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Diabetic mastopathy in an elderly woman misdiagnosed as breast cancer: A case report and review of the literature

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World Journal of Clinical Cases 2021年第14期9卷 3458-3465页

作者： Xiao-Xiao Chen shi-jun shao Hua Wan Department of Breast Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 200001China

BACKGROUND Diabetic mastopathy is a rare benign disease in clinical practice that mainly occurs in young and middle-aged women with type 1 *** has also been reported that this disease can be found in patients with type 2 diabetes and other autoimmune diseases,such as Hashimoto's thyroiditis,as well as in *** pathogenesis of diabetic mastopathy is not yet clear,and it is easily confused with breast cancer due to their similar clinical manifestations and imaging *** SUMMARY A 69-year-old female patient was admitted because of painless breast masses,with a history of type 2 *** imaging and physical examination suggested a high risk of breast *** histopathological analysis showed dense lymphocytes infiltrating around the lobules of the breast,and extensive fibrosis of the surrounding ***,diabetic mastopathy was *** The diagnosis of diabetic mastopathy in elderly patients with painless breast masses is difficult to distinguish from breast cancer,and its imaging manifestations are not specific.

关键词： Diabetic mastopathy Diabetes Mammary gland disease Literature review Autoimmunity Case report

Effect of Calix[4]pyrrole as Addition Reagent on Anions Separation in Capillary Zone Electrophoresis (CZE)

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Chinese Chemical Letters 2001年第6期12卷 511-512页

作者： Li jun HE Qing Song CAI shi jun shao Sheng Xiang JIANG Lanzhou Institute of Chemical Physics Chinese Academy of sciencesLanzhou 730000

Supramolecular interaction of calix[4]pyrroles with several inorganic anions is reported by addition of calix[4]pyrroles to background electrolyte (BGE) in CZE. The retention time (t(R)) of all anions increased with i... 详细信息

关键词： Supramolecular interaction calixpyrroles CZE retention time.

New Subsidiary Interaction Mode of Counteranions with the Periphery Cavity of Calix[4]pyrroles Binding with the Anion Subunits

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Chinese Chemical Letters 2006年第3期17卷 387-390页

作者： Kai LIU Yong GUO Jian XU shi jun shao Sheng Xiang JIANG Key Laboratory for Natural Medicine of Gansu Province Lanzhou Institute of Chemical Physics Chinese Academy of Sciences Lanzhou 730000 Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences Beijing 100039

The solution binding properties of calix[4]pyrroles with anion （as tetraalkylammonium salts） were investigated using UV-Vis spectroscopic techniques. The obvious red-shift of absorption maximum band of calix[4]pyrrole in EtOH in the presence of the tetramethylammonium （TMA^＋） salts or tetraethylammonium （TEA^＋） salts were observed, due to the charge-transfer interactions between the electron-rich pyrrole rings of calix[4]pyrroles and TMA^＋ or TEA^＋ cation subunit. The results indicated that calix[4]pyrrole receptors, which link the anionic species through multiple hydrogen bonding interactions, can use the periphery cavity for selectively binding cation subunits by cation-π charge-transfer interaction. The subsidiary interaction mode helps to further stabilize the calix[4]pyrrole-anion complex.

关键词： Anion recognition calixpyrrole charge-transfer interactions tetraalkylammonium salts.

Separation of Phenolic Compounds and Organic Anions Using ODS Column Coated with Meso-octamethylcalix[4]pyrrole and Water as Eluent

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Chinese Chemical Letters 2003年第9期14卷 946-947页

作者： Li jun HE, shi jun shao, Yong GUO, Hua Jiao MA, Xia LIU, Sheng Xiang JIANG Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000 Lanzhou Institute of Chemical Physics Chinese Academy of Sciences

Octadecylsilanized silica (ODS) was coated with meso-octamethylcalix[4]pyrrole to obtain a novel calix[4]pyrrole containing stationary phase for HPLC. Compared to ODS, the new stationary phase showed a relatively large retention and an improved separation for phenolic compounds and organic anions, using pure water as mobile phase. The results can be ascribed to the interaction between analytes and calix[4]pyrrole.

关键词： Meso-octamethylcalixpyrrole coated-column phenolic compounds anions HPLC.

Physical Diffusion and Electron-transfer Dynamics of Electroactive Solutes in Polymer Electrolytes Ⅰ. Effect of the Nature of Electroactive Solutes

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Chinese Chemical Letters 1997年第10期8卷 825-828页

作者： Li Ming DING Hua Fang ZHOU Zhong shi and shao jun DONG(Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022) Changchun Inst. of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China

The diffusion coefficients(Dapp) and the heterogeneous electron-transfer rate constants(ks)for ferrocene and its seven derivatives in MPEG/LiClO4 electrolyte were determined by using steadystate voltammetry. The two parameters increase with increasing temperature, indicating Arrhenius behavior. The effects of the nature of electroactive solute molecules on Dapp, ks, and the half-wave potentials(E1/2) are discussed.

关键词： Nature Physical Diffusion and Electron-transfer Dynamics of Electroactive Solutes in Polymer Electrolytes Effect of the Nature of Electroactive Solutes

Carotid endarterectomy for treatment of carotid in-stent restenosis:longterm follow-up results and surgery experiences from one single centre

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Stroke & Vascular Neurology 2017年第3期2卷 140-146页

作者： Le-Bao Yu Wei Yan Qian Zhang Ji-Zong Zhao Yan Zhang Rong Wang jun-shi shao Dong Zhang Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases(NCRC-ND) BeijingChina Center of Stroke Beijing Institute for Brain DisordersBeijingChina Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease BeijingChina Department of Neurosurgery Beijing Mi Yun HospitalCapital Medical UniversityBeijingChina

Objective Few studies have reported the surgical treatment of carotid in-stent restenosis(ISR),more data and longer follow-up are *** describe the surgical treatment of ISR by standard carotid endarterectomy(CEA)with stent removal,including long-term follow-up in 10 patients from our *** Ten patients from our centre who underwent CEA with stent removal for ISR were retrospectively analysed,including nine symptomatic and one asymptomatic ISR of at least 70%with mean age 67.3,the median time between carotid artery stenting and CEA was 17 months(range,2-54 months).results Standard CEA with stent removal was performed in all 10 patients without much technical difficulty(9 male and 1 female,mean age 67.3).Two cases were performed in hybrid operation *** were a total of three complications that happened in three patients(30%)*** asymptomatic dissecting aneurysm was formed on the petrous internal carotid artery in one patient who was followed up without *** the second case,dissection occurred in the arterial wall distal to the site of the stent after stent removal revealed by intraoperative angiography,and another stent was *** patient sustained temporary hypoglossal nerve dysfunction *** third patient suffered cerebral hyperperfusion with complete recovery when *** neurological complications occurred in other seven *** follow-up of 25 months(range,11-54 months),one patient died of rectal cancer without ischaemic attack and restenosis 4 years postoperation;in one patient occurred recurrent symptomatic restenosis(90%)1 year later;all other patients remained asymptomatic and without recurrent restenosis(>50%)by follow-up carotid ultrasound or CT *** It seems that CEA with stent removal is a reasonable choice,by experienced hand,for symptomatic ISR with higher but acceptable *** indication of stent removal for asymptomatic ISR needs further observati

关键词： carotid restenosis sustained

Synthesis of Calix[4]pyrroles: A Class of New Molecular Receptor

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Chinese Chemical Letters 1999年第3期10卷 193-194页

作者： shi jun shao Xian Da YU Shu Qin CAO(Lanzhou Institute of Chemical Physics,Chinese Academy of Sciences,342 Tianshui Rd., Lanzhou 730000) Chinese Acad Sci Lanzhou Inst Chem Phys Lanzhou 730000 Peoples R China

Calix[4]pyrroles, as a class of new molecular receptor in the area of supramolecular chemistry, have displayed interesting anion and neutral substrate binding properties. In this paper, several new calix[4]pyrrole mac... 详细信息

关键词： calixpyrroles porphyrinogen condensation pyrrole ketone homologues

肝脏“代谢-转运互作”及其对药物药代动力学、疗效和毒性影响的研究进展

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中国医院药学杂志 2020年第5期40卷 579-585页

作者：师少军华中科技大学同济医学院附属协和医院药学部湖北武汉430022

肝脏是药物代谢和排泄的主要器官。肝脏药物代谢酶和膜转运体对肝细胞内药物处置及其临床疗效和毒性产生重要影响。近年来,国内外学者发现被称为"代谢-转运互作"的动力学现象,其对药物药代动力学(生物利用度)、药物相互作用具有显著影... 详细信息

肝脏是药物代谢和排泄的主要器官。肝脏药物代谢酶和膜转运体对肝细胞内药物处置及其临床疗效和毒性产生重要影响。近年来,国内外学者发现被称为"代谢-转运互作"的动力学现象,其对药物药代动力学(生物利用度)、药物相互作用具有显著影响。药物代谢酶与转运体间的功能相互作用是目前药物代谢和药代动力学研究的热点之一。本文对肝脏代谢-转运互作进行了探究,并系统阐述了这种互作对药物(特别是Ⅱ相药物代谢)的药物相互作用、药代动力学、临床疗效和毒性反应的影响。今后应进一步阐明肝脏代谢-转运互作机制,有助于研究体内药物处置及药物相互作用,为临床合理用药提供新思路和新技术。

关键词：药物代谢酶药物转运体互作肝脏药物相互作用药代动力学临床疗效毒性

肠道“药物代谢酶-外排转运体偶联”对黄酮类化合物生物利用度影响的研究进展

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中国医院药学杂志 2019年第20期39卷 2107-2112页

作者：师少军华中科技大学同济医学院附属协和医院药学部

黄酮类化合物为广泛存在于食物和药物中的一类多酚化合物,具有多种药理作用,但其生物利用度低限制了其临床应用,这与其肠道吸收和代谢密切相关。黄酮类化合物主要在肠道吸收,并经Ⅱ相药物代谢酶:葡萄糖醛酸转移酶(UGTs),硫酸转移酶(SUL... 详细信息

黄酮类化合物为广泛存在于食物和药物中的一类多酚化合物,具有多种药理作用,但其生物利用度低限制了其临床应用,这与其肠道吸收和代谢密切相关。黄酮类化合物主要在肠道吸收,并经Ⅱ相药物代谢酶:葡萄糖醛酸转移酶(UGTs),硫酸转移酶(SULTs)和谷胱甘肽-S-转移酶(GSTs)广泛代谢为Ⅱ相代谢产物,其极性增加,难以通过被动扩散穿透肠上皮细胞膜。肠道外排转运体P-糖蛋白(P-gp)、乳腺癌耐药蛋白(BCRP)、多药耐药相关蛋白(MRPs)作为一个"旋转门",可调控肠上皮细胞内Ⅱ相代谢物外排至肠腔或进入体循环。本文对黄酮类化合物在肠道处置以及肠道药物代谢酶-外排转运体偶联进行了探究,这种偶联作用可显著影响黄酮类化合物生物利用度,进而影响其临床疗效与毒副作用。阐明肠道代谢酶-外排转运体偶联作用及其机制,将为提高黄酮类化合物体内生物利用度和增加其临床疗效奠定基础。

关键词：黄酮类化合物生物利用度肠道药物代谢酶外排转运体偶联作用