哌啶氮氧自由基与MeI在室温反应 5h。分离混合物 ,得到粘稠状红色液体 ,加入正己烷 ,在 -2 0℃条件下储存 ,结晶出针状深红色的晶体。熔点 :4 2～ 4 3℃ ,产率 70

关键词：氮氧自由基 TEMPO 选择性氧化

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95例成人结核性脑膜炎临床分析

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新发传染病电子杂志 2018年第1期3卷 12-14,20页

作者：冯俊颜兴艳文江雄石白茹邬小萍南昌大学第一附属医院感染科南昌330006

目的探讨结核性脑膜炎早期临床特点、实验室检查及影像学改变,提高对该病的诊断能力。方法回顾性分析2012年1月至2017年9月南昌大学第一附属医院95例诊断为结核性脑膜炎患者的临床资料。结果本组95例患者中,以发热、头痛、恶心、呕吐、... 详细信息

目的探讨结核性脑膜炎早期临床特点、实验室检查及影像学改变,提高对该病的诊断能力。方法回顾性分析2012年1月至2017年9月南昌大学第一附属医院95例诊断为结核性脑膜炎患者的临床资料。结果本组95例患者中,以发热、头痛、恶心、呕吐、脑膜刺激征为主要临床症状;脑脊液检查中有核细胞数增多,淋巴细胞占优势;蛋白升高,糖及氯化物降低,外周血T-SPOT阳性率为56%。脑影像学检查以脑膜强化、脑梗死、脑积水、结核瘤较常见。其中82例好转,12例病情恶化,死亡1例。结论本研究中成人结核性脑膜炎以中老年人较多见,临床表现多样化,脑脊液改变缺乏特异性,病原学检出率低,早期诊断和及时治疗是提高本病预后的关键。

关键词：结核性胸膜炎临床分析诊断脑脊液

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Flexible Strain Sensors with Ultra-High Sensitivity and Wide Range Enabled by Crack-Modulated Electrical Pathways

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NANO-MICRO LETTERS 2025年第1期17卷 1-19页

作者： bai, Yunzhao Zhou, Yunlei Wu, Xuanyu Yin, Mengfei Yin, Liting Qu, shiyuan Zhang, Fan Li, Kan Huang, Yongan Huazhong Univ Sci & Technol State Key Lab Intelligent Mfg Equipment & Technol Wuhan 430074 Peoples R China Huazhong Univ Sci & Technol Flexible Elect Res Ctr Wuhan 430074 Peoples R China Xidian Univ Hangzhou Inst Technol Hangzhou 311200 Peoples R China Xidian Univ Sch Mechanoelect Engn Xian 710071 Peoples R China Univ Southern Calif Dept Aerosp & Mech Engn Los Angeles CA 90089 USA

This study presents a breakthrough in flexible strain sensor technology with the development of an ultra-high sensitivity and wide-range sensor, addressing the critical challenge of reconciling sensitivity with measurement range. Inspired by the structure of bamboo slips, we introduce a novel approach that utilises liquid metal to modulate the electrical pathways within a cracked platinum fabric electrode. The resulting sensor demonstrates a gauge factor greater than 108 and a strain measurement capability exceeding 100%. The integration of patterned liquid metal enables customisable tuning of the sensor's response, while the porous fabric structure ensures superior comfort and air permeability for the wearer. Our design not only optimises the sensor's performance but also enhances the electrical stability that is essential for practical applications. Through systematic investigation, we reveal the intrinsic mechanisms governing the sensor's response, offering valuable insights for the design of wearable strain sensors. The sensor's exceptional performance across a spectrum of applications, from micro-strain to large-strain detection, highlights its potential for a wide range of real-world uses, demonstrating a significant advancement in the field of flexible electronics.

关键词： Flexible strain sensor Fabric Crack Response regulation Epidermal device

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Integrating lipidomics and gut microbiota to study the anti-hyperlipidemia effect of Sargentodoxae Caulis extract

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Traditional Medicine Research 2025年第1期10卷 1-11页

作者： Xiao-Xiao Zhang Li Jia Xiu-Jun Zhan Charity Ngina Qing-rui Zhang Xiao-Ge Li Qi-Bao Jiang shi bai Miao-Miao Jiang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjin 301617China Haihe Laboratory of Modern Chinese Medicine Tianjin 301617China School of Medicine Taizhou UniversityTaizhou 318000China.

Background:Sargentodoxae Caulis(SC)is the vine stem of Sargentodoxa Cuneata(Oliv.)Rehd.&*** in ***,and it in traditional Chinese medicine has been known for promoting blood circulation and removing blood stasis as recorded in the ancient book“Illustrated Classics of Materia Medica”.It has been used effectively to treat blood stasis too in modern clinical ***,the anti-hyperlipidemia effect of SC is not fully *** paper aims at exploring the use of SC stems to improve the balance of blood lipids in the body,and its new role in treating ***:The effects of SC extract on hyperlipidemia were explored by combining lipidomics and gut ***,we explored the potential mechanism of SC in treating hyperlipidemia by pathway ***:The results showed that the stem extract of SC could restore the physiological and biochemical indices of hyperlipidemia in mice,as well as repair the morphological and structural damage to *** to the Model group,the SC extract significantly reduced the liver index,epididymal fat index,and Lee’s *** also significantly decreased serum levels of total cholesterol,triglycerides,low-density lipoprotein cholesterol,peroxisome proliferator-activated receptor gamma(PPAR-γ),D-lactate,and free fatty acids,while significantly increasing the relative content of peroxisome proliferator-activated receptor alpha(PPAR-α).These changes were statistically ***-targeted lipidomics,based on LC-MS,were utilized to investigate the lipid metabolism characteristics in serum,liver,and epididymal fat of the *** was observed that,compared to the blank group,the Model group exhibited significant changes primarily in glycerol lipids and *** treatment group also displayed alterations in these lipids.A total of 38,81,and 27 differential lipids were identified in serum,liver,and epididymal fat samples,*** these,14 common differenti

关键词： hyperlipidemia Sargentodoxae Caulis lipidomics intestinal flora

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