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Microvascular structural changes in esophageal squamous cell carcinoma pathology according to intrapapillary capillary loop types under magnifying endoscopy

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3471-3480页

作者： Wei-Yang Shu Yan-Yan shi Jiu-Tian Huang Ling-Mei Meng He-Jun Zhang Rong-Li Cui Yuan Li shi-gang ding Department of Gastroenterology Peking University Third HospitalBeijing 100191China Research Center of Clinical Epidemiology Peking University Third HospitalBeijing 10019China Department of Gastroenterology Pathology Laboratory Peking University Third HospitalBeijing 100191China Department of Gastroenterology Peking University International HospitalBeijing 102206China

BACKGROUND The intrapapillary capillary loop(IPCL)characteristics,visualized using magnifying endoscopy,are commonly assessed for preoperative evaluation of the infiltration depth of esophageal squamous cell carcinoma(ESCC).Japan Esophageal Society(JES)classification is the most widely used *** structural changes are evaluated by magnifying endoscopy for the presence or absence of each morphological factor:tortuosity,dilatation,irregular caliber,and different ***,the pathological characteristics of IPCLs have not been thoroughly investigated,especially the microvascular structures corresponding to the deepest parts of the lesions'*** To investigate differences in pathological microvascular structures of ESCC,which correspond to the deepest parts of the lesions'*** Patients with ESCC and precancerous lesions diagnosed at Peking University Third Hospital were enrolled between January 2019 and April *** first underwent magnified endoscopic examination,followed by endoscopic submucosal dissection or surgical *** images were scanned using a threedimensional slice scanner,and the pathological structural differences in different types,according to the JES classification,were analyzed using nonparametric tests and *** The 35 lesions were divided into four groups according to the JES classification:A,B1,B2,and *** analyses revealed significant differences(aP0.05).However,significant differences in the short calibers,long calibers,and area of IPCL were observed between types B1 and B3(aP0.05).CONCLUSION Pathological structures of IPCLs in the deepest infiltrating regions differ among va

关键词： Esophageal squamous cell carcinoma Intrapapillary capillary loop The Japan Esophageal Society classification Magnifying endoscopy Pathological characteristics

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Clinical manifestation,lifestyle,and treatment patterns of chronic erosive gastritis:A multicenter real-world study in China

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World Journal of Gastroenterology 2024年第9期30卷 1108-1120页

作者： Ying-Yun Yang Ke-Min Li Gui-Fang Xu Cheng-Dang Wang Hua Xiong Xiao-Zhong Wang Chun-Hui Wang Bing-Yong Zhang Hai-Xing Jiang Jing Sun Yan Xu Li-Juan Zhang Hao-Xuan Zheng Xiang-Bin Xing Liang-Jing Wang Xiu-Li Zuo shi-gang ding Rong Lin Chun-Xiao Chen Xing-Wei Wang Jing-Nan Li Department of Gastroenterology Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100730China Department of Gastroenterology Nanjing Drum Tower HospitalNanjing 21000Jiangsu ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005Fujian ProvinceChina Department of Gastroenterology Renji HospitalShanghai 200127China Department of Gastroenterology Union Hospital of Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina Department of Gastroenterology West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Gastroenterology and Hepatology The People’s Hospital of Zhengzhou UniversityThe Henan Provincial People’s HospitalZhengzhou 450003Henan ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai Jiao Tong UnivesrityRuijin HospitalSchool MedicineShanghai 200025China Department of Gastroenterology and Hepatology China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina Department of Gastroenterology Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina Department of Gastroenterology Nanfang HospitalGuangzhou 510080Guangdong ProvinceChina Department of Gastroenterology The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina Department of Gastroenterology The Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Gastroenterology Shandong University Qilu HospitalJinan 250012Shandong ProvinceChina Department of Gastroenterology Peking University Third HospitalBeijing 100191China Department of Gastroenterology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei Pr

BACKGROUND Although chronic erosive gastritis(CEG)is common,its clinical characteristics have not been fully *** lack of consensus regarding its treatment has resulted in varied treatment *** To explore the clinical characteristics,treatment patterns,and short-term outcomes in CEG patients in *** We recruited patients with chronic non-atrophic or mild-to-moderate atrophic gastritis with erosion based on endoscopy and *** and treating physicians completed a questionnaire regarding history,endoscopic findings,and treatment plans as well as a follow-up questionnaire to investigate changes in symptoms after 4 wk of *** Three thousand five hundred sixty-three patients from 42 centers across 24 cities in China were *** pain(68.0%),abdominal distension(62.6%),and postprandial fullness(47.5%)were the most common presenting *** was classified as chronic non-atrophic in 69.9%of *** those with erosive lesions,72.1%of patients had lesions in the antrum,51.0%had multiple lesions,and 67.3%had superficial flat *** patients with epigastric pain,the combination of a mucosal protective agent(MPA)and proton pump inhibitor was more *** those with postprandial fullness,acid regurgitation,early satiety,or nausea,a MPA appeared more *** CEG is a multifactorial disease which is common in Asian patients and has non-specific *** may play a major role in its detection and *** should be individualized based on symptom profile.

关键词： Chronic erosive gastritis Symptom Endoscopic findings Treatment pattern Real-world

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Microbiome changes in the gastric mucosa and gastric juice in different histological stages of Helicobacter pylori-negative gastric cancers

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World Journal of Gastroenterology 2022年第3期28卷 365-380页

作者： Qing-Hua Sun Jing Zhang Yan-Yan shi Jing Zhang Wei-Wei Fu shi-gang ding Department of Gastroenterology Peking University Third HospitalBeijing 100191China Research Center of Clinical Epidemiology Peking University Third HospitalBeijing 10019China

BACKGROUND The gastric microbiota in patients with gastric cancer(GC)has received increasing attention,but the profiling of the gastric microbiome through the histological stages of gastric tumorigenesis remains poorly understood,especially for patients with Helicobacter pylori-negative GC(HPNGC).AIM To characterize microbial profiles of gastric mucosa and juice for HPNGC carcinogenesis and identify distinct taxa in precancerous *** The 16S rRNA gene analysis was performed on gastric mucosa from 134 Helicobacter pylori-negative cases,including 56 superficial gastritis(SG),9 atrophic gastritis(AG),27 intestinal metaplasia(IM),29 dysplasia(Dys),and 13 GC cases,to investigate differences in gastric microbial diversity and composition across the disease *** addition,paired gastric mucosa and juice samples from 18 SG,18 IM,and 18 Dys samples were analyzed.α-Diversity was measured by Shannon and Chao1 indexes,andβ-diversity was calculated using partial least squares discrimination analysis(PLS-DA).Differences in the microbial composition across disease stages in different sample types were assessed using the linear discriminant analysis effect *** The diversity and composition of the bacterial microbiota in the gastric mucosa changed progressively across stages of gastric *** diversity of the gastric mucosa microbiota was found to be significantly lower in the IM and Dys groups than in the SG group,and the patients with GC had the lowest bacterial community richness(P<0.05).Patients with IM and those with Dys had similar gastric mucosa microbiota profiles with Ralstonia and Rhodococcus as the predominant *** network analysis showed that there was increasing correlation strength between IM and Dys(|correlation threshold|≥0.5,P<0.05).GC and its precancerous lesions have distinguishable bacterial taxa;our results identified HPNGC-associated bacteria Streptococcaceae and Lactobacillaceae(P<0.05).Additionally,across precan

关键词： Gastric mucosa Gastric juice Microbiota Stomach neoplasms Histological stages 16s RNA gene sequencing

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Large magnetostriction of Nd_(0.2)Tb_(0.3)Dy_(0.5)Fe_(1.93)/epoxy composites in a wide temperature range

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Journal of Rare Earths 2024年第4期42卷 705-709页

作者： Hehe ding Yangguang shi Shaolong Tang MIIT Key Laboratory of Aerospace Information Materials and Physics Department of Applied PhysicsNanjing University of Aeronautics and AstronauticsNanjing210016China National Laboratory of Solid State Microstructures Nanjing UniversityNanjing210093China

We report the magnetostrictive performance of the Nd_(0.2)Tb_(0.3)Dy_(0.5)Fe_(1.93)/epoxy *** of M?ssbauer spectra and the XRD results indicate that the easy magnetic direction of the Nd_(0.2)Tb_(0.3)Dy_(0.5)Fe_(1.93)compound is alongdirection with spontaneous magnetostrictionλ111 of1900 ***-oriented Nd_(0.2)Tb_(0.3)Dy_(0.5)Fe_(1.93)/epoxy composites with particle volume fractions of20 vol%-55 vol%were *** measurements demonstrate that the composite is highly *** raw material cost of Nd_(0.2)Tb_(0.3)Dy_(0.5)Fe_(1.93)is about 85%of that of the Terfenol-D(Tb_(0.3)Dy_(0.7)Fe_(2))***_(0.2)Tb_(0.3)Dy_(0.5)Fe_(1.93)/epoxy composites possess comparable magnetostriction with those composites made of Tb_(0.3)Dy_(0.7)Fe_(2)*** room temperature,the magnetostrictionλ_Ⅱof the Nd_(0.2)Tb_(0.3)Dy_(0.5)Fe_(1.93)/epoxy composite reaches 420 ppm at a low field of 80 kA/m and about1000 ppm at 239 kA/*** addition,the composite exhibits a large saturation magnetostrictionλ_Ⅱover1200 ppm from 300 to 100 K,suggesting its potential applications as a low-cost magnetostrictive material in a wide temperature ***,the current study offers an opportunity to widen the operating temperature range of the magnetostrictive composite.

关键词： Magnetostrictive composite Nd_(0.2)Tb_(0.3)Dy_(0.5)Fe_(1.93) Wide temperaturerange Laves phase Rare earths

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Effects of surface energy and substrate on modulus determination of biological films by conical indentation

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Science China(Technological Sciences) 2024年第6期67卷 1757-1764页

作者： ding Yue LI Cheng-Ya NIU XinRui WANG gang-Feng Department of Engineering Mechanics SVLXi’an Jiaotong UniversityXi’an710049China Department of Mechanical Engineering City University of Hong KongHong Kong SAR999077China

Micro-/nano-indentation has become prevalent in evaluating the mechanical characteristics of biological samples,such as cells and ***,the existing contact models describing conical indentation ignore the joint effects of surface energy and substrate,and consequently cannot accurately extract the Young's modulus of biological samples deposited on *** finite element methods,we examine the conical indentation of biological films on substrates while taking surface energy into *** on the dimensional analysis,the explicit relationship between load and indentation depth is achieved for films with their moduli varying from 0.001 to 100 times that of the *** the classical Sneddon's model was employed to analyze the load-depth data,the measured modulus could reach 18 times the real modulus for films on harder substrates,but only 4%of the real modulus for films on softer ***,in micro-/nano-indentations,neglecting the contribution of surface energy would result in an overestimation of the Young's modulus of films depending on the contact *** analytical expression provided here can be utilized to precisely deduce the mechanical characteristics of biological films deposited on substrate from the load and indentation depth data of a conical indentation.

关键词： biological film surface effect substrate effect indentation

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Designing ultrastrong and thermally stable FeCrAl alloys with the fine-grained structure

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Journal of Materials Science & Technology 2024年第4期171卷 198-208页

作者： Shuaiyang Liu Jinyu Zhang Hui Wang gang Liu Xiangdong ding Jun Sun State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an 710049China Science and Technology on Reactor Fuel and Materials Laboratory Nuclear Power Institute of ChinaChengdu 610041China

Designing microstructurally stable FeCrAl alloys with excellent strength-ductility synergy is highly desir-able for their engineering ***,due to the preference nucleation of precipitates at grain boundaries(GBs),the improved precipitation strengthening of these alloys is usually accompanied by in-tergranular ***,we propose a novel thermomechanical processing route coupled with the Si alloying strategy via precipitation of coherent deformable Laves precipitates inside equiaxed fine-grains to achieve FeCrAl alloys with ultrahigh yield strength over∼992 MPa,excellent uniform elongation of∼7.6%at room temperature,and superior thermal stability at temperature∼1200℃.The Si alloying not only decreases the stacking fault energy of Laves precipitates favorable for their stacking-fault-mediated deformation but also hinders grain coarsening at 1200℃due to the Si-enrichment favorable for GB pin-ning *** results prove the possibility of achieving the collaborative enhancement of mutually exclusive properties in alloys,such as strength-ductility-thermal stability via nanoprecipitation engineer-ing,and offer a promising route to prepare dispersion-strengthened materials.

关键词： FeCrAl alloys Si alloying Mechanical properties Thermal stability Laves phase

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Stability of the Phase Separation State for Compressible Navier-Stokes/Allen-Cahn System

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Acta Mathematicae Applicatae Sinica 2024年第1期40卷 45-74页

作者： Ya-zhou Chen Hakho Hong Xiao-ding shi Department of Mathematics College of Mathematics and PhysicsBeijing University of Chemical TechnologyBeijing100029China Institute of Mathematics State Academy of SciencesPyongyangKorea

This paper is concerned with the large time behavior of the Cauchy problem for Navier-Stokes/AllenCahn system describing the interface motion of immiscible two-phase flow in 3-D. The existence and uniqueness of global solutions and the stability of the phase separation state are proved under the small initial perturbations. Moreover, the optimal time decay rates are obtained for higher-order spatial derivatives of density,velocity and phase. Our results imply that if the immiscible two-phase flow is initially located near the phase separation state, then under small perturbation conditions, the solution exists globally and decays algebraically to the complete separation state of the two-phase flow, that is, there will be no interface fracture, vacuum, shock wave, mass concentration at any time, and the interface thickness tends to zero as the time t → +∞.

关键词： Navier-Stokes/Allen-Cahn system existence uniqueness large time behavior decay rate

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Chord length sampling correction analysis for dispersion fuel in Monte Carlo simulation

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Nuclear Science and Techniques 2024年第4期35卷 57-64页

作者： Zhao-Yu Liang ding She Yu-Tong Wen Lei shi Institute of Nuclear and New Energy Technology(INET) Key Laboratory of Advanced Reactor Engineering and Safety of Ministry of EducationTsinghua UniversityBeijing 100084China

Dispersion fuels,knowned for their excellent safety performance,are widely used in advanced reactors,such as hightemperature gas-cooled *** with deterministic methods,the Monte Carlo method has more advantages in the geometric modeling of stochastic *** explicit modeling method has high computational accuracy and high computational *** chord length sampling(CLS)method can improve computational efficiency by sampling the chord length during neutron transport using the matrix chord length?s probability density *** study shows that the excluded-volume effect in realistic stochastic media can introduce certain deviations into the CLS.A chord length correction approach is proposed to obtain the chord length correction factor by developing the Particle code based on equivalent transmission *** numerical analysis against reference solutions from explicit modeling in the RMC code,it was demonstrated that CLS with the proposed correction method provides good accuracy for addressing the excludedvolume effect in realistic infinite stochastic media.

关键词： Stochastic media Monte Carlo Chord length sampling Excluded-volume effect Chord length correction

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The unimodal latitudinal pattern of K,Ca and Mg concentration and its potential drivers in forest foliage in eastern China

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Forest Ecosystems 2024年第3期11卷 318-328页

作者： Zhijuan shi Sining Liu Yahan Chen Dongdong ding Wenxuan Han Key Laboratory of Plant-Soil Interactions Ministry of EducationCollege of Resources and Environmental SciencesChina Agricultural UniversityBeijing100193China Forestry Ecological Engineering in the Upper Reaches of the Yangtze River Key Laboratory of Sichuan Province&National Forestry and Grassland Administration Key Laboratory of Forest Resources Conservation and Ecological Safety on the Upper Reaches of the Yangtze River College of ForestrySichuan Agricultural UniversityChengdu611130China Institute of Botany Chinese Academy of SciencesBeijing100093China

Potassium(K),calcium(Ca),and magnesium(Mg)are essential elements with important physiological functions in *** studies showed that leaf K,Ca,and Mg concentrations generally increase with increasing ***,recent meta-analyses suggested the possibility of a unimodal pattern in the concentrations of these elements along latitudinal *** authenticity of this unimodal latitudinal pattern,however,requires validation through large-scale field experimental data,and exploration of the underlying mechanisms if the pattern is ***,we collected leaves of common species of woody plants from 19 montane forests in the north-south transect of eastern China,including 322 species from 160 genera,67 families;and then determined leaf K,Ca,and Mg concentrations to explore their latitudinal patterns and driving *** results support unimodal latitudinal patterns for all three elements in woody plants across eastern China,with peak values at latitude 36.5±1.0°*** shift of plant-functional-type compositions from evergreen broadleaves to deciduous broadleaves and to conifers along this latitudinal span was the key factor contributing to these *** factors,mainly temperature,and to a lesser extent solar radiation and precipitation,were the main environmental *** factors,by altering the composition of plant communities and regulating plant physiological activities,influence the latitudinal patterns of plant nutrient *** findings also suggest that high leaf K,Ca,and Mg concentrations may represent an adaptive strategy for plants to withstand water stress,which might be used to predict plant nutrient responses to climate changes at large scales,and broaden the understanding of biogeochemical cycling of K,Ca,and Mg.

关键词： Potassium Calcium Magnesium Mid-latitudes Latitudinal pattern Plant functional type Water stress Woody plant

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Winter Wheat Yield Estimation Based on Sparrow Search Algorithm Combined with Random Forest:A Case Study in Henan Province,China

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Chinese Geographical Science 2024年第2期34卷 342-356页

作者： shi Xiaoliang CHEN Jiajun ding Hao YANG Yuanqi ZHANG Yan College of Geomatics Xi’an University of Science and TechnologyXi’an 710054China

Precise and timely prediction of crop yields is crucial for food security and the development of agricultural ***,crop yield is influenced by multiple factors within complex growth *** research has paid relatively little attention to the interference of environmental factors and drought on the growth of winter ***,there is an urgent need for more effective methods to explore the inherent relationship between these factors and crop yield,making precise yield prediction increasingly *** study was based on four type of indicators including meteorological,crop growth status,environmental,and drought index,from October 2003 to June 2019 in Henan Province as the basic data for predicting winter wheat *** the sparrow search al-gorithm combined with random forest(SSA-RF)under different input indicators,accuracy of winter wheat yield estimation was *** estimation accuracy of SSA-RF was compared with partial least squares regression(PLSR),extreme gradient boosting(XG-Boost),and random forest(RF)***,the determined optimal yield estimation method was used to predict winter wheat yield in three typical *** are the findings:1)the SSA-RF demonstrates superior performance in estimating winter wheat yield compared to other *** best yield estimation method is achieved by four types indicators’composition with SSA-RF)(R^(2)=0.805,RRMSE=9.9%.2)Crops growth status and environmental indicators play significant roles in wheat yield estimation,accounting for 46%and 22%of the yield importance among all indicators,respectively.3)Selecting indicators from October to April of the follow-ing year yielded the highest accuracy in winter wheat yield estimation,with an R^(2)of 0.826 and an RMSE of 9.0%.Yield estimates can be completed two months before the winter wheat harvest in June.4)The predicted performance will be slightly affected by severe *** with severe drought year(201

关键词： winter wheat yield estimation sparrow search algorithm combined with random forest(SSA-RF) machine learning multi-source indicator optimal lead time Henan Province,China

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