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Palladium-assisted Metal Patterning on Polyimide Surfaces

Chinese Journal of Polymer Science 2022年第10期40卷 1287-1296,I0011页

作者： shi-long zhong Bai-Yang Zhou Xi-Rui Gu Ding-Shan Yu Xu-Dong Chen Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education Key Laboratory of High Performance Polymer-based Composites of Guangdong Province School of Chemistry Sun Yat-sen UniversityGuangzhou 510275China

A novel method of patterning high precision copper conductive micropatterns on flexible polymer substrate(polyimide)is *** utilized the coordination effect between palladium salts and pyridine structures to fix the palladium chloride(PdCl_(2))on the surface of polymer film while the 2,6-dimethylpyridine structures formed in the specific areas under ultraviolet light guaranteed the resolution of final *** thermal reduction of PdCl_(2) on the surface can be achieved in the process of thermal cyclization of the polymer *** a consequence,the obtained polyimide(PI)film can be patterned with conductive copper micropatterns directly by electroless *** particular,we accomplished the deposition of high precision copper pattern with a minimum line width of 50μm and minimum line spacing of 20μm on PI thin films(thickness~10μm)by electroless *** prepared conductive copper micropatterns exhibit a low resistivity of 1.78μΩ·cm the same as the pure block *** the relationship between the structures of the polymer chains and the physical properties of polymer substrates,such as the dimensional stability,mechanical and dielectric properties were also discussed in *** simple and novel method of patterning metal on the polymer surface does not need to achieve the catalytic metal adhesion required for electroless plating at the cost of destroying the substrate surface and avoiding the introduction of unstable *** patterning method is compatible with the current roll-to-roll production process and can be used to develop high-performance micro-integrated circuits.

关键词： Polyimide Metal patterning Electroless plating Palladium chloride Coordination effect

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Phosphoinositide-3-kinase,catalytic,alpha polypeptide RNA interference inhibits growth of colon cancer cell SW948

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World Journal of Gastroenterology 2012年第26期18卷 3458-3464页

作者： Wen-Sheng Huang Tian-Bao Wang Yao He Yu-Jun Chen shi-long zhong Min Tan Departmentof Surgery the First Affiliated Hospital Sun Yat-sen UniversityGuangzhou 510080 Guangdong Province China Department of Gastroenterology theFirst Affiliated Hospital of Sun Yat-sen University Guangzhou510080 Guangdong Province China Medical Research Center of GuangdongProvincial Hospital Guangzhou 510080 Guangdong ProvinceChina

AIM:To investigate the gene knock-down effect by the phosphoinositide-3-kinase,catalytic,alpha polypeptide(PIK3CA)-targeted double-stranded RNA(dsRNA) and its effect on cell proliferation and cycle distribution in ***:Two PIK3CA-targeted dsRNAs were constructed and transfected into SW948 *** were performed using lipofectamine TM *** transfection effectiveness was calculated basing on the rate of fluorescence cell of SW948 at 6 h after *** messenger RNA was extracted from these cells using the RNeasy kit,and semiquantitative reverse transcription polymerase chain reaction was performed to detect the down-regulation of PIK3CA,AKT1,MYC,and CCND1 gene *** were harvested,proteins were resolved,and western blot was employed to detect the expression levels of PIK3CA,AKT1,MYC,and CCND1 *** proliferation was assessed by 3-(4,5)-dimethylthiahiazo(-z-y1)-3,5-di-phenytetrazoliumromide assay and the inhibition rate was *** agar colony formation assay was performed basing on colonies greater than 60 μm in diameter at ×100 *** effect on cell cycle distribution and apoptosis was assessed by flow *** experiments were performed in ***:Green fluorescence was observed in SW948 cell transfected with plasmid Pgenesil-1,and the transfection effectiveness was about 65%.Forty-eight hours post-transfection,mRNA expression of PIK3CA in SW948 cells was 0.51 ± 0.04 vs 0.49 ± 0.03 vs 0.92 ± 0.01 vs 0.93 ± 0.03(P = 0.001) in Pgenesil-CA1,Pgenesil-CA2,negative and blank group *** expression of AKT1 was 0.50 ± 0.03 vs 0.48 ± 0.01 vs 0.93 ± 0.04 vs 0.92 ± 0.02(P = 0.000) in Pgenesil-CA1,Pgenesil-CA2,negative and blank group *** expression of MYC was 0.49 ± 0.01 vs 0.50 ± 0.04 vs 0.90 ± 0.02 vs 0.91 ± 0.03(P = 0.001) in the four groups *** expression of CCND1 was 0.45 ± 0.02 vs 0.51 ± 0.01 vs 0.96 ± 0.03 vs 0.98 ± 0.01(P = 0.001) in the four gro

关键词： Phosphoinositide-3-kinase, catalytic, alphapolypeptide RNA interference Colon cancer Phos-phoinositide-3-kinase pathway

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Side-Chain-Type Polyimide-Cu Complexes with Suppressed Activation Energy of Relaxation for Advanced High-Temperature Capacitor

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Chinese Journal of Polymer Science 2024年第8期42卷 1038-1048页

作者： Bai-Yang Zhou Ze-Tong Ma shi-long zhong Zhen-Jie Huang Qi Guo Deng-Chong Feng zhong-Ke Yuan Shao-Lin Lu Yu-Zhao Yang Cheng Wang Ding-Shan Yu Xu-Dong Chen Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education Guangdong Engineering Technology Research Centre for High Performance Organic and Polymer Photoelectric Functional FilmsSchool of ChemistrySun Yat-sen UniversityGuangzhou 510275China School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhou 510006China Guangdong Provincial Laboratory of Chemistry and Fine Chemical Industry Jieyang Centre Jieyang 515200China Chemistry and Chemical Engineering Guangdong Laboratory Shantou 515031China

The burgeoning growth of the new energy vehicles and aviation industry has escalated the need for energy storage capacitors capable of stable operation in harsh *** advent of metal-polyimide complexes has illuminated a novel approach for preparing tem perature-resistant ***,the general application of these metal-polyimide com plexes is impeded by the high dielectric loss and low breakdown strength,consequences of main-chain coordination and excessive metal ions ***,our study proposes a novel polyimideCu complex material(POP-Cu)predicated on side-chain-type pyridine-Cu coordination,utilizing the structural backbone PMDA-ODA of mature commercial PI(Kapton)with reliable *** to the high degree of freedom afforded by the side chain with suppressed relaxation activation energy and the long-range electron delocalization formed by d-πcoordination,the dielectric constant of this material containing merely 2.7 mol%Cu increases from 3.25(POPI)to 5.58,while maintaining a remarkably low dielectric loss of ***,this material exhibits a substantial DC breakdown strength of 436.2 MV·m^(-1)and a high energy density of 5.42 J·cm^(-3),coupled with superior mechanical and thermal *** at 150℃,it retains over 90%of its room-temperature energy density,demon strating notable dielectric stability under high *** attributes underscore its promising application for capacitors operating in harsh environments.

关键词： Dielectric performance Polyimide complexes Side-Chain-Type High-temperature capacitor

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Genetic and epigenetic predispositions underlying cardiovascular outcomes among patients treated with clopidogrel and aspirin

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中国药理学与毒理学杂志 2018年第4期32卷 343-344页

作者： Wan-ping zhong He-ping LEI Hong WU Ji-yan CHEN Xi-yong YU Yan-hong KANG Li-yun CAI Meng-zhen ZHANG Li-ping MAI shi-long zhong Guangdong Cardiovascular Institute Guangdong General Hospital Guangdong Academy of Medical Sciences Guangdong Guangzhou 510080 China

Coronary artery disease(CAD) is a major cause of death and disability worldwide,and consumes a considerable amount of medical resources every *** is a first-line *** therapy for CHD,butit is associated with substantial variability in PK and pharmacodynamics *** date,gene variants explain only a smallproportion of the *** study aimed to identify new genetic loci-modifying antiplatelet response to clopidogrel in Chinese patients with CAD by a systematic analysis combining antiplatelet effects and PK,and further to investigate the PON1 gene promoter DNA methylation and genetic variations possibly influencing clinical outcomes in *** undergoing *** identified novel variants in two transporter genes(SLC14 A2 rs12456693,ATP-binding cassette [ABC]A1 rs2487032) and in N6 AMT1(rs2254638) associated with P2Y12 reaction unit(PRU) and plasma active metabolite(H4) *** new variants dramatically *** the predictability of PRU variability to 37.7%.The associations between these loci and PK *** of clopidogrel and H4 were observed in additional patients,and its function on the activation of clopidogrel was validated in liver S9 fractions(P<0.05).Rs2254638 was further identified to exert a marginal risk effect formajor adverse cardiac events in an independent *** logistic regression analysis indicated that PON1 methylation level at CpG site-161(OR=0.95;95% CI=0.92–0.98;P<0.01) and the use of angiotensin converting enzyme inhibitors(OR=0.48;95% CI=0.26–0.89;P<0.01) were associated with decreased risk of bleeding *** conclusion,new genetic variants were systematically identified as risk factors for the reduced efficacy of clopidogrel *** *** expression of DNA methylation-regulating key genes in the pharmacokinetic and *** pathways of clopidogrel and aspirin may modify clinical outcomes in dual antiplatelet-treated patients undergoing PCI.

关键词：冠心病遗传学临床分析医学研究

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基于自适应小波的织物疵点自动分割研究

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纺织高校基础科学学报 2007年第2期20卷 206-211页

作者：石美红龙世忠西安工程大学计算机科学学院陕西西安710048

根据小波正交条件,通过使用疵点图像的疵点区与无疵点区能量均值比为优化目标函数,构造与织物纹理模式相匹配的二维自适应平稳小波.实验证明,构造的小波具有更好的鲁棒性和检测能力.

关键词：织物疵点小波变换非抽样小波自适应小波

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超视距目标信息仿真测试技术研究

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系统仿真学报 2004年第8期16卷 1701-1703,1707页

作者：朱士龙张佳忠顾浩江苏自动化研究所连云港222006

超视距导弹武器系统是集远程目标指示,通讯与指挥,武器控制于一体的作战系统,如何构造仿真测试系统对超视距导弹武器系统的功能、性能指标进行测试,对其作战效能进行分析评估是必须研究和解决的问题。本文描述了超视距导弹武器系统仿真... 详细信息

超视距导弹武器系统是集远程目标指示,通讯与指挥,武器控制于一体的作战系统,如何构造仿真测试系统对超视距导弹武器系统的功能、性能指标进行测试,对其作战效能进行分析评估是必须研究和解决的问题。本文描述了超视距导弹武器系统仿真测试系统的体系结构和主要功能,以及建立仿真测试系统的关键技术超视距目标信息仿真。

关键词：超视距仿真测试主题解算请信息仿真

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一种强高斯噪声的图像滤波方法

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计算机应用 2007年第7期27卷 1637-1640页

作者：石美红毛江辉梁颖龙世忠西安工程大学计算机科学学院西安710048

针对图像中高方差的强高斯噪声特点,提出了一种图像噪声联合滤波的新方法。算法将受强高斯噪声污染的图像分为强噪声点集和弱噪声点集两部分,首先通过邻域像素强度值的变化特征,定位强噪声像素点,并采用改进的自适应均值滤波方法滤除,... 详细信息

针对图像中高方差的强高斯噪声特点,提出了一种图像噪声联合滤波的新方法。算法将受强高斯噪声污染的图像分为强噪声点集和弱噪声点集两部分,首先通过邻域像素强度值的变化特征,定位强噪声像素点,并采用改进的自适应均值滤波方法滤除,然后基于简化的脉冲耦合神经网络(PCNN)平滑弱噪声点像素。经实验结果验证,与已有的其他滤波方法相比,该算法在较好地滤除噪声的同时,具有良好的图像边缘保护和自适应能力。

关键词：高斯噪声脉冲耦合神经网络滤波保护边缘自适应

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数字金融发展对粮食安全的影响研究——来自地级市层面的证据

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技术经济与管理研究 2023年第7期 51-55页

作者：李荣强施龙中陈轩华中农业大学经济管理学院湖北武汉430070 华中农业大学双水双绿研究院湖北武汉430070

在“双循环”背景下,数字金融发展与乡村振兴的多重机遇叠加,为提升粮食安全提供了历史性机遇。选取2012—2020年地级市层面数据,运用固定效应模型、中介效应模型以及门限模型研究数字金融发展对粮食安全的影响。结果显示:数字金融发展... 详细信息

在“双循环”背景下,数字金融发展与乡村振兴的多重机遇叠加,为提升粮食安全提供了历史性机遇。选取2012—2020年地级市层面数据,运用固定效应模型、中介效应模型以及门限模型研究数字金融发展对粮食安全的影响。结果显示:数字金融发展对粮食安全提升具有显著促进作用;中介效应分析表明数字金融发展可以通过提升创新水平和扩大信贷规模促进粮食安全提升;进一步分析可知创新水平与信贷规模对粮食安全的影响存在基于数字金融发展的门限效应。因此,当前应促进数字金融发展,并使其努力跨越门限值,以期通过拓展数字金融发展溢出空间多维度来提升粮食安全。

关键词：数字金融粮食安全创新水平信贷规模

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从RGB到HSV色彩空间转换公式的修正

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纺织高校基础科学学报 2008年第3期21卷 351-356页

作者：石美红申亮龙世忠胡西民西安工程大学计算机科学学院陕西西安710048

针对从RGB色彩空间到HSV色彩空间的转换方式为非线性变换,会产生奇异点和不稳定点的问题,对转换公式作了修正.原公式在饱和度为零时色度未定义,在低饱和度时色度不稳定,这些情况下色度为黑色、灰色或者白色,将色度分量的低值区域和高值... 详细信息

针对从RGB色彩空间到HSV色彩空间的转换方式为非线性变换,会产生奇异点和不稳定点的问题,对转换公式作了修正.原公式在饱和度为零时色度未定义,在低饱和度时色度不稳定,这些情况下色度为黑色、灰色或者白色,将色度分量的低值区域和高值区域分别用来表示黑白色或者偏黑和偏白的低饱和度色.不但能够消除色度奇异点和不稳定点,而且可以用单纯H分量来表述色彩图像的主色调信息,简化了图像计算的复杂度.通过分析和实验验证,方法是有效的.

关键词： RGB HSV 色彩空间奇异点不稳定点

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Genotype and haplotype association of PONlwith susceptibility to coronary artery diseaseand clinical outcomes in dual antiplatelet-treated Han Chinese patients

Genotype and haplotype association of PONlwith susceptibilit...

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中国药理学会第三届全国治疗药物监测学术年会

作者： Yan-Hong Kang Hai-Yan Lao Hong Wu Wei-Hua Lai Xin-Xin Li Xi-Yong Yu Ji-Yan Chen shi-long zhong Medical Research Center Guangdong General Hospital Department of Pharmacy of Guangdong General Hospital Sun Yat-sen Memorial Hospital Sun Yat-sen University Department of Cardiology Guangdong Cardiovascular InstituteGuangdong Academy of Medical Sciences

Aim:To evaluate the association of PON1 genetic variants with the susceptibility to coronary artery disease(CAD) as well as clinical endpoints in aspirin and clopidogrel dualantiplatelet-treated Han Chinese patients with CAD after percutaneous coronary intervention (PCI). Methods:538 Han Chinese patients undergoing PCI and received dual-antiplatelet therapy were sequentially recruited and followed up to 1 year.539 healthy controls were enrolled during the same *** effect of 5 genetic variants in PON1 and CYP2C19*2 on the disease risk and clinical outcome of major adverse cardiac events(MACE) in 1 year or bleeding in 6 months was assessed. Results:CYP2C19*2 was associated with a higher risk of MACE(P= 0.0098),but a lower risk of bleeding events(adjusted P = 0.0016).PON1 Q192R was significantly associated with a lower risk of bleeding events(OR:0.61,95%CI:0.43-0.87,P = 0.0066).Haplotype bearing PON1 -126C allele was associated with a higher risk to CAD(OR:1.48,95%CI:1.04-2.09,P = 0.029) and a higher risk of bleeding events(OR:1.68,95%CI:1.10-2.56,P = 0.017),compared to the most frequent *** transcription activity of haplotype p-162A-126C-108C in PON1 promoter was 2.6 fold higher than that of the most frequent haplotype (p-162G-126G-108T).Conclusions:Haplotype bearing PON1 -126C allele contributes to the disease risk and the risk of bleeding events in dual antiplatelet-treated CAD patients after PCI.

关键词： paraoxonase 1 genetic variant dualantiplatelet bleeding

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