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Bidirectional regulation of the brain-gut-microbiota axis following traumatic brain injury

Neural Regeneration Research 2025年第8期20卷 2153-2168页

作者： Xinyu You Lin Niu Jiafeng Fu shining Ge Jiangwei shi Yanjun zhang Pengwei Zhuang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjinChina Haihe Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjinChina First Teaching Hospital of Tianjin University of Traditional Chinese Medicine TianjinChina National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion TianjinChina

Traumatic brain injury is a prevalent disorder of the central nervous *** addition to primary brain parenchymal damage,the enduring biological consequences of traumatic brain injury pose long-term risks for patients with traumatic brain injury;however,the underlying pathogenesis remains unclear,and effective intervention methods are *** dysfunction is a significant consequence of traumatic brain *** the most densely innervated peripheral tissue in the body,the gut possesses multiple pathways for the establishment of a bidirectional“brain-gut axis”with the central nervous *** gut harbors a vast microbial community,and alterations of the gut niche contribute to the progression of traumatic brain injury and its unfavorable prognosis through neuronal,hormonal,and immune pathways.A comprehensive understanding of microbiota-mediated peripheral neuroimmunomodulation mechanisms is needed to enhance treatment strategies for traumatic brain injury and its associated *** comprehensively reviewed alterations in the gut microecological environment following traumatic brain injury,with a specific focus on the complex biological processes of peripheral nerves,immunity,and microbes triggered by traumatic brain injury,encompassing autonomic dysfunction,neuroendocrine disturbances,peripheral immunosuppression,increased intestinal barrier permeability,compromised responses of sensory nerves to microorganisms,and potential effector nuclei in the central nervous system influenced by gut ***,we reviewed the mechanisms underlying secondary biological injury and the dynamic pathological responses that occur following injury to enhance our current understanding of how peripheral pathways impact the outcome of patients with traumatic brain *** review aimed to propose a conceptual model for future risk assessment of central nervous system-related diseases while elucidating novel insights into the bidirectional effec

关键词： traumatic brain injury brain-gut-microbiome axis gut microbiota neuroimmune immunosuppression host defense vagal afferents bacterial infection dorsal root ganglia nociception neural circuitry

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AAV mediated carboxyl terminus of Hsp70 interacting protein overexpression mitigates the cognitive and pathological phenotypes of APP/PS1 mice

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Neural Regeneration Research 2025年第1期20卷 253-264页

作者： Zhengwei Hu Jing Yang Shuo zhang Mengjie Li Chunyan Zuo Chengyuan Mao Zhongxian zhang Mibo Tang Changhe shi Yuming Xu Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Academy of Medical Sciences of Zhengzhou University ZhengzhouHenan ProvinceChina NHC Key Laboratory of Prevention and treatment of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Henan Key Laboratory of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Institute of Neuroscience Zhengzhou UniversityZhengzhouHenan ProvinceChina Sino-British Research Centre for Molecular Oncology National Centre for International Research in Cell and Gene TherapySchool of Basic Medical SciencesAcademy of Medical SciencesZhengzhou UniversityZhengzhouHenan ProvinceChina Department of Gerontology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina

The E3 ubiquitin ligase,carboxyl terminus of heat shock protein 70(Hsp70)interacting protein(CHIP),also functions as a co-chaperone and plays a crucial role in the protein quality control *** this study,we aimed to investigate the neuroprotective effect of overexpressed CHIP on Alzheimer’s *** used an adeno-associated virus vector that can cross the blood-brain barrier to mediate CHIP overexpression in APP/PS1 mouse *** overexpression significantly ameliorated the performance of APP/PS1 mice in the Morris water maze and nest building tests,reduced amyloid-βplaques,and decreased the expression of both amyloid-βand phosphorylated *** also alleviated the concentration of microglia and astrocytes around *** APP/PS1 mice of a younger age,CHIP overexpression promoted an increase in ADAM10 expression and inhibitedβ-site APP cleaving enzyme 1,insulin degrading enzyme,and neprilysin *** of HSP70 and HSP40,which have functional relevance to CHIP,were also *** nuclei transcriptome sequencing in the hippocampus of CHIP overexpressed mice showed that the lysosomal pathway and oligodendrocyte-related biological processes were up-regulated,which may also reflect a potential mechanism for the neuroprotective effect of *** research shows that CHIP effectively reduces the behavior and pathological manifestations of APP/PS1 ***,overexpression of CHIP could be a beneficial approach for the treatment of Alzheimer’s disease.

关键词： adeno-associated virus Alzheimer’s disease APP/PS1 mice carboxyl terminus of Hsp70 interacting protein gene therapy

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低品位复杂矿烧结碱度优化试验

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钢铁 2016年第1期51卷 8-12页

作者：武强朱子宗曾见华熊浩孟宪涛张士桥重庆大学材料科学与工程学院重庆400044 新兴铸管新疆有限公司新疆和静841300

为了合理利用新疆区域的贫矿资源,优化高炉炉料结构,开展优化烧结矿碱度的试验研究。利用50 kg烧结杯,针对新疆复杂矿做了7组碱度为1.65~2.00的烧结杯试验。通过对烧结矿机械强度、冶金性能及矿物组成分析,得出碱度为1.80~1.85时,烧结... 详细信息

为了合理利用新疆区域的贫矿资源,优化高炉炉料结构,开展优化烧结矿碱度的试验研究。利用50 kg烧结杯,针对新疆复杂矿做了7组碱度为1.65~2.00的烧结杯试验。通过对烧结矿机械强度、冶金性能及矿物组成分析,得出碱度为1.80~1.85时,烧结矿中铁酸钙质量分数明显增加,烧结矿的ISO转鼓强度较高,成品率最高达到78%,还原度和低温还原粉化指数均得到改善,软熔区间最窄,为最优的烧结碱度区间;而碱度为1.65~1.75时,转鼓强度降低、熔滴性能变差,处于烧结矿的粉化区间,配加新疆区域复杂矿烧结生产时应避开此碱度区间。

关键词：烧结矿碱度矿物组成转鼓强度熔滴性能

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Efficient photocatalytic reduction of CO2 to formate by a molecular noble metal-free system

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Science China Chemistry 2025年第1期 152-156页

作者： Lihua zhang Lingjing Chen Huatian shi Yue Wei Gui Chen Tai-Chu Lau School of Environment and Civil Engineering Research Center for Eco-environmental Engineering Dongguan University of Technology Department of Chemistry and Institute of Molecular Functional Materials City University of Hong Kong

Reducing CO2to carbon-neutral solar fuels can not only alleviate the energy demand but also mitigate the greenhouse *** present,developing an efficient non-noble metal photo/electrocatalytic system for converting CO2to a specific product beyond CO is still a big ***,we report a new cobalt complex bearing 2,2′-bi-1,10-phenanthroline ligand that can photocatalytically reduce CO2to formate （HCOO-）.Turnover number （TON） for HCOO-up to 677 with 99%selectivity can be achieved using organic dyes purpurin as photosensitizer and 1,3-dimethyl-2-phenyl-2,3-dihydro-1H-benzo[d]imidazole （BIH） as sacrificial reductant in a CO2-saturated NMP/TEA （v/v,3:1） solution under visible light *** potential electrolysis at-1.41 V （***/Ag Cl） in the presence of 12 m M Et3NHBF4also produced HCOO-with Faradaic efficiency of 39%.Spectroscopic and electrochemical studies suggest that a[CoI-H]species is the key intermediate for CO2reduction.

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发展经济学教学改革研究

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教育教学论坛 2020年第2期 167-168页

作者：何明霞张诗乔四川轻化工大学四川自贡643000 四川师范大学影视与传媒学院四川成都610066

为提高发展经济学教学质量和教学效率,需要通过发展经济学教学改革来优化教学结构,作者以《发展经济学教学改革研究》为课题,从发展经济学教学现状入手,对其进行了全方位、深层次的剖析,并在此基础上探究了发展经济学教学改革策略,给出... 详细信息

为提高发展经济学教学质量和教学效率,需要通过发展经济学教学改革来优化教学结构,作者以《发展经济学教学改革研究》为课题,从发展经济学教学现状入手,对其进行了全方位、深层次的剖析,并在此基础上探究了发展经济学教学改革策略,给出了具有代表性的个人建议。

关键词：发展经济学教学现状教学改革策略

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Direct Photolithography of WO_x Nanoparticles for High-Resolution Non-Emissive Displays

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NANO-MICRO LETTERS 2025年第1期17卷 1-13页

作者： Gu, Chang Yang, Guojian Wang, Wenxuan shi, Aiyan Fang, Wenjuan Qian, Lei Hu, Xiaofei zhang, Ting Xiang, Chaoyu zhang, Yu-Mo Chinese Acad Sci Ningbo Inst Mat Technol & Engn Lab Optoelect Informat Technol & Devices Ningbo 315201 Peoples R China Qianwan Inst CNITECH Hangzhou Bay Lab Adv Nanooptoelectron Mat & Device Ningbo 315336 Peoples R China Zhejiang Univ Innovat Ctr Yangtze River Delta Smart Mat Architecture Res Lab Jiaxing 314100 Peoples R China Univ Sci & Technol China Hefei 230026 Peoples R China Jilin Univ Coll Chem State Key Lab Supramol Struct & Mat Changchun 130012 Peoples R China

High-resolution non-emissive displays based on electrochromic tungsten oxides (WOx) are crucial for future near-eye virtual/augmented reality interactions, given their impressive attributes such as high environmental stability, ideal outdoor readability, and low energy consumption. However, the limited intrinsic structure of inorganic materials has presented a significant challenge in achieving precise patterning/pixelation at the micron scale. Here, we successfully developed the direct photolithography for WOx nanoparticles based on in situ photo-induced ligand exchange. This strategy enabled us to achieve ultra-high resolution efficiently (line width m, the best resolution for reported inorganic electrochromic materials). Additionally, the resulting device exhibited impressive electrochromic performance, such as fast response ( 3600 cycles), as well as promising applications in electronic logos, pixelated displays, flexible electronics, etc. The success and advancements presented here are expected to inspire and accelerate research and development (R&D) in high-resolution non-emissive displays and other ultra-fine micro-electronics.

关键词： Electrochromic Direct photolithography WOx nanoparticles In situ photo-induced ligand exchange High-resolution displays

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High Fe‑Loading Single‑Atom Catalyst Boosts ROS Production by Density Effect for Efficient Antibacterial Therapy

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Nano-Micro Letters 2025年第2期17卷 187-203页

作者： Si Chen Fang Huang Lijie Mao Zhimin zhang Han Lin Qixin Yan Xiangyu Lu Jianlin shi Department of Cardiology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200092People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China Shanghai Frontiers Science Center of Nanocatalytic Medicine School of MedicineTongji UniversityShanghai 200092People’s Republic of China

The current single-atom catalysts(SACs)for medicine still suffer from the limited active site ***,we develop a synthetic method capable of increasing both the metal loading and mass-specific activity of SACs by exchanging zinc with *** constructed iron SACs(h^(3)-FNC)with a high metal loading of 6.27 wt%and an optimized adjacent Fe distance of~4 A exhibit excellent oxidase-like catalytic performance without significant activity decay after being stored for six months and promising antibacterial ***,a“density effect”has been found at a high-enough metal doping amount,at which individual active sites become close enough to interact with each other and alter the electronic structure,resulting in significantly boosted intrinsic activity of single-atomic iron sites in h^(3)-FNCs by 2.3 times compared to low-and medium-loading ***,the overall catalytic activity of h^(3)-FNC is highly improved,with mass activity and metal mass-specific activity that are,respectively,66 and 315 times higher than those of commercial Pt/*** addition,h^(3)-FNCs demonstrate efficiently enhanced capability in catalyzing oxygen reduction into superoxide anion(O_(2)·^(−))and glutathione(GSH)*** in vitro and in vivo assays demonstrate the superior antibacterial efficacy of h^(3)-FNCs in promoting wound *** work presents an intriguing activity-enhancement effect in catalysts and exhibits impressive therapeutic efficacy in combating bacterial infections.

关键词： Nanocatalytic medicine Single-atom catalysts Reactive oxygen species(ROS) High metal loading Oxidase catalysis

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A novel flexible nerve guidance conduit promotes nerve regeneration while providing excellent mechanical properties

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Neural Regeneration Research 2025年第7期20卷 2084-2094页

作者： Tong Li Quhan Cheng Jingai zhang Boxin Liu Yu shi Haoxue Wang Lijie Huang Su zhang Ruixin zhang Song Wang Guangxu Lu Peifu Tang Zhongyang Liu Kai Wang Department of Orthopedics the Fourth Medical Center of Chinese PLA General HospitalBeijingChina Department of Training and Sports Medicine Characteristic Medical Center of Chinese People’s Armed Police ForceTianjinChina Medical School of Chinese PLA BeijingChina Key Laboratory of Bioactive Materials for the Ministry of Education College of Life SciencesNankai UniversityTianjinChina Department of Orthopedics Tianjin HospitalTianjinChina Department of Rehabilitation Medicine Er Quan Hospital of PAPWuxiJiangsu ProvinceChina

Autografting is the gold standard for surgical repair of nerve defects>5 mm in length;however,autografting is associated with potential complications at the nerve donor *** an alternative,nerve guidance conduits may be *** ideal conduit should be flexible,resistant to kinks and lumen collapse,and provide physical cues to guide nerve *** designed a novel flexible conduit using electrospinning technology to create fibers on the innermost surface of the nerve guidance conduit and employed melt spinning to align ***,we prepared disordered electrospun fibers outside the aligned fibers and helical melt-spun fibers on the outer wall of the electrospun fiber *** presence of aligned fibers on the inner surface can promote the extension of nerve cells along the *** helical melt-spun fibers on the outer surface can enhance resistance to kinking and compression and provide *** novel conduit promoted nerve regeneration and functional recovery in a rat sciatic nerve defect model,suggesting that it has potential for clinical use in human nerve injuries.

关键词： aligned fibers anti-kinking helical fibers nerve guidance conduit nerve regeneration peripheral nerve injury topological guidance

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贵阳城区40岁以上非超重居民代谢综合征发病率增高的危险因素分析

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中国现代医学杂志 2017年第2期27卷 86-90页

作者：袁新李红时立新张巧彭年春胡颖贵州医科大学附属医院内分泌代谢病科贵州贵阳550004

目的研究贵阳城区40岁以上非超重社区居民代谢综合征(MS)发病情况。方法通过非超重MS发病者基线与随访终点比较、非超重发病者与非超重未发病者比较,经统计学分析,研究非超重MS发病者的发病情况及相关危险因子的作用。结果经过3年的随访... 详细信息

目的研究贵阳城区40岁以上非超重社区居民代谢综合征(MS)发病情况。方法通过非超重MS发病者基线与随访终点比较、非超重发病者与非超重未发病者比较,经统计学分析,研究非超重MS发病者的发病情况及相关危险因子的作用。结果经过3年的随访,女性MS总发病率高于男性,非超重者MS发病率占总发病率的比例分别为男性25.11%、女性59.73%;受试者工作特征曲线分析相关危险因子与MS发病作用的结果显示男性腰围身高比的曲线下面积(AUC)值最高(0.909,95%CI:0.881,0.937),Cutoff值为0.52;女性三酰甘油(TG)的AUC值最高(0.807,95%CI:0.784,0.830),Cutoff值为1.70 mmol/L。结论贵阳城区40岁以上社区居民非超重者的MS发病情况值得重视,特别是女性非超重者发病率较高。在男性非超重发病者中腰围身高比有着较好的MS发病预测作用,而在女性则是TG水平。

关键词：代谢综合征非超重发病率

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胆囊牵拉影响心功能的传出效应分析

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生理学报 1980年第1期 55-60页

作者：乔健天张士儒乔丽荫山西医学院生理教研组山西医学院生理教研组太原

本工作观察了胆囊牵拉(或充气)对麻醉狗的心脏泵血功能的影响,并对与此有关的肾上腺素能受体的活动作了分析。实验表明,胆囊牵拉不影响用来反映左室射血分数的 PEP/ET 值,但引起有显著意义的心率加快和平均动脉压的升高;如预先给动物注... 详细信息

本工作观察了胆囊牵拉(或充气)对麻醉狗的心脏泵血功能的影响,并对与此有关的肾上腺素能受体的活动作了分析。实验表明,胆囊牵拉不影响用来反映左室射血分数的 PEP/ET 值,但引起有显著意义的心率加快和平均动脉压的升高;如预先给动物注射心得安,则牵拉不再能引起心率改变,但仍引起血压的升高,同时出现泵血功能的下降;如预先给动物注射酚妥拉明,牵拉不再引起血压改变,但出现心率的加快和泵血功能的增强。实验结果说明,胆囊牵拉可能通过心脏的β-肾上腺素能受体和动脉血管的α-肾上腺素能受体影响心脏的泵血功能,而这两种作用在正常情况下有可能相互抵消,造成胆囊激惹不显著影响泵血功能的假象。对这一现象在临床上的意义作了初步讨论。

关键词：牵拉心血管胆囊胆道平均动脉压心功能

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