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Intracellular potassium modulates calcium spark through RyRs as a counterion

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Intracellular potassium modulates calcium spark through RyRs...

第十一次中国生物物理学术大会暨第九届全国会员代表大会

作者： Jing-Chao Li,Ai-Hui Tang and shi-qiang wang State Key Laboratory of Biomembrane and Membrane Biotechnology,College of Life Sciences,Peking University,Beijing 100871

＜正＞Calcium release from sarcoplasmic reticulum（SR）though Ryanodine receptors plays an important role in excitation contraction coupling of cardiac *** trans-membrane

关键词： calcium spark intracellular potassium SR membrane potential ryanodine receptor SR potassium channel

An investigation on the wind profiles and gravity wave dynamics in MLT region based on the meteor radars from the Meridian Project

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Earth and Planetary Physics 2025年第1期9卷 29-38页

作者： Tai Liu Zhe wang MengXi shi Willie Soon shiCan Qiu Department of Geophysics College of the Geology Engineering and GeomaticsChang’an UniversityXi’an 710054China Center for Environmental Research and Earth Sciences(CERES) SalemMA 01970USA Institute of Earth Physics and Space Science(ELKH EPSS) 9400SopronHungary

The meteor radar can detect the zenith angle,azimuth,radial velocity,and altitude of meteor trails so that one can invert the wind profiles in the mesosphere and low thermosphere(MLT)region,based on the Interferometric and Doppler *** this paper,the horizontal wind field,gravity wave(GW)disturbance variance,and GW fluxes are analyzed through the meteor radar observation from 2012−2022,at Mohe(53.5°N,122.4°E)and Zuoling(30.5°N,114.6°E)stations of the(Chinese)Meridian *** Lomb−Scargle periodogram method has been utilized to analyze the periodic variations for time series with observational data *** results show that the zonal winds at both stations are eastward dominated,while the meridional winds are southward *** variance of GW disturbances in the zonal and meridional directions increases gradually with height,and there is a strong pattern of annual *** zonal momentum flux of GW changes little with height,showing weak annual *** meridional GW flux varies gradually from northward to southward with height,and the annual periodicity is *** both stations,the maximum values of zonal and meridional wind occur close to the peak heights of GW flux,with opposite *** observational evidence is consistent with the filtering *** horizontal wind velocity,GW flux,and disturbance variance of the GW at Mohe are overall smaller than those at Zuoling,indicating weaker activities in the MLT at *** power spectral density(PSD)calculated by the Lomb−Scargle periodogram shows that there are 12-month period and 6-month period in horizontal wind field,GW disturbance variance and GW flux at both stations,and especially there is also a 4-month cycle in the disturbance *** PSD of the 12-month and 6-month cycles exhibits maximum values below 88 km and above 94 km.

关键词： meteor radar wind field gravity wave Lomb−Scargle method

Prediction and optimization of flue pressure in sintering process based on SHAP

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 346-359页

作者： Mingyu wang Jue Tang Mansheng Chu Quan shi Zhen Zhang School of Metallurgy Northeastern UniversityShenyang 110819China Liaoning Low-Carbon Steelmaking Technology Engineering Research Center Northeastern UniversityShenyang 110819China Engineering Research Center of Frontier Technologies for Low-Carbon Steelmaking(Ministry of Education) Shenyang 110819China

Sinter is the core raw material for blast *** pressure,which is an important state parameter,affects sinter *** this paper,flue pressure prediction and optimization were studied based on the shapley additive explanation(SHAP)to predict the flue pressure and take targeted adjustment ***,the sintering process data were collected and processed.A flue pressure prediction model was then constructed after comparing different feature selection methods and model algorithms using SHAP+extremely random-ized trees(ET).The prediction accuracy of the model within the error range of±0.25 kPa was 92.63%.SHAP analysis was employed to improve the interpretability of the prediction *** effects of various sintering operation parameters on flue pressure,the relation-ship between the numerical range of key operation parameters and flue pressure,the effect of operation parameter combinations on flue pressure,and the prediction process of the flue pressure prediction model on a single sample were analyzed.A flue pressure optimization module was also constructed and analyzed when the prediction satisfied the judgment *** operating parameter combination was then *** flue pressure was increased by 5.87%during the verification process,achieving a good optimization effect.

关键词： sintering process flue pressure shapley additive explanation prediction optimization

β1- but not β2-adrenergic signaling accelerates the ryanodine receptor response to a single L-type Ca2+ channel in heart ceils

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β1- but not β2-adrenergic signaling accelerates the ryanod...

中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Peng ZHOU,Yan-Ting ZHAO,shi-qiang wang ’State Key Laboratory of Biomembrane and Membrane Biotechnology,College of Life Sciences,Peking University,China

β-Adrenergic receptor(βAR) carrys out the positive inotropic effect of the heart by enhancing L-type Ca channel(LCC) Ca influx and elevating sarcoplasmic reticulum(SR) Ca release flux via ryanodine receptors (RyRs).Our resent work shows thatβAR signaling accelerates cardiac RyR response to a single LCC by activating cAMP-dependent protein kinase(PKA).Bothβ- andβ-AR have positive inotropic effect,but their exact roles in regulating LCC-RyR coupling reminds *** using the loose-seal patch-clamp technique combined with confocal imaging,we measured the response of a single RyR Ca release unit,in form of a Ca spark,to Ca sparklet from a single *** the presence of theβAR antagonist ICI 118551,βAR agonist isoproterenol(ISO) increased Ca spark amplitude,accelerated RyR response to LCC Ca sparklets,increased the LCC-RyR coupling fidelity, indicating thatβAR stimulation could reproduce theβAR effects on LCC-RyR *** contrast,theβAR agonist salbutamol could neither increase spark amplitude nor alter the LCC-RyR coupling latency and fidelity, indicating thatβAR signaling did not modify the RyR response to give LCC *** salbutamol did accelerate the activation and increase the density of LCC current,the curtailed time lag of Ca sparks after loose-patch depolarization could only be attributed to increased probability of LCC *** mβCD was present to deplete membrane cholesterol,salbutamol mimicked the effect ofβAR,suggesting that caveolae/lipid rafts might be involved in preventingβAR from modifying *** RyRs are residing 12 nm away from the cell membrane,our results demonstrated thatβAR signaling is confined to a nanoscale microdomain,playing a regulatory role distinct from that ofβAR.

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Interleukin-1β Decreases Calcium Elevation in Excited Cultured Cortical Neurons

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Interleukin-1β Decreases Calcium Elevation in Excited Cultu...

“基因、进化与生理功能多样性”海内外学术研讨会暨中国生理学会第七届比较生理学学术会议

作者： Juan-Juan Zhao,Chen Zhou,shi-qiang wang,Zhen Chai~* State Key Laboratory of Biomembrane and Membrane Biotechnology,College of Life Sciences, Peking University,Beijing 100871

Interleukin-1,the first discovered proinflammatory cytokine,plays a key role in numerous central nervous system *** have previously shown that interleukin-1βdownregulated Ca currents by decreasing L-type Ca channel *** present study,we examined the effect of interleukin-1β（10ng/mL,24h） on the elevation of intracellular Ca concentration in cultured rat cortical neurons depolarized with high K solution（90 mM）.The calcium imaging results indicated interleukin-1βreduces calcium elevation by about 30%.This effect was blocked by PKC inhibitor chelerythrine chloride （1μM,24.5h）.Then we investigated p38- MAPK,a downstream target of PKC,with its specific inhibitor SB203580（1μM,24.5h）, which blocked the effect of interleukin-1βon intracellular *** results show interleukin- 1βdecreases intracellular calcium elevation in excited cultured cortical neurons via PKC-p38- MAPK pathway.

关键词： Interleukin-1β Calcium Cortical neuron PKC p38-MAPK

The role of window Ca2+ current in hypothermic Ca2+ overload in non-hibernators

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The role of window Ca2+ current in hypothermic Ca2+ overload...

中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Xiao-Chen LI,Xue-Mei HAO,shi-qiang wang State Key Laboratory of Biomembrane and Membrane Biotechnology,College of Life Sciences,Peking University,Beijing 100871,China

While hibernating mammals are able to regulate their body temperature between 37℃and the freezing point,non-hibernating mammals,including humans,could not survive hypothermia lower than～20℃.We found that low temperature results in intracellular calcium overload and incomplete relaxation as indicated by the marked increase in the resting tension of myocardium in non-hibernating *** of nifedipine,an inhibitor of L-type calcium channels,could reverse the effect of cooling,suggesting that the calcium influx(I) could be a determinant of the hypothermia-induced intracellular calcium *** test this hypothesis,we compared the temperature-dependence of I between the rat,a nonhibernating mammal,and the ground squirrel(Citellus dauricus), a *** the temperature was lowered,I declined significantly in both rats and ground squirrels, without changing the reversal *** activation curve showed that the I in rats exhibited a more negative half-activation potential(V) than in ground *** the temperature was lowered,the V in rats shifted even further to the left,whereas that in ground squirrels to the opposite *** of the availability curves showed that the half-inactivation potential(V) also changed distinctly in two *** the result,the window current of I was much larger,and increased dramatically with lowing temperature in rats,but not in round *** increased window current in rats would lead to continuous calcium influx in the background of reduced calcium handling capacity at the low temperature,and thus is a key reason for the hypothermia-induce calcium overload and cardiac dysfunction in non-hibernating *** the adaptive mechanisms of hibernating models would provide new ideas for cryo-medicine and organ preservation.

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Boosting hydrocarbon conversion via Cu-doping induced oxygen vacancies on CeO2 in CO2 electroreduction

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Journal of Energy Chemistry 2025年第1期100卷 66-76页

作者： Lei Xue Tong shi Chenhui Han Heng Zhang Fenrong Liu Haorun Li Yan wang Xiaojun Gu Shanghong Zeng Inner Mongolia Key Laboratory of Chemistry and Physics of Rare Earth Materials School of Chemistry and Chemical Engineering Inner Mongolia University State Key Laboratory of Coal Conversion Institute of Coal Chemistry Chinese Academy of Sciences Institute of Catalysis Department of Chemistry Zhejiang University National Key Laboratory of Baiyunobo Rare Earth Resource Research and Comprehensive Utilization Baotou Research Institute of Rare Earths

Conversion of CO2back to hydrocarbons is the most direct way of closing the“carbon cycle”,and its significance is further enlarged if this process is driven by renewable energies such as ***,precisely controlling the product selectivity towards hydrocarbons against the competitive hydrogen evolution remains challenging,especially for Cu-based ***,we report a novel defect engineering strategy,by which Cu-doping-induced oxygen vacancies on CeO2nanorods were effectively created,with adjustable vacancy/Cu *** resulting optimum catalyst shows up to 79% catalytic current density to hydrocarbons （excluding CO）,with 49% faradaic efficiency to *** and density functional theory unveil that the ratio between oxygen vacancy and Cu affects significantly the formation of*CHO and activation of H2O,which leads to the following deep hydrogenation to *** findings may spur new insights for designing and developing more controllable chemical process relevant to CO2utilization.

关键词： Oxygen vacancy Hydrocarbon production Reaction mechanism

羊瘙痒因子感染小鼠脑组织中MicroRNA—375对PDK1蛋白表达调控研究

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中华实验和临床病毒学杂志 2018年第1期32卷 27-31页

作者：石强张丽娜王晶高晨中国疾病预防控制中心病毒病预防控制所传染病预防控制国家重点实验室北京102206

目的研究羊瘙痒因子139 A感染小鼠脑组织中3＇磷酸肌醇依赖的激酶1（3＇-phosphoinositide-dependert kinase 1,PDK1）和micro RNA-375（miR-375）含量的变化;探讨miR-375在朊病毒病发生发展过程中对PDK1蛋白表达的影响.方法以羊瘙痒... 详细信息

目的研究羊瘙痒因子139 A感染小鼠脑组织中3＇磷酸肌醇依赖的激酶1（3＇-phosphoinositide-dependert kinase 1,PDK1）和micro RNA-375（miR-375）含量的变化;探讨miR-375在朊病毒病发生发展过程中对PDK1蛋白表达的影响.方法以羊瘙痒因子139 A感染的终末期小鼠脑组织为研究对象,通过Western blot方法检测脑组织中PDK1蛋白的含量;采用RT-PCR和二代测序的方法检测脑组织中miR-375含量的变化;利用了PmiR-REPORT报道系统检测miR-375对PDK1 3＇UTR调控的影响.结果 PDK1在羊瘙痒因子139 A感染小鼠脑组织中的表达量相对于正常对照组增高6倍左右,而miR-375表达量降低（P＜0.05）;PmiR-REPORT报道系统结果表明PDK1 3＇UTR是miR-375的调控靶点.结论在羊瘙痒因子139 A感染小鼠终末期脑组织中PDK1的含量明显增加,可能与miR-375对PDK1 3＇UTR的调控有关.

关键词：羊瘙痒因子139 A miR-375 PDK1 朊病毒病

Intracellular potassium modulates calcium spark through RyRs as a counterion

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生物物理学报 2009年第S1期25卷 214-214页

作者： Jing-Chao Li, Ai-Hui Tang and shi-qiang wang State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Peking University, Beijing 100871

Calcium release from sarcoplasmic reticulum (SR) though Ryanodine receptors plays an important role in excitation contraction coupling of cardiac myocytes. This

关键词： calcium spark intracellular potassium SR membrane potential ryanodine receptor SR potassium channel