检索结果-南通市图书馆

Treatment Options for Hepatocellular Carcinoma Using Immunotherapy: Present and Future

在线全文

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2024年第4期12卷 389-405页

作者： Hongbin Wei chunlu Dong Xun Li The First School of Clinical Medicine Lanzhou UniversityLanzhouGansuChina The First Hospital of Lanzhou University LanzhouGansuChina Key Laboratory Biotherapy and Regenerative Medicine of Gansu Province LanzhouGansuChina Cancer Prevention and Treatment Center of Lanzhou University School of Medicine LanzhouGansuChina Hepatopancreatobiliary Surgery Institute of Gansu Province LanzhouGansuChina Clinical Research Center for General Surgery of Gansu Province LanzhouGansuChina

Hepatocellular carcinoma(HCC)is a common cancer,and the body’s immune responses greatly affect its progression and the prognosis of *** suppression and the maintenance of self-tolerance in the tumor microenvironment are essential responses,and these form part of the theoretical foundations of *** this review,we first discuss the tumor microenvironment of HCC,describe immunosuppression in HCC,and review the major biomarkers used to track HCC progression and response to *** then examine antibody-based therapies,with a focus on immune checkpoint inhibitors(ICIs),monoclonal antibodies that target key proteins in the immune response(programmed cell death protein 1,anti-cytotoxic T-lymphocyte associated protein 4,and programmed deathligand 1)which have transformed the treatment of HCC and other *** may be used alone or in conjunction with various targeted therapies for patients with advanced HCC who are receiving first-line treatments or subsequent *** also discuss the use of different cellular immunotherapies,including T cell receptor(TCR)T cell therapy and chimeric antigen receptor(CAR)T cell *** then review the use of HCC vaccines,adjuvant immunotherapy,and oncolytic virotherapy,and describe the goals of future research in the development of treatments for HCC.

关键词： Hepatocellular carcinoma Liver cancer Immunotherapy Vaccines

Controllable Condensation of Aromatics and Its Mechanisms in Carbonization

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China Petroleum Processing & Petrochemical Technology 2024年第1期26卷 34-46页

作者： Fan Xi Wang chunlu Luo Yang Ren Qiang Shen Haiping Long Jun Sinopec Research Institute of Petroleum Processing Co. Ltd.Beijing 100083China

In order to obtain liquefied products with higher yields of aromatic molecules to produce mesophase pitch,a good understanding of the relevant reaction mechanisms is *** molecular dynamics simulations were used to study the thermal reactions of pyrene,1-methylpyrene,7,8,9,10-tetrahydrobenzopyrene,and mixtures of pyrene with 1-octene,cyclohexene,or *** reactant conversion rates,reaction rates,and product distributions were calculated and compared,and the mechanisms were analyzed and *** results demonstrated that methyl and naphthenic structures in aromatics might improve the conversion rates of reactants in hydrogen transfer processes,but their steric hindrances prohibited the generation of high *** naphthenic structures could generate more free radicals and presented a more obvious inhibition effect on the condensation of polymers compared with the methyl side *** was discovered that when different olefins were mixed with pyrene,1-octene primarily underwent pyrolysis reactions,whereas cyclohexene mainly underwent hydrogen transfer reactions with pyrene and styrene,mostly producing superconjugated biradicals through condensation reactions with *** the mixture systems,the olefins scattered aromatic molecules,hindering the formation of pyrene trimers and higher *** to the reactive molecular dynamics simulations,styrene may enhance the yield of dimer and enable the controlled polycondensation of pyrene.

关键词： carbonization controllable condensation aromatics mechanisms molecular simulation

急性心肌梗死病人介入术后分层随访路径的构建

在线全文

学校读者我要写书评

暂无评论

护理研究 2020年第12期34卷 2073-2078页

作者：史春璐张文杰江苏大学附属医院江苏212001

[目的]构建急性心肌梗死病人介入术后分层随访路径。[方法]采用全球急性冠状动脉事件注册评分(GRACE)进行风险分层,初步构建不同病情危险程度的急性心肌梗死病人出院后的随访路径。通过两轮德尔菲法专家函询,确定最终的分层随访路径。[... 详细信息

[目的]构建急性心肌梗死病人介入术后分层随访路径。[方法]采用全球急性冠状动脉事件注册评分(GRACE)进行风险分层,初步构建不同病情危险程度的急性心肌梗死病人出院后的随访路径。通过两轮德尔菲法专家函询,确定最终的分层随访路径。[结果]两轮函询问卷的有效回收率均为100%,专家权威系数为0.85,两轮肯德尔协调系数分别为0.11(P<0.05)、0.21(P<0.05);最终确定的分层随访路径包括5个一级条目,中低危病人随访路径包括26个二级条目,高危病人在此基础上调整补充为16个二级条目。[结论]急性心肌梗死病人介入术后分层随访路径明确了不同病情风险等级的急性心肌梗死病人的随访时间、形式和内容,为开展院外延续性分层随访管理提供参考。

关键词：心肌梗死,急性随访分层管理临床护理路径德尔菲法

An uncertainty investigation for liner impedance eduction methods

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2024年第3期37卷 49-59页

作者： Weihao shi Xiaodong JING School of Energy and Power Engineering Beihang UniversityBeijing 100191China

Impedance eduction methods have been developed for decades to meet the increasing need for high-quality impedance data in the design and optimization of acoustic *** this end,it is important to fully investigate the uncertainty problem,to which only limited attention has been devoted so *** paper considers the possibility of acoustically-induced structural vibration as a nonnegligible uncertainty or error source in impedance eduction *** the frequency moves away from the resonant frequency,with the increase in the value of cavity reactance,the acoustic particle velocity inside liner orifices possibly decreases to the extent comparable to the vibration velocity of liner facing ***,the acoustically-induced vibration,although generally being weak except at the inherent structural frequencies,may considerably affect the impedance eduction results near the anti-resonant frequency where the liner has poor *** demonstrate the effect of structural vibration,the vibration velocity of liner facing sheet is estimated from the experimentally educed admittance of the liner samples whose orifices are sealed with ***,a three-dimensional numerical model is set up,in which normal particle velocity is introduced over the solid portion of liner facing sheet to imitate structural vibration,rather than directly solving the acoustic-structural coupling *** shown by the results,the vibration of liner facing sheet,whose velocity is as small as estimated by the experiment,can result in anomalous deviation of the educed impedance from the impedance model near the anti-resonant *** trend that the anomalous deviation varies with frequency is numerically captured.

关键词： Impedance eduction Uncertainty analysis Acoustically-induced structural vibration Anti-resonant frequency Perforated liner

No Reference Image Sharpness Assessment Based on Global Color Difference Variation

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Electronics 2024年第1期33卷 293-302页

作者： Chenyang shi Yandan LIN School of Artificial Intelligence Anhui Polytechnic University School of Mechanical Engineering Anhui Polytechnic University Department of Light Sources and Illuminating Engineering Fudan University Academy for Engineering & Technology Fudan University

Image quality assessment(IQA) model is designed to measure the image quality in consistent with subjective ratings by computational models. In this research, a valid no reference IQA(NR-IQA) model for color image sharpness assessment is proposed based on local color difference map in a color space. In the proposed model, the absolute color difference variation and relative color difference variation are combined to evaluate sharpness in YIQ color space(a color coordinate system for the development of the United States color television system). The difference between sharpest and blurriest spot of an image is represented by the absolute color difference variation, and relative color difference variation expresses the variation in the image content. Extensive experiments are performed on five publicly available benchmark synthetic blur databases and two real blur databases, and the results prove that the proposed model work better than the other state-of-the-art and latest NR-IQA models for the prediction accuracy on blurry images. Besides, the model maintains the lowest computational complexity.

关键词： Image quality TV Image color analysis Databases Computational modeling Color Predictive models

Adaptive Space Expansion for Fast Motion Planning

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1499-1514页

作者： Shenglei shi Jiankui Chen State Key Laboratory of Digital Manufacturing Equipment and Technology School of Mechanical Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

The sampling process is very inefficient for sam-pling-based motion planning algorithms that excess random sam-ples are generated in the planning *** this paper,we pro-pose an adaptive space expansion(ASE)approach which belongs to the informed sampling category to improve the sampling effi-ciency for quickly finding a feasible *** ASE method enlarges the search space gradually and restrains the sampling process in a sequence of small hyper-ellipsoid ring subsets to avoid exploring the unnecessary ***,for a con-structed small hyper-ellipsoid ring subset,if the algorithm cannot find a feasible path in it,then the subset is ***,the ASE method successively does space exploring and space expan-sion until the final path has been ***,we present a particular construction method of the hyper-ellipsoid ring that uniform random samples can be directly generated in *** last,we present a feasible motion planner BiASE and an asymptoti-cally optimal motion planner BiASE*using the bidirectional exploring method and the ASE *** demon-strate that the computation speed is much faster than that of the state-of-the-art *** source codes are available at https://***/shshlei/ompl.

关键词： Adaptive space expansion(ASE) hyper-ellipsoid ring informed sampling motion planning.

Quantization and Event-Triggered Policy Design for Encrypted Networked Control

在线全文

学校读者我要写书评

暂无评论

IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 946-955页

作者： Yongxia shi Ehsan Nekouei the Department of Electrical Engineering City University of Hong KongHong KongChina

This paper proposes a novel event-driven encrypted control framework for linear networked control systems(NCSs),which relies on two modified uniform quantization policies,the Paillier cryptosystem,and an event-triggered *** to the fact that only integers can work in the Pailler cryptosystem,both the real-valued control gain and system state need to be first quantized before *** is dramatically different from the existing quantized control methods,where only the quantization of a single value,e.g.,the control input or the system state,is *** handle this issue,static and dynamic quantization policies are presented,which achieve the desired integer conversions and guarantee asymptotic convergence of the quantized system state to the ***,the quantized system state is encrypted and sent to the controller when the triggering condition,specified by a state-based event-triggered strategy,is *** doing so,not only the security and confidentiality of data transmitted over the communication network are protected,but also the ciphertext expansion phenomenon can be ***,by tactfully designing the quantization sensitivities and triggering error,the proposed event-driven encrypted control framework ensures the asymptotic stability of the overall closedloop ***,a simulation example of the secure motion control for an inverted pendulum cart system is presented to evaluate the effectiveness of the theoretical results.

关键词： Cyber-security encrypted control event-triggered control(ETC) networked control systems(NCSs) semi-homomorphic encryption

Families of Schmidt-number witnesses for high dimensional quantum states

在线全文

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2024年第8期76卷 44-51页

作者： Xian shi College of Information Science and Technology Beijing University of Chemical TechnologyBeijing 100029China

Higher dimensional entangled states demonstrate significant advantages in quantum information processing tasks. The Schmidt number is a quantity of the entanglement dimension of a bipartite state. Here we build families of k-positive maps from the symmetric information complete positive operator-valued measurements and mutually unbiased bases, and we also present the Schmidt number witnesses, correspondingly. At last, based on the witnesses obtained from mutually unbiased bases, we show the distance between a bipartite state and the set of states with a Schmidt number less than k.

关键词： Schmidt number entanglement witness mutually unbiased bases

Cloud-Edge Collaborative Federated GAN Based Data Processing for IoT-Empowered Multi-Flow Integrated Energy Aggregation Dispatch

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2024年第7期80卷 973-994页

作者： Zhan shi Electric Power Dispatching Control Center Guangdong Power Grid Co.Ltd.Guangzhou510030China

The convergence of Internet of Things(IoT),5G,and cloud collaboration offers tailored solutions to the rigorous demands of multi-flow integrated energy aggregation dispatch data *** generative adversarial networks(GANs)are instrumental in resource scheduling,their application in this domain is impeded by challenges such as convergence speed,inferior optimality searching capability,and the inability to learn from failed decision making ***,a cloud-edge collaborative federated GAN-based communication and computing resource scheduling algorithm with long-term constraint violation sensitiveness is proposed to address these *** proposed algorithm facilitates real-time,energy-efficient data processing by optimizing transmission power control,data migration,and computing resource *** employs federated learning for global parameter aggregation to enhance GAN parameter updating and dynamically adjusts GAN learning rates and global aggregation weights based on energy consumption constraint *** results indicate that the proposed algorithm effectively reduces data processing latency,energy consumption,and convergence time.

关键词： IoT federated learning generative adversarial network data processing multi-flowintegration energy aggregation dispatch