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Laparoscopic surgery for early gallbladder carcinoma:A systematic review and meta-analysis

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World Journal of Clinical Cases 2020年第6期8卷 1074-1086页

作者： Xu Feng Jia-Sheng Cao Ming-Yu Chen Bin Zhang Sarun Juengpanich Jia-Hao Hu Win Topatana shi-jie li Ji-liang Shen Guang-Yuan Xiao Xiu-Jun Cai Hong Yu Department of General Surgery Sir Run-Run Shaw HospitalZhejiang UniversityHangzhou 310016Zhejiang ProvinceChina Department of General Surgery Jiaxing Hospital of Traditional Chinese MedicineJiaxing 314000Zhejiang ProvinceChina

BACKGROUND There is a controversy as to whether laparoscopic surgery leads to a poor prognosis compared to the open approach for early gallbladder carcinoma (GBC)We hypothesized that the laparoscopic approach is an alternative for early *** To identify and evaluate the safety and feasibility of laparoscopic surgery in the treatment of early *** A comprehensive search of online databases,including MEDliNE (PubMed),Cochrane libraries,and Web of Science,was performed to identify noncomparative studies reporting the outcomes of laparoscopic surgery and comparative studies involving laparoscopic surgery and open surgery in early GBC from January 2009 to October 2019.A fixed-effects meta-analysis was performed for 1-and 5-year overall survival and postoperative complications,while 3-year overall survival,operation time,blood loss,the number of lymph node dissected,and postoperative hospital stay were analyzed by random-effects *** The review identified 7 comparative studies and 8 non-comparative studies.1068 patients (laparoscopic surgery:613;open surgery:455) were included in the meta-analysis of 1-,3-,and 5-year overall survival with no significant differences observed [(HR=0.54;95%CI:0.29-1.00;12=0.0%;P=0.051),(HR=0.75;95%CI:0.34-1.65;I^2=60.7%;P=0.474),(HR=0.71;95%CI:0.47-1.08;I^2=49.6%;P=0.107),respectively].There were no significant differences in operation time[weighted mean difference (WMD)=18.69;95%CI:-19.98-57.36;I^2=81.4%;P=0.343],intraoperative blood loss (WMD=-169.14;95%CI:-377.86-39.57;I2=89.5%;P=0.112),the number of lymph nodes resected (WMD=0.12;95%CI:-2.95-3.18;I^2=73.4%;P=0.940),and the complication rate (OR=0.69;95%CI:0.30-1.58;I2=0.0%;P=0.377) between the two groups,while patients who underwent laparoscopic surgery had a reduced length of hospital stay (WMD=-5.09;95%CI:-8.74--1.45;I2=91.0%;P=0.006).CONCLUSION This systematic review and meta-analysis confirms that laparoscopic surgery is a safe and feasible alternative to open sur

关键词： Laparoscopic surgery Open surgery Early gallbladder carcinoma Survival Meta-analysis

手持式直读红外光谱仪快速测定在用润滑油总酸值和总碱值的方法

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光谱学与光谱分析 2017年第2期37卷 452-455页

作者：杨琨吴桐邹毛石立杰武汉理工大学能源与动力工程学院可靠性工程研究所湖北武汉430063 武汉理工大学国家水运安全工程技术研究中心湖北武汉430063 斯派超科技(北京)有限公司北京100176

总酸值(TAN)和总碱值(TBN)能提供关于润滑油氧化程度和碱储备性能方面的信息,其值大小可以判断某些酸性添加剂的加量是否足够,常用于设备润滑油的老化度测量,以避免设备出现异常磨损、腐蚀、沉淀、堵塞过滤器等问题。润滑油的总酸性和... 详细信息

总酸值(TAN)和总碱值(TBN)能提供关于润滑油氧化程度和碱储备性能方面的信息,其值大小可以判断某些酸性添加剂的加量是否足够,常用于设备润滑油的老化度测量,以避免设备出现异常磨损、腐蚀、沉淀、堵塞过滤器等问题。润滑油的总酸性和总碱性的检测标准都以酸碱滴定为基础,多采用电位滴定法。然而,这种方法需要复杂的操作、昂贵的耗材、大量的油样、熟练的操作人员以及危险试剂的处理问题。由于润滑油的氧化产物和碱性添加剂在红外光谱中都有较强的信息,因此,可以通过红外光谱图研究对润滑油总酸值和总碱值的监测。建立了一种基于酸碱中和反应的定量中红外光谱总酸值和总碱值的手持式直读红外光谱方法,通过油品归类、建立油样库和多元回归三个步骤,可获得准确可靠的量化总酸值和总碱值。此方法获得最新的ASTM D7889标准支持,相比于其他方法,这种方法具有分析速度快、无需任何溶剂、直接得到检测结果并且结果准确,操作相对简单,并一定程度提高了检测速度。可广泛应用于离线实验室和现场在线油液检测。

关键词：润滑油检测总酸值总碱值直读红外

Artificial intelligence in gastroenterology and hepatology:Status and challenges

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World Journal of Gastroenterology 2021年第16期27卷 1664-1690页

作者： Jia-Sheng Cao Zi-Yi Lu Ming-Yu Chen Bin Zhang Sarun Juengpanich Jia-Hao Hu shi-jie li Win Topatana Xue-Yin Zhou Xu Feng Ji-liang Shen Yu liu Xiu-Jun Cai Department of General Surgery Sir Run-Run Shaw HospitalZhejiang UniversityHangzhou 310016Zhejiang ProvinceChina Zhejiang University School of Medicine Zhejiang UniversityHangzhou 310058Zhejiang ProvinceChina School of Medicine Wenzhou Medical UniversityWenzhou 325035Zhejiang ProvinceChina College of life Sciences Zhejiang UniversityHangzhou 310058Zhejiang ProvinceChina

Originally proposed by John McCarthy in 1955,artificial intelligence(AI)has achieved a breakthrough and revolutionized the processing methods of clinical medicine with the increasing workloads of medical records and digital *** are paying attention to AI technologies for various diseases in the fields of gastroenterology and *** review will illustrate AI technology procedures for medical image analysis,including data processing,model establishment,and model ***,we will summarize AI applications in endoscopy,radiology,and pathology,such as detecting and evaluating lesions,facilitating treatment,and predicting treatment response and prognosis with excellent model *** current challenges for AI in clinical application include potential inherent bias in retrospective studies that requires larger samples for validation,ethics and legal concerns,and the incomprehensibility of the output ***,doctors and researchers should cooperate to address the current challenges and carry out further investigations to develop more accurate AI tools for improved clinical applications.

关键词： Artificial intelligence Gastroenterology Hepatology Status Challenges

Purification of a Novel Antibacterial Short Peptide in Earthworm Eisenia foetida

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Acta Biochimica et Biophysica Sinica 2004年第4期36卷 297-302页

作者： Yan-Qin liU1,2, Zhen-Jun SUN1*, Chong WANG1, shi-jie li2, and Yu-Zhi liU2 College of Resource and Environment Science, China Agricultural University, Beijing 100094, China 2College of Animal Science, Hebei Agricultural University, Baoding 071001, China College of Resource and Environment Science China Agricultural UniversityBeijing 100094 China College of Animal Science Hebei Agricultural UniversityBaoding 071001 China

A novel antimicrobial short peptide was purified from earthworm (Eisenia foetida) by a five-step protocol including ammonium sulfate precipitation, ultrafiltration, DE-52 ion exchange chromatography, Sephadex G-10 column chromatography, and C-18 reversed-phase HPLC techniques. The purified peptide was applied to the MALDI-TOF MS to determine the molecular mass and was also subjected to TOF MS-MS analysis to determine the amino acid sequence. As a result, a novel antibacterial peptide, named OEP3121, was obtained, with the molecular mass of 510.8 Da and the sequence being “ACSAG”.

关键词： antibacterial peptide earthworm purification

红细胞生成性原卟啉病并发肝脏病变三例临床病理特征观察

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中华病理学杂志 2017年第10期46卷 704-707页

作者：师杰李晓青卢朝辉中国医学科学院北京协和医学院北京协和医院病理科 100730 中国医学科学院北京协和医学院北京协和医院消化内科 100730

目的探讨红细胞生成性原卟啉病（erythropoietic protoporphyria，EPP）并发肝脏病变的临床及肝脏病理学改变。方法回顾性分析2011年7月至2014年8月3例EPP并发肝脏病变的临床资料及穿刺组织病理资料，并结合相关文献进行复习。结果3例... 详细信息

目的探讨红细胞生成性原卟啉病（erythropoietic protoporphyria，EPP）并发肝脏病变的临床及肝脏病理学改变。方法回顾性分析2011年7月至2014年8月3例EPP并发肝脏病变的临床资料及穿刺组织病理资料，并结合相关文献进行复习。结果3例患者均以持续性腹痛难以缓解入院．伴明显黄疸及肝功能异常等，影像学提示肝脏体积均匀性增大；病理检查示肝细胞体积弥漫性增大．胞质粉染颗粒状或泡沫状；在部分肝细胞胞质内、Kuffer细胞胞质内、肝细胞间的微胆管内及部分扩张的肝窦内均可见棕黄色颗粒状及棕褐色浓缩的块状物质沉积，其大小不等、分布不均；在偏光显微镜下可呈现红色双折光及特征性的中央黑色十字架结构（马耳他十字，Maltese Cross）。此外，肝组织内还可见肝索肿胀、拥挤、部分肝细胞点灶状坏死及脂肪样变性，汇管区可见散在、灶性淋巴细胞浸润伴纤维组织增生及汇管区小胆管增生等非特异性改变，未见胆管管腔明显扩张。结论充分了解和认识EPP并发肝脏病变的临床及肝脏病理学改变，有助于我们在临床实践中筛查出那些以腹部症状为主要表现的卟啉病患者，使其尽早得到有效的治疗。

关键词：原卟啉病红细胞生成性活组织检查针吸诊断鉴别

高铁网络可达性测度及经济潜力分析——以安徽省为例

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长江流域资源与环境 2017年第9期26卷 1323-1331页

作者：陶世杰李俊峰安徽师范大学国土资源与旅游学院安徽芜湖241003

高速铁路的开通给沿线城市的建设带来了重大影响。基于可达性测度以及修正的经济潜力模型,利用GIS对安徽省高铁可达性以及经济潜力进行深入分析。研究表明:(1)高铁开通后安徽省可达性显著提高,但总体格局保持不变,呈现出以合肥为中心,... 详细信息

高速铁路的开通给沿线城市的建设带来了重大影响。基于可达性测度以及修正的经济潜力模型,利用GIS对安徽省高铁可达性以及经济潜力进行深入分析。研究表明:(1)高铁开通后安徽省可达性显著提高,但总体格局保持不变,呈现出以合肥为中心,淮南、芜湖等地为副中心的"多核心"模式。池州、铜陵两城市可达性上升幅度最大,黄山紧随其后,芜湖、滁州变化最小。高铁开通后,滁州可达性排名下降5名,下降幅度最大,合肥、淮南、黄山最为稳定,其他城市均有小幅变化。(2)可达性的提升对城市经济潜力造成了一定影响,总体呈现出以合肥为中心的外围扩展模式。池州、铜陵经济潜力增长最为显著,黄山位列第3,可达性的提升直接影响了池州、铜陵、黄山三市的经济发展。高铁开通后,合肥、芜湖经济潜力排名始终位于前二,传统经济中心地位不变。马鞍山排名上升4名,幅度最大,池州、黄山两市处于末端,经济潜力仍然较为薄弱。(3)高铁开通后,时空收敛效应明显,可达性的提升令城市经济潜力增长显著,但受多方面因素影响,可达性与经济潜力呈现不完全契合关系。

关键词：高铁可达性加权平均旅行时间经济潜力安徽省

“通调三焦,化浊导滞”治疗湿热型便秘验案举隅

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中华中医药杂志 2023年第4期38卷 1652-1655页

作者：金雨青施丽婕天津中医药大学第一附属医院、国家中医针灸临床医学研究中心天津300193

便秘是常见的消化系统疾病,然而目前临床中提及湿热型便秘的治法和讨论较少,因为若使用利水渗湿药清理下焦湿热会涉及到“利小便,实大便”,与治疗便秘发生冲突,黄连、黄柏等清热燥湿药也有加重便秘的可能。故文章提出从“通调三焦,化浊... 详细信息

便秘是常见的消化系统疾病,然而目前临床中提及湿热型便秘的治法和讨论较少,因为若使用利水渗湿药清理下焦湿热会涉及到“利小便,实大便”,与治疗便秘发生冲突,黄连、黄柏等清热燥湿药也有加重便秘的可能。故文章提出从“通调三焦,化浊导滞”的角度治疗湿热型便秘,并分享3则验案进行印证。

关键词：湿热型便秘三焦皂荚子蚕沙通调三焦化浊导滞经验施丽婕

Whether Syndrome Differentiation Affects Treatment Result:Study Protocol of MaZiRenWan(麻子仁丸)for Functional Constipation in A Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2019年第3期25卷 175-181页

作者： CHENG Chung-wah ZHANG li ZHAO Chen ZHONG linda LD shi li-jie DAI liang ZHENG Rui CHEN Jing li Ge ZHAI Jing-bo KUN Wai LU Ai-ping SHANG Hong-cai BIAN Zhao-xiang Hong Kong Chinese Medicine Clinical Study Centre School of Chinese Medicine Hong Kong Baptist University Department of Clinical Pharmacology the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine Department of Gastroenterology the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Graduate School Tianjin University of Traditional Chinese Medicine Department of Health Care Baokang Affiliated Hospital of Tianjin University of Traditional Chinese Medicine School of Traditional Chinese Medicine Tianjin University of Traditional Chinese Medicine Research Institute of Traditional Chinese Medicine Tianjin University of Traditional Chinese Medicine Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing Dongzhimen Hospital Beijing University of Chinese Medicine

Background: Syndrome is one of the most important concepts in Chinese medicine(CM) theory. However, it was not well accounted in most of randomized controlled trials(RCTs). Objective: To determine whether CM syndrome differentiation affects the treatment results, functional constipation(FC) was selected as a target disease, and MaZiRenWan(麻子仁丸, MZRW), a classic CM formula commonly used for constipation with excessive heat syndrome, was selected for study. Methods: It is an 18-week prospective double-blinded, doubledummy RCT, including 2-week run-in, 8-week treatment and 8-week post treatment follow-up. A total of 120 FC patients diagnosed as excessive heat syndrome will be recruited from the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine and the Baokang Affiliated Hospital of Tianjin University of Traditional Chinese Medicine. Patients will be randomly allocated into fixed MZRW(f_MZRW) granule group, modified MZRW(m_MZRW) granule group or bisacodyl group. For m_MZRW group, no more than two herbal granules can be added according to the syndrome differentiation for individual participants. The primary end point is the mean of complete spontaneous bowel movements(CSBMs) per week during the treatment period. Secondary end points include mean of CSBMs per week during follow-up, stool form, global symptom improvement, constipation and constipation-related symptoms assessment, CM syndrome change, and reported adverse events. Discussion: This trial is designed to evaluate the effectiveness of these three interventions for FC patients with the CM syndrome of excessive heat, and to determine the change of CM syndrome and the progress of disease during the treatment course. The results are important to explore whether syndrome differentiation is important for the therapeutic effect of a formula on a disease.

关键词： functional constipation Chinese herbal medicine syndrome differentiation MaZiRenWan randomized controlled trial

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血管内皮细胞中的凝血物质:理论研究新进展

中国组织工程研究 2017年第4期21卷 627-632页

作者：叶梓王世杰李辉刘璐武警后勤学院学员二旅一营药学131 天津市300309 武警后勤学院学员二旅七营救援131 天津市300309 武警陕西总队铜川支队卫生队陕西省铜川市727100 武警后勤学院化学教研室天津市300309

背景:血管内皮细胞在凝血过程中能够分泌众多凝血物质参与凝血级联反应或收缩血管促进凝血进程。目的:综述血管内皮细胞分泌的不同凝血物质的作用机制,为凝血功能材料的筛选提供理论依据。方法:应用计算机检索中国知网、Pub Med数据库1... 详细信息

背景:血管内皮细胞在凝血过程中能够分泌众多凝血物质参与凝血级联反应或收缩血管促进凝血进程。目的:综述血管内皮细胞分泌的不同凝血物质的作用机制,为凝血功能材料的筛选提供理论依据。方法:应用计算机检索中国知网、Pub Med数据库1988至2016年收录的与血管内皮细胞凝血物质相关的文献。英文检索词为"Vascular endothelial cells,endothelin,AngⅡ,TXA2,tissue factor,Collagen,fibronectin,von wilbrand factor,thrombospondin,platelet activating factor,plasminogen activator inhibitor,proaccelerin,antihemophlic factor",中文检索词为"血管内皮细胞,组织因子,胶原,纤维连接蛋白,血小板激活因子,纤溶酶原激活物抑制物,凝血因子Ⅴ、Ⅷ,内皮素,血管紧张素Ⅱ,血栓素",最终纳入文献38篇进行综述。结果与结论:血管损伤时血管内皮细胞产生的众多凝血因子在凝血、炎症反应以及血栓形成过程中发挥着重要的作用。凝血过程中,血管内皮细胞分泌众多促凝因子和凝血因子Ⅴ和Ⅷ直接参与凝血级联瀑布反应,促进血栓形成;同时血管内皮细胞分泌的收缩血管因子使血管腔狭小,辅助凝血过程,间接促进血栓形成。

关键词：内皮细胞血液凝固因子内皮缩血管肽类组织工程组织构建血管内皮细胞促凝因子血管收缩因子