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Mitochondria-targeted nano-AIEgens as a powerful inducer for evoking immunogenic cell death

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Chinese Chemical Letters 2024年第5期35卷 338-343页

作者： Kun-Heng Li Hong-Yang Zhao Dan-Dan Wang Ming-Hui Qi Zi-Jian Xu Jia-Mi Li Zhi-Li Zhang shi-wen Huang Key Laboratory of Biomedical Polymers of Ministry of Education Department of ChemistryWuhan UniversityWuhan 430072China

AIEgens can serve as an effective platform for the construction of photosensitizer-based immunogenic cell death(ICD)*** date,several mitochondria or endoplasmic reticulum(ER)-targeted aggregationinduced emission(AIE)molecules have been developed and have evoked massive ICD in ***,due to the complex physicochemical environment in cells,these small AIE molecules cannot maintain a stable aggregate state,which not only affects the fluorescence intensity of the photosensitizer but also decreases the generation of reactive oxygen species(ROS),and thus reducing the effect of the photosensitizer to elicit ***-based nanomicelles,which maintain a stable micellar structure,can prevent defects of AIE molecules in photodynamic therapy(PDT)***,in this study,a mitochondria-targeted AIE nanophotosensitizer was synthesized and used as a highly potent ICD inducer for vaccine preparation and tumor prevention.

关键词： Aggregation induced emission Photodynamic therapy Immunogenic cell death Reactive oxygen species Nanophotosensitizer Mitochondria

Preparation of Fe-As alloys by mechanical alloying and vacuum hot-pressed sintering:microstructure evolution,mechanical properties,and mechanisms

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Rare Metals 2024年第8期43卷 3876-3892页

作者： Fei Chai Fei-Ping Zhao Zhan Hu shi-Yi wen Ben-Hammouda Samia Ze-Lin Fu Xin-Ting Lai Yan-Jie Liang Xiao-Bo Min Li-Yuan Chai School of Metallurgy and Environment Central South UniversityChangsha 410083China Chinese National Engineering Research Center for Control&Treatment of Heavy Metal Pollution Institute of Environmental EngineeringCentral South UniversityChangsha 410083HunanChin State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China Department of Building Civiland Environmental EngineeringConcordia UniversityMontreal H3G 1M8Canada

Arsenic materials have attracted great attention due to their unique ***,research concerning iron-arsenic(Fe-As) alloys is very scarce due to the volatility of As at low temperature and the high melting point of ***,a new Fe-As alloy was obtained by mechanical alloying(MA) followed by vacuum hot-pressed sintering(VHPS).Moreover,a systematic study was carried out on the microstructural evolution,phase composition,leaching toxicity of As,and physical and mechanical properties of Fe-As alloys with varying weight fractions of As(20%,25%,30%,35%,45%,55%,65%,and 75%).The results showed that pre-alloyed metallic powders(PAMPs) have a fine grain size and specific supersaturated solid solution after MA,which could effectively improve the mechanical properties of Fe-As alloys by VHPS.A high density(> 7.350 g·cm^(-3)),low toxicity,and excellent mechanical properties could be obtained for FeAs alloys sintered via VHPS by adding an appropriate amount of As,which is more valuable than commercial Fe-As *** Fe-25% As alloy with low toxicity and a relatively high density(7.635 g·cm^(-3)) provides an ultra-high compressive strength(1989.19 MPa),while the Fe-65% As alloy owns the maximum Vickers hardness(HVo.5 899.41).After leaching by the toxicity characteristic leaching procedure(TCLP),these alloys could still maintain good mechanical performance,and the strengthening mechanisms of Fe-As alloys before and after leaching were *** in the grain size,micro structure,and phase distribution induced significant differences in the compressive strength and hardness.

关键词： Mechanical alloying Vacuum hot-pressed sintering High-pressure Arsenic-iron alloys Mechanical properties

Reinfection and Risk Factors of SARS-CoV-2 during an Omicron Wave 2022 in Shanghai

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Biomedical and Environmental Sciences 2024年第2期37卷 204-209页

作者： WANG Pei Qin WANG Xiao Hang WANG Jian shi Zhi wen CHU Dong Mei WANG Zhi Fei ZHANG Mu Bai LIU Wei ZHOU Zi Jie XIE Wei Fen Department of Gastroenterology Changzheng HospitalNaval Medical UniversityShanghai 200003China Health examination center Changzheng HospitalNaval Medical UniversityShanghai 200003China

Multiple waves of coronavirus disease 2019(COVID-19) outbreaks have affected numerous countries worldwide. The first case of SARS-CoV-2 reinfection was reported in Hong Kong in August 2020^([1]), leading to increased interest in the effectiveness of natural immunity acquired from primary infection. While data reports vary across countries, all findings indicate that prior SARS-CoV-2 infection provides substantial protection against reinfection^([2]). However, natural immunity from infection with previous non-Omicron or early Omicron sub-lineages offers lower levels of protection against Omicron reinfection, with rates below 60%^([3]) and approximately 75%[4], respectively.

关键词： immunity infection Omi

Herb pair of Huangqi-Danggui exerts anti-tumor immunity to breast cancer by upregulating PIK3R1

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Animal Models and Experimental Medicine 2024年第3期7卷 234-258页

作者： Hai-Xin Liu Li Lian Li-Li Hou Cai-Xia Liu Jin-Hong Ren Yuan-Biao Qiao shi-Yuan wen Qing-Shan Li College of Traditional Chinese Medicine and Food Engineering Shanxi University of Chinese MedicineTaiyuanChina Shanxi Key Laboratory of Innovative Drug for the Treatment of Serious Diseases Basing on the Chronic Inflammation College of Traditional Chinese Medicine and Food EngineeringShanxi University of Chinese MedicineTaiyuanChina College of Basic Medical Sciences Shanxi Medical UniversityTaiyuanChina

Background:According to traditional Chinese medicine(TCM),drugs supplementing the vital energy,Qi,can eliminate tumors by restoring host *** objective of this study is to investigate the underlying immune mechanisms of anti-tumor activity associated with Qi-supplementing herbs,specifically the paired use of Huangqi and ***:Analysis of compatibility regularity was conducted to screen the combination of Qi-supplementing *** the MTT assay and a transplanted tumor mice model,the anti-tumor effects of combination TCMs were investigated in vitro and in *** content analysis and flow cytometry were then used to evaluate cellular immunity,followed by network pharmacology and molecular docking to dissect the significant active compounds and potential ***,the anti-tumor activity and the mechanism of the active ingredients were verified by molecular ***:There is an optimal combination of Huangqi and Danggui that,administered as an aqueous extract,can activate immunity to suppress tumor and is more effective than each drug on its own in vitro and in *** on network pharmacology analysis,PIK3R1 is the core target for the anti-tumor immunity activity of combined Huangqi and *** docking analysis shows 6 components of the combined Danggui and Huangqi extract(quercetin,jaranol,isorhamnetin,kaempferol,calycosin,and suchilactone)that bind to *** is the most important component against breast *** suchilactone/jaranol combination and,especially,the suchilactone/kaempferol combination are key for immunity enhancement and the anti-tumor effects of the ***:The combination of Huangqi and Danggui can activate immunity to suppress breast cancer and is more effective than the individual drugs alone.

关键词： anti-tumor Danggui Huangqi immunity

基于平稳小波变换的光伏直流串联电弧故障检测

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电力系统保护与控制 2024年第12期52卷 82-93页

作者：王桐史雯石浩渊康子良内蒙古电力集团有限责任公司内蒙古电力科学研究院内蒙古呼和浩特010020 内蒙古电力集团有限责任公司呼和浩特供电分公司内蒙古呼和浩特010020 燕山大学电气工程学院河北秦皇岛066004

光伏系统直流串联电弧故障具有随机性和隐蔽性的特点,且容易受到外部环境和光伏系统内部噪声的影响,难以检测。利用小波变换提取的电流时频域特征对电弧故障有很好的辨识度,但面临小波基选取的问题。在采集大量电弧故障数据的基础上,通... 详细信息

光伏系统直流串联电弧故障具有随机性和隐蔽性的特点,且容易受到外部环境和光伏系统内部噪声的影响,难以检测。利用小波变换提取的电流时频域特征对电弧故障有很好的辨识度,但面临小波基选取的问题。在采集大量电弧故障数据的基础上,通过小波变换分析和对比实验,提出一种针对常用电弧故障特征指标提取的最优小波基选取方法。通过此方法确定bior4.4小波基为提取电弧故障特征的最优小波基,并由此构建基于bior4.4平稳小波变换的时频域特征。通过对比试验发现,基于bior4.4的时频域特征对电弧故障的辨识度明显提高,且表现出对正常噪声信号的抑制作用。为从多角度反映电弧故障特征,补充时域特征,并与时频域特征结合构成电流特征库,利用随机森林算法实现电弧故障的诊断。电弧故障检测准确率达到98.58%,正常信号的误判率仅为0.76%。

关键词：电弧故障平稳小波变换最优小波基近似熵样本熵随机森林算法

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14世纪至16世纪中国与意大利陶瓷人物装饰比较研究——以青花瓷与马约里卡陶器为例

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中国陶瓷 2024年第5期60卷 82-88,101页

作者：史文轩同济大学设计创意学院上海200082

14世纪至16世纪,中国青花瓷与意大利马约里卡陶器,由于制瓷技艺、城市建筑兴起及上层阶级品味的影响,人物装饰主题的陶瓷器物大量出现。研究为了探究中国与意大利陶瓷艺术背后的文化的差异,通过比较研究的分析方法,对比了青花瓷与马约... 详细信息

14世纪至16世纪,中国青花瓷与意大利马约里卡陶器,由于制瓷技艺、城市建筑兴起及上层阶级品味的影响,人物装饰主题的陶瓷器物大量出现。研究为了探究中国与意大利陶瓷艺术背后的文化的差异,通过比较研究的分析方法,对比了青花瓷与马约里卡陶器三种主要人物装饰在形式、审美及社会价值维度的异同。二者的差异性在于,明代青花瓷以用笔用线的绘画方式表现人物个性,具有东方审美的意蕴,官窑青花瓷代表了精英阶层的品位,而马约里卡陶器色彩丰富,以绘画的透视法则再现人物形象,突出叙事的装饰特点,是社会道德与个人身份的象征。其相似性是二者都借鉴了文学文本与其他艺术门类题材,人物形象是艺术情感的寄托。

关键词：青花瓷马约里卡陶器人物装饰比较研究

Identification and Validation of SLC9A2 as A Potential Tumor Suppressor in Colorectal Cancer:Integrating Bioinformatics Analysis with Experimental Confirmation

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Current Medical Science 2024年第3期44卷 529-544页

作者： Yan-min LIU Tie-cheng YANG Xiao-chang FANG Li-jie YANG Li-wen shi Hua-qiao WANG Ting-ting DOU Lin SHU Tian-Liang CHEN Jun HU Xiao-ming YU Xuan-fei LI Department of Gastroenterology the Central Hospital of WuhanKey Laboratory for Molecular Diagnosis of Hubei ProvinceTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430014China Department of Gastrointestinal Surgery Zhongnan Hospital of Wuhan UniversityWuhan430071China Clinical Medical Research Center of Peritoneal Cancer of Wuhan Wuhan430071China Hubei Provincial Clinical Research Center for Cancer Hubei Key Laboratory of Tumor Biological Behavi Wuhan430071China Department of General Surgery Taihe HospitalHubei University of MedicineShiyan442000China Department of Gastrointestinal Surgery Huangshi Central HospitalAffiliated Hospital of Hubei Polytechnic UniversityWuhan435001China

Objective To uncover the mechanisms underlying the development of colorectal cancer(CRC),we applied bioinformatic analyses to identify key genes and experimentally validated their possible roles in CRC onset and *** We performed Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis on differentially expressed genes(DEGs),constructed a protein-protein interaction(PPI)network to find the top 10 hub genes,and analyzed their expression in colon adenocarcinoma(COAD)and rectum adenocarcinoma(READ).We also studied the correlation between these genes and immune cell infiltration and prognosis and validated the expression of SLC9A2 in CRC tissues and cell lines using qRT-PCR and Western *** experiments were conducted in vitro to investigate the effects of SLC9A2 on tumor growth and *** We found 130 DEGs,with 45 up-regulated and 85 down-regulated in *** analysis indicated that these DEGs were primarily enriched in functions related to the regulation of cellular pH,zymogen granules,and transmembrane transporter *** pathway analysis revealed that the DEGs played pivotal roles in pancreatic secretion,rheumatoid arthritis,and the IL-17 signaling *** identified 10 hub genes:CXCL1,SLC26A3,CXCL2,MMP7,MMP1,SLC9A2,SLC4A4,CLCA1,CLCA4,and *** enrichment analysis showed that these hub genes were predominantly involved in the positive regulation of *** expression analysis revealed that CXCL1,CXCL2,MMP1,and MMP7 were highly expressed in CRC,whereas CLCA1,CLCA4,SLC4A4,SLC9A2,SLC26A3,and ZG16 were expressed at lower *** analysis revealed that 5 key genes were significantly associated with the prognosis of *** mRNA and protein expression levels of SLC9A2 were markedly reduced in CRC tissues and cell ***,SLC9A2 overexpression in SW480 cells led to a notable inhibition of cell proliferation,migration,and *** blotting analysis revealed tha

关键词： SLC9A2 colorectal cancer bioinformatic analysis biomarkers immune infiltrate

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海洋平台膨胀弯结构安装极限尺寸分析

船舶力学 2024年第8期28卷 1244-1253页

作者：刘健石文波王宇哈尔滨工程大学航天与建筑工程学院哈尔滨150001

海底管道膨胀弯安装是铺设海底管道施工过程中的重要组成部分。由于在生产制造海洋管道过程中存在加工误差,另外施工中对接膨胀弯管与海洋立管或者海底平管也存在偏差,因此安装膨胀弯过程中存在极限尺寸偏差方面的问题。本文运用有限元... 详细信息

海底管道膨胀弯安装是铺设海底管道施工过程中的重要组成部分。由于在生产制造海洋管道过程中存在加工误差,另外施工中对接膨胀弯管与海洋立管或者海底平管也存在偏差,因此安装膨胀弯过程中存在极限尺寸偏差方面的问题。本文运用有限元分析软件ABAQUS,按照实际结构尺寸和材料参数建立带有法兰接头的膨胀弯仿真模型,针对实际安装膨胀弯过程中存在的三种类型的偏差工况,在满足实际施工对海管强度要求规范下,计算膨胀弯安装极限尺寸偏差,并得到结构在不同工况下的应力和应变的分布情况。详细讨论和分析膨胀弯在安装对接立管和平管过程的受力与形变情况。得到的相关结论有望为海洋平台中海管实际施工安装提供相应的理论依据,对海上油气田的开发建设具有一定的工程意义。

关键词：膨胀弯结构静力分析 ABAQUS有限元仿真海洋管道

Severe hypoxemia after radiofrequency ablation for atrial fibrillation in palliatively repaired tetralogy of Fallot: A case report

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World Journal of Cardiology 2024年第3期16卷 161-167页

作者： Zhi-Hang Li Lian Lou Yu-Xiao Chen wen shi Xuan Zhang Jian Yang Department of Cardiovascular Medicine The First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Cardiology The First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Patients with tetralogy of Fallot(TOF)often have arrhythmias,commonly being atrial fibrillation(AF).Radiofrequency ablation is an effective treatment for AF and does not usually cause severe postoperative hypoxemia,but the risk of complications may increase in patients with conditions such as *** SUMMARY We report a young male patient with a history of TOF repair who developed severe hypoxemia after radiofrequency ablation for AF and was ultimately confirmed to have a new right-to-left *** patient subsequently underwent atrial septal occlusion and eventually *** Radiofrequency ablation may cause iatrogenic atrial septal injury;thus possible complications should be predicted in order to ensure successful treatment and patient safety.

关键词： Atrial fibrillation Radiofrequency ablation Tetralogy of Fallot Right-to-left shunt Hypoxemia Medical decision Case report