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液压支架侧护板生产工艺

机械管理开发 2024年第3期39卷 259-261页

作者：孟海岗史向阳无棣县鑫苑热力有限公司山东滨州251906 三一重型装备有限公司辽宁沈阳110027

为解决液压支架侧护板因制造误差、下料焊接变形等因素引起的安装困难、使用时动作不灵活等问题,对侧护板各生产工序进行了分析研究,对生产过程中常出现的一些问题提供了解决方案,并在此基础上制定了较为详尽的生产工艺,明确了下料切割... 详细信息

为解决液压支架侧护板因制造误差、下料焊接变形等因素引起的安装困难、使用时动作不灵活等问题,对侧护板各生产工序进行了分析研究,对生产过程中常出现的一些问题提供了解决方案,并在此基础上制定了较为详尽的生产工艺,明确了下料切割方法、拼焊方法等,以有效降低制造误差及变形的影响,提高侧护板成品的合格率,更好地为车间生产提供技术指导。

关键词：液压支架生产工艺侧护板

低密度路网条件下国省道改扩建工程交通组织——以某国省道改扩建项目为例

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交通工程 2024年第7期24卷 118-122页

作者：刘秉宸史斯萌耿昭师师向阳福建师范大学福州350007 中交华安科技有限公司北京100088

国省道公路的改扩建施工在交通组织方案设计、施工各区段的设置、限速方案等方面都存在很大差异,有必要针对其特点,开展相应的低密度国省干道改扩建的交通组织方案研究。本文利用微观交通仿真软件vissim建立施工区微观仿真模型,对某国... 详细信息

国省道公路的改扩建施工在交通组织方案设计、施工各区段的设置、限速方案等方面都存在很大差异,有必要针对其特点,开展相应的低密度国省干道改扩建的交通组织方案研究。本文利用微观交通仿真软件vissim建立施工区微观仿真模型,对某国省道公路上游缓冲区长度、作业区长度、作业区限速3个主要影响交通组织的因素综合分析,通过仿真建模得出组合条件下16种工况的延误时间和平均速度的结果数据。研究结果表明:作业区的长度对施工路段的延误时间和速度最为显著,作业区越长延误时间越长,其次是作业区限速,作业区的限速值为30 km/h时,施工路段的通行能力最大,缓冲区的长度对施工路段的影响较小。

关键词：交通组织改扩建国省道交通延误交通仿真

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高聚物/淀粉共混体系化学增容进展

塑料 2024年第2期53卷 108-112页

作者：夏学莲史向阳刘嘉旋马一超张越新郭茗丽河南城建学院材料与化工学院河南平顶山467036

淀粉是富含羟基、不具备热塑性的天然高分子材料,与高聚物共混时,极性与基体材料相差较大,两相界面不相容。淀粉进行化学改性后,在得到了热塑性的同时,还可改变其极性,然后,采用热熔加工将其与高聚物共混,得到相容性较好的高聚物/淀粉... 详细信息

淀粉是富含羟基、不具备热塑性的天然高分子材料,与高聚物共混时,极性与基体材料相差较大,两相界面不相容。淀粉进行化学改性后,在得到了热塑性的同时,还可改变其极性,然后,采用热熔加工将其与高聚物共混,得到相容性较好的高聚物/淀粉复合材料。反应原理为改性剂与淀粉大分子链上的羟基发生接枝、酯化、交联、氧化等反应,可将其从亲水性转变为疏水性,极性与高聚物接近,甚至还可通过化学反应将淀粉与聚合物用共价键连接。改性淀粉加入到高聚物基体中,能提高其与聚合物的相容性,从而制备出综合性能较好、成本较低的高聚物/淀粉复合材料。除此以外,低成本、高活性、功能性改性剂的研发、淀粉极性可调控、改性工艺的优化将成为未来研究发展方向。

关键词：淀粉聚合物相容性复合材料化学增容

Apoptosis-enhanced ferroptosis therapy of pancreatic carcinoma through PAMAM dendrimer-iron(Ⅲ)complex-based plasmid delivery

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Science China Chemistry 2022年第4期65卷 778-788页

作者： Wenjing Ma Yue Gao Zhijun Ouyang Yu Fan Hongwei Yu Mengsi Zhan Han Wang xiangyang shi Mingwu Shen State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative MedicineCollege of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai 201620China Department of Radiology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China

The development of promising strategies to improve the treatment efficacy of pancreatic carcinoma still remains to be a challenging *** report here the development of a new dendrimer-based nanomedicine formulation to tackle pancreatic carcinoma through apoptosis-enhanced ferroptosis *** this article,G5 dendrimers were partially modified with a Fe(Ⅲ)chelator hydroxyquinoline-2-carboxylic acid(8-HQC)on their periphery,entrapped with gold nanoparticles(Au NPs)within their internal cavities,and chelated with Fe(Ⅲ).The thus created dendrimer-entrapped Au NPs(Fe-Au DENP-HQC)with an Au core size of 1.9 nm and 20.0 Fe(Ⅲ)ions complexed per dendrimer are stable,have a pH-dependent Fe(Ⅲ)release profile,and can generate reactive oxygen species under the tumor microenvironment(TME)and effectively compact plasmid DNA encoding p53 protein to form polyplexes with a hydrodynamic size of 143.9 nm and a surface potential of 33.6 *** show that cancer cells treated with the created Fe-Au DENP-HQC/p53 polyplexes can be more significantly inhibited through vector-mediated chemodynamic therapy(CDT)effect via Fe(Ⅲ)-induced Fenton reaction and the p53 gene delivery-boosted cell apoptosis and oxidative stress in the TME than single-mode CDT and gene *** investigations using a xenografted tumor model validated the effectiveness of apoptosis-enhanced ferropotosis therapy through the downregulation of GPX-4 and SLC7A11proteins,upregulation of p53 and PTEN proteins,as well as histological ***,the dendrimer nanoplatform enabled tumor fluorescence imaging through gene delivery-mediated enhanced green fluorescent protein *** Fe(Ⅲ)-complexed dendrimer vector system may be developed as a promising theranostic nanoplatform for ferroptosis or ferroptosis-based combination therapy of other cancer types.

关键词： dendrimers ferroptosis gene delivery pancreatic carcinoma fluorescence imaging

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原位改性浇铸尼龙6复合材料的合成与表征

工程塑料应用 2024年第6期52卷 129-134页

作者：夏学莲毛艳丽王光普史向阳陈兴华刘伟刘晓蕊张家旺河南城建学院材料与化工学院河南平顶山467036 平顶山市产品质量检验检测中心河南平顶山467000 平顶山市华兴浮选工程技术服务有限公司河南平顶山467000

为了提高单体浇铸尼龙6(MCPA6)的综合性能,在MCPA6合成体系中添加乙烯-辛烯共聚物(POE)、聚氨酯包覆空心玻璃微珠(TPU@HGM)进行原位改性,制备了MCPA6/POE和MCPA6/POE/TPU@HGM复合材料,研究POE及POE/TPU@HGM对材料结构和性能的影响。傅... 详细信息

为了提高单体浇铸尼龙6(MCPA6)的综合性能,在MCPA6合成体系中添加乙烯-辛烯共聚物(POE)、聚氨酯包覆空心玻璃微珠(TPU@HGM)进行原位改性,制备了MCPA6/POE和MCPA6/POE/TPU@HGM复合材料,研究POE及POE/TPU@HGM对材料结构和性能的影响。傅里叶变换红外光谱表征结果显示合成的聚合物为MCPA6。力学性能测试结果表明,POE加入可提高材料的断裂伸长率和缺口冲击强度,但会降低拉伸强度;MCPA6/POE/TPU@HGM复合材料的拉伸强度、断裂伸长率、缺口冲击强度与纯MCPA6相比分别提高了32.23%,110.07%,114.36%,实现了增强增韧的效果。POE和TPU@HGM的加入提高了复合材料分解温度和残炭率,热稳定性提高。此外,POE和TPU@HGM对复合材料中MCPA6的结晶有阻碍作用,使MCPA6的结晶温度降低、结晶速度减慢、结晶结构不完善、熔点降低。

关键词：浇铸尼龙原位改性复合材料增强增韧

Tumor‑Anchoring Drug‑Loaded Fibrous Microspheres for MR Imaging‑Guided Local Chemotherapy and Metastasis Inhibition

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Advanced Fiber Materials 2022年第4期4卷 807-819页

作者： Beilei Zhang Yue Gao Rui Yang Zhijun Ouyang Hongwei Yu Han Wang xiangyang shi Mingwu Shen State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano‑Biomaterials and Regenerative MedicineCollege of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai 201620China CQM-Centro de Quimica da Madeira Universidade da Madeira9020‑105 FunchalPortugal Department of Radiology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China

Unobtrusive metastasis and invasion of malignant tumors are major causes for the death of cancer patients,and unfortunately the lack of specificity and abrupt release of anticancer drugs applied to the primary tumors are causing serious side effects in cancer ***,the development of controlled local drug delivery systems that can effectively treat primary tumors and inhibit tumor metastasis is of critical importance for improved cancer ***,we developed hyaluronic acid(HA)-modified porous fibrous microspheres as a drug delivery system with the functions of long-acting local chemotherapy,tumor metastasis inhibition and magnetic resonance(MR)***(lactic-co-glycolic acid)(PLGA)short fibers obtained by combined electrospinning and homogenization techniques were successfully modified with gadolinium(Gd^(3+))chelates and HA,which were subsequently mixed with doxorubicin(DOX)to obtain the multifunctional drug-loaded fibrous microspheres of DOX-PLGA-PEI-DTPA-Gd/HA(DOX−PGH)by electrospray and further *** developed DOX−PGH microspheres with an average diameter of 118.8μm possess good structural stability and a high r1 relaxivity,and can achieve long-term DOX *** cellular and animal experiments demonstrated that the DOX−PGH microspheres could facilitate targeted delivery of DOX to accelerate 4T1 cell death while reducing cancer cell metastasis due to the cooperative actions of long-term DOX-mediated chemotherapy and the fibrous microsphere-induced tumor anchoring to likely avoid primary tumor cell shedding,and render MR imaging of tumors during the *** developed DOX−PGH microspheres may represent one of the updated local tumor chemotherapy formulations for improved tumor therapy with justified antitumor and anti-metastasis efficacy.

关键词： Electrospinning Porous fibrous microspheres Tumor anchoring Local chemotherapy Tumor metastasis

Preparation and investigation of a novel iodine-based visible polyvinyl alcohol embolization material

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Journal of Interventional Medicine 2022年第2期5卷 72-78页

作者： Yupeng Yang Rui Yang Beilei Zhang Ye Tian Yanqi Lu Xiao An xiangyang shi State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative MedicineCollege of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai 201620China Department of Pharmacy Zhengzhou Railway Vocational&Technical CollegeShanghai 00080China Department of Neoplasms and Interventional Radiology Shanghai General HospitalShanghai Jiao Tong University School of MedicineZhengphou451460China

Polyvinyl alcohol(PVA) embolization particles, currently used in clinical practice, have good expansibility and are capable of permanent embolization. However, the lack of adhesion of embolization particles contributes to facilitated recanalization after embolization, while the lack of visualization facilitates misembolization. At present, embolization materials with good expansion, adhesion, and visualization potential are urgently required in clinical practice. Here, we report the development of PVA/gelatin/iohexol(I) fiber blocks as a novel embolization material for liver embolization in rats. In our work, electrospun PVA/gelatin/I nanofibrous mats were first prepared, homogenized, centrifuged in a gradient manner, and freeze-dried to obtain fiber blocks(fiber diameter =296.2 ± 74.23 nm, length 99.6 ± 17.0 μm × width 46.9 ± 13.3 μm). The fiber blocks exhibited excellent cytocompatibility and hemocompatibility. Fiber blocks with a PVA/gelatin/I mass ratio of 8:2:10 were selected due to their excellent expansibility and adhesive properties. The PVA/gelatin/I fiber blocks display excellent liver embolic effects and computed tomography(CT) imaging potential due to a combination of the following characteristics: expansibility of PVA and gelatin, adhesive property of gelatin, and CT imaging potential of I. The developed fiber block material is an embolic material that may potentially be used in interventional medicine.

关键词： Electrospinning PVA/Gelatin/I embolic material Fiber blocks Visualization Embolization

Construction of Electrospun Organic/Inorganic Hybrid Nanofibers for Drug Delivery and Tissue Engineering Applications

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Advanced Fiber Materials 2019年第1期1卷 32-45页

作者： Wei Huang Yunchao Xiao xiangyang shi State Key Laboratory for Modifcation of Chemical Fibers and Polymer Materials International Joint Laboratory for Advanced Fiber and Low-dimension MaterialsCollege of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai 201620People’s Republic of China CQM-Centro de Química da Madeira Universidade da MadeiraCampus da Penteada9000-390 FunchalPortugal

Electrospun nanofibers hold a great potential in biomedical applications due to their advantages of large specific surface area,good biocompatibility,easy fabrication and surface *** particular,organic/inorganic hybrid nanofibers exhibit enhanced mechanical properties and long-term sustained release or controlled release profile of encapsulated drugs,which enables hybrid nanofibers to serve as desired platform for drug delivery and tissue engineering *** review summarizes the recent progresses in the preparation,performances and applications of hybrid nanofibers as drug delivery vectors for antibacterial and antitumor therapy,and as nanofibrous scaffolds for bone tissue engineering or other types of tissue engineering *** doped with various types of inorganic nanoparticles(e.g.,halloysite,laponite®,nano-hydroxyapatite,attapulgite,carbon nanotubes,and graphene,etc.)are introduced and summarized in *** perspectives are also briefly discussed.

关键词： Electrospun nanofibers Hybrid nanofibers Drug delivery Tissue engineering

Nanogels as Contrast Agents for Molecular Imaging

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Chinese Journal of Chemistry 2016年第6期34卷 547-557页

作者： Jianzhi Zhu Wenjie Sun xiangyang shi College of Chemistry Chemical Engineering and Biotechnology Donghua University Shanghai 201620 China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Donghua University Shanghai 201620 China

Nanogels （NGs） as soft nanosized materials have gained a variety of interests in biomedical fields. The versatile NG scaffolds with 3-dimensional spherical shape, high loading efficiency, tunable surface functionalization, and excellent biocompatibility afford their uses as carrier to load mono- or multi-mode molecular imaging contrast agents （CAs）. This review summarizes the synthesis routes and applications of NGs as CAs for molecular imaging applications including magnetic resonance （MR）, computed tomography （CT）, radionuclide, optical, and dual/mul- ti-modality imaging.

关键词： nanogels contrast agents MR imaging CT imaging radionuclide imaging optical imaging dual/multi-modality imaging