检索结果-南通市图书馆

Epidermal growth factor prevents gut atrophy and maintains intestinal integrity in rats with acute pancreatitis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2000年第5期6卷 762-765页

作者： Chen DL Wang wz Wang JY Fourth Mil Med Univ Xijing Hosp Dept Gastrointestinal Surg Xian 710032 Shaanxi Provinc Peoples R China

INTRODUCTIONThere is abundant evidence that stressful insults suchas acute pancreatitis may significantly alter themetabolism of the gut mucosa and therefore itsbarrier integrity,resulting in an increase in mucosalpermeability and subsequent translocation of entericbacteria and their *** fact thatmost bacteria associated with acute pancreatic andperipancreatic infections are of enteric originimplies that the gut plays a major role in

关键词： pancreatitis epidermal growth factor parenteral nutrition total intestinal mucosa DNA proteins

Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 3025-3039页

作者： Jia Fang Zhuangzhuang Li Pengjun Wang Xiaoxu Zhang Song Mao Yini Li Dongzhen Yu Xiaoyan Li Yazhi Xing Haibo shi Shankai Yin Department of Otolaryngology Head and Neck Surgery Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineOtolaryngology Institute of Shanghai Jiao Tong UniversityShanghai Key Laboratory of Sleep Disordered BreathingShanghaiChina Department of Otorhinolaryngology-Head and Neck Surgery Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial ***,their use leads to irreversible hearing damage by causing apoptosis of hair cells as their direct *** addition,the hearing damage caused by aminoglycosides involves damage of spiral ganglion neurons upon *** investigate the mechanisms underlying spiral ganglion neuron degeneration induced by aminoglycosides,we used a C57BL/6J mouse model treated with *** found that the mice exhibited auditory deficits following the acute loss of outer hair *** ganglion neurons displayed hallmarks of pyroptosis and exhibited progressive degeneration over *** profiling of these neurons showed significant upregulation of genes associated with inflammation and immune response,particularly those related to the NLRP3 *** of the canonical pyroptotic pathway in spiral ganglion neurons was observed,accompanied by infiltration of macrophages and the release of proinflammatory *** intervention targeting NLRP3 using Mcc950 and genetic intervention using NLRP3 knockout ameliorated spiral ganglion neuron degeneration in the injury *** findings suggest that NLRP3 inflammasome-mediated pyroptosis plays a role in aminoglycoside-induced spiral ganglion neuron *** of this pathway may offer a potential therapeutic strategy for treating sensorineural hearing loss by reducing spiral ganglion neuron degeneration.

关键词： degeneration hearing loss macrophages Mcc950 neuroinflammation NLRP3 inflammasome ototoxicity pyroptosis sensorineural hearing loss spiral ganglion neuron

Progress in Numerical Simulation of Solidification Process of Shaped Casting

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 1995年第5期11卷 313-322页

作者： LIU, BC SHEN, HF LI, wz

Solidification simulation of manufacturing shaped casting which plays an important role in assuring the soundness and quality of castings, in minimizing the trial production time and in reducing the manufacturing cost becomes one of the hottest topics of the new research frontiers of foundry technology at home and abroad. Practical three dimensional computer numerical simulation system for temperature distribution during solidification as well as shrinkage cavity and porosity prediction has already been put into application all over the world. Further fundamental researches on fluid flow, thermal stress and micro-modeling as well as practical approaches of numerical simulation of solidification process of shaped castings for routine analysis of foundry industry are still underway.

关键词： Ph Simulation Progress in Numerical Simulation of Solidification Process of Shaped Casting

THE SOLVABILITY CONDITIONS FOR THE INVERSE PROBLEM OF MATRICES POSITIVE SEMIDEFINITE ON A SUBSPACE

在线全文

学校读者我要写书评

暂无评论

Journal of Computational Mathematics 1994年第1期12卷 78-87页

作者： HU, XY ZHANG, L DU, wz HUNAN UNIV CHANGSHAPEOPLES R CHINA HUNAN COMP CTR CHANGSHAPEOPLES R CHINA

This paper studies the following two problems: Problem I. Given X, B is-an-element-of R(n x m), find A is-an-element-of P(s,n), such that AX = B, where Ps, n = {A is-an-element-of SR(n x n)\x(T) Ax greater-than-or-equal-to 0, for-all S(T) x = 0, for given S is-an-element-of R(p)n x p}. Problem II. Given A* is-an-element-of R(n x n), find A is-an-element-of S(E), such that \\A*-A\\ = inf(A is-an-element-of S(E) \\A*-A\\ where S(E) denotes the solution set of Problem I. The necessary and sufficient conditions for the solvability of Problem I, the expression of the general solution of Problem I and the solution of Problem II are given for two cases. For the general case, the equivalent form of conditions for the solvability of Problem I is given.

关键词： eigenvalue symmetric holds nonnegative solvability matrices inverse convex satisfying Hunan

T cell interactions with microglia in immune-inflammatory processes of ischemic stroke

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1277-1292页

作者： Yuxiao Zheng Zilin Ren Ying Liu Juntang Yan Congai Chen Yanhui He Yuyu shi Fafeng Cheng Qingguo Wang Changxiang Li Xueqian Wang School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijingChina Library Beijing University of Chinese MedicineBeijingChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

The primary mechanism of secondary injury after cerebral ischemia may be the brain inflammation that emerges after an ischemic stroke,which promotes neuronal death and inhibits nerve tissue *** the first immune cells to be activated after an ischemic stroke,microglia play an important immunomodulatory role in the progression of the *** an ischemic stroke,peripheral blood immune cells(mainly T cells)are recruited to the central nervous system by chemokines secreted by immune cells in the brain,where they interact with central nervous system cells(mainly microglia)to trigger a secondary neuroimmune *** review summarizes the interactions between T cells and microglia in the immune-inflammatory processes of ischemic *** found that,during ischemic stroke,T cells and microglia demonstrate a more pronounced synergistic ***1,Th17,and M1 microglia can co-secrete proinflammatory factors,such as interferon-γ,tumor necrosis factor-α,and interleukin-1β,to promote neuroinflammation and exacerbate brain ***2,Treg,and M2 microglia jointly secrete anti-inflammatory factors,such as interleukin-4,interleukin-10,and transforming growth factor-β,to inhibit the progression of neuroinflammation,as well as growth factors such as brain-derived neurotrophic factor to promote nerve regeneration and repair brain *** interactions between microglia and T cells influence the direction of the subsequent neuroinflammation,which in turn determines the prognosis of ischemic stroke *** trials have been conducted on the ways to modulate the interactions between T cells and microglia toward anti-inflammatory communication using the immunosuppressant fingolimod or overdosing with Treg cells to promote neural tissue repair and reduce the damage caused by ischemic ***,such studies have been relatively infrequent,and clinical experience is still *** summary,in ischemic stroke,T cell subsets and activated micro

关键词： brain immune inflammation interaction ischemic stroke mechanism microglia neuron secondary injury T cells

Sr-Nd-Pb isotopes of Tertiary volcanics of King George Island, Antarctica

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 1997年第22期42卷 1913-1918页

作者： Xing, GF Shen, wz Wang, DZ Jin, QM Nanjing Inst Geol & Mineral Resources Nanjing 210016 Peoples R China

1 Geological settingThe King George Island is the largest one in South Shetland Islands, West Antarctica,with an area of 1200 km^2. Most of it is covered by ice and snow all the year round. It consistsmainly of Tertia... 详细信息

关键词： Sr-Nd-Pb isotopes Tertiary volcanics King George Island Antarctica.

Programmed cell death 1 inhibitor sintilimab plus S-1 and gemcitabine for liver metastatic pancreatic ductal adenocarcinoma

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2025年第2期16卷 29-35页

作者： shi-Qiong Zhou Peng Wan Seng Zhang Yuan Ren Hong-Tao Li Qing-Hua Ke Department of Chemoradiotherapy The First Affiliated Hospital of Yangtze UniversityJingzhou 434000Hubei ProvinceChina

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a highly aggressive cancer with poor *** it metastasizes to the liver,treatment options become particularly limited and *** treatment options for liver metastatic PDAC are limited,and chemotherapy alone often proves ***,particularly programmed cell death 1(PD-1)inhibitors like sintilimab,shows potential efficacy for various cancers but has limited reports on *** study compares the efficacy and safety of sintilimab plus S-1 and gemcitabine vs S-1 and gemcitabine alone in liver metastatic *** To explore the feasibility and effectiveness of combined PD-1 inhibitor sintilimab and S-1 and gemcitabine(combination group)vs S-1 and gemcitabine used alone(chemotherapy group)for treating liver metastatic pancreatic *** Eligible patients were those with only liver metastatic PDAC,an Eastern Cooperative Oncology Group performance status of 0-1,adequate organ and marrow functions,and no prior anticancer *** in the combination group received intravenous sintilimab 200 mg every 3 weeks,oral S-140 mg/m²twice daily on days 1-14 of a 21-day cycle,and intravenous gemcitabine 1000 mg/m²on days 1 and 8 of the same cycle for up to eight cycles or until disease progression,death,or unacceptable *** in the chemotherapy group received oral S-140 mg/m²twice daily on days 1-14 of a 21-day cycle and intravenous gemcitabine 1000 mg/m²on days 1 and 8 of the same cycle for up to eight *** June 2020 and December 2021,66 participants were enrolled,with 32 receiving the combination treatment and 34 receiving chemotherapy *** The group receiving the combined therapy exhibited a markedly prolonged median overall survival(18.8 months compared to 10.3 months,P<0.05)and progression-free survival(9.6 months vs 5.4 months,P<0.05).compared to the chemotherapy *** incidence of severe adverse events did not differ sign

关键词： Immunotherapy Programmed cell death 1 inhibitor Sintilimab Chemotherapy Metastatic Pancreatic ductal adenocarcinoma

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

微小RNA与脑缺血后自噬

国际脑血管病杂志 2017年第11期25卷 1053-1056页

作者：何芳李斌史文珍燕玉娥陈霞高莉洁韩楠楠史欢欢赵宁朱旭蓉王天仲田晔西安交通大学 710061 西安市第三医院神经内科 710016 西安市中心医院神经内科 710005

微小RNA是一类在转录后水平对基因表达进行调控的短链非编码RNA，可参与调控肿瘤、神经变性疾病、心血管病等病理生理学过程。近年来的研究显示，微小RNA可通过自噬对缺血性脑损伤发挥调控作用。文章对微小RNA对脑缺血后自噬的影响及其... 详细信息

微小RNA是一类在转录后水平对基因表达进行调控的短链非编码RNA，可参与调控肿瘤、神经变性疾病、心血管病等病理生理学过程。近年来的研究显示，微小RNA可通过自噬对缺血性脑损伤发挥调控作用。文章对微小RNA对脑缺血后自噬的影响及其可能机制进行了综述。

关键词：脑缺血自噬微RNAs

基于钢结构BIM模型的结构分析数据转换和软件开发

在线全文

学校读者我要写书评

暂无评论

哈尔滨工业大学学报 2025年第1期57卷 161-169页

作者：赵诗华刘栋余香林石永久清华大学土木工程系北京100084

为解决当前在钢结构建筑信息模型(building information modeling,BIM)与结构分析模型之间进行数据转换时存在的关键技术问题,本文在分析工业基础类(industry foundation classes,IFC)标准表达方法的基础上,以ABAQUS为结构分析平台,开... 详细信息

为解决当前在钢结构建筑信息模型(building information modeling,BIM)与结构分析模型之间进行数据转换时存在的关键技术问题,本文在分析工业基础类(industry foundation classes,IFC)标准表达方法的基础上,以ABAQUS为结构分析平台,开发了钢结构BIM模型数据转换算法,运用C#语言和Xbim工具包,实现了结构构件信息提取、构件空间位置调整和分析数据自动添加,并形成了相应的转换软件;通过钢框架结构实例分析验证了该软件的可靠性和准确性,并将其应用于安阳市游客集散中心的BIM模型转换和结构分析。结果表明,所开发的算法和软件解决了生成的结构分析模型节点不连接和人工添加分析数据工作量大等问题,实现了BIM中的钢结构设计模型或深化设计模型向ABAQUS结构分析模型数据的准确转换。与传统的在ABAQUS中直接建立结构分析模型相比,本文提出的方法能大大提高复杂钢结构的结构分析建模速度和效率。

关键词：钢结构建筑信息模型(BIM) IFC标准模型转换结构分析