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Design and Synthesis of 3-Substituedmethylenethiochroman-4-ones as Anticancer Agents

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Chemical Research in Chinese Universities 2011年第5期27卷 787-791页

作者： MA Zheng-yue ZHANG Xing-hua LI Chun-na ZheNG Ya-jun yang Geng-liang WANG shi-kui he yang Key Laboratory for Pharmaceutical Quality Control of hebei Province College of Pharmaceutical Sciences Hebei University Baoding 071002 P R. China

A series of 3-substituedmethylenethiochroman-4-ones was designed and synthesized, and their structures were confirmed by 1H NMR, 13C NMR, MS, IR, UV and elemental analysis. The results of their anticancer activity studies show that almost all 3-chloromethylenethiochroman-4-ones exhibit high anticancer activities and their activities are all better than reference cisplatin. Their IC50 against cancer cells is in a range of 0.80―9.17 μg/mL. Thus they could be promising candidates for anticancer drugs. However, compound 5 has no activity against cancer cells, thus chloromethylene at the 3 position of thiochroman-4-ones seems to play an important role in observed anticancer activities.

关键词： Anticancer activity 3-Chloromethylene Thiochromanone

Uniform arrays of gold nanoparticles with different surface roughness for surface enhanced Raman scattering

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Chinese Chemical Letters 2015年第11期26卷 1426-1430页

作者： Yan Zhang Lian-Meng Wang En-Zhong Tan shi-he yang Li-Dong Li Lin Guo School of Chemistry and Environment Beihang University Department of Mathematics and Physics Beijing Institute of Technology Petrochemical Department of Chemistry The Hongkong University of Science and Technology

Uniform arrays of coarse and smooth gold nanoparticles with diameter about 130 nm were successfully synthesized through seed-mediated growth method, separately. Scanning and transmission electron microscopy （SEM and TEM） and X-ray diffraction （XRD） have been used to study the formation and structure of the nanocomposites. The high enhancement factor for surface-enhanced Raman scattering of coarse and smooth gold nanoparticles were estimated to be about 3.1 × 10^6 and 2.0 × 10^6, respectively. It is evident that the coarse gold nanostructures has higher influence factor than the smooth gold nanostructures. Therefore, these unique properties of the coarse Au nanoparticles appear to be very Dromising for applications as high-performance SERS subsrrares.

关键词： NanoparticlesDifferent RoughnessSERS

Magnetic Co_3O_4 nanowires,preparation and properties

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Chinese Chemical Letters 2012年第7期23卷 851-854页

作者： Mai Xia Ma Wei Meng Chen Lin Guo Jing Hong Li Chin Ping Chen shi he yang School of Chemistry and Environment Beijing University of Aeronautics and AstronauticsBeijing 100191China 'Department of Physics Peking UniversityBeijing 100871China Department of Chemistry Beijing Key Laboratory for Microanalytical Methods and InstrumentationKey Laboratory of Bioorganic Phosphorus Chemistry&Chemical BiologyTsinghua UniversityBeijing 100084China Department of Chemistry The Hong Kong University of Science and TechnologyHong KongChina Faculty of Chemistry and Material Science Langfang Teachers CollegeLangfang 065000China

The Co3O4 nanowires have been successfully synthesized via modified template *** as-prepared products have been characterized by EDS,TEM and HRTEM *** magnetic behavior of it is investigated by a magnetic property measurement *** nanowires exhibit some novel magnetic properties,which are different from its bulk *** temperature dependence curves of magnetization in zero-field-cooling and field-cooling exhibit two peaks of antiferromagnetic at blocking temperature of～23 K and～31 K,*** field dependent M（H） curves of the Co_3O_4 nanowires at T = 5 and 300 K both exhibit PM ***,the diameter of nanowires is hence determined according to the finite size effect as approximately 7-11 nm,in consistent with the characterizations by HRTEM.

关键词： Nanostructures Oxides Magnetic properties

Relationship between critical seismic acceleration coefficient and static factor of safety of 3D slopes

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Journal of Central South University 2021年第5期28卷 1546-1554页

作者： shi he-yang CheN Guang-hui School of Civil Engineering Central South UniversityChangsha 410075China

Many analytical methods have been adopted to estimate the slope stability by providing various stability numbers,*** safety of factor(static FoS)or the critical seismic acceleration coefficient,while little attention has been given to the relationship between the slope stability numbers and the critical seismic acceleration *** study aims to investigate the relationship between the static FoS and the critical seismic acceleration coefficient of soil slopes in the framework of the upper-bound limit *** on the 3D rotational failure mechanism,the critical seismic acceleration coefficient using the pseudo-static method and the static FoS using the strength reduction technique are first ***,the relationship between the static FoS and the critical seismic acceleration coefficient is presented under considering the slope angleβ,the frictional angleφ,and the dimensionless coefficients B/H and c/γ***,a fitting formula between the static FoS and the critical seismic acceleration coefficient is proposed and validated by analytical and numerical results.

关键词： static safety of factor critical seismic acceleration coefficient upper-bound limit analysis 3D rotational failure mechanism

CFD Simulation of the Flow Field Inside Screw Powder Feeder

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International Journal of Plant Engineering and Management 2011年第3期16卷 146-149页

作者： shi yang-he SHAO Zong-heng East China Jiaotong University Nanchang 330013 P. R. China

A screw powder feeder is an important device for industrial applications. There are many parameters which affect the performance of the screw powder feeder, such as the shapes of the helical screw impeller, the number of screw pitches, etc. This paper presents an analysis of a gas-solid two-phase through screw powder feeder by using a commercial Computational Fluid Dynamics（CFD） code, Fluent. The K-ε model is used to simulate gas flow. Particle trajectory is obtained by the use of a discrete phase model. The results show the effects of gas velocity and panicle size on the transportation performance.

关键词： screw powder feeder gas-solid two-phase flow CFD

Axiomatic Design of Micro Quartz Rate Sensor

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International Journal of Plant Engineering and Management 2007年第4期12卷 214-220页

作者： shi yang-he ZHANG Hong-hai LIU Sheng Institute of Microsystems Huazhong University of Science and Technology Wuhan 430074 P. R. China East China Jiaotong University Nanchang 330013 P. R. China Wuhan National Laboratory for Optoelectronics Wuhan 430074 P. R. China

Quartz rate sensors （QRS） made out of one single piece of quartz crystal are inertial devices which can be used for general rate control, stabilization, automotive and aerospace/defense markets, etc. The mechanical design of the QRS has been investigated based on axiomatic design. The axiomatic design matrix of the mechanical structure of Coriolis Vibratory Gyroscopes （CVG） has been proposed. The mechanical function of QRS is divided into three Function Requirements （FR） , i. e. , FR1 is the drive mode, FR2 is the sense mode, FR3 is a coupled connection where the Coriolis force can couple the two modes with a term proportional to the rotational rate. A new QRS which is easy to be fabricated has been put forward. Furthermore, the new QRS indicated that the axiomatic design is a help to functional design of products.

关键词： axiomatic design QRS CVG

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论侦查权的优化配置

法学论坛 2008年第5期23卷 110-116页

作者：何诗扬北京大学法学院北京100871

现代刑事诉讼法的发展和进步离不开对侦查权的制约,在侦查阶段,公民权利与国家权力发生直接冲突,如何对侦查权进行配置,直接体现了一国刑事诉讼法的价值取向,对刑事诉讼程序有决定性的影响。我国侦查权的配置与其他国家相比,具有较鲜明... 详细信息

现代刑事诉讼法的发展和进步离不开对侦查权的制约,在侦查阶段,公民权利与国家权力发生直接冲突,如何对侦查权进行配置,直接体现了一国刑事诉讼法的价值取向,对刑事诉讼程序有决定性的影响。我国侦查权的配置与其他国家相比,具有较鲜明的特点,也存在着特有的问题。近年来,理论界和实务界对侦查权的优化配置问题展开了热烈的讨论,总体认为对侦查权进行司法控制、实行检警一体化改革是优化侦查权配置的两个主要方向,不过,在我国现行司法结构和宪政体制下,这种改革动议也面临着现实障碍,如警察权力过大,司法不独立,检察官、法官素质有待提高等。

关键词：侦查权司法控制检警一体化

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数控机床的预防性保养的方法

机床与液压 2005年第12期33卷 193-193,169页

作者：施阳和华东交通大学江西南昌330013

通过对数控机床的故障及有关的设备故障诊断技术的分析和研究,提出了数控机床的预防性保养的方法。

关键词：数控机床预防性保养

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磁化悬浮-感应驱动型动量球系统

中国惯性技术学报 2016年第4期24卷 524-530页

作者：范达范春石贺杨宋坚张南中国空间技术研究院钱学森空间技术实验室北京100094

磁悬浮动量球是一种高功能密度比的微小卫星三轴姿控部件。磁悬浮与驱动原理的选择、磁极拓扑结构的布局以及传感方式的选用,从悬浮-旋转兼容性和空间结构干涉性上制约着磁悬浮动量球的可实现性。提出了一种新型的悬浮-旋转解耦、结构... 详细信息

磁悬浮动量球是一种高功能密度比的微小卫星三轴姿控部件。磁悬浮与驱动原理的选择、磁极拓扑结构的布局以及传感方式的选用,从悬浮-旋转兼容性和空间结构干涉性上制约着磁悬浮动量球的可实现性。提出了一种新型的悬浮-旋转解耦、结构简单紧凑的磁化悬浮-感应驱动型动量球系统,以单轴实现为例详细论述了系统组成与工作原理,对子模块的设计、硬件实现与建模开展了研究。针对开环不稳定悬浮系统,提出一种基于构造法的控制参数设计方法,并给出了系统的三轴拓展方式。仿真和实验结果表明,该系统可以实现悬浮与旋转功能,悬浮球体在有旋转和无旋转时的位移稳定度分别约为1.6μm和4.7μm,球形转子的转速可达720 r/min。

关键词：磁悬浮动量球三轴姿控磁化悬浮感应驱动