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SEMG-based fighter pilot muscle fatigue analysis and operation performance research

Medicine in Novel Technology and Devices 2022年第4期16卷 345-349页

作者： Biyun Zhou Bo Chen huijuan shi Lihao Xue Yingfang Ao Li Ding Beijing Advanced Innovation Center for Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityNo.37 XueYuan RoadHaiDian DistrictBeijing100191China Institute of Sports Medicine Peking University Third HospitalBeijing Key Laboratory of Sports InjuriesBeijing100191China Biomechanics Laboratory College of Human Movement Science Beijing Sport University Beijing100084China

Fatigue has a tremendously adverse impact on pilot *** study aims to explore the Biceps Brachii(BB),Rectus Femoris(RF),Flexor Carpi Radialis(FCR),and Tibialis Anterior(TA)activities of fighter pilots in the early and late combat stages,and the target hitting time.A total of 13 volunteers were recruited to conduct simulated combats inside a real fighter *** surface Electromyography(sEMG)was collected from all volunteers in the initial and final 20s of flight,and the target hitting time during three simulated combats was *** root mean square(RMS)values of right BB and TA were significantly higher than the left side values(p<0.001),while insignificant differences were found in the RMS values between the bilateral RF and *** to the early flight period,the median frequency(MF)values of BB and TA were significantly lower during the late flight period,and the RMS values were significantly higher(p<0.047).Contrastively,the RMS values of FCR and RF differed insignificantly during the late flight *** the target hitting time,a significant difference was noted between task 1 and *** exhibit varying levels of muscle fatigue for different muscle groups before and after the *** muscle fatigue levels are asymmetrical on the left and right *** fatigue might reduce the pilots'operational *** study provides a reference for fighter pilot fatigue protection and treatment.

关键词： Surface electromyography Flight fatigue Operation performance Daubechies wavelet

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Effects of visual restoration on gait performance and kinematics of lower extremities in patients with age-related cataract

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Chinese Medical Journal 2023年第5期136卷 596-603页

作者： Mingxin Ao huijuan shi Xuemin Li Hongshi Huang Yingfang Ao Wei Wang Department of Ophthalmology Beijing Key Laboratory of Restoration of Damaged Ocular NervePeking University Third HospitalBeijing 100191China Department of Sports Medicine Institute of Sports Medicine of Peking UniversityBeijing Key Laboratory of Sports InjuriesPeking University Third HospitalBeijing 100191China.

Background:Visual inputs are critical for locomotor navigation and sensorimotor integration in the elderly;however,the mechanism needs to be explored *** present study assessed the gait pattern after cataract surgery to investigate the effects of visual restoration on ***:The prospective study recruited 32 patients(70.1±5.2 years)with bilateral age-related cataracts in the Department of Ophthalmology at Peking University Third Hospital from October 2016 to December *** temporal-spatial gait parameters and kinematic parameters were measured by the Footscan system and inertial measurement *** t-test was employed to compare data normally distributed and Wilcoxon rank-sum test for non-normally ***:After visual restoration,the walking speed increased by 9.3%(1.19±0.40 m/s vs.1.09±0.34 m/s,P=0.008)and exhibited an efficient gait pattern with significant decrease in gait cycle(1.02±0.08 s vs.1.04±0.07 s,P=0.012),stance time(0.66±0.06 s vs.0.68±0.06 s,P=0.045),and single support time(0.36±0.03 s vs.0.37±0.02 s,P=0.011).High amplitude of joint motion was detected in the sagittal plane in the left hip(37.6°±5.3°vs.35.5°±6.2°,P=0.014),left thigh(38.0°±5.2°vs.36.4°±5.8°,P=0.026),left shank(71.9°±5.7°vs.70.1°±5.6°,P=0.031),and right knee(59.1°±4.8°vs.56.4°±4.8°,P=0.001).The motor symmetry of thigh improved from 8.35±5.30%to 6.30±4.73%(P=0.042).Conclusions:The accelerated gait in response to visual restoration is characterized by decreased stance time and increased range of joint *** programs for improving muscle strength of lower extremities might be helpful to facilitate the adaptation to these changes in gait.

关键词： Biomechanical phenomena Cataract Gait Rehabilitation Visual perception

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Prediction of Protein Homo-Oligomer Types by Using IB1 Algorithm

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Wuhan University Journal of Natural Sciences 2011年第2期16卷 121-124页

作者： SONG Chaohong shi Feng XIONG huijuant College of Science Huazhong Agricultural University Wuhan430070 Hubei China

Protein homo-oligomers play an important role in various vital activities. Successful prediction of protein homo-oligomers directly from primary sequence is very beneficial to understand their protein function. In this paper, a total of 14 238 homo-oligomeric protein sequences are predicted by IB1 algorithm. 10-fold cross-validation test is applied to test the predictive capability of the proposed method. The predictive results show that overall prediction accuracy is 90.46%, which is at least 9% higher than that of previous results; furthermore,the sensitivity and Matthew＇s correlation coefficient for each class of homo-oligomers are also improved significantly. The results show that IB1 algorithm is effective and feasible,and very suitable for predicting protein homo-oligomer types.

关键词： homo-oligomers IB1 algorithm amino acids composition

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EMC10 governs male fertility via maintaining sperm ion balance

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Journal of Molecular Cell Biology 2018年第6期10卷 503-514页

作者： Yuchuan Zhou Fei Wu Man Zhang Zuquan Xiong Qianqian Yin Yanfei Ru huijuan shi Jinsong Li Shanhua Mao Yanliang Li Xinyi Cao Renming Hu Chong Wee Liew Qiang Ding Xuanchun Wang Yonglian Zhang State Key Laboratory of Molecular Biology Shanghai Key Laboratory of Molecular AndrologyCAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China Department of Urology Huashan HospitalFudan UniversityShanghai 200040China State Key Laboratory of Cell Bioloy Shanghai Key Laboratory of Molecular AndrologyCAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China China National Population and Family Planning Key Laboratory of Contraceptive Drugs and Devices Shanghai Institute of Planned Parenthood Research Shanghai 200030China Department of Endocrinology Huashan HospitalFudan UniversityShanghai 200040China Department of Physiology &Biophysics College of MedicineUniversity of lllinois at ChicagoChicagoIL 60612USA

Infertility is a severe public health problem worldwide that prevails up to 15% in reproductive-age couples,and male infertility accounts for half of total *** on genetically modified animal models have identifed lots of genes involved in the pathogenesis of male *** underlying causes,however,remain largely *** this study,we provide evidence that EMCIO,one subunit of endoplasmic reticulum (ER)membrane protein complex (EMC),is required for male ***10 is significantly decreased in spermatozoa from patients with asthenozoospermia and positively associated with human sperm motility. Male mice lacking Emc10 gene are completely ***10-null spermatozoa exhibit multiple defects including abnormal morphology,decreased motility,impaired capacitation,and impotency of acrosome reaction,thereby which are incapable of fertilizing intact or ZP-free ***,intracytoplasmic sperm injection could rescue this defect caused by EMC10 deletion. Mechanistically,EMC10 deficiency leads to inactivation of Na/K-ATPase,in turn giving rise to an increased level of intraceltutar Na^+ in spermatozoa,which contributes to decreased sperm motility and abnormal *** mechanistic investigations demonstrate that the absence of EMC10 results in a reduction of HCO3^- entry and subsequent decreases of both cAMP-dependent protein kinase A substrate phosphorylation and protein tyrosine *** data demonstrate that EMC10 is indispensable to mate fertility via maintaining sperm ion balance of Na^+ and HCO3^-,and also suggest that EMC10 is a promising biomarker for male fertility and a potential pharmaceutical target to treat male infertility.

关键词： Emc10 knockout sperm maturation male infertility ion imbalance Na/K-ATPase

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Corrosion Study of Two-step Deposition Coatings on Copper Foil

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Journal of Wuhan University of Technology(Materials Science) 2023年第4期38卷 911-916页

作者：师慧娟唐云志 TAN Yuhui LIAO Shuling ZHANG Yusong DU Pengkang School of Materials Metallurgy and Chemical EngineeringJiangxi University of Science and TechnologyGanzhou341000China

To improve corrosion inhibition performance of copper foil with a novel two-step electrochemical modification processes,the surface of 35μm copper foils was coated with graphene oxide(GO)via electrochemical method at first step,then was further coated with 3-aminopropyltrimethoxysilane(APTS)at the second *** the first step the copper foil acted as anode,and as cathode for the second one(we labeled it as E-GO).Optimum coating parameters for the preparation of E-GO coating are 5 V and 1 min with ratio of APTS/deionized water(DI)1.5/98.5(v/v).The physicochemical properties of modified coating were studied by X-ray diffraction(XRD),scanning electron microscopy(SEM)and hydrophilicity *** behavior of different samples were also *** experimental results indicate that anti-corrosion performance is significantly improved with two-step modified *** E-GO coating shows more positive corrosion potential and the highest corrosion resistance rate than others according to the Tafel *** is also found that surface hydrophobicity of E-GO coating is significantly improved.

关键词： graphene oxide silane coupling agent electrochemical deposition corrosion resistance

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Reconstruction characteristics of gut microbiota from patients with type 1 diabetes affect the phenotypic reproducibility of glucose metabolism in mice

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Science China Life Sciences 2025年第1期68卷 176-188页

作者： Zhiyi Wang Mengxue Gong Yuanyuan Fang huijuan Yuan Chenhong Zhang State Key Laboratory of Microbial Metabolism School of Life Sciences and BiotechnologyShanghai Jiao Tong University Department of Endocrinology Henan Provincial People's HospitalPeople's Hospital of Zhengzhou University

The human microbiota-associated(HMA) mice model, especially the germ-free(GF)-humanized mice, has been widely used to probe the causal relationships between gut microbiota and human diseases such as type 1 diabetes(T1D). However, most studies have not clarified the extent to which the reconstruction of the human donor microbiota in recipient mice correlates with corresponding phenotypic reproducibility. In this study, we transplanted fecal microbiota from five patients with T1D and four healthy people into GF mice, and microbiota from each donor were transplanted into 10 mice. Mice with similar microbiota structure to the donor exhibited better phenotypic reproducibility. The characteristics of the microbial community assembly of donors also influenced the phenotypic reproducibility in mice, and individuals with a higher proportion of stochastic processes showed more severe disorders. Microbes enriched in patients with T1D had a stronger colonization potential in mice with impaired glucose metabolism, and microbiota functional features related to T1D were better reproduced in these mice. This indicates that assembly traits and colonization efficacy of microbiota influence phenotypic reproducibility in GF-humanized mice. Our findings provide important insights for using HMA mice models to explore links between gut microbiota and human diseases.

关键词： gut microbiome human microbiota-associated animal model type 1 diabetes

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新的免疫组织化学抗体在软组织肿瘤病理诊断中的应用和新进展

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中华病理学杂志 2022年第3期51卷 177-182页

作者：石慧娟韩安家中山大学附属第一医院病理科广州510080

近年来随着软组织肿瘤的新类型不断被报道,用于这些肿瘤诊断的免疫组织化学抗体也相继出现,为便于国内学者熟悉和了解新的免疫组织化学抗体在软组织肿瘤病理诊断特别是新类型中的应用,该文重点介绍其在软组织肿瘤病理诊断中的应用及其... 详细信息

近年来随着软组织肿瘤的新类型不断被报道,用于这些肿瘤诊断的免疫组织化学抗体也相继出现,为便于国内学者熟悉和了解新的免疫组织化学抗体在软组织肿瘤病理诊断特别是新类型中的应用,该文重点介绍其在软组织肿瘤病理诊断中的应用及其新进展,有助于病理医师作出正确的病理诊断和鉴别诊断。

关键词：肿瘤病理诊断软组织肿瘤病理医师免疫组织化学诊断和鉴别诊断肿瘤诊断国内学者抗体

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陕西省分区城镇化路径研究

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城市发展研究 2014年第12期21卷 88-96页

作者：文雯史怀昱石会娟陕西省城乡规划设计研究院

区域发展的不均衡现象是十分普遍的,各地区由于自然条件、历史基础、文化脉络、人口资源环境等原因均存在发展基础和发展模式的差异。进一步细化陕西省城镇化发展分区,从不同区域的现状特征、发展动力、面临挑战入手,探讨差异化城镇发... 详细信息

区域发展的不均衡现象是十分普遍的,各地区由于自然条件、历史基础、文化脉络、人口资源环境等原因均存在发展基础和发展模式的差异。进一步细化陕西省城镇化发展分区,从不同区域的现状特征、发展动力、面临挑战入手,探讨差异化城镇发展路径,提出分区城镇化发展的建议及措施。

关键词：分区城镇化陕西省

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A sequence of 28S rRNA-derived small RNAs is enriched in mature sperm and various somatic tissues and possibly associates with inflammation

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Journal of Molecular Cell Biology 2017年第3期9卷 256-259页

作者： Chu, Chen Yu, Lu Wu, Bin Ma, Li Gou, Lan-Tao He, Miao Guo, Yunli Li, Zhi-Tong Gao, Wei shi, huijuan Liu, Mo-Fang Wang, Hongyan Chen, Charlie Degui Drevet, Joel R. Zhou, Yuchuan Zhang, Yonglian Univ Chinese Acad Sci Chinese Acad Sci Shanghai Inst Biochem & Cell BiolState Key Lab M CAS Ctr Excellence Mol Cell SciShanghai Key Lab Shanghai 200031 Peoples R China Fudan Univ SIPPR China Natl Populat & Family Planning Key Lab Cont Shanghai 200032 Peoples R China Univ Chinese Acad Sci Chinese Acad Sci Shanghai Inst Biochem & Cell Biol CAS Ctr Excellence Mol Cell SciState Key Lab Mol Shanghai 200031 Peoples R China Univ Calif San Diego Dept Cellular & Mol Med San Diego CA 92093 USA Chinese Acad Sci Shanghai Inst Biol Sci State Key Lab Neurosci Inst Neurosci Shanghai 200031 Peoples R China Shanghai Jiao Tong Univ Shanghai Gen Hosp Dept Geratol Shanghai 200080 Peoples R China Univ Clermont Auvergne CNRS UMR6293 INSERM U1103 Genet Reprod & Dev Lab Clermont Ferrand France

Dear Editor, The growing understanding concerning the definition, classification, and function of small non-coding RNAs （sncRNAs） has led to the discovery of new sncRNA spe- cies of various sizes. Recent studies high- lighted a group of tsRNAs derived from the 5＇ end of tRNAs （Peng et al., 2012; Zhang et al., 2014; Chen et al., 2016; Sharma et al., 2016）, which raises the question whether there are similar small RNAs derived from other housekeeping RNAs, such as rRNAs.

关键词：小RNA rRNA 28S 体细胞炎症精子成熟

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基于改进k均值与高斯混合模型的宫颈图像分割

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中国生物医学工程学报 2018年第2期37卷 138-145页

作者：刘君余婷婷石慧娟南昌航空大学江西省图像处理与模式识别重点实验室南昌330063 南昌航空大学信息工程学院南昌330063

针对宫颈癌智能化筛查系统需要从阴道镜图像中分割出宫颈区域的问题,提出一种改进的k均值与高斯混合模型相结合的图像分割方法。首先根据宫颈区域的代表性颜色和其距离图像中心点的距离,构造出待分类的数据集;其次通过对宫颈区域代表性... 详细信息

针对宫颈癌智能化筛查系统需要从阴道镜图像中分割出宫颈区域的问题,提出一种改进的k均值与高斯混合模型相结合的图像分割方法。首先根据宫颈区域的代表性颜色和其距离图像中心点的距离,构造出待分类的数据集;其次通过对宫颈区域代表性颜色的重新计算,一种使待分类数据集可随着迭代的进行而动态调整的规则被加入到k均值算法中,使得k均值算法适用于多种光照环境下的目标图像分割;最后利用k均值的聚类结果,初始化高斯混合模型的参数,并得到最终的分割结果。75套来源于不同成像条件下的宫颈图像上的实验结果显示,该方法的平均分割精度达到65.1%,比采用基本k均值算法进行初始化的高斯混合模型算法高出5.5%,比模糊C均值聚类算法高出5.8%,比基本高斯混合模型算法高出8.5%;其均方差达到11.5%,与水平集算法相比降低5.6%。实验结果证明,该方法在阴道镜视野下的宫颈区域分割中是行之有效的。

关键词：宫颈癌筛查宫颈图像分割 k均值算法高斯混合模型

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