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Bisphosphonate-based hydrogel mediates biomimetic negative feedback regulation of osteoclastic activity to promote bone regeneration

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Bioactive Materials 2022年第7期7卷 9-22页

作者： Zhuo Li Haixing Wang Kunyu Zhang Boguang Yang Xian Xie Zhengmeng Yang Lingchi Kong Peng shi Yuan Zhang Yi-Ping Ho zhi-Yong Zhang Gang Li Liming Bian Department of Biomedical Engineering The Chinese University of Hong KongSha TinNew Territories999077Hong KongChina Department of Orthopaedic and Traumatology The Chinese University of Hong KongSha TinNew Territories999077Hong KongChina Department of Materials Science and Engineering Johns Hopkins UniversityBaltimoreMD21218USA Department of Orthopaedic Surgery Affiliated Sixth People’s HospitalShanghai Jiao Tong UniversityShanghai200233China School of Biomedical Sciences and Engineering South China University of TechnologyGuangzhou510006China Translational Research Centre of Regenerative Medicine and 3D Printing of Guangzhou Medical University Guangdong Province Engineering Research Center for Biomedical EngineeringState Key Laboratory of Respiratory DiseaseThe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou CityGuangdong Province510150China National Engineering Research Center for Tissue Restoration and Reconstruction South China University of TechnologyGuangzhou510006China Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education South China University of TechnologyGuangzhou510006China

The intricate dynamic feedback mechanisms involved in bone homeostasis provide valuable inspiration for the design of smart biomaterial scaffolds to enhance in situ bone *** this work,we assembled a biomimetic hyaluronic acid nanocomposite hydrogel(HA-BP hydrogel)by coordination bonds with bisphosphonates(BPs),which are antiosteoclastic *** HA-BP hydrogel exhibited expedited release of the loaded BP in response to an acidic *** in vitro studies showed that the HA-BP hydrogel inhibits mature osteoclastic differentiation of macrophage-like RAW264.7 cells via the released ***,the HA-BP hydrogel can support the initial differentiation of primary macrophages to preosteoclasts,which are considered essential during bone regeneration,whereas further differentiation to mature osteoclasts is effectively inhibited by the HA-BP hydrogel via the released *** in vivo evaluation showed that the HA-BP hydrogel can enhance the in situ regeneration of *** work demonstrates a promising strategy to design biomimetic biomaterial scaffolds capable of regulating bone homeostasis to promote bone regeneration.

关键词： Bisphosphonate Hydrogel Tissue engineering Bone regeneration

Research Status and Prospect of Larix *** Modification

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Chinese Forestry Science and Technology 2012年第3期11卷 83-84页

作者： shi qiang Zhang Shougong Lv Jianxiong Bao Fucheng Shun Xiaomei Research Institute of Forestry Chinese Academy of Forestry(CAF) Research Institute of Wood Industry CAF

Larix *** is one of the major fast-growing tree species in China,which also has the most forest storage in the northeast of *** key properties modification methods and achievements of Larix *** were summarized based o... 详细信息

关键词： Larix spp. wood modification research status development trend

氧化铝催化7-表-紫杉醇转化为紫杉醇的机理探索

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生物工程学报 2000年第3期16卷 378-382页

作者：张志强苏志国中国科学院化学冶金研究所生化工程国家重点实验室北京100080

在碱性氧化铝作用下 ,云南红豆杉浸膏中 7 表紫杉醇被催化转化为紫杉醇。该异构化反应是由氧化铝表面L酸中心、碱中心的协同作用而催化 ,在室温条件下就可进行 ,氧化铝表面酸碱中心的种类和强度都将影响反应进行的程度。

关键词：氧化铝 7-表-紫杉醇紫杉醇催化机理抗癌药物

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CIMS中的产品开发和设计分系统研究

铸造 2000年第10期49卷 780-784页

作者：许映秋高志强东南大学机械系江苏南京210096

以某阀门厂计算机集成制造系统 (CIMS)为背景 ,详细介绍了离散型制造业CIMS中产品开发和设计分系统(DDS)的主要内容 ,包括需求分析、结构设计、功能设计、信息设计、资源设计以及关键技术分析等。

关键词： CIMS DDS 体系结构功能模型信息模型资源需求

Perirenal space blocking restores gastrointestinal function in patients with severe acute pancreatitis

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World Journal of Gastroenterology 2013年第46期19卷 8752-8757页

作者： Jun-Jun Sun zhi-Jie Chu Wei-Feng Liu shi-Fang Qi Yan-Hui Yang Peng-Lei Ge Xiao-Hui Zhang Wen-Sheng Li Cheng Yang Yu-Ming Zhang Department of General Surgery the First Affiliated Hospital of Henan University of Science and Technology

AIM:To investigate effects of perirenal space blocking(PSB)on gastrointestinal function in patients with severe acute pancreatitis(SAP).METHODS:Forty patients with SAP were randomly allocated to receive PSB or no PSB(NPSB).All the SAP patients received specialized medical therapy(SMT).Patients in the PSB group received PSB+SMT when hospitalized and after diagnosis,whereas patients in the NPSB group only received SMT.A modifed gastrointestinal failure(GIF)scoring system was used to assess the gastrointestinal function in SAP patients after *** severity(visual analog scale,0 to100)was monitored every 24 h for 72 ***:Modified GIF score decreased in both groups during the 10-d study *** median score decrease was initially significantly greater in the PSB group than in the NPSB group after PSB was *** the 72-h study period,pain intensity decreased in both *** median pain decrease was significantly greater in the PSB group than in the NPSB group at single time *** in the PSB group had significantly lower incidences of hospital mortality,multiple organ dysfunction syndrome,systemic inflammatory response syndrome,and pancreatic infection,and stayed in the intensive care unit for a shorter ***,no difference in terms of operation incidence was found between the two ***:PSB could ameliorate gastrointestinal dysfunction or failure during the early stage of ***,PSB administration could improve prognosis and decrease the mortality of SAP patients.

关键词： Perirenal space blocking Therapeutics Severe acute pancreatitis Gastrointestinal function Prognosis

The clinical analysis of three methods in the treatment of intracranial bacterial infection

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Journal of Pharmaceutical Analysis 2009年第4期21卷 263-266页

作者： Rui-zhi Wang,Wei shi Department of Neurosurgery,the Second Affiliated Hospital,Medical School of Xi’an Jiaotong University,Xi’an 710004,China Department of Neurosurgery Second Affiliated Hospital Medical School of Xi'an Jiaotong University Xi'an 710004 China

Objective To analyze the effect of three therapeutic methods to find an optimal approach to the treatment of intracranial bacterial infection by retrospectively reviewing 33 intracranial bacterial infection patients who were admitted from 1995 to 2008 in our *** The treatments by intermittent lumbar puncture,continuous lumbar subarachnoid space drainage,and embedment of Ommaya cyst for continuous drainage from the ventricles were performed in 15 cases,12 cases,and 6 cases respectively along with intravenous application of full dose of *** Nineteen cases were cured and the best prognosis was from the group of Ommaya cyst embedment and continuous drainage from the *** Management goals are prompt recognition of the central nervous system(CNS)infection,rapid identification of causative organisms and initiation of treatment with the optimal management methods for *** of Ommaya cyst for continuous drainage from the ventricle is a safe and effective treatment for intracranial bacterial infection.

关键词： intracranial bacterial infection lumbar puncture cerebrospinal fluid(CSF) Ommaya cyst

Interface stabilization of 1,1,2,2-tetrafluoroethyl-2,2,3,3-tetrafluoropropyl ether to high-voltage Li-rich Mn-based layered cathode materials

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Rare Metals 2022年第3期41卷 822-829页

作者： A-Lin Li Guo-Hua Li shi-Gang Lu zhi-Min Ren Jian-Tao Wang Hao-Xiang Zhuo Wei Quan Gang-Ning Zhang Fu-Juan Han Yi-Mian Xia Jing Wang Yi Zhang National Power Battery Innovation Center Grinm Group Company LtdBeijing 100088China China Automotive Battery Research Institute Company Ltd Beijing 101407China General Research Institute for Nonferrous Metals Beijing 100088China Materials Genome Institute Shanghai UniversityShanghai 200444China

Non-aqueous electrolyte solvents play a pivotal role in improving the cycling performance of high-voltage Li-rich Mn-based layered cathode materials. In this study, a fluoroether (1,1,2,2-tetrafluoroethyl-2,2,3,3-tetrafluoropropyl ether, TFEPE) was added to 1.2 mol·L^(-1)LiPF_(6)EC/EMC/DEC at different concentrations to synthesize a series of electrolytes for enhancing the cycling performance of highvoltage Li_(1.18)Mn_(0.50)Ni_(0.26)Co_(0.06)O_(2)(LMNC).

关键词： materials. cycling 1,2

Rapid and Visualized Detection Method of Canine Parvovirus Using Loop-Mediated Isothermal Amplification

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Animal Husbandry and Feed Science 2010年第1期2卷 34-37页

作者： YANG Hui QU Guang-gang ZHAO Yuan-kai SHEN zhi-qiang Shandong LuDu Bio-science Industry Co. Ltd. Binzhou 256600 China Shandong Binzhou Animal Science and Veterinary Medicine Academy Binzhou 256600 China

[Objective] To develop a rapid and visualized detection method using loop-mediated isothermal amplification （LAMP）, improve the detection rate of canine parvovirus （CPV） and reduce the testing cost. [ Method] According to the conserved regions of the VP2 gene of CPV, six primers were designed to amplify the special DNA sequences by LAMP. In addition, the reaction conditions of LAMP were optimized, and the sensitivity, specificity, repeatability and stability were verified. [ Result] The optimal reaction time of the LAMP method for CPVwas 60 min. The products obtained by LAMP had high specificity without cross-reaction with other generic viruses. The sensitivity of the LAMP was 100 times higher than that of PCR. [ Conclusion] The LAMP method for detecting CPV has high practical value. It has many advantages such as high specificity, high sensitivity, simple operation, low cost and rapid analysis, and it does not require special equipment. Therefore, this method is more suitable for the detection of CPV.

关键词： Canine parvovirus Loop-mediated isothermal amplification Diagnosis method

回火保温时间对新型贝氏体铸钢组织和性能的影响

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铸造技术 2005年第11期26卷 994-996页

作者：程巨强刘志学西安工业学院材料与化工学院陕西西安710032

研究了回火保温时间对ZG30CrMn2Si2Mo新型贝氏体钢组织和力学性能的影响。结果表明,不同回火时间下材料的组织为贝氏体铁素体和残余奥氏体组成,2 h以下回火材料的强度、韧性、硬度升高,超过2 h回火,随着回火时间的增加,材料的硬度、韧... 详细信息

研究了回火保温时间对ZG30CrMn2Si2Mo新型贝氏体钢组织和力学性能的影响。结果表明,不同回火时间下材料的组织为贝氏体铁素体和残余奥氏体组成,2 h以下回火材料的强度、韧性、硬度升高,超过2 h回火,随着回火时间的增加,材料的硬度、韧性趋于稳定,超过3 h回火抗拉强度保持稳定,随着回火时间增加,组织中的残余奥氏体量减少。ZG30CrMn2Si2Mo长时间回火对性能不敏感。

关键词： ZG30CrMn2Si2Mo钢回火保温时间组织性能