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The effect of NDGA-modified etchant on the enzymatic degradation resistance and mechanical properties of collagen matrix

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Chinese Chemical Letters 2018年第1期29卷 205-208页

作者： shi-qiang gong Zhen-Jie Xue Shu-Teng Liao Ya-Bo Wu Yan Liu Center of Stomatology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Beijing National Laboratory for Molecular Science Key Laboratory of Analytical Chemistry for Living Biosystems Institute of Chemistry the Chinese Academy of Sciences Laboratory of Biomimetic Nanomaterials Department of Orthodontics Peking University School and Hospital of Stomatology National Engineering Laboratory for Digital and Material Technology of Stomatology Beijing Key Laboratory of Digital Stomatology

Enzymatic degradation of demineralized collagen matrix seriously impairs durable resin-dentin bonding. In this study, we evaluated the effect of nordihydroguaiaretic acid （NDGA）-modified etchant on the resistance to enzymatic degradation and mechanical properties of demineralized collagen matrix. Dentin beams were randomly demineralized by following solutions： 1 ） 10% phosphoric acid （PhA） solution, 2） 10% dimethyl sulfoxide （DMSO）-PhA solution, 3） NDGA-modified etchant, and 4） proanthocyanidins （PA）-modified etchant. The demineralized dentin collagen was then digested by type l collagenase solution. The collagenase degradation resistance was evaluated by measuring loss of dry mass, hydroxyproline release, and elastic modulus change. The degradation rate and hydroxyproline release of dentin collagen treated with NDGA-modified etchant were significantly lower than those in the other groups （P〈 0.001）. The elastic modulus of dentin beams treated with NDGA-modified etchant did not increase significantly. However, after 48 h of collagenase degradation, the loss of elastic modulus of dentin beams treated with NDGA-modified etchant was significantly lower than that of the control group （P〈 0.001）. The NDGA-modified etchant could improve the resistance to enzymatic degradation of type l collagenase degradation, and the stability of the mechanical properties of dentin collagen. This proof-of-concept study validates the etch-and-crosslink technique that improves durability of dentin bonding through simultaneous dentin etching and collagen crosslinking.

关键词： NDGACrosslinkDegradationMechanical propertiesCollagen

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基于数据驱动的监控系统数据服务器设计

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计算机工程与应用 2002年第20期38卷 244-246页

作者：周强史有群巩敦卫中国矿业大学信息与电气工程学院徐州221008

分布式监控系统由多个监控子系统组成,负责监控多种设备。文章根据现场监测设备种类多、结构复杂等特点,针对工控信息、管理信息集成等需求,提出了一种基于数据驱动的数据服务器结构。该数据服务器实现了控制系统实时数据采集、处理、... 详细信息

分布式监控系统由多个监控子系统组成,负责监控多种设备。文章根据现场监测设备种类多、结构复杂等特点,针对工控信息、管理信息集成等需求,提出了一种基于数据驱动的数据服务器结构。该数据服务器实现了控制系统实时数据采集、处理、存储、发布的统一管理,采用数据服务的在线监督,将工控网络同管理网络分隔开,实现了数据的安全、动态发布。系统采用数据驱动的交换式结构,数据处理组件化,系统结构灵活、扩展方便。

关键词：数据驱动监控系统数据服务器设计

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高危泵机械密封辅助系统改造

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石油化工设备 2019年第4期48卷 77-81页

作者：宋云平余洪涛史工强中国石油兰州石化分公司炼油厂

兰州石化分公司炼油厂0.8Mt/a连续重整装置以及0.4Mt/a芳烃抽提装置中高危泵数量众多,在生产运行中机械密封频繁泄漏。以热载体泵机械密封失效为例,通过对失效密封检查及其辅助系统实际运行状况的监测,认为冷却器堵塞造成冲洗液温度过... 详细信息

兰州石化分公司炼油厂0.8Mt/a连续重整装置以及0.4Mt/a芳烃抽提装置中高危泵数量众多,在生产运行中机械密封频繁泄漏。以热载体泵机械密封失效为例,通过对失效密封检查及其辅助系统实际运行状况的监测,认为冷却器堵塞造成冲洗液温度过高是机械密封泄漏的重要原因。从冷却器结构设计缺陷及冷却水质不达标两方面分析了冷却器堵塞的原因,提出了改造冷却器结构、在冷却器冲洗液入口增设限流孔板、在冷却器冷却水入口管路加装过滤器的改造措施。改造后机械密封寿命延长,冷却器换热效果良好,经济效益显著,可为同类高危泵的运行维护提供参考。

关键词：高危泵机械密封冷却器辅助系统失效分析改造

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冷胁迫诱导、咖啡因抑制的水稻根新基因片段的分离及表达分析

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生物工程学报 2002年第4期18卷 468-471页

作者：殷奎德张兴梅刘世强李乐攻黑龙江八一农垦大学基因工程研究中心密山158308 沈阳农业大学

利用差异显示 (Differentialdisplay)及H .Y Yellow琼脂糖凝胶分离等方法 ,从冷胁迫和甘露醇共同处理的冷敏感水稻 (Wasetoitsu)根的总RNA中 ,分离出冷胁迫诱导的cDNA片段 ,经过测序和同源比较 ,发现它是一尚未报道的新基因片段。这一... 详细信息

利用差异显示 (Differentialdisplay)及H .Y Yellow琼脂糖凝胶分离等方法 ,从冷胁迫和甘露醇共同处理的冷敏感水稻 (Wasetoitsu)根的总RNA中 ,分离出冷胁迫诱导的cDNA片段 ,经过测序和同源比较 ,发现它是一尚未报道的新基因片段。这一基因的表达对温度具有敏感的反应特性 ,4℃时表达水平明显增加 ,在正常温度 (2 5℃ )下 ,其表达水平又可快速降低。当幼苗根用 0 .5mol L甘露醇预处理 2h后 ,转入冷胁迫 ,其低温诱导的表达水平增加更为明显。在甘露醇预处理之前加入咖啡因处理根 1h ,其表达水平明显降低 ,几乎与正常温度下的对照相同。据此推测 ,这一基因可能参与了冷胁迫或水分胁迫诱导的耐冷过程中咖啡因敏感信号的传导。

关键词：冷胁迫诱导咖啡因抑制水稻根新基因片段分离表达分析差异显示

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Modular assembly of complex C-alkyl glycoside enabled via cooperative NHC and photoredox catalysis

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Science China Chemistry 2025年

作者： Rui-qiang Jiao Ming Li Xi Chen Mei-Ze Xu Tian Ding Xiao-Ping gong Zhuo-Mei Li Xue-Yuan Liu Yong-Min Liang State Key Laboratory of Applied Organic Chemistry Lanzhou University College of Chemistry and Chemical Engineering Northwest Normal University

C-Alkyl glycosides are found in natural products and are indispensable in drug development programs,owing to their diverse range of medicinal ***-component reactions involving glycosyl radical addition are well documented and proved efficient for the C-alkyl glycosides ***,multicomponent reactions for the rapid and controllable construction of structurally diversified C-alkyl glycosides in a single step remains a significant challenge due to the issues associated with balancing reactivity,compatibility,and ***,we report an NHC and photoredox co-catalyzed three-component method to access complex and valuable C-alkyl *** protocol exhibits broad substrate scope and excellent chemoand ***,nine types of sugars are compatible with this *** addition,the generality of this catalytic strategy was further highlighted by the potential for scalable production,the feasibility of further modifications of the products and its successful application in the late-stage functionalization of pharmaceutical skeletons.

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Recent progress in metal-organic frameworks(Part II—material application)

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Science China Chemistry 2025年

作者： Jiandong Pang Wentao Jiang Xue-Wen Zhang Hao-Long Zhou Yuxiu Sun Wei gong Bin Wang Fuyin Ma Linwei He Long Chen qiang Chen He-Qi Zheng Yuanjing Cui Wen-Jie shi Chao Zhang Mei Wang Yue-Biao Zhang Jie-Peng Zhang Chongli Zhong Yong Cui Shuao Wang Jian-Rong Li Guodong Qian Tong-Bu Lu Huan Pang Xian-He Bu Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology School of Chemistry and Chemical Engineering Yangzhou University School of Materials Science and Engineering Nankai University School of Physical Science and Technology ShanghaiTech University MOE Key Laboratory of Bioinorganic and Synthetic Chemistry GBRCE for Functional Molecular Engineering School of Chemistry IGCMESun Yat-sen University Department of Chemistry Shantou University School of Chemical Engineering and Technology Tiangong University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences Soochow University College of Materials Science & Engineering Beijing University of Technology State Key Laboratory of Silicon and Advanced Semiconductor Materials Cyrus Tang Center for Sensor Materials and ApplicationsSchool of Materials Science & Engineering Zhejiang University

As a class of functional crystalline porous materials, metal-organic frameworks(MOFs) gained rapid development in the past three decades and a large number of MOFs with ordered structures, high surface areas, and functionalized channels have been investigated. MOFs and MOF-derived/composite materials show great potential in many application fields. In this review, we discussed the main applications of MOFs and MOF-derived/composite materials in small molecule storage, separation, luminescence, sensing, multitype catalysis, and energy storage. In addition, challenges and problems in the future research of MOFsrelated fields are also discussed.

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Pd Close Coupled Catalyst

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Chinese Chemical Letters 2006年第9期17卷 1271-1274页

作者： Zhong Hua shi Mao Chu gong Yao qiang CHEN College of Chemistry Sichuan University Chengdu 610064

A catalyst comprised novel high surface area alumina support was prepared to control emission of automobiles. The results showed that prepared catalyst could satisfy the requirements of a high performance close couple... 详细信息

关键词： Close coupled catalyst cold start high surface area support exhaust gas.

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Enhanced subacute ischemic stroke treatment via multistage drug delivery system design for combination therapy

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Science China Chemistry 2025年

作者： Xihan Xu Juan-Juan Li Jiamin Li Hui-Yan Zhang Yilin Qi Bing-Sen shi Tianqi Li Shan-Shan Su Weitao Zhao Chang Chen Zhongying gong Huiyu Liu Ke-Rang Wang Dong-Sheng Guo Xue Xue State Key Laboratory of Medicinal Chemical Biology College of Pharmacy Nankai University College of Chemistry State Key Laboratory of Elemento-Organic Chemistry Key Laboratory of Functional Polymer Materials (Ministry of Education) Frontiers Science Center for New Organic Matter Collaborative Innovation Center of Chemical Science and EngineeringNankai University College of Chemistry and Materials Science State Key Laboratory of New Pharmaceutical Preparations and Excipients Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education) Key Laboratory of Chemical Biology of Hebei Province Hebei Research Center of the Basic Discipline of Synthetic Chemistry Hebei University Department of Neurology Tianjin First Central Hospital School of Medicine Nankai University Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic-Inorganic Composites Beijing Laboratory of Biomedical Materials Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of BioprocessBeijing University of Chemical Technology

The management of acute ischemic stroke remains challenging due to its abrupt onset and the narrow treatment window,resulting in high rates of disability and *** therapy for neuroprotection and neurorepair strategies provided new hopes for subacute stroke *** we designed a multistage nanodelivery system that matches the unique microenvironment of the subacute phase of stroke,which utilizes calixarene as a building block to effectively load the neuroprotective drug *** calixarene is designed with glycosidic linkages targeting the glucose transporter 1 (GLUT1)on the blood-brain barrier (BBB) and azo bonds that are responsive to hypoxic ***,the decomposed calixarene molecules themselves possess intrinsic bio-activation to modulate inflammatory responses,achieving a multistage therapeutic approach that transitions from targeting to release and finally to *** approach combines anti-inflammation and neuroprotection,providing a multi-level treatment *** system was validated in a rat model of permanent middle cerebral artery occlusion (pMCAO),demonstrating that intravenous administration of the nanodelivery system repairs brain damage and improves motor function 24 h post-pMCAO *** work offers a precise and integrative strategy for stroke patients missing the acute therapy window to improve functional recovery and enhance the effect of comprehensive treatment.

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Mechanics of molecular beacons for mRNA detecting

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Acta Mechanica Sinica 2021年第2期37卷 187-193页

作者： Yulong gong Xinghua shi Laboratory of Theoretical and Computational Nanoscience CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyChinese Academy of Sciences.Beijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Decoding genetic information is crucial for gene therapy and cancer diagnosis,which has attracted growing interest in the field of clinical medicine and life *** this study,we conducted a comprehensive exploration to obtain the detection mechanism of molecular beacons from a mechanics point of *** potential energy function of molecular beacon/target system is established firstly,based on which the profile of molecular beacons is solved by genetic algorithm *** length of stem and the total energy are further calculated when the target is hybridized with loop and *** results show that the hybridization between target and stem is energetically favorable compared with that between target and loop,indicating a new detection *** analyses may cast light on understanding the mechanism of molecular beacons detection,and further help to design novel molecular beacons with high resolution and quantification.

关键词： Molecular beacon Detection mechanism Finite deformation model Energy release rate

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A LOW ORDER NONCONFORMING ANISOTROPIC FINITE ELEMENT APPROXIMATION TO PARABOLIC PROBLEM

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Journal of Systems Science & Complexity 2009年第3期22卷 518-532页

作者： Dongyang shi Wei gong Department of Mathematics Zhengzhou University Zhengzhou 450052 China. Institute of Systems Science Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190 China.

A low order nonconforming finite element is applied to the parabolic problem with *** the semidiscrete and fully discrete forms are *** superclose properties andsuperconvergence are obtained through some novel approac... 详细信息

关键词： Anisotropic meshes nonconforming element parabolic problem superclose superconveygence.

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