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Longitudinal associations of cardiovascular health and vascular events with incident dementia

Stroke & Vascular Neurology 2024年第4期9卷 418-428,I0066-I0130页

作者： Ya-Nan Ou Kevin Kuo Liu Yang Ya-Ru Zhang Shu-Yi Huang shi-dong chen Yue-Ting Deng Yu Guo Rui-Qi Zhang Bang-Sheng Wu Lan Tan Qiang dong Jian-Feng Feng Wei cheng Jin-Tai Yu Department of Neurology Qingdao Municipal HospitalQingdao UniversityQingdaoShandongPeople's Republic of China Department of Neurology and National Center for Neurological Disorders Huashan HospitalState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain ScienceShanghai Medical CollegeFudan UniversityShanghaiPeople's Republic of China Institute of Science and Technology for Brain-inspired Intelligence Fudan UniversityShanghaiPeople's Republic of China Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence Fudan UniversityMinistry of EducationShanghaiPeople's Republic of China

Introduction Evidence supporting cardiovascular diseases could increase the risk of dementia remains fragmented.A comprehensive study to illuminate the distinctive associations across different dementia types is still *** study is sought to:(1)determine the clinical validity of Framingham General Cardiovascular Risk Score(FGCRS)for dementia assessment and(2)examine the associations between cardiovascular diseases and the risk of *** A total of 432079 dementia-free individuals at baseline from UK Biobank were *** Cox proportional hazard models were used to investigate the prospective associations for FGCRS and a series of cardiovascular diseases with all-cause dementia(ACD)and its major components,Alzheimer’s disease(AD)and vascular dementia(VaD).Results During a median follow-up of 110.1 months,4711 individuals were diagnosed with *** was associated with increased risks across the dementia *** stratification analysis,high-risk groups have demonstrated the greatest dementia burdens,particularly to *** 74 traits,9 adverse associations,such as chronic ischaemic heart disease(ACD:HR=1.354;AD:HR=1.269;VaD:HR=1.768),atrioventricular block(ACD:HR=1.562;AD:HR=1.556;VaD:HR=2.069),heart failure(ACD:HR=1.639;AD:HR=1.543;VaD:HR=2.141)and hypotension(ACD:HR=2.912;AD:HR=2.361;VaD:HR=3.315)were *** distinctions were also found,with atrial fibrillation,cerebral infarction,and haemorrhage only associated with greater risks of ACD and *** By identifying distinctive associations between cardiovascular diseases and dementia,this study has established a comprehensive‘mapping’that may untangle the long-standing *** has demonstrated its predictivity beyond cardiovascular diseases burdens,suggesting potential opportunities for implantation.

关键词： cardiovascular diseases supporting

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UNSTEADY FLOW ANALYSIS AND EXPERIMENTAL INVESTIGATION OF AXIAL-FLOW PUMP

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Journal of Hydrodynamics 2010年第1期22卷 35-43页

作者： ZHANG De-sheng shi Wei-dong chen Bin GUAN Xing-fan Technical and Research Center of Fluid Machinery Engineering Jiangsu University Zhenjiang 212013 China

The three-dimensional unsteady turbulent flow in axial-flow pumps was simulated based on Navier-Stoke solver embedded with k - ε RNG turbulence model and SIMPLEC algorithm. Numerical results show that the unsteady prediction results are more accurate than the steady results, and the maximal error of unsteady prediction is only 4.54%. The time-domain spectrums show that the static pressure fluctuation curves at the inlet and outlet of the rotor and the outlet of the stator are periodic, and all have four peaks and four valleys. The pressure fluctuation amplitude increases from the hub to the tip at the inlet and outlet of the rotor, but decreases at the outlet of the stator. The pressure fluctuation amplitude is the greatest at the inlet of the rotor, and the average amplitude decreases sharply from the inlet to the outlet. The frequency spectrums obtained by Fast Fourier Transform （FFT） show that the dominant frequency is approximately equal to the blade passing frequency. The static pressure on the pressure side of hydrofoil on different stream surfaces remains almost consistent, and increases gradually from the blade inlet to the exit on the suction side at different time steps. The axial velocity distribution is periodic and is affected by the stator blade number at the rotor exit. The experimental results show that the flow is almost axial and the pre-rotation is very small at the rotor inlet under the conditions of 0.8 QN -1.2 QN Due to the clearance leakage, the pressure, circulation and meridional velocity at the rotor outlet all decrease near the hub leakage and tip clearance regions.

关键词： axial-flow pump unsteady flow pressure fluctuation high efficiency flow field measurement

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Dual metal ions/BNQDs boost PMS activation over copper tungstate photocatalyst for antibiotic removal:Intermediate,toxicity assessment and mechanism

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Journal of Materials Science & Technology 2024年第3期170卷 11-24页

作者： Ruyao chen Haiyue Zhang Yuming dong Haifeng shi School of Science Jiangnan UniversityWuxi214122China The Key Laboratory of Synthetic and Biological Colloids Ministry of EducationJiangnan UniversityWuxi214122China National Laboratory of Solid State Microstructures Nanjing UniversityNanjing210093China

In the metal-based peroxymonosulfate(PMS)activation process,the sluggish surface redox cycle of metal ions generally hampered the efficiency of PMS activation for pollutant ***,Codoped CuWO 4/BN quantum dots(CW/Co/BNQDs)photocatalysts were developed to realize Cu^(2+)/Cu+and Co^(2+)/Co^(3+)dual ions redox cycles for PMS activation,which would facilitate the tetracycline(TC)***/4Co/2BNQDs could degrade 94.8%TC within 30 min in PMS/Vis system,and the apparent rate constant of CW/4Co/2BNQDs was 2.7 times and 1.2 times higher than those of CW and CW/4Co,*** improved TC degradation performance could be attributed to the synergetic effect between BNQDs and dual redox cycles.X-ray photoelectron spectroscopy(XPS)spectra of samples before and after the reaction demonstrated that BNQDs were beneficial for accelerating the Cu^(2+)/Cu+and Co^(2+)/Co^(3+)redox cycles in CW/4Co/2BNQDs,further boosting the activation of PMS in TC *** of different radical scavengers revealed that the SO_(4)^(·−)/·OH/h+/^(1)O_(2)reactive species participated in the PMS activation for the TC degradation *** possible TC degradation pathway and intermediate toxicity were detailed *** addition,CW/4Co/2BNQDs exhibited outstanding photocatalytic activity over five consecutive cycles,which illustrated that it was supposed to be a reliable PMS activator over antibiotic elimination for practical *** this work shed new light on constructing dual redox cycles for efficient PMS activation.

关键词： Dual redox cycles Photocatalysis Peroxymonosulfate BN quantum dots Toxicity assessment

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Biomimetic MXene membranes with negatively thermo-responsive switchable 2D nanochannels for graded molecular sieving

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Green Energy & Environment 2024年第6期9卷 1058-1067页

作者： Yi Wang Yangyang Wang Chang Liu dongjian shi Weifu dong Baoliang Peng Liangliang dong Mingqing chen The Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxiJiangsu214122China International Research Center for Photo-responsive Molecules and Materials Jiangnan UniversityWuxiJiangsu214122China Research Institute of Petroleum Exploration&Development(RIPED) PetroChina/Key Laboratory of Oilfield ChemistryCNPCBeijing100083China

Negatively thermo-responsive 2D membranes,which mimic the stomatal opening/closing of plants,have drawn substantial interest for tunable molecular separation ***,these membranes are still restricted significantly on account of low water permeability and poor dynamic tunability of 2D nanochannels under temperature ***,we present a biomimetic negatively thermo-responsive MXene membrane by covalently grafting poly(N-isopropylacrylamide)(PNIPAm)onto MXene *** uniformly grafted PNIPAm polymer chains can enlarge the interlayer spacings for increasing water permeability while also allowing more tunability of 2D nanochannels for enhancing the capability of gradually separating multiple molecules of different *** expected,the constructed membrane exhibits ultrahigh water permeance of 95.6 L m^(-2) h^(-1) bar^(-1) at 25℃,which is eight-fold higher than the state-of-the-art negatively thermoresponsive 2D ***,the highly temperature-tunable 2D nanochannels enable the constructed membrane to perform excellent graded molecular sieving for dye-and antibiotic-based ternary *** strategy provides new perspectives in engineering smart 2D membrane and expands the scope of temperature-responsive membranes,showing promising applications in micro/nanofluidics and molecular separation.

关键词： Thermo-responsive 2D membrane MXene nanosheets PNIPAm Temperature-tunable 2D nanochannels Graded molecular sieving

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Quasi-normal modes,emission rate,and shadow of charged AdS black holes with perfect fluid dark matter

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Chinese Physics C 2024年第8期48卷 246-256页

作者： Hao chen shi-Hai dong Sepehr Hassanabadi Narges Heidari Hassan Hassanabadi School of Physics and Electronic Science Zunyi Normal UniversityZunyi 563006China Research Center for Quantum Physics Huzhou UniversityHuzhou 313000China Centro de Investigación en Computación Instituto Politécnico NacionalUPALMMexico City 07700Mexico Department of Physics University of TehranNorth Karegar AvenueTehran 14395-547Iran Faculty of Physics Shahrood University of TechnologyShahroodIran Department of Physics University of Hradec KrálovéRokitanského 6250003 Hradec KrálovéCzechia

In this study,we comprehensively investigated charged AdS black holes surrounded by a distinct form of dark *** particular,we focused on key elements including the Hawking temperature,quasi-normal modes(QNMs),emission rate,and *** first calculated the Hawking temperature,thereby identifying critical values such as the critical radius and maximum temperature of the black hole,essential for determining its phase *** analysis focused on the QNMs of charged AdS black holes immersed in perfect fluid dark matter(PFDM)within the massless scalar field *** the Wentzel-Kramers-Brillouin(WKB)method,we accurately derived the frequencies of these ***,we conducted a meticulous assessment of how the intensity of the PFDM parameterαinfluences the partial absorption cross sections of the black hole,along with a detailed study of the frequency variation of the energy emission *** pivotal role of geodesics in understanding astrophysical black hole characteristics is ***,we examined the influence of the dark matter parameter on photon evolution by computing the shadow radius of the black *** findings distinctly demonstrate the significant impact of the PFDM parameterαon the boundaries of this shadow,providing crucial insights into its features and *** also provide profound insights into the intricate dynamics between a charged AdS black hole,novel dark matter,and various physical phenomena,elucidating their interplay and contributing valuable knowledge to the understanding of these cosmic entities.

关键词： black hole dark matter quasi-normal modes greybody factor shadow radius

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Adaptive Space Expansion for Fast Motion Planning

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IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1499-1514页

作者： Shenglei shi Jiankui chen State Key Laboratory of Digital Manufacturing Equipment and Technology School of Mechanical Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

The sampling process is very inefficient for sam-pling-based motion planning algorithms that excess random sam-ples are generated in the planning *** this paper,we pro-pose an adaptive space expansion(ASE)approach which belongs to the informed sampling category to improve the sampling effi-ciency for quickly finding a feasible *** ASE method enlarges the search space gradually and restrains the sampling process in a sequence of small hyper-ellipsoid ring subsets to avoid exploring the unnecessary ***,for a con-structed small hyper-ellipsoid ring subset,if the algorithm cannot find a feasible path in it,then the subset is ***,the ASE method successively does space exploring and space expan-sion until the final path has been ***,we present a particular construction method of the hyper-ellipsoid ring that uniform random samples can be directly generated in *** last,we present a feasible motion planner BiASE and an asymptoti-cally optimal motion planner BiASE*using the bidirectional exploring method and the ASE *** demon-strate that the computation speed is much faster than that of the state-of-the-art *** source codes are available at https://***/shshlei/ompl.

关键词： Adaptive space expansion(ASE) hyper-ellipsoid ring informed sampling motion planning.

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Inverting the rock mass P-wave velocity field ahead of deep buried tunnel face while borehole drilling

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International Journal of Mining Science and Technology 2024年第5期34卷 681-697页

作者： Liu Liu Shaojun Li Minzong Zheng dong Wang Minghao chen Junbo Zhou Tingzhou Yan Zhenming shi State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan 430071China China Railway Eryuan Engineering Group CO. LTD.Chengdu 610031China Department of Hydraulic and Hydropower Engineering Tsinghua UniversityBeijing 100084China Hubei Communications Planning and Design Institute CO. LTD.Wuhan 430051China Key Laboratory of Geotechnical and Underground Engineering of Ministry of Education Tongji UniversityShanghai 200092China

Imaging the wave velocity field surrounding a borehole while drilling is a promising and urgently needed approach for extending the exploration range of the borehole *** paper develops a drilling process detection(DPD)system consisting of a multifunctional sensor and a pilot geophone installed at the top of the drilling rod,geophones at the tunnel face,a laser rangefinder,and an onsite computer.A weighted adjoint-state first arrival travel time tomography method is used to invert the P-wave velocity field of rock mass while borehole drilling.A field experiment in the ongoing construction of a deep buried tunnel in southwestern China demonstrated the DPD system and the tomography ***-frequency analysis of typical borehole drilling detection data shows that the impact drilling source is a pulse-like seismic exploration wavelet.A velocity field of the rock mass in a triangular area defined by the borehole trajectory and geophone receiving line can be *** the borehole core and optical image validate the inverted P-wave velocity field.A numerical simulation of a checkerboard benchmark model is used to test the tomography *** rapid convergence of the misfits and consistent agreement between the inverted and observed travel times validate the P-wave velocity imaging.

关键词： Deep buried tunnel Wave velocity field Borehole drilling Tomography Rock mass

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Novel modified min-sum decoding algorithm for low-density parity-check codes

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The Journal of China Universities of Posts and Telecommunications 2010年第4期17卷 1-5,46页

作者： LIU Hai-yang , QU Wen-ze, LIU Bin, LI Jiang-peng, LUO shi-dong, chen Jie Institute of Microelectronics, Chinese Academy of Sciences, Beijing 100029, China Institute of Microelectronics Chinese Academy of Sciences Beijing 100029 China

The problem of improving the performance of min-sum decoding of low-density parity-check （LDPC） codes is considered in this paper. Based on min-sum algorithm, a novel modified min-sum decoding algorithm for LDPC codes is proposed. The proposed algorithm modifies the variable node message in the iteration process by averaging the new message and previous message if their signs are different. Compared with the standard min-sum algorithm, the modification is achieved with only a small increase in complexity, but significantly improves decoding performance for both regular and irregular LDPC codes. Simulation results show that the performance of our modified decoding algorithm is very close to that of the standard sum-product algorithm for moderate length LDPC codes.

关键词： LDPC codes sum-product algorithm min-sum algorithm modified min-sum algorithm

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Computing Persistent Homology by Spanning Trees and Critical Simplices

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Research 2024年第2期2023卷 519-527页

作者： Dinghua shi Zhifeng chen Chuang Ma Guanrong chen Department of Mathematics Cllege of ScienceShanghai UniversityShanghaiChina School of Big Data Fuzhou University of International Studies and TradeFuzhouChina Department of Data Science and Big Data Technology School of InternetAnhui UniversityHefeiChina Department of Electrical Engineering City University of Hong KongHong KongChina

Topological data analysis can extract effective information from higher-dimensional *** mathematical basis is persistent *** persistent homology can calculate topological features at different spatiotemporal scales of the dataset,that is,establishing the integrated taxonomic relation among points,lines,and ***,the simplicial network composed of all-order simplices in a simplicial complex is *** the sequence of nested simplicial subnetworks can be regarded as a discrete Morse function from the simplicial network to real values,a method based on the concept of critical simplices can be developed by searching all-order spanning *** this new method,not only the Morse function values with the theoretical minimum number of critical simplices can be obtained,but also the Betti numbers and composition of all-order cavities in the simplicial network can be calculated ***,this method is used to analyze some examples and compared with other methods,showing its effectiveness and feasibility.

关键词： Morse establishing topological

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Drug delivery systems for colorectal cancer chemotherapy

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Chinese Chemical Letters 2024年第2期35卷 163-175页

作者： Wen chen Kun shi Yan Yu Peipei Yang Zhongwu Bei dong Mo Liping Yuan Meng Pan Yu chen Zhiyong Qian Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China

Colorectal cancer causes the third most common type of malignant tumors with high morbidity and *** is currently one of the most effective and common treatments for colorectal ***,the poor water solubility of some chemotherapeutics,untargeted drug delivery,and the undesirable systemic side effects of conventional treatment remain the major issues for colorectal cancer ***,drug delivery systems(DDS)based on biomaterials have been widely investigated and found to be capable of resolving those issues with good ***,the main goal of this review is to summarize and discuss the progress and potential advantages of different DDS for colorectal cancer *** not only reviewed the nanocarriers used to improve the solubility of chemotherapeutics,including liposomes,micelles,and nanoparticles,but also discussed targeted DDS based on specific ligand-receptor recognition and tumor microenvironmental stimulus ***,locally administered systems based on hydrogels and microspheres,which have been shown to increase drug accumulation at the tumor site while decreasing systemic toxicity,were also *** provides a good option for improving the efficacy of chemotherapy in the treatment of colorectal cancer.

关键词： Colorectal cancer Chemotherapy Drug delivery systems Solubility Targeted Local administration

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