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Deep geodynamics of far field interconti- nental back-arc extension: Formation of Cenozoic volcanoes in northeastern China

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Acta Seismologica Sinica(English Edition) 2004年第Z1期17卷 1-8页

作者： shi yao-lin(石耀霖) ZHANG Jian(张健) Laboratory of Computational Geodynamics Graduate School of Chinese Academy of Sciences Beijing 100039China

There are three cases of variation of trench location possible to occur during subduction: trench fixed, trench ad- vancing, and trench retreating. Retreat of trench may lead to back-arc extension. The Pacific plate subducts at low angle beneath the Eurasia plate, tomographic results indicate that the subducted Pacific slab does not penetrate the 670 km discontinuity, instead, it is lying flat above the interface. The flattening occurred about 28 Ma ago. Geo- dynamic computation suggests: when the frontier of the subducted slab reaches the phase boundary of lower and upper mantle, it may be hindered and turn flat lying above the boundary, facilitates the retreat of trench and back-arc extension. Volcanism in northeastern China is likely a product of such retreat of subduction, far field back-arc extension, and melting due to reduce of pressure while mantle upwelling.

关键词： back-arc basin Cenozoic volcano geodynamics northeastem China

Developments of borehole strain observa- tion outside China

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Acta Seismologica Sinica(English Edition) 2004年第Z1期17卷 172-178页

作者： QIU Ze-hua(邱泽华) shi yao-lin(石耀霖) Institute of Crustal Dynamics China Earthquake Administration Beijing 100085 China Graduate School of the Chinese Academy of Sciences Beijing 100039 China

Borehole strain observation is playing an increasingly important role in the study on the crustal movements. It has been used by many countries such as China, USA, Japan, Peru, Australia, South Africa, Iceland and Italy, in re- search fields of plate tectonics, earthquake, volcanic eruption, dam safety, oil field subsidence, mining collapse and so on. Borehole strainmeter has been improved rapidly and tends to get more and more components included in one probe. Based on observations by this kind of instruments, studies on seismic strain step, slow earthquake, earthquake precursor and volcanic eruption forecasting have made remarkable achievements. In the coming years, borehole strain observation is going to become one major geodetic means, together with GPS and InSAR.

关键词： crustal deformation borehole strain observation borehole strainmeter

Prevalence of incidental prostate cancer in patients undergoing radical cystoprostatectomy： data from China and other Asian countries

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Asian Journal of Andrology 2009年第1期11卷 104-108页

作者： Yi-Ping Zhu Ding-Wei Ye Xu-Dong yao shi-lin Zhang Bo Dai Hai-Liang Zhang Yi-Jun Shen yao Zhu Guo-Hai shi Department of Urology Cancer Hospital Fudan University Shanghai 200032 China

The purpose of this study is to investigate the frequency of prostate cancer （Pca） discovered incidentally in radical cystoprostatectomy specimens in Asia and to determine the feasibility of prostate-sparing cystectomy （PSC） for Asian patients. Ninety-two male bladder cancer patients who underwent radical cystoprostatectomy at our center between January 2003 and January 2008 were included in this study. The mean age of patients was 67.1 years （range： 32-75 years）. Prostate-specific antigen （PSA） levels and digital rectal examination （DRE） results before surgery were obtained retrospectively. Prostates of all patients were embedded and sectioned at 5-mm intervals. The same pathologist examined the prostatic tissues from radical cystoprostatectomy specimens. Finally, a structured literature review was performed using MEDlinE and PUBMED to estimate the occurrence of incidental Pca in Asia. Of the 92 patients, 3 （3.3%） were found to have Pca; in one out of three （33.3%） patients the disease was clinically significant due to a Gleason grade 4 carcinoma. Eight articles were included in our review. The overall incidence of Pca discovered incidentally in radical cystoprostatectomy specimens in Asia was 9.9% （64/642）. When age was restricted to 〈 60 years, only 7 out of 222 （3.2%） patients were found to have synchronous Pca, and none of the cases was clinically significant. The occurrence of Pca in radical cystoprostatectorny specimens in Asia is much lower than that in Western countries. PSC might be feasible for Asian patients under a strict preoperative selection.

关键词： bladder cancer cystoprostatectomy incidental prostate cancer prostate-sparing cystectomy

An elevated serum miR-141 level in patients with bone-metastatic prostate cancer is correlated with more bone lesions

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Asian Journal of Andrology 2013年第2期15卷 231-235,I0007页

作者： Hai-Liang Zhang Xiao-Jian Qin Da-Long Cao yao Zhu Xu-Dong yao shi-lin Zhang Bo Dai Ding-Wei Ye Department of Urology Fudan University Shanghai Cancer Center Shanghai 200032 China

The skeleton is the most common metastatic organ in patients with prostate cancer （PCa）. Non-invasive biomarkers that can facilitate the detection and monitoring of bone metastases are highly desirable. We designed this study to assess the expression patterns of serum miR-141 in patients with bone-metastatic PCa. Serum samples were collected to measure the miR-141 level in 56 patients, including six with benign prostatic hyperplasia （BPH）, 20 with localized PCa and 30 with bone-metastatic PCa （10 with hormone-naive PCa, 10 with hormone-sensitive PCa and 10 with hormone-refractory PCa）. A bone scan was performed for each patient with PCa to assess the number of bone lesions. The quantification of serum miR-141 levels was assayed by specific TaqMan qRT-PCR. The results showed that serum miR-141 levels were elevated in patients with bone metastasis （P〈O.O01）. There was no statistically significant difference in the serum miR-141 levels between patients with BPH and patients with localized PCa. Using Kendall＇s bivariate correlation test, both the Gleason score and the number of bone-metastatic lesions were found to correlate with serum miR-141 levels （P=0.012 and P〈O.O01, respectively）. The serum miR-141 level was found to be positively correlated with alkaline phosphatase （ALP） level in patients with skeletal metastasis, using Pearson＇s bivariate correlation test. No relationship was found between the serum miR-141 level and the serum prostate-specific antigen （PSA） level. We concluded that serum miR-141 levels are elevated in patients with bone-metastatic PCa and that patients with higher levels of serum miR-141 developed more bone lesions. Furthermore, serum miR-141 levels are correlated with serum ALP levels but not serum PSA levels.

关键词： alkaline phosphatase (ALP) biological markers bones metastasis microRNAs miR-141 prostate-specific antigen(PSA) prostatic neoplasms serum

CABYR RNAi plasmid construction and NF-κB signal transduction pathway

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World Journal of Gastroenterology 2010年第39期16卷 4980-4985页

作者： lin-Xiang shi,yao-Ming He,lin Fang,Hong-Bo Meng,Li-Jun Zheng,Department of General Surgery,Shanghai Tenth People’s Hospital,Tongji University,Shanghai 200072,China Department of General Surgery Shanghai Tenth People's Hospital Tongji University Shanghai 200072 China. ajijinwei@***

AIM:To construct the CABYR RNAi plasmid and study its relation with the nuclear factor(NF)-κB signal transduction ***:Human CABYR mRNA sequence was obtained from *** structure of cDNA sequence for the short hairpin RNA was BbsⅠ+sense+loop+ antisense+transcription terminator+KpnⅠ+Bam HⅠ.A CABYR silencing plasmid was constructed and transfected into the human embryo cell line *** real-time polymerase chain reaction was used to analyze CABYR and NF-κB gene ***:The CABYR and NF-κB expressions were detected in 293T *** oligonucleotide(5'-GCT-CAGATGTTAGGTAAAG-3')efficiently silenced the expression of *** expression of NF-κB was not significantly affected by silencing CABYR(P=0.743).CONCLUSION:CABYR can be found in the human embryo cell line *** 2 can efficiently silence its target,CABYR,indicating that CABYR is not related with the NF-κB signal transduction pathway.

关键词： CABYR Plasmid Nuclear factor-κB Signal transduction RNAi Cabyrmid 2

基于Monte Carlo方法的由GPS观测计算地应变率的误差分析

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地球物理学报 2007年第3期50卷 806-811页

作者：朱守彪石耀霖中国地震局地壳应力研究所北京100085 中国科学院研究生院计算地球动力学实验室北京100049

在利用GPS观测计算地应变率中,应变率的误差分布在地球动力学研究中非常重要.为解决这一问题,文中提出基于MonteCarlo技术,利用GPS观测的速度计算地应变率进行误差分析的方法;以青藏高原地区为例,利用带有误差的GPS观测数据进行了大量... 详细信息

在利用GPS观测计算地应变率中,应变率的误差分布在地球动力学研究中非常重要.为解决这一问题,文中提出基于MonteCarlo技术,利用GPS观测的速度计算地应变率进行误差分析的方法;以青藏高原地区为例,利用带有误差的GPS观测数据进行了大量、独立的应变率重复计算,然后运用统计方法给出了应变率分量及其误差的分布.结果显示青藏高原的喜马拉雅及中东部地区地应变率的东西向、南北向及剪应变率分量的误差相对较大,但整个青藏高原及附近地区应变率结果稳定可靠;研究结果进一步表明,由GPS观测计算应变率的误差主要决定于GPS观测速度的误差,在变形小的区域(如中国东部地区),目前GPS的观测精度还不能完全满足地应变率计算的要求.

关键词：应变率误差分析 Monte Carlo方法 GPS观测青藏高原

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有限元模拟弹性位错的等效体力方法

地球物理学报 2015年第5期58卷 1666-1674页

作者：张贝张怀石耀霖中国科学院大学中国科学院计算地球动力学实验室北京100049

计算地震位错造成的位移场和应力场,对于估计大地震引起的后续地震活动发展趋势十分重要.本文提出在弹性位错问题的有限元模拟中,用等效体力代替位错源,从而在构建几何模型时不用包含断层,却可以处理包含任意复杂断层的问题,极大降低建... 详细信息

计算地震位错造成的位移场和应力场,对于估计大地震引起的后续地震活动发展趋势十分重要.本文提出在弹性位错问题的有限元模拟中,用等效体力代替位错源,从而在构建几何模型时不用包含断层,却可以处理包含任意复杂断层的问题,极大降低建模的难度.使用此方法,本文计算并讨论了在球形地球模型下2011年日本Tohoku-Oki特大地震对华北地区断层的影响,结果表明此次地震使华北主要断层趋于稳定.

关键词：不连续有限元地震位错同震库仑应力 Tohoku-Oki地震华北

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巴西构造应力场的遗传有限单元法反演

地球物理学报 2000年第2期43卷 166-174页

作者：石耀霖 Marcelo Assumpcao 中国科学技术大学研究生院北京100039 Institute of Astronomy and Geophysics University of Sao Paulobrazil01065

基于观测的主应力方位资料，应用遗传有限单元法对巴西及邻区边界位移和板内力源进行了反演，确认了前人的研究结果：板块边界作用是控制区域应力场的主要因素，山脉和海岸地形造成的扩展力是控制应力场的一个重要因素．同时显示了板块... 详细信息

基于观测的主应力方位资料，应用遗传有限单元法对巴西及邻区边界位移和板内力源进行了反演，确认了前人的研究结果：板块边界作用是控制区域应力场的主要因素，山脉和海岸地形造成的扩展力是控制应力场的一个重要因素．同时显示了板块在垂直载荷下的弯曲对局部水平应力场造成相当的影响．反演结果也表明，除了过去公认的东西向挤压作用外，巴西还受到相当明显的南北向构造作用．它的存在与最近ＧＰＳ资料的分析是一致的．研究还表明遗传有限单元法是偏微分方程反演问题求解的一种有效方法．

关键词：构造应力场地球物理反演问题巴西遗传有限元

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金星非单调冷却热演化历史分析

地球物理学报 2007年第1期50卷 146-152页

作者：张健石耀霖中国科学院研究生院计算地球动力学重点实验室北京100049

金星表层年龄和构造活动特点表明其岩石层在最近的地质历史时期经历过广泛的更新.这种全球性的表层改造与其内部热演化历史进程密切相关.如果金星存在相变形成的上、下地幔,依据现今所了解的金星物理性质和参量化的热对流理论,并且考虑... 详细信息

金星表层年龄和构造活动特点表明其岩石层在最近的地质历史时期经历过广泛的更新.这种全球性的表层改造与其内部热演化历史进程密切相关.如果金星存在相变形成的上、下地幔,依据现今所了解的金星物理性质和参量化的热对流理论,并且考虑金星地幔相变边界层状态对对流的控制作用,我们计算了金星热演化历史.结果表明,金星的热演化历史是一种非单调的冷却过程,在这种非单调的热演化历史进程中,金星地幔会出现大体等周期的翻转.由于参数选取的不同,翻转时金星上、下地幔的温差随时间可能出现稳定变化、逐渐加强、逐渐减弱三种不同演化模式,目前尚不能确定实际金星热演化历史究竟是哪一种模式.金星地幔相变边界层的穿透对流可能是推动其表层岩石层全球性更新的关键,导致其表层火山活动和地表构造以大致500 Ma时间间隔更新和重造.

关键词：金星热演化相变边界层穿透对流周期性翻转