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A vectorial model for the nonlinear gradient force exerted on metallic Rayleigh nanoparticles

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Chinese Optics Letters 2024年第2期22卷 207-213页

作者：朱政张聿全闵长俊 Aurèle J.LAdam h.Paul Urbach 袁小聪 Research Center for humanoid Sensing Research Institute of Intelligent SensingZhejiang LabHangzhou 311100China Nanophotonics Research Center Institute of Microscale Optoelectronics&State Key Laboratory of Radio Frequency Heterogeneous IntegrationShenzhen UniversityShenzhen 518060China Optics Research Group ImPhys DepartmentFaculty of Applied SciencesDelft University of TechnologyDelft 2628 CJThe Netherlands

Optical tweezers have proved to be a powerful tool with a wide range of *** gradient force plays a vital role in the stable optical trapping of *** scalar method is convenient and effective for analyzing the gradient force in traditional optical ***,when the third-order nonlinear effect of the nano-object is stimulated,the scalar method cannot adequately present the optical response of the metal nanoparticle to the external optical ***,we propose a theoretical model to interpret the nonlinear gradient force using the vector *** combining the optical Kerr effect,the polarizability vector of the metallic nanoparticle is derived.A quantitative analysis is obtained for the gradient force as well as for the optical potential *** vector method yields better agreement with reported experimental *** suggest that this method could lead to a deeper understanding of the physics relevant to nonlinear optical trapping and binding phenomena.

关键词： gradient forces nonlinear effect metallic nanoparticles

Eugenol targeting CrtM inhibits the biosynthesis of staphyloxanthin in Staphylococcus aureus

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Food Science and human Wellness 2024年第3期13卷 1368-1377页

作者： Jiang Chang Bo Chen Zeqian Du Bowen Zhao Jiahui Li Ziyi Li Kannappan Arunachalam Ting shi Dongqing Wei Chunlei shi MOST-USDA Joint Research Center for Food Safety School of Agriculture and BiologyState Key Laboratory of Microbial MetabolismShanghai Jiao Tong UniversityShanghai 200240China School of Life Sciences and Biotechnology Shanghai Jiao Tong UniversityShanghai 200240China

Staphylococcus aureus is a serious foodborne pathogen threatening food safety and public *** the emergence of methicillin-resistant Staphylococcus aureus(MRSA)increased the difficulty of *** *** is a crucial virulence factor of *** staphyloxanthin production could help the host immune system counteract the invading *** *** this study,we first screened for staphyloxanthin inhibitors using a virtual screening *** outcome of the virtual screening method resulted in the identification of eugenol(300μg/mL),which significantly inhibits the staphyloxanthin production in *** ATCC 29213,*** Newman,MRSA ATCC 43300 and MRSA ATCC BAA1717by 84.2%,63.5%,68.1%,and 79.5%,*** outcome of the growth curve assay,field-emission scanning electron,and confocal laser scanning microscopy analyses confirmed that eugenol at the test concentration did not affect the morphology and growth of ***,the survival rate of *** ATCC 29213 and MRSA ATCC 43300 under h_(2)O_(2) pressure decreased to 51.9%and 45.5%in the presence of eugenol,*** quantitative RT-PCR and molecular simulation studies revealed that eugenol targets staphyloxanthin biosynthesis by downregulating the transcription of the crtM gene and inhibiting the activity of the CrtM *** together,we first determined that eugenol was a prominent compound for staphyloxanthin inhibitor to combat *** especially MRSA infections.

关键词： Staphylococcus aureus Staphyloxanthin Eugenol Virtual screening 4 4’-Diapophytoene synthase(CrtM)

Schisanhenol ameliorates non-alcoholic fatty liver disease via inhibiting miR-802 activation of AMPK-mediated modulation of hepatic lipid metabolism

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Acta Pharmaceutica Sinica B 2024年第9期14卷 3949-3963页

作者： Li B. Xiao Q. Zhao h. Zhang J. Yang C. Zou Y. Zhang B. Liu J. Sun h. Liu h. State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Medicinal Plant Development Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100193 China Institute of Basic Medical Sciences Chinese Academy of Medical Sciences Department of Pathophysiology Peking Union Medical College Beijing 100005 China

Non-alcoholic fatty liver disease (NAFLD), characterized by hepatic steatosis, is a common metabolic liver disease worldwide. Currently, satisfactory drugs for NAFLD treatment remain lacking. Obesity and diabetes are the leading causes of NAFLD, and compounds with anti-obesity and anti-diabetic activities are considered suitable candidates for treating NAFLD. In this study, biochemical and histological assays revealed that a natural lignan schisanhenol (SAL) effectively decreased lipid accumulation and improved hepatic steatosis in free fatty acid (FFA)-treated hepG2 cells and high-fat diet (hFD)-induced NAFLD mice. Further, molecular analyses, microRNA (miRNA)-seq, and bioinformatics analyses revealed that SAL may improve NAFLD by targeting the miR-802/adenosine monophosphate-activated protein kinase (AMPK) pathway. Liver-specific overexpression of miR-802 in NAFLD mice significantly impaired SAL-mediated liver protection and decreased the protein levels of phosphorylated (p)-AMPK and PRKAB1. Dual-luciferase assay analysis further confirmed that miR-802 inhibits hepatic AMPK expression by binding to the 3' untranslated region of mouse Prkab1 or human PRKAA1. Additionally, genetic silencing of PRKAA1 blocked SAL-induced AMPK pathway activation in FFA-treated hepG2 cells. The results demonstrate that SAL is an effective drug candidate for treating NAFLD through regulating miR-802/AMPK-mediated lipid metabolism. © 2024 The Authors

关键词： AMPK hepatic steatosis Lipid metabolism miR-802 Non-alcoholic fatty liver disease PPARα Schisanhenol SREBP-1c

Two-dimensional silica enhanced solid polymer electrolyte for lithium metal batteries

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Particuology 2024年第2期85卷 146-154页

作者： Zh.h.ng Luo Weiyong Li Chong Guo Ya Song Mingxia Zhou Yan shi Jing Xu Long Li Bin shi Quansheng Ouyang Jiao-jing Shao Guangmin Zhou School of Materials and Metallurgy Guizhou UniversityGuiyang550025China State Key Laboratory of Advanced Chemical Power Sources Zunyi563003China Graphene Materials Engineering Research Center of Guizhou Colleges and Universities Guiyang550025China Tsinghua-Berkeley Shenzhen Institute&Tsinghua Shenzhen International Graduate Schoo Tsinghua UniversityShenzhen518055China

Solid polymer electrolytes(SPEs)are promising substitutes for current flammable liquid electrolytes to achieve high-safety and high-energy-density lithium metal *** oxide(PEO)based solid polymer electrolytes have attracted increasing attention because of their excellent flexibility,manufacturability,light weight,and low-cost processing,while they often suffer from low ionic con-ductivity at room temperature,low lithium transference number and unsatisfactory interfacial resis-tance,which largely restrain their practical ***,two-dimensional holey silica nanosheets(2D-hSN)as the fillers,together with LiNO_(3) as the electrolyte additive,are introduced in a PEO/poly(-vinylidene fiuoride-co-hexafluoropropylene)(PVDF-hFP)blended polymer matrix to obtain a *** incorporation of hSN filler creates supplementary channels for lithium ion migration and lowers the crystallinity of the polymer,thereby facilitating the movement of lithium *** hSN-based SPE demonstrates higher ionic conductivity up to 3.7 x 10-4 S cm-1 at 30℃,larger Li+transference number close to 0.34,and more stable lithium plating/stripping than that without the fillers,and hSN can promote the formation of more stable solid electrolyte interphase(SEI)*** as-assembled LiFePO4||Li batteries deliver a high specific capacity of 159 mA h g-1 with the capacity retention of 95.5%after 200 cycles at 30℃,as well as superior rate performance and cycling stability compared to that using the blank SPE.

关键词： Vermiculite nanosheets Two-dimensional silica Solid polymer electrolytes FillersLithium metal batteries

Inactivated h9N2 vaccines developed with early strains do not protect against recent h9N2 viruses:Call for a change in h9N2 control policy

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Journal of Integrative Agriculture 2024年第6期23卷 2144-2148页

作者： Yanjing Liu Qingqing Yu Xiangyu Zhou Wenxin Li Xinwen he Yan Wang Guohua Deng Jianzhong shi Guobin Tian Xianying Zeng hualan Chen College of Veterinary Medicine Gansu Agricultural UniversityLanzhou 730070China State Key Laboratory for Animal Disease Control and Prevention Key Laboratory for Prevention and Control of Avian Influenza and Other Major Poultry DiseasesMinistry of Agriculture and Rural Affairs/Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150009China National Poultry Laboratory Animal Resource Center Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150009China harbin Weike Biotechnology Co. Ltd.Harbin 150009China

h9N2 virus has been widely distributed in wild birds and poultry around the world since its first emergence in the United States of America in 1966(Gu et al.2017;Carnaccini and Perez 2020).The virus appeared in chickens in China in the early 1990s,and over the last two decades has gradually become the dominant epidemic subtype(Sun and Liu 2015;Bi et al.2020).Although.h.N2 virus infection alone cannot cause severe disease or death in poultry,h9N2 virus-infected birds experience a degree of egg production drop and can be easily infected by other pathogens,thus causing economic losses for poultry industry.

关键词： h9N2 poultry policy

Evaluation of large language models for the classification of medical device software

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BIO-DESIGN AND MANUFACTURING 2024年第5期7卷 819-822页

作者： han, Yu Ceross, Aaron Bourgeois, Florence Savaget, Paulo Bergmann, Jeroen h. M. Univ Oxford Dept Engn Sci Old Rd Campus Oxford OX3 7DQ England harvard Med Sch Harvard MIT Ctr Regulatory Sci Boston MA 02115 USA Univ Southern Denmark Dept Technol & Innovat Odense Denmark Boston Childrens hosp Computat Hlth Informat Program CHIP Boston MA USA

Amidst the rapidly expanding integration of large language models(LLMs)across various sectors(ranging from everyday applications to specialized fields demanding stringent regulatory adherence),our investigation seeks to determine how well these models can support medical device software *** device classification functions to systematically categorize devices according to their designated use,associated risk levels,and requisite regulatory oversight,thereby providing a structured framework for ensuring safety and efficacy as mandated by regulatory authorities.

关键词： everyday demanding thereby

Exfoliation of bulk 2h-MoS_(2)into bilayer 1T-phase nanosheets via ether-induced superlattices

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Nano Research 2024年第6期17卷 5705-5711页

作者： Xiuling shi Dongmei Lin Zhuorui Xiao Yibo Weng hanxiang Zhou Xiaoying Long Zhiyu Ding Fuyuan Liang Yan huang Guohua Chen Kaikai Li Tong-Yi Zhang School of Materials Science and Engineering Harbin Institute of TechnologyShenzhen 518055China Department of Mechanical Engineering Research Institute for Smart EnergyThe Hong Kong Polytechnic UniversityHong KongChina School of Energy and Environment City University of Hong KongTat Chee AvenueKowloonHong KongChina The hong Kong University of Science and Technology(Guangzhou) Guangzhou Municipal Key Laboratory of Materials InformaticsAdvanced Materials Thrust and Sustainable Energy and Environment ThrustNanshaGuangzhou 511400China

The exfoliation of bulk 2h-molybdenum disulfide(2h-MoS_(2))into few-layer nanosheets with 1T-phase and controlled layers represents a daunting challenge towards the device applications of MoS_(2).Conventional ion intercalation assisted exfoliation needs the use of hazardous n-butyllithium and/or elaborate control of the intercalation potential to avoid the decomposition of the MoS_(2).This work reports a facile strategy by intercalating Li ions electrochemically with ether-based electrolyte into the van der Waals(vdW)channels of MoS_(2),which successfully avoids the decomposition of MoS_(2)at low *** co-intercalation of Li+and the ether solvent into MoS_(2)makes a first-order phase transformation,forming a superlattice phase,which preserves the layered structure and hence enables the exfoliation of bulk 2h-MoS_(2)into bilayer nanosheets with *** with the pristine 2h-MoS_(2),the bilayer 1T-MoS_(2)nanosheets exhibit better electrocatalytic performance for the hydrogen evolution reaction(hER).This facile method should be easily extended to the exfoliation of various transition metal dichalcogenides(TMDs).

关键词： exfoliation of MoS_(2) phase transformations superlattices ether electrolyte hydrogen evolution reaction(hER)

Nanoindentation responses of NiCoFe medium-entropy alloys from cryogenic to elevated temperatures

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Journal of Iron and Steel Research International 2024年第8期31卷 2068-2077页

作者： Qin-qin Xu Kamran Karimi Amirhossein h.Naghdi Wen-yi huo Chong Wei Stefanos Papanikolaou NOMATEN Centre of Excellence National Centre for Nuclear ResearchOtwock 05-400MazowszePoland College of Mechanical and Electrical Engineering Nanjing Forestry UniversityNanjing 210037JiangsuChina Science and Technology on Thermo Structural Composite Materials Laboratory Northwestern Polytechnical UniversityXi'an 710072ShaanxiChina School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi'an 710072ShaanxiChina

NiCoFe alloy,a medium-entropy alloy,shows potential for applications in extreme ***,there is a theoretical barrier concerning the unclear understanding of its high-temperature dislocation motion *** load response exhibits distinct signatures relevant to thermal activation,most notably a decrease in critical force(i.e,softening)from cryogenic to elevated temperatures,e.g.,from 200 to 1000 *** onset of plasticity is characterized by the nucleation of stacking faults and prismatic loops at low temperatures,whereas the surface nucleation of Shockley partial dislocations dominates plasticity at elevated *** show that thermal effects lead to non-uniform atom pile-ups and control the rate of phase transformation with increasing indentation *** findings in this work extend the understanding of the mechanical response of NiCoFe alloys under indentation at different temperatures,shedding light on the underlying dislocation motion mechanisms and surface deformation *** observed transformation-induced plasticity mechanism has implications for the properties of medium-entropy alloys and their potential applications in extreme environments.

关键词： Orientation Dislocations Mechanical behaviors Phase transition

Ballistic design and testing of a composite armour reinforced by CNTs suitable for armoured vehicles

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Defence Technology（防务技术） 2024年第2期32卷 173-195页

作者： Evangelos Ch.Tsirogiannis Evangelos Daskalakis Mohamed h.h.ssan Abdalla M.Omar Paulo Bartolo EODh SA Research and Development DepartmentLakkoma Chalkidikis63080Greece School of Mechanical Aerospace and Civil EngineeringUniversity of ManchesterManchesterM139PLUK Singapore Centre for 3D Printing School of Mechanical and Aerospace EngineeringNanyang Technological University639798Singapore

This paper is investigating the use of composite armour reinforced by nanomaterials, for the protection of light armoured(LAV) and medium armoured military vehicles(MAV), and the interaction between the composite materials and high-performance ballistic projectiles. Four armour materials, consisted of front hybrid fibre reinforced polymer cover layer, ceramic strike-face, fibre reinforced polymer intermediate layer and the metal matrix composite reinforced backplate, were manufactured and assembled by adhesive technology. The proposed laminated protection system is suitable for armoured ground vehicles;however, it could be used as armour on ground, air and naval platforms. The design of the protection system, including material selection and thickness, was elaborated depending on the performance requirements of Level 4 + STANAG 4569 military standard(projectile 14.5 mm × 114 mm API B32) and especially on a design philosophy which is analysed with the specifications. The backplate of this new composite is a hybrid material of Metal Matrix Composite(MMC) reinforced with carbon nanotubes(CNTs), manufactured with the use of powder metallurgy technique. The composite backplate material was morphologically, mechanically and chemically analysed. Results show that all plates are presenting high mechanical properties and ballistic characteristics, compared to commonly used armour plates. Real military ballistic tests according to AEP-STANAG 4569 were carried out for the total composite armour systems. After the ballistic tests, AA2024-CNT3 showed the best protection results, compared with the other plates(AA2024-CNT1 and AA2024-CNT2), with the projectile being unable to fully penetrate the composite plate.

关键词： Passive armour protection Protective armour Ballistic performance hybrid composites Vehicle protection