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A matrix metalloproteinase-responsive hydrogel system controls angiogenic peptide release for repair of cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2025年第2期20卷 503-517页

作者： Qi liu Jianye Xie Runxue Zhou Jin Deng Weihong Nie Shuwei Sun Haiping Wang Chunying shi Department of Human Anatomy Histology and EmbryologySchool of Basic MedicineQingdao UniversityQingdaoShandong ProvinceChina Department of Neurology The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina Department of General Practice The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina

Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic ***,conventional topical drug delivery often results in a burst release of the drug,leading to transient retention(inefficacy)and undesirable diffusion(toxicity)in ***,a drug delivery system that responds to changes in the microenvironment of tissue regeneration and controls vascular endothelial growth factor release is crucial to improve the treatment of ischemic *** metalloproteinase-2(MMP-2)is gradually upregulated after cerebral ***,vascular endothelial growth factor mimic peptide QK was self-assembled with MMP-2-cleaved peptide PLGLAG(TIMP)and customizable peptide amphiphilic(PA)molecules to construct nanofiber hydrogel ***-TIMP-QK was found to control the delivery of QK by MMP-2 upregulation after cerebral ischemia/reperfusion and had a similar biological activity with vascular endothelial growth factor in *** results indicated that PA-TIMP-QK promoted neuronal survival,restored local blood circulation,reduced blood-brain barrier permeability,and restored motor *** findings suggest that the self-assembling nanofiber hydrogel PA-TIMP-QK may provide an intelligent drug delivery system that responds to the microenvironment and promotes regeneration and repair after cerebral ischemia/reperfusion injury.

关键词： angiogenesis biomaterial blood-brain barrier cerebral ischemia/reperfusion injury control release drug delivery inflammation QK peptides matrix metalloproteinase-2 neuroprotection self-assembling nanofiber hydrogel

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Identifying the dynamic behaviors in complete reconstruction of Co-based complex precatalysts during electrocatalytic oxygen evolution

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Journal of Energy Chemistry 2025年第1期100卷 226-233页

作者： Jingfang Zhang Danyang Wu Linke Cai Youluan Lu Fanpeng Cheng Lijuan shi Qun Yi Yao liu Yi Huang Key Laboratory of Green Chemical Engineering Process of Ministry of Education Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of Education Hubei Key Laboratory of Novel Reactor and Green Chemical Technology School of Chemical Engineering & Pharmacy Wuhan Institute of Technology Key Laboratory of Pesticide & Chemical Biology of Ministry of Education Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction of Ministry of Education College of Chemistry Central China Normal University College of Materials Science and Engineering Fuzhou University

Transition metal-based nanomaterials have emerged as promising electrocatalysts for oxygen evolution reaction（OER）. Considerable research efforts have shown that self-reconstruction occurs on these nanomaterials under operating conditions of OER process. However, most of them undergo incomplete reconstruction with limited thickness of reconstruction layer, leading to low component utilization and arduous exploration of real catalytic mechanism. Herein, we identify the dynamic behaviors in complete reconstruction of Co-based complexes during OER. The hollow phytic acid（PA） cross-linked CoFe-based complex nanoboxes with porous nanowalls are designed because of their good electrolyte penetration and mass transport ability, in favor of the fast and complete reconstruction. A series of experiment characterizations demonstrate that the reconstruction process includes the fast substitution of PA by OH-to form Co（Fe）(OH)xand subsequent potential-driven oxidation to Co（Fe）OOH. The obtained CoFeOOH delivers a low overpotential of 290 mV at a current density of 10 mA cm-2and a long-term *** experiment results together with theory calculations reveal that the Fe incorporation can result in the electron rearrangement of reconstructed CoFeOOH and optimization of their electronic structure,accounting for the enhanced OER activity. The work provides new insights into complete reconstruction of metal-based complexes during OER and offers guidelines for rational design of high-performance electrocatalysts.

关键词： Oxygen evolution reaction

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Boosting hydrocarbon conversion via Cu-doping induced oxygen vacancies on CeO2 in CO2 electroreduction

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Journal of Energy Chemistry 2025年第1期100卷 66-76页

作者： Lei Xue Tong shi Chenhui Han Heng Zhang Fenrong liu Haorun Li Yan Wang Xiaojun Gu Shanghong Zeng Inner Mongolia Key Laboratory of Chemistry and Physics of Rare Earth Materials School of Chemistry and Chemical Engineering Inner Mongolia University State Key Laboratory of Coal Conversion Institute of Coal Chemistry Chinese Academy of Sciences Institute of Catalysis Department of Chemistry Zhejiang University National Key Laboratory of Baiyunobo Rare Earth Resource Research and Comprehensive Utilization Baotou Research Institute of Rare Earths

Conversion of CO2back to hydrocarbons is the most direct way of closing the“carbon cycle”,and its significance is further enlarged if this process is driven by renewable energies such as ***,precisely controlling the product selectivity towards hydrocarbons against the competitive hydrogen evolution remains challenging,especially for Cu-based ***,we report a novel defect engineering strategy,by which Cu-doping-induced oxygen vacancies on CeO2nanorods were effectively created,with adjustable vacancy/Cu *** resulting optimum catalyst shows up to 79% catalytic current density to hydrocarbons （excluding CO）,with 49% faradaic efficiency to *** and density functional theory unveil that the ratio between oxygen vacancy and Cu affects significantly the formation of*CHO and activation of H2O,which leads to the following deep hydrogenation to *** findings may spur new insights for designing and developing more controllable chemical process relevant to CO2utilization.

关键词： Nanorods

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pH和硫酸盐浓度对基因工程菌*** FBR5发酵木糖的影响

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酿酒科技 2008年第9期 17-19,22页

作者：刘亭君 shijie liu 胡若飞林鹿华南理工大学制浆造纸工程国家重点实验室

考察了磷酸缓冲液用量和硫酸钠浓度对基因工程菌***5发酵木糖生成乙醇的影响,发现在添加12mL缓冲液的情况下,木糖利用率最高(为96.5%)。10g/L硫酸钠对发酵速度有一定影响,但对最终乙醇浓度影响不大。20g/L硫酸钠对FBR5的生长和乙醇合成... 详细信息

考察了磷酸缓冲液用量和硫酸钠浓度对基因工程菌***5发酵木糖生成乙醇的影响,发现在添加12mL缓冲液的情况下,木糖利用率最高(为96.5%)。10g/L硫酸钠对发酵速度有一定影响,但对最终乙醇浓度影响不大。20g/L硫酸钠对FBR5的生长和乙醇合成都有明显抑制。

关键词：燃料乙醇 E.coli 木糖发酵

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High‑Entropy Electrode Materials:Synthesis,Properties and Outlook

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Nano-Micro Letters 2025年第1期17卷 472-506页

作者： Dongxiao Li Chang liu Shusheng Tao jieming Cai Biao Zhong jie Li Wentao Deng Hongshuai Hou Guoqiang Zou Xiaobo Ji College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083People’s Republic of China School of Chemistry and Chemical Engineering Hunan Institute of EngineeringXiangtan 411104People’s Republic of China

High-entropy materials represent a new category of high-performance materials,first proposed in 2004 and extensively investigated by researchers over the past two *** definition of high-entropy materials has continuously *** the last ten years,the discovery of an increasing number of high-entropy materials has led to significant advancements in their utilization in energy storage,electrocatalysis,and related domains,accompanied by a rise in techniques for fabricating high-entropy electrode ***,the research emphasis has shifted from solely improving the performance of high-entropy materials toward exploring their reaction mechanisms and adopting cleaner preparation ***,the current definition of high-entropy materials remains relatively vague,and the preparation method of high-entropy materials is based on the preparation method of single metal/low-or medium-entropy *** should be noted that not all methods applicable to single metal/low-or medium-entropy materials can be directly applied to high-entropy *** this review,the definition and development of high-entropy materials are briefly ***,the classification of high-entropy electrode materials is presented,followed by a discussion of their applications in energy storage and catalysis from the perspective of synthesis ***,an evaluation of the advantages and disadvantages of various synthesis methods in the production process of different high-entropy materials is provided,along with a proposal for potential future development directions for high-entropy materials.

关键词： High-entropy Energy storage Electrode materials

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咪喹莫特诱导的银屑病样小鼠皮肤抗细菌感染能力的研究

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临床皮肤科杂志 2018年第4期47卷 200-204页

作者：史航刘洁宋智琦大连医科大学附属第一医院皮肤科辽宁大连116044 大连医科大学附属第二医院麻醉科辽宁大连116027

目的:观察咪喹莫特诱导的银屑病样小鼠皮肤抵抗细菌感染的能力。方法:Balb/c小鼠,背部脱毛后涂抹5%咪喹莫特乳膏,制作银屑病样小鼠模型。取银屑病样小鼠及正常小鼠各10只,在其背部皮内分别注射1×10^(11)菌落形成单位(CFU)/L、1×10^(12... 详细信息

目的:观察咪喹莫特诱导的银屑病样小鼠皮肤抵抗细菌感染的能力。方法:Balb/c小鼠,背部脱毛后涂抹5%咪喹莫特乳膏,制作银屑病样小鼠模型。取银屑病样小鼠及正常小鼠各10只,在其背部皮内分别注射1×10^(11)菌落形成单位(CFU)/L、1×10^(12)CFU/L金黄色葡萄球菌液及链球菌菌液各40μL,观察皮肤的红斑、脓肿等炎症反应程度,行组织病理检查及取金黄色葡萄球菌脓肿检测组织荷菌量。结果:1×10^(11) CFU/L金黄色葡萄球菌菌液在正常小鼠皮肤造成直径3~8 mm的脓肿,银屑病样小鼠则无明显改变;1×10^(12) CFU/L金黄色葡萄球菌菌液在正常小鼠皮肤造成直径10~13 mm的巨大脓肿,在银屑病样小鼠皮肤造成直径2~5 mm的结痂;1×10^(11) CFU/L链球菌菌液在正常小鼠皮肤引发红色小丘疹,银屑病样小鼠无反应;1×10^(12) CFU/L链球菌菌液导致正常小鼠皮肤出现小脓点及结痂,4~7 d愈合,银屑病样小鼠皮肤出现红色小丘疹,持续存在,并逐渐隆起。银屑病样小鼠皮肤的金黄色葡萄球菌脓肿的荷菌量显著少于正常小鼠。结论:咪喹莫特诱导的小鼠银屑病样皮损对金黄色葡萄球菌及链球菌急性感染的抵抗力显著增强,对链球菌存在迟发的炎症反应。

关键词：银屑病样皮损咪喹莫特金黄色葡萄球菌溶血性链球菌

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Double [5]carbohelicene: facile synthesis, chiroptical properties,isomerization study, and lasing application

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Science China Chemistry 2025年第1期68卷 233-240页

作者： Peipei liu Yantong Li Meng-Xiang Wu Hao Kang Xiao-Li Zhao Lin Xu Linlin liu Xiaodong Li Junfeng Fang Zhiwei Fang Ya Cheng Hai-Bo Yang Huakang Yu Xueliang shi State Key Laboratory of Petroleum Molecular & Process Engineering Shanghai Key Laboratory of Green Chemistry and Chemical ProcessesSchool of Chemistry and Molecular Engineering East China Normal University School of Physics and Optoelectronics South China University of Technology Institute of Polymer Optoelectronic Materials & Devices State Key Laboratory of Luminescent Materials & Devices South China University of Technology School of Physics and Electronic Science Engineering Research Center of Nanophotonics & Advanced Instrument Ministry of EducationEast China Normal University State Key Laboratory of Precision Spectroscopy School of Physics and Electronic Science East China Normal University

Double carbohelicenes have attracted considerable attention due to their aesthetic structures, distinct π-conjugation extension, inherent chirality, and intriguing optical and electronic properties. Herein, the concise de novo synthesis of a new double[5]carbohelicene 1 together with its chiroptical properties, isomerization process and lasing application is presented. 1 was synthesized by a simple protocol involving the formation of a 6,6′-bipentacene as the key intermediate. It is worth noting that1 existed as two diastereomers 1-PP/MM and 1-PM, which were successfully isolated and unambiguously confirmed by Xray crystallography. The optical resolution of the racemic 1-PP/MM was successfully achieved by chiral-phase highperformance liquid chromatography（HPLC）, and 1-PP and 1-MM were characterized by circular dichroism. Interestingly, it was found that 1-PP/MM could be completely isomerized to 1-PM upon heating, and the detailed thermodynamics and kinetics of the isomerization process were systematically investigated. 1-PM exhibited deep-red luminescence with emission maximum at 723 nm and fluorescence quantum yield as high as 32.95%. Consequently, we can showcase the lasing application of 1-PM by doping with epoxy resin to assemble a bottle microlaser spontaneously, which the lasing wavelength is 796.6 nm at a threshold of 0.8 m J cm-2. We believe that our studies, including the facile synthesis methodology, detailed isomerization studies, and lasing application, will shed some light on the design and synthesis of novel carbohelical systems with more functions.

关键词： double carbohelicene optical resolution organic laser isomerization X-ray diffraction

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Study on End Milling Generation Surface Model and Simulation in View of Main Axle's Tolerance

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厦门大学学报（自然科学版） 2002年第S1期41卷 39-页

作者： LI shi-jie, liu Riu-su, ZHANG Ai-jun (Department of Mechanical Engineering, Hebei University of Technology, Tianjin 300130, China)

In accordance with the relative movement between end-milling cutter and workpiece surface, a theoretical generation model for milled surface was established with the movement error of principal axle considered. Then the milled surfaces under various cutting condition were simulated, the results of which showed that end milled surfaces were of "vaulted profile", heights of surface irregularty at various points to be different with maximum value in the middle and smaller at both sides, the difference were determined by diameter of milling cutter, feeding speed, ratio between the diameter of milling cutter and teeth point curve radius and width of workpiece. The study results can be applied to quality prediction of milled surfaces for precision and/or super precision milling operation.

关键词： end milling milled surface generation model simulation vaulted profile

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Sulfolane‑Based Flame‑Retardant Electrolyte for High‑Voltage Sodium‑Ion Batteries

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Nano-Micro Letters 2025年第2期17卷 498-516页

作者： Xuanlong He jie Peng Qingyun Lin Meng Li Weibin Chen Pei liu Tao Huang Zhencheng Huang Yuying liu Jiaojiao Deng Shenghua Ye Xuming Yang Xiangzhong Ren Xiaoping Ouyang Jianhong liu Biwei Xiao Jiangtao Hu Qianling Zhang Graphene Composite Research Center College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen 518060People’s Republic of China Center of Electron Microscopy State Key Laboratory of Silicon and Advanced Semiconductor MaterialsSchool of Materials Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China GRINM(Guangdong)Research Institute for Advanced Materials and Technology FoshanGuangdong 528051People’s Republic of China College of Energy Engineering Zhejiang UniversityHangzhouZhejiang 310027People’s Republic of China School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105People’s Republic of China Shenzhen Eigen-Equation Graphene Technology Co.Ltd Shenzhen 518000People’s Republic of China

Sodium-ion batteries hold great promise as next-generation energy storage ***,the high instability of the electrode/electrolyte interphase during cycling has seriously hindered the development of *** particular,an unstable cathode–electrolyte interphase(CEI)leads to successive electrolyte side reactions,transition metal leaching and rapid capacity decay,which tends to be exacerbated under high-voltage ***,constructing dense and stable CEIs are crucial for high-performance *** work reports localized high-concentration electrolyte by incorporating a highly oxidation-resistant sulfolane solvent with non-solvent diluent 1H,1H,5H-octafluoropentyl-1,1,2,2-tetrafluoroethyl ether,which exhibited excellent oxidative stability and was able to form thin,dense and homogeneous *** excellent CEI enabled the O3-type layered oxide cathode NaNi_(1/3)Mn_(1/3)Fe_(1/3)O_(2)(NaNMF)to achieve stable cycling,with a capacity retention of 79.48%after 300 cycles at 1 C and 81.15%after 400 cycles at 2 C with a high charging voltage of 4.2 *** addition,its nonflammable nature enhances the safety of *** work provides a viable pathway for the application of sulfolane-based electrolytes on SIBs and the design of next-generation high-voltage electrolytes.

关键词： Sodium-ion batteries Sulfolane-based electrolyte High voltage Layered oxide cathode Flame retardant

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婴幼儿食品接触用制品的标签标识技术规范

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包装工程 2021年第17期42卷 62-68页

作者：张丽媛李洁君石鎏杰上海市质量监督检验技术研究院上海200233

目的研究婴幼儿食品接触用制品标签技术规范,以期为生产企业设计标签的合规性提供技术指导。方法调研市面上婴幼儿食品接触用制品的标签,分析该类制品标签标识存在的常见问题,针对现有的法律法规和相关标准,归纳婴幼儿食品接触用制品标... 详细信息

目的研究婴幼儿食品接触用制品标签技术规范,以期为生产企业设计标签的合规性提供技术指导。方法调研市面上婴幼儿食品接触用制品的标签,分析该类制品标签标识存在的常见问题,针对现有的法律法规和相关标准,归纳婴幼儿食品接触用制品标签的技术要求。结论归纳总结了现行有效的标准和法规中婴幼儿制品标签的规定,提出了标签标注要素,并对关键要素的标注进行了技术解读,为生产企业设计标签提供了参考,建议生产企业可结合行业实际情况执行标签标识团体标准或制定团体联盟标准。

关键词：婴幼儿食品接触用制品标准标签标识

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