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Neuroscience Bulletin 2024年第2期40卷 182-200页

作者： Yang Zhu hao Huang Zhi Chen Yong Tao Ling-Yi Liao shi-hao gao Yan-Jiang Wang Chang-Yue gao Department of Rehabilitation Medicine Daping HospitalArmy Medical UniversityChongqing 400042China Department of Neurology and Center for Clinical Neuroscience Daping HospitalArmy Medical UniversityChongqing 400042China Department of Special Medicine Daping HospitalArmy Medical UniversityChongqing 400042China

Intermittent theta burst stimulation(iTBS),a time-saving and cost-effective repetitive transcranial magnetic stimulation regime,has been shown to improve cognition in patients with Alzheimer’s disease(AD).However,the specific mechanism underlying iTBS-induced cognitive enhancement remains *** studies suggested that mitochondrial functions are modulated by magnetic ***,we showed that iTBS upregulates the expression of iron-sulfur cluster assembly 1(ISCA1,an essential regulatory factor for mitochondrial respiration)in the brain of APP/PS1 *** vivo and in vitro studies revealed that iTBS modulates mitochondrial iron-sulfur cluster assembly to facilitate mitochondrial respiration and function,which is required for ***,iTBS rescues cognitive decline and attenuates AD-type pathologies in APP/PS1 *** present study uncovers a novel mechanism by which iTBS modulates mitochondrial respiration and function via ISCA1-mediated iron-sulfur cluster assembly to alleviate cognitive impairments and pathologies in *** provide the mechanistic target of iTBS that warrants its therapeutic potential for AD patients.

关键词： Intermittent theta burst stimulation Alzheimer’s disease Iron-sulfur cluster assembly 1 Mitochondrial dysfunction Neurodegeneration

Activation of Dopamine D2 Receptors Alleviates Neuronal Hyperexcitability in the Lateral Entorhinal Cortex via Inhibition of HCN Current in a Rat Model of Chronic Inflammatory Pain

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Neuroscience Bulletin 2022年第9期38卷 1041-1056页

作者： shi-hao gao Yong Tao Yang Zhu hao Huang Lin-Lin Shen Chang-Yue gao Department of Rehabilitation Daping HospitalArmy Medical UniversityChongqing400042China Department of Respiratory and Critical Care Medicine Xinqiao HospitalArmy Medical UniversityChongqing400037China Army 953 Hospital Army Medical UniversityShigatse857000China

Functional changes in synaptic transmission from the lateral entorhinal cortex to the dentate gyrus(LEC-DG)are considered responsible for the chronification of ***,the underlying alterations in fan cells,which are the predominant neurons in the LEC that project to the DG,remain ***,we investigated possible mechanisms using a rat model of complete Freund’s adjuvant(CFA)-induced inflammatory *** found a substantial increase in hyperpolarization-activated/cyclic nucleotide-gated currents(Ih),which led to the hyperexcitability of LEC fan cells of CFA *** phenomenon was attenuated in CFA slices by activating dopamine D2,but not D1,*** activation of the ventral tegmental area-LEC projection had a D2 receptor-dependent analgesic ***-LEC microinjection of a D2 receptor agonist also suppressed CFA-induced behavioral hypersensitivity,and this effect was attenuated by pre-activation of the *** findings suggest that down-regulating the excitability of LEC fan cells through activation of the dopamine D2 receptor may be a strategy for treating chronic inflammatory pain.

关键词： Inflammatory pain Lateral entorhinal cortex Neuronal hyperexcitability Dopamine D2 receptor HCN current

Influence of sintering time on microstructure and properties of hot oscillatory pressing sintered W–Cu refractory alloys

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Tungsten 2024年第2期6卷 323-332页

作者： Zi-Qian Wu Wei Zhao Ka gao shi-hao Du Qing-Quan Kong De-Jian Sun Yang gao School of Materials Science and Engineering Zhengzhou University of AeronauticsZhengzhou 450015China School of Mechanical Engineering University of Shanghai for Science and TechnologyShanghai 200093China Department of General Medicine Changhai HospitalShanghai 200000China Hubei Key Laboratory of Mechanical Transmission and Manufacturing Engineering Wuhan University of Science and TechnologyWuhan 430081China Sichuan Province Engineering Technology Research Center of Powder Metallurgy Chengdu UniversityChengdu 610106China

W–Cu refractory alloys are widely used in aerospace,aviation,electronics,power,and other fi ***,because of its large melting point diff erence between alloy elements,the conventional powder metallurgy method required a long time of high temperature sintering is very likely to cause low density and abnormal grain size ***,90W-10Cu refractory alloys were successfully prepared by hot oscillatory pressing(HOP)under diff erent sintering time in this *** the infl uence of sintering time on the microstructure,grain size,density,Vickers hardness,room-tensile property,and electrical conductivity of the W–Cu refractory alloy was systematically *** results showed that during the short sintering time(30–90 min),the density,Vickers hardness,tensile strength,and electrical conductivity of the W–Cu refractory alloy increased signifi cantly to 98.7%,163.29 HV 30,507.3 MPa,and 14.2%International Annealed Copper Standard with the sintering time increasing,respectively,while its grain size showed no obvious *** the sintering time further increased to 120 min,the density was basically consistent with the sintering time of 90 ***,the prolonged high temperature sintering resulted in the grain growth of the samples,which caused the deterioration of the Vickers hardness,room-tensile strength,and conductivity properties of the W–Cu refractory *** the same sintering time,the density,Vickers hardness,and electrical conductivity of the HOP sintered W–Cu refractory alloy were signifi cantly higher than those of the HP sintered *** was indicated that high density,fi ne-grain,and excellent properties W–Cu refractory alloys could be prepared by hot oscillatory pressing under appropriate sintering time.

关键词： W–Cu refractory alloy Hot oscillatory pressing Sintering time Microstructure Property

A compact X-band backward traveling-wave accelerating structure

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Nuclear Science and Techniques 2024年第5期35卷 13-29页

作者： Xian-Cai Lin hao Zha Jia-Ru shi Qiang gao Fang-Jun Hu Qing-Zhu Li Huai-Bi Chen Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Particle and Radiation Imaging(Tsinghua University) Ministry of EducationBeijing 100084China

Very high-energy electrons(VHEEs)are potential candidates for FLASH radiotherapy for deep-seated *** proposed a compact VHEE facility based on an X-band high-gradient high-power *** this study,we investigated and realized the first X-band backward traveling-wave(BTW)accelerating structure as the buncher for a VHEE facility.A method for calculating the parameters of single cell from the field distribution was introduced to simplify the design of the BTW ***-domain circuit equations were applied to calculate the transient beam parameters of the buncher in the unsteady state.A prototype of the BTW structure with a thermionic cathode-diode electron gun was designed,fabricated,and tested at high power at the Tsinghua X-band high-power test *** structure successfully operated with 5-MW microwave pulses from the pulse compressor and outputted electron bunches with an energy of 8 MeV and a pulsed current of 108 mA.

关键词： Backward traveling-wave accelerating structure Equivalent circuit model High-power test Very high-energy electron radiotherapy

A Hf-doped dual-phase high-entropy alloy: phase evolution and wear features

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Rare Metals 2024年第1期43卷 324-333页

作者： hao Ren Rui-Run Chen Xue-Feng gao Tong Liu Gang Qin Yu-Lung Chiu shi-Ping Wu Jing-Jie Guo National Key Laboratory for Precision Hot Processing of Metals School of Materials Science and EngineeringHarbin Institute of TechnologyHarbin 150001China School of Metallurgy and Materials University of BirminghamEdgbastonBirmingham B152TTUK

Initially defined high entropy alloys(HEAs)usually exhibit a single-phase solid-solution ***,two and/or more types of phases in HE As possibly induce the desired microstructure features,which contribute to improving the wear properties of HE ***,we prepare a series of(AlCoCrFeNi)_(100-x)Hf_(x)(x=0,2,4and 6;at%) HEAs and concern their phase compositions,micro structures and wear *** leads to the formation of(Ni,Co)_(2)Hf-type Laves phase and tailors the microstructure from a body-centered cubic(BCC) singlephase structure to a hypoeutectic *** increased hardness from~HV 512.3 to~HV 734.1 is due to solid-solution strengthening,grain refinement strengthening and precipitated phase *** a few oxides(Al_(2)O_(3)+Cr_(2)O_(3)) caused by the wear heating contribute to an 85.5% decrease in wear rate of the HEA system from6.71×10^(-5) to 0.97×10^(-5) m^(3)·N^(-1)·m^(-1).In addition,Hf addition changes the wear mechanism from abrasive wear,mild oxidative wear and adhesive wear to oxidative wear and adhesive wear.

关键词： High entropy alloy Laves phase Hardness Wear mechanism

Introduction of rare-earth element Sc in alloy design to modify wear features of dual-phase high-entropy alloy

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Rare Metals 2024年第2期43卷 817-828页

作者： hao Ren Rui-Run Chen Xue-Feng gao Tong Liu Gang Qin Yu-Lung Chiu shi-Ping Wu Jing-Jie Guo Guo National Key Laboratory for Precision Hot Processing of Metals School of Materials Science and EngineeringHarbin Institute of TechnologyHarbin150001China School of Metallurgy and Materials University of BirminghamBirminghamB152TTUK

Tailoring the alloy composition,which induces the hard secondary phase to increase hardness and strength to improve the wear features,is a feasible approach for developing wear-resistant metal ***,a group of(AlCoCrFeNi)_(100–x)Sc_(x)(x=0–2.0,at%)high-entropy alloys(HEAs)are designed and the phase compositions and wear behaviors are ***-doped HEA series contain the primary body-centered cubic(BCC)and eutectic phases,in which the eutectic phase is composed of the alternately grown BCC and Laves *** addition promotes the diffusion of Ni atoms from BCC phase to form the Sc-rich Laves phase at the grain *** hardness increases due to solid solution strengthening and second phase *** the second phase strengthening plays a more significant role relative to solid solution *** phase and the oxides caused by wear heating prevent the direct contact between friction pair and HEAs,thus inducing a decreased wear rate from 6.82×10^(−5) to 3.47×10^(−5)m^(3)·N^(−1)·m^(−1).Moreover,the wear mechanism changes from adhesive wear,abrasive wear and oxidative wear to abrasive wear and oxidative wear.

关键词： High entropy alloy(HEA) Laves phase Hardness Wear mechanism

Study of the multi-physics field-coupled model of the two-stage electrostatic precipitator

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Building Simulation 2024年第3期17卷 387-398页

作者： Wenjia hao Yu Guo Yukun Wang Tao Yu hao gao Zhengwei Long Tianjin Key Laboratory of Indoor Air Environmental Quality Control School of Environmental Science and EngineeringTianjin UniversityWeijin Road 92Tianjin300072China Wuhan Second ship Design and Research Institute WuhanChin

The two-stage electrostatic precipitator is widely used to purify oil mist ***,there is limited research on the influences of relative humidity,particle deposition characteristics,and the generation of gaseous ***,this paper established a numerical model of the electrostatic oil mist purifier and applied it to a two-stage electrostatic *** the model was used to investigate the corona discharge characteristics under different relative humidity conditions in the charged zone,the particle deposition characteristics,the purification efficiency,the ozone concentration distribution,and the oil vapor concentration distribution in the collection *** results indicate that,with a constant temperature,the corona current decreases as relative humidity increase,and there is a quadratic relationship between relative humidity and *** variation in relative humidity has little impact on the purification *** maximum ozone concentration occurs near the electrode line,and its concentration is influenced by the discharge current and inlet airflow *** oil vapor concentration reaches its maximum value at the side plates,with a value of 19 ppb,while it reaches the minimum value at the collecting zone electrode plate,with a value of 2 *** temperature is the main factor affecting the volatilization of the oil film,with higher temperatures resulting in higher oil vapor.

关键词： two-stage ESPs particle deposition corona discharge oil vapor

Advancements in machine learning for material design and process optimization in the field of additive manufacturing

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China Foundry 2024年第2期21卷 101-115页

作者： hao-ran Zhou hao Yang Huai-qian Li Ying-chun Ma Sen Yu Jian shi Jing-chang Cheng Peng gao Bo Yu Zhi-quan Miao Yan-peng Wei National Key Laboratory of Advanced Casting Technologies Shenyang Research Institute of Foundry Co.Ltd.CAMShenyang 110022China Department of Mechanical Engineering Tsinghua UniversityBeijing 100084China Key Laboratory of Space Physics Beijing 100076China School of Materials Science and Engineering Nanyang Technological University639798Singapore

Additive manufacturing technology is highly regarded due to its advantages,such as high precision and the ability to address complex geometric ***,the development of additive manufacturing process is constrained by issues like unclear fundamental principles,complex experimental cycles,and high *** learning,as a novel artificial intelligence technology,has the potential to deeply engage in the development of additive manufacturing process,assisting engineers in learning and developing new *** paper provides a comprehensive overview of the research and applications of machine learning in the field of additive manufacturing,particularly in model design and process ***,it introduces the background and significance of machine learning-assisted design in additive manufacturing *** then further delves into the application of machine learning in additive manufacturing,focusing on model design and process ***,it concludes by summarizing and forecasting the development trends of machine learning technology in the field of additive manufacturing.

关键词： additive manufacturing machine learning material design process optimization intersection of disciplines embedded machine learning

An Improved Thermal Conductivity Measurement Scheme for Macroscopic Graphitic Films Using the Laser Flash Method

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Journal of Thermal Science 2024年第4期33卷 1480-1490页

作者： ZHANG Peijuan MING Xin LIU Yingjun WANG Xuelong shi Hang hao Yuanyuan LU Jiahao LIU Zheng LAI Haiwen ZHANG Ying gao Weiwei XU Zhen gao Chao MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringKey Laboratory of Adsorption and Separation Materials&Technologies of Zhejiang ProvinceZhejiang UniversityHangzhou310027China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan030032China Special Equipment Safety Supervision and Inspection Institute of Jiangsu Province National Graphene Products Quality Inspection and Testing Center(Jiangsu)Wuxi214174China Hangzhou gaoxi Technol Co. LtdHangzhou311113China China Academy of Aerospace Aerodynamics Beijing100074China

Achieving efficient thermal management urges to exploit high-thermal-conductivity materials to satisfy the boosted demand of heat *** is critical to adopt standardized characterization protocols to evaluate the intrinsic thermal conductivity of thermal management ***,for the most representative laser flash method,the lack of standard measurement methodology and systematic description on the thermal diffusivity and influencing factors has led to significant deviations and confusion of the thermal conduction performance in the emerging thermal management ***,the measurement error factors of thermal diffusivity by the common laser flash analyzer(LFA)are *** high-thermal-conductivity graphitic film(GF)as a typical case,the key factors are analyzed to guide the measurement protocol of related carbon-based thermal management *** basic principle of the LFA measurement,actual pre-processing conditions,instrument parameters setting,and data analysis are elaborated for accurate ***,the graphene thick films and common isotropic materials are also extended to meet various thermal measurement *** on the existing practical problems,we propose a feasible test flow to achieve a unified and standardized thermal conductivity measurement,which is beneficial to the rapid development of carbon-based thermal management materials.

关键词： thermal management graphitic film laser flash method thermal conductivity thermal diffusivity

Generating diverse clothed 3D human animations via a generative model

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Computational Visual Media 2024年第2期10卷 261-277页

作者： Min shi Wenke Feng Lin gao Dengming Zhu School of Control and Computer Engineering North China Electric Power UniversityBeijing 102206China Institute of Computing Technology Chinese Academy of SciencesBeijing 100190China

Data-driven garment animation is a current topic of interest in the computer graphics *** approaches generally establish the mapping between a single human pose or a temporal pose sequence,and garment deformation,but it is difficult to quickly generate diverse clothed human *** address this problem with a method to automatically synthesize dressed human animations with temporal consistency from a specified human motion *** the heart of our method is a twostage ***,we first learn a latent space encoding the sequence-level distribution of human motions utilizing a transformer-based conditional variational autoencoder(Transformer-CVAE).Then a garment simulator synthesizes dynamic garment shapes using a transformer encoder-decoder *** the learned latent space comes from varied human motions,our method can generate a variety of styles of motions given a specific motion *** means of a novel beginning of sequence(BOS)learning strategy and a self-supervised refinement procedure,our garment simulator is capable of efficiently synthesizing garment deformation sequences corresponding to the generated human motions while maintaining temporal and spatial *** verify our ideas *** is the first generative model that directly dresses human animation.

关键词： Transformer garment animation conditional variational autoencoder(CVAE) computer graphics