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Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future

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Neural Regeneration Research 2025年第4期20卷 946-959页

作者： Zhiyuan Yin Jiahui Kang Xuan Cheng Hui Gao Shujia huo Haiwei Xu Key Lab of Visual Damage and Regeneration&Restoration of Chongqing Southwest Eye HospitalSouthwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased *** lower vertebrates like zebrafish,these cells assume responsibility for spontaneous retinal regeneration,wherein endogenous Müller glia undergo proliferation,transform into Müller glia-derived progenitor cells,and subsequently regenerate the entire retina with restored ***,Müller glia in the mouse and human retina exhibit limited neural reprogramming.Müller glia reprogramming is thus a promising strategy for treating neurodegenerative ocular disorders.Müller glia reprogramming in mice has been accomplished with remarkable success,through various *** in molecular,genetic,epigenetic,morphological,and physiological evaluations have made it easier to document and investigate the Müller glia programming process in ***,there remain issues that hinder improving reprogramming efficiency and ***,understanding the reprogramming mechanism is crucial toward exploring factors that will improve Müller glia reprogramming efficiency,and for developing novel Müller glia reprogramming *** review describes recent progress in relatively successful Müller glia reprogramming *** also provides a basis for developing new Müller glia reprogramming strategies in mice,including epigenetic remodeling,metabolic modulation,immune regulation,chemical small-molecules regulation,extracellular matrix remodeling,and cell-cell fusion,to achieve Müller glia reprogramming in mice.

关键词： cell fusion chemical small-molecules epigenetic extracellular matrix immune metabolic mice Müller glia neurodegenerative diseases reprogramming retina regeneration

Advancements and Challenges in Organic–Inorganic Composite Solid Electrolytes for All‑Solid‑State Lithium Batteries

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Nano-Micro Letters 2025年第1期17卷 46-97页

作者： Xueyan Zhang shichao Cheng Chuankai Fu Geping Yin Liguang Wang Yongmin Wu Hua huo State Key Laboratory of Space Power‑Sources School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001People’s Republic of China College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310058People’s Republic of China State Key Laboratory of Space Power-Sources 2965 Dongchuan RoadMinhang DistrictShanghai 200240People’s Republic of China

To address the limitations of contemporary lithium-ion batteries,particularly their low energy density and safety concerns,all-solid-state lithium batteries equipped with solid-state electrolytes have been identified as an up-and-coming *** the various SEs,organic–inorganic composite solid electrolytes(OICSEs)that combine the advantages of both polymer and inorganic materials demonstrate promising potential for large-scale ***,OICSEs still face many challenges in practical applications,such as low ionic conductivity and poor interfacial stability,which severely limit their *** review provides a comprehensive overview of recent research advancements in ***,the influence of inorganic fillers on the main functional parameters of OICSEs,including ionic conductivity,Li+transfer number,mechanical strength,electrochemical stability,electronic conductivity,and thermal stability are systematically *** lithium-ion conduction mechanism of OICSE is thoroughly analyzed and concluded from the microscopic ***,the classic inorganic filler types,including both inert and active fillers,are categorized with special emphasis on the relationship between inorganic filler structure design and the electrochemical performance of ***,the advanced characterization techniques relevant to OICSEs are summarized,and the challenges and perspectives on the future development of OICSEs are also highlighted for constructing superior ASSLBs.

关键词： Composite solid electrolytes Inorganic filler Interfacial stability Li-ion conduction mechanism Characterization techniques

Motion-pressure coupled control and simulation of long-endurance capability for multicapsule stratospheric airships

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Chinese Journal of Aeronautics 2024年第6期37卷 137-150页

作者： Zhiguang shi Wei huo Zongyu ZUO School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China Beijing Near Space Airship Technology Development Co. LtdBeijing 100070China

The current study focuses on the motion-pressure coupled control for a multicapsule stratospheric airship and transforms the path-tracking and heading-hold control of airships into guidance tracking with a time-varying weighted sum of longitudinal and lateral velocities by the definition of compound ***,an improved nonlinear predictive control method is provided to reduce the control energy consumption by the rolling optimization of controller parameters based on finite time intervals,ensuring infinite-time path-tracking ***,combined with the proposed cyclic regulation process of safe pressure between internal and external capsules,this study can fully reflect the force-thermal coupled rule of airships under the actions of atmospheric environment and maneuvering force,while evaluating the long-endurance capability of airships under the conditions of safe superheating and *** effectiveness of the motionpressure coupled controller was verified through numerical simulations,which can overcome the influence of environmental wind and achieve a tracking effect for the desired cruise path and compound *** airspeed provided during the cyclic circadian time caused the maximum superheating of the helium controlled within 30*** helium in the internal and external capsules achieved circadian *** equivalent micropore diameter of the capsule of 5 mm can achieve 55 days of long-endurance *** controller satisfies the requirements of cruise-flight application modes for multicapsule stratospheric airships with important engineering value.

关键词： Compound speed Nonlinear predictive control Cyclic pressure regulation Long-endurance capability Stratospheric airship

Complex Semblance and Its Application

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Journal of Earth Science 2019年第4期30卷 849-852页

作者： Taikun shi Shoudong huo Key Laboratory of Petroleum Resources Research Institute of Geology and Geophysics Chinese Academy of Sciences

Semblance,a measure of multi-trace coherence,has been used extensively in seismic data processing and interpretation such as velocity analysis and fault detection. The traditional algorithm has a difficulty at zero-crossings of seismic recordings. This problem is alleviated by applying a smoothing window at the cost of losing vertical resolutions. In this paper,we improve the algorithm by computing semblance from complex traces. Our initial results show that the complex semblance is smooth at zero-crossings. Because the smoothing time window becomes unnecessary,the higher vertical resolution can be achieved by using small windows or none. Some geological features,like faults and unconformities,appear clearer and easier to identify with the complex semblance. As the advantages are obvious and the implementation is straight-forward with the Hilbert transform,this new algorithm may replace the traditional one in future applications.

关键词： semblance complex trace Hilbert transform velocity analysis fault detection

The Vignetting Effect of a LAMOST-Type Schmidt Telescope

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Chinese Journal of Astronomy and Astrophysics 2008年第5期8卷 580-590页

作者： Yuan Xue huo-Ming shi National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China

Optical vignetting of a Schmidt reflector is caused mainly by the spherical primary mirror not being big enough and by the effective light-collecting area of the corrector, which depends on the direction of the star light. Calculations of the vignetting of LAMOST, a special reflecting Schmidt telescope, are made by ray-tracing methods. The results show various features due to LAMOST＇s structure and observing modes. The un-vignetted field is small compared with its field of view. In the outmost portions of the field vignetting in- creases rapidly with the distance to the field center. The vignetting at a general position within the field of view is a function of both its distance to the field center and its position angle. Vignetting varies when the telescope points at different declinations and during observations. There is difference in vignetting between direct imaging and multi-fiber spectroscopy. Vignetting distorts the relative intensity of celestial objects at different positions in a field and also affects accurate sky-estimation and sky-subtraction. The determined vignetting functions may be used to correct the vignetting effect; alternatively flat-fielding may be adopted for the calibration. The effective apertures, which affect the signal-to-noise ratio of the observations, depend on the different declinations the telescope is pointing at and also different positions within a field due to vignetting.

关键词： telescope - methods miscellaneous

Filters for manufacturability in design optimization of variable stiffness composites

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Chinese Journal of Aeronautics 2021年第4期34卷 153-159页

作者： Ye TIAN Yuhang huo Tielin shi Qi XIA State Key Laboratory of Digital Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan 430074China State Key Laboratory of Structural Analysis for Industrial Equipment Dalian University of TechnologyDalian 116024China

In the design optimization of variable stiffness composites,manufacturing constraints imposed by the automated fiber placement technology must be *** the present paper,two filters are proposed to address this issue,and they are incorporated into the Shepard interpolation-based design optimization framework developed in our previous *** fiber angle arrangement of a composite is represented by a continuous function that interpolates fiber angles at scattered design *** filters are appointed for each design point to deal with two typical manufacturing constraints,i.e.,fiber curvature and gap/*** each design point,the sensitivity is first filtered in a rectangular region around this point,and by this means the fiber curvature is controlled;then in another rectangular region around this design point,the filtered sensitivities are averaged,and the result is used to update the corresponding design *** numerical examples are investigated,and the results show that the proposed method is effective.

关键词： Composite laminates Design optimization Fiber angle Filter Manufacturing constraints

N-Positive ion activated rapid addition and mitochondrial targeting ratiometric fluorescent probes for in vivo cell H_(2)S imaging

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Frontiers of Chemical Science and Engineering 2022年第1期16卷 64-71页

作者： Yan shi Fangjun huo Yongkang Yue Caixia Yin Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Institute of Molecular ScienceShanxi UniversityTaiyuan 030006China College of Food Sciences Shanxi Normal UniversityLinfen 041004China Research Institute of Applied Chemistry Shanxi UniversityTaiyuan 030006China

Heterocyclic compound quinoline and its derivatives exist in natural compounds and have a broad spectrum of biological *** play an important role in the design of new structural entities for medical ***,indoles and their derivatives are found widely in *** acids,alkaloids and auxin are all derivatives of indoles,as are dyes,and their condensation with aldehydes makes it easy to construct reaction sites for nucleophilic addition *** this work,we combine these two groups organically to construct a rapid response site(within 30 s)for H_(2)S,and at the same time,a ratiometric fluorescence response is presented throughout the process of H_(2)S *** such,the lower detection limit can reach 55.7 nmol/L for H_(2)*** addition,cell imaging shows that this probe can be used for the mitochondrial targeted detection of endogenous and exogenous H_(2)***,this probe application was verified by imaging H_(2)S in nude mice.

关键词： heterocyclic compound hydrogen sulfide ratiometric mitochondrial targeted

Investigation on mechanical exhaust of cabin fire in large-space building

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Science China(Technological Sciences) 2008年第1期51卷 65-76页

作者： shi CongLing ZHONG MaoHua huo Ran China Academy of Safety Sciences and Technology Beijing 100029China State Key Laboratory of Fire Science University of Science and Technology of ChinaHefei 230026China

A calculation model for mechanical exhaust rate in large-space building in the case of cabin fire is proposed through theoretical analysis. Full-scale hot smoke tests are then performed to study the cabin fire spreading to large-space building at dif- ferent air change rates (ACH). The result indicates that under the standard pre- scribed ACH, the effective air heights in the large spaces are respectively 6, 4 and 2 m in the case of cabin fires of 0.34, 0.67 and 1 MW. Numerical experiment has been conducted using self-developing two-zone model. The smoke control effi- ciency is compared by varying the large space’s air change rate in the case of cabin fires ranging from 0.25 to 4 MW. The calculation results show that the air change rates are respectively 3, 6, 10 and 10 ACH when the smoke layer is kept above 5 m, indicating that the centralized exhaust rates far exceed the standard prescribed value. To address this problem, a set of subsidiary distributed mechanical exhaust installing in the cabin with high fire loads is proposed. The simulation shows that both from the safety and economy point of view, the adoption of subsidiary dis- tributed cabin exhaust design may effectively reduce the demand of designed air change rate for large-space building.

关键词： large-space cabin mechanical exhaust spill plume transfer lag time

Facile synthesis of composite polyferric magnesium-silicate-sulfate coagulant with enhanced performance in water and wastewater

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International Journal of Minerals,Metallurgy and Materials 2024年第3期31卷 574-584页

作者： Xiangtao huo Rongxia Chai Lizheng Gou mei Zhang Min Guo School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China

The coagulation process is a widely applied technology in water and wastewater *** composite polyferric mag-nesium-silicate-sulfate(PFMS)coagulants were synthesized using Na_(2)SiO_(3)·9H_(2)O,Fe_(2)(SO_(4))_(3),and MgSO_(4) as raw materials in this *** effects of aging time,Fe:Si:Mg,and OH:M molar ratios(M represents the metal ions)on the coagulation performance of the as-pre-pared PFMS were systematically investigated to obtain optimum *** results showed that PFMS coagulant exhibited good co-agulation properties in the treatment of simulated humic acid-kaolin surface water and reactive dye *** the molar ratio was controlled at Fe:Si:Mg=2:2:1 and OH:M=0.32,the obtained PFMS presented excellent stability and a high coagulation *** removal efficiency of ultraviolet UV254 was 99.81%,and the residual turbidity of the surface water reached 0.56 NTU at a dosage of 30 mg·L^(-1).After standing the coagulant for 120 d in the laboratory,the removal efficiency of UV254 and residual turbidity of the surface wa-ter were 88.12%and 0.68 NTU,respectively,which accord with the surface water treatment *** addition,the coagulation performance in the treatment of reactive dye wastewater was greatly improved by combining the advantages of magnesium and iron *** with polyferric silicate-sulfate(PFS)and polymagnesium silicate-sulfate(PMS),the PFMS coagulant played a better decolor-ization role within the pH range of 7-13.

关键词： polyferric-magnesium-silicate-sulfate composite coagulants water and wastewater excellent stability high coagulation ef-ficiency decolorization