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Interleukin-6 in epilepsy and its neuropsychiatric comorbidities: How to bridge the gap

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World Journal of Psychiatry 2025年第1期15卷 1-6页

作者： Xiao-Man Chen Shuo Zhang shi-qi Gao Michael Xu Department of Neurology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina Department of Rehabilitation Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110004Liaoning ProvinceChina International Education School China Medical UniversityShenyang 110004Liaoning ProvinceChina

There is growing evidence that interleukin(IL)-6 plays an important role in neurological and psychiatric *** editorial comments on the study published in the recent issue of the World Journal of Psychiatry,which employed Mendelian randomization to identify a causal relationship between IL-6 receptor blockade and decreased epilepsy *** purpose of this editorial is to highlight the dual effects of IL-6 in epilepsy and its related neuropsychiatric ***-6 plays a critical role in the facilitation of epileptogenesis and maintenance of epileptic seizures and is implicated in neuroinflammatory proce-sses associated with ***,IL-6 significantly influences mood regulation and cognitive dysfunction in patients with epilepsy,highlighting its involvement in neuropsychiatric *** summary,IL-6 is not only a pivotal factor in the pathogenesis of epilepsy but also significantly contributes to the emergence of epilepsy-related neuropsychiatric *** resear-ch should prioritize elucidating the specific mechanisms by which IL-6 operates across different subtypes,stages and neuropsychiatric comorbidities of epilepsy,with the aim of developing more precise and effective ***,the potential of IL-6 as a biomarker for the early diagnosis and prognosis of epile-psy warrants further investigation.

关键词： Epilepsy Interleukin-6 Neuropsychiatric comorbidities Depression Tocilizu-mab Neuroinflammation Interleukin-6 receptor blockade

Theoretical Investigation of Uniform and Non-uniform Penetrable Sphere Fluid

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Communications in Theoretical Physics 2006年第2X期46卷 323-331页

作者： ZHOU shi-qi Institute of Modern Statistical Mechanics Hunan University of Technology Zhuzhou 412008 China

A bridge function approximation is proposed for a single-component fluid consisting of penetrable sphere interacting via a potential that remains finite and constant for center-center distance smaller than the particle diameter and is zero otherwise. The radial distribution function from the Ornstein-Zernike integral equation combined with the present bridge function approximation is in satisfactory agreement with the corresponding simulation data for all of the investigated state points. The presently calculated excess Helmholtz free energy respectively based on virial route and compressibility route is highly self-consistent, and is in very good agreement with simulational results for the case of low temperatures. The present bridge function approximation, combined with the bridge density functional approximation, can reproduce very accurately density profiles of the penetrable sphere fluid confined in a hard spherical cavity for all the cases where simulational results are available.

关键词： complex fluids structure density profile

Influence of Solvent-Solvent and Solute-Solvent Interaction Properties on Solvent-Mediated Potential

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Communications in Theoretical Physics 2005年第2X期44卷 365-370页

作者： ZHOU shi-qi Institute of Modern Statistical Mechanics Zhuzhou Institute of Technology Zhuzhou 412008 China

A recently proposed universal calculational recipe for solvent-mediated potential is applied to calculate excess potential of mean force between two large Lennard-Jones (LJ) or hard core attractive Yukawa particles immersed in small LJ solvent bath at supercritical state. Comparison between the present prediction with a hypernetted chain approximation adopted for solute-solute correlation at infinitely dilute limit and existing simulation data shows high accuracy for the region with large separation, and qualitative reliability for the solute particle contact region. The calculational simplicity of the present recipe allows for a detailed investigation on the effect of the solute-solvent and solvent-solvent interaction details on the excess potential of mean force. The resultant conclusion is that gathering of solvent particles near a solute particle leads to repulsive excess PMF, while depletion of solvent particles away from the solute particle leads to attractive excess PMF, and minor change of the solvent-solvent interaction range has large influence on the excess PMF.

关键词： excess potential of mean force density function theory

Coupled effects of climate change and human activities on vegetation dynamics in the Southwestern Alpine Canyon Region of China

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Journal of Mountain Science 2024年第10期21卷 3234-3248页

作者： LAI Jinlin qi shi School of Soil and Water Conservation Beijing Forestry UniversityBeijing 100083China

The driving effects of climate change and human activities on vegetation change have always been a focal point of ***,the coupling mechanisms of these driving factors across different temporal and spatial scales remain *** Southwestern Alpine Canyon Region of China(SACR),as an ecologically fragile area,is highly sensitive to the impacts of climate change and human *** study constructed a vegetation cover dataset for the SACR based on the Enhanced Vegetation Index(EVI)from 2000 to *** autocorrelation,Theil-Sen trend,and Mann-Kendall tests were used to analyze the spatiotemporal characteristics of vegetation cover *** main drivers of spatial heterogeneity in vegetation cover were identified using the optimal parameter geographic detector,and an improved residual analysis model was employed to quantify the relative contributions of climate change and human activities to interannual vegetation cover *** main findings are as follows:Spatially,vegetation cover exceeds 60%in most areas,especially in the southern part of the study ***,the border area between Linzhi and Changdu exhibits lower vegetation *** factors are the primary drivers of spatial heterogeneity in vegetation cover,with temperature having the most significant influence,as indicated by its q-value,which far exceeds that of other ***,the interaction q-value between the two factors significantly increases,showing a relationship of bivariate enhancement and nonlinear *** terms of temporal changes,vegetation cover shows an overall improving trend from 2000 to 2020,with significant increases observed in 68.93%of the study *** these,human activities are the main factors driving vegetation cover change,with a relative contribution rate of 41.31%,while climate change and residual factors contribute 35.66%and 23.53%,*** thoroughly exploring the coupled mechanisms of vegetation change,this

关键词： Enhanced vegetation index Climate change Human activities Spatial heterogeneity Coupled mechanisms

FEM Simulation of the Hydrogen Diffusion in X80 Pipeline Steel During Stacking for Slow Cooling

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Acta Metallurgica Sinica(English Letters) 2014年第3期27卷 416-421页

作者： Zhenyi Huang qi shi Fuqiang Chen Yunfeng shi School of Metallurgical Engineering Anhui University of Technology Heavy Plate Mill Baoshan Iron and Steel Co. Ltd

The influence of temperature on the hydrogen diffusion behavior in X80 pipeline steel during stacking for slow cooling was studied using electrochemical penetration method, the temperature field and the hydrogen diffusion in this pipeline steel during stacking for slow cooling were simulated by ABAQUS finite element method （FEM） software. The results show that in this process there is a reciprocal relationship between the natural logarithm of hydrogen diffusion coefficient and temperature. The cooling rate decreases gradually with the increase of steel plate thickness. The hydrogen content is higher at high temperature （500-400 ℃） than that in low temperature region （300-100 ℃）. The FEM simulation results are consistent with the experimental ones, and the model can be used to predict the hydrogen diffusion behavior in industrial production of X80 pipeline steel.

关键词： X80 pipeline steel Stacking Slow cooling Hydrogen diffusion Finite element method (FEM) Electrochemical penetration

Northeastern Asia humidification at the end of the Miocene drives the boost of mammalian dispersals from the Old to New World

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Journal of Palaeogeography 2023年第1期12卷 50-68页

作者： qigao Jiangzuo shi-qi Wang Key Laboratory of Orogenic Belts and Crustal Evolution School of Earth and Space SciencesPeking UniversityBeijing 100871China Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijing 100871China CAS Center for Excellence in Life and Paleoenvironment Beijing 100871China Division of Paleontology American Museum of Natural HistoryNew YorkNY 10024-5102USA

Mammals have high dispersal ability,and many lineages can spread across the continents when a landbridge ***,we summarize the dispersal of mammals between the Old and New World at the end of the *** analysis suggested that the three phases of dispersal represented the largest dispersal tide during the Neogene,and the direction of dispersal is dominated by being from the Old to New *** from the components that crossed the dispersal corridor,the Arctic environment near the Beringia corridor in the first phase(~7.5 Ma)is a mixed environment,and in the second phase(~6.5 Ma)is an open environment,and in the third phase(~5.8 Ma and continue to the Pliocene)is a wooded(closed)environment.A clear trend of eastern Asian humidification driven by Asian monsoon and the global C4 grassland expansion explain this dispersal *** boost of mammalian dispersals is controlled by the heterogeneity of environmental changes in different continents.

关键词： Eastern asia North America Carnivora Dispersal Late miocene

Investigation on Electronic Structures and Spectra for the Substituted Fullerene C_(77)B^-

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Chinese Journal of Structural Chemistry 2006年第6期25卷 694-698页

作者： WU shi TENG qi-Wen Department of Chemistry Zhejiang University Hangzhou 310027 China

The structures and stabilities of all the 21 possible isomers for C77B^- based on C78 （C2v） were studied by the INDO series of methods. The most two stable geometries are C77B^-（10） and C77B^-（7）, where B（10） and B（7） are located at the apexes among two hexagons and a pentagon near the shortest axis of C78 （C2v）, and the former is more stable than the latter by 0.1902 eV. Based on the optimized geometries, the electronic spectra of the C77B^- isomers were investigated with the INDO/CIS method and the electronic transitions were assigned. The reason for the red-shift of the first absorption peaks for C77B^- compared with that of C78 （C2v） was discussed.

关键词： C77B^- electronic spectra INDO

Effect of C-Tetramethyl Calix[4]resorcinarene Acrylate on Curing Behavior and Film Properties of Thiol-acrylate Coating System

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Chemical Research in Chinese Universities 2009年第5期25卷 760-766页

作者： FU qi shi Wen-fang Joint Laboratory of Polymer Thin Films and Solution Department of Polymer Science and Engineering University of Science and Technology of China Hefei 230026 P. R. China

An octa-functional acrylate of C-tetramethyl calix[4]resorcinarene（CMC-4-RA） was facilely synthesized and characterized with ^1H NMR, ^13C NMR and FTIR spectroscopy. The CMC-4-RA was added to a thiol-acrylate system with different mass ratios, and exposed to a middle pressure mercury lamp. The maximum photopolymerization rate and final vinyl group conversion in the cured film increased greatly along with CMC-4-RA addition that was monitored with Photo-DSC. The tensile strength and pendulum hardness were improved significantly after the addition of CMC-4-RA. With increasing the content of CMC-4-RA to 60%（mass fraction）, the glass transition temperature increased from 34.2 ℃ to 84.1 ℃; the cross-link density was calculated to be increased from 23.83 mmol/cm^3 to 82.40 mmol/cm^3 according to dynamic mechanical thermal analysis; the thermostability was greatly improved.

关键词： Calixresorcinarene Acrylate UV curing Film

Evaluating refractive index and birefringence of nonlinear optical crystals:Classical methods and new developments

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Chinese Journal of Structural Chemistry 2023年第1期42卷 46-63页

作者： qi shi Lingyun Dong Ying Wang College of Chemistry and Materials Science Hebei UniversityBaoding071002China College of Biochemistry and Environmental Engineering Baoding UniversityBaoding071002China

Nonlinear optical(NLO)materials play an increasingly important role in laser *** is one of the most important parameters for NLO materials to realize angle phase-matching *** comparison with other desirable optical properties,the availability of birefringence and refractive index dispersion is especially problematic owing to the strict requirements for single *** this review,we described how to obtain the refractive index and birefringence of NLO materials from crystals sub-millimeters to centimeters in ***-cially,recently developed methods including the minimum deflection angle method,auto-collimation method,prism coupling method,oil immersion technique,interference color method,and theoretical calculation(DFT)for rapid assessment of birefringence are summarized,the contents of which are mainly focused on the principles and typical applications,together with the advantages and *** addition,representative examples of bire-fringent measurements were *** purpose of this work is to provide a useful perspective on the characterization of birefringence for NLO *** is hoped that this review can give a clear description of the birefringence measurements and accelerate the discovery of new NLO crystals.

关键词： Nonlinear optical crystals Refractive index Birefringence DFT calculation Phase-matching