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FRONTIERS OF MEDICINE 2024年第4期18卷 757-761页

作者： Wang, Juan shi, dongni Wang, Yaochen Zhang, Xuanqi Li, Han Wang, Xihong Luo, Shufeng Hu, Lihan Deng, Jiashuai Zhang, Lin Lau, Chung Tai Cheng, Chung Wah Han, Fei Li, Ji Wang, Ping Lyu, Aiping Bian, Zhaoxiang Zhang, Xuan Hong Kong Baptist Univ Inst Res & Continuing Educ Shenzhen 518057 Peoples R China Hong Kong Baptist Univ Chinese EQUATOR Ctr Hksar 999077 Peoples R China Hong Kong Baptist Univ Sch Chinese Med Hksar 999077 Peoples R China Hong Kong Baptist Univ Ctr Chinese Herbal Med Drug Dev Hksar 999077 Peoples R China Tianjin Univ Tradit Chinese Med Sch Tradit Chinese Med Tianjin 301617 Peoples R China Beijing Univ Chinese Med Sch Chinese Med Beijing 100105 Peoples R China China Acad Chinese Med Sci Guanganmen Hosp Dept Pediat Beijing 100053 Peoples R China China Acad Chinese Med Sci Xiyuan Hosp Beijing 100091 Peoples R China

Transparency and reporting characteristics of randomized controlled trials with Chinese herbal medicine formulas interventions

关键词： Transparency reporting characteristics trials herbal medicine

五格式净粪池与三格式化粪池处理农村生活污水效果及成本对比

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环境工程技术学报 2024年第3期14卷 953-962页

作者：蒋进元陈朱迪罗勇谭伟宋浩洋石冬妮中国环境科学研究院重庆交通大学河海学院

针对三格式化粪池(TcST)出水COD及氮、磷浓度高,直排或溢流造成当地局部水体污染或黑臭的问题,构建了等容积五格式净粪池(FcPTR),并以实际生活污水为处理对象,对比研究2种反应器的运行特性和单位污染物去除成本。结果表明:FcPTR连续运行... 详细信息

针对三格式化粪池(TcST)出水COD及氮、磷浓度高,直排或溢流造成当地局部水体污染或黑臭的问题,构建了等容积五格式净粪池(FcPTR),并以实际生活污水为处理对象,对比研究2种反应器的运行特性和单位污染物去除成本。结果表明:FcPTR连续运行120 d,出水COD平均值为74 mg/L,TN、NH_(4)^(+)-N、TP平均浓度分别为26、20、1.6 mg/L,在我国进水水质相似的农村地区使用时,可满足11个省(区、市)发布的农村生活污水处理设施水污染排放地方标准二级水质要求。厌氧折流区、好氧区填料与污泥上变形菌门(Proteobacteria)的生长代谢促进了含氮和含磷物质的去除。相比于TcST,FcPTR明显增强了系统对有机物的降解和脱氮除磷效果,提高了系统的抗冲击负荷能力。经成本核算,在设计容积和运行场景相同时运行10年,FcPTR削减1 kg COD、1 kgNH_(4)^(+)-N的成本均比TcST降低19.8%。

关键词：农村生活污水三格式化粪池五格式净粪池分散式污水处理运行特性

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微生物燃料电池工作原理及产电性能提升策略

环境工程技术学报 2024年第2期14卷 699-709页

作者：蒋进元张月何绪文谭伟宋浩洋石冬妮赵洪兵中国环境科学研究院环境污染控制工程技术研究中心中国矿业大学(北京)化学与环境工程学院四川省广元生态环境监测中心站

微生物燃料电池(MFC)是一种解决其他能源在环境方面不足的新技术,目前低能量输出是MFC实际应用的关键瓶颈。基于MFC工作原理,提出微生物活性差、电子迁移阻力、质子传输阻力及阴极还原反应缓慢是MFC能量输出的限制因素,并从以下5个方面... 详细信息

微生物燃料电池(MFC)是一种解决其他能源在环境方面不足的新技术,目前低能量输出是MFC实际应用的关键瓶颈。基于MFC工作原理,提出微生物活性差、电子迁移阻力、质子传输阻力及阴极还原反应缓慢是MFC能量输出的限制因素,并从以下5个方面综述了提升MFC产电性能策略:调节pH和选择最佳盐度,加强微生物代谢活性;改性阳极材料,降低电子迁移阻力;增强电解液电导率、优化隔膜材料及缩短电极间距减小质子传输阻力;制备高效阴极催化剂和选择优异电子受体加快阴极还原反应速率;改进MFC反应器构型,提高整体产电性能。未来,可在合成新型阴极催化剂、降低膜污染、优化微生物生长环境、制备优异的电极材料和改进MFC反应器配置5个方面开展重点研究。

关键词：微生物燃料电池(MFC) 产电性能输出功率微生物活性策略

宫颈环形电切术治疗宫颈癌患者对其血清基质金属蛋白酶-9、瘦素水平及宫颈癌复发率的影响

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中国性科学 2024年第7期33卷 52-56页

作者：邵华萍石冬妮覃明辉钟晓英常德市妇幼保健院妇科湖南常德415101 鼎城区妇幼保健院妇科湖南常德415100 临澧县人民医院妇产科湖南常德415129

目的探讨宫颈环形电切术治疗宫颈癌患者对其血清基质金属蛋白酶-9(MMP-9)、瘦素水平及宫颈癌复发率的影响。方法选取2020年1月至2022年9月常德市妇幼保健院收治的200例宫颈癌患者作为研究对象,随机分为观察组和对照组,每组100例。观察... 详细信息

目的探讨宫颈环形电切术治疗宫颈癌患者对其血清基质金属蛋白酶-9(MMP-9)、瘦素水平及宫颈癌复发率的影响。方法选取2020年1月至2022年9月常德市妇幼保健院收治的200例宫颈癌患者作为研究对象,随机分为观察组和对照组,每组100例。观察组采用宫颈环形电切术治疗,对照组采用冷刀锥切术治疗;比较两组围手术期指标、并发症发生率、复发率、视觉模拟评分法(VAS)评分;比较两组血清应激因子、免疫球蛋白、MMP-9及瘦素水平。结果治疗后观察组术中出血量少于对照组,住院时间、排气时间短于对照组,淋巴清扫数大于对照组,差异具有统计学意义(P<0.05)。观察组术后复发率低于对照组,差异具有统计学意义(P<0.05)。治疗后观察组免疫球蛋白A(IgA)、免疫球蛋白G(IgG)及免疫球蛋白M(IgM)水平显著高于对照组,生长激素(GH)、皮质醇(Cor)、血管紧张素Ⅱ(AngⅡ)、MMP-9及瘦素水平显著低于对照组,差异具有统计学意义(P<0.05)。术后1 d、术后1周,观察组VAS评分显著低于对照组,差异具有统计学意义(P<0.05)。术后1年内观察组复发率低于对照组,差异具有统计学意义(P<0.05)。结论宫颈癌患者采用宫颈环形电切术治疗,可有效降低血清MMP-9、瘦素、应激因子水平,提升免疫球蛋白水平,围手术期指标好,复发率低,安全性好。

关键词：基质金属蛋白酶-9 瘦素宫颈环形电切术宫颈癌复发

基于“互联网+”的下肢力量训练在膝关节骨性关节炎患者居家康复中的应用

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中华现代护理杂志 2024年第18期30卷 2441-2446页

作者：朱欣艳张静张屈云宋倩史冬妮宁荣李霞首都医科大学附属北京友谊医院麻醉手术中心北京100050 北京大学第三医院麻醉科北京100191 国家电网公司北京电力医院手术室北京100073

目的探讨基于"互联网+"实施下肢力量训练在膝关节骨性关节炎(KOA)患者居家康复中的应用效果。方法采用便利抽样法,选取2021年5月—2022年12月在首都医科大学附属北京友谊医院疼痛门诊就诊的80例KOA患者,根据随机数字表法分为观察组和对... 详细信息

目的探讨基于"互联网+"实施下肢力量训练在膝关节骨性关节炎(KOA)患者居家康复中的应用效果。方法采用便利抽样法,选取2021年5月—2022年12月在首都医科大学附属北京友谊医院疼痛门诊就诊的80例KOA患者,根据随机数字表法分为观察组和对照组,各40例。对照组采用常规居家康复护理,观察组在对照组基础上实施基于"互联网+"的下肢力量训练,均干预3个月,比较两组患者的膝关节疼痛程度(VAS评分)、膝关节功能(KOOS评分)及锻炼依从性。结果干预后,观察组VAS评分低于对照组,KOOS评分高于对照组,差异有统计学意义(P<0.05)。观察组高依从性26例、部分依从11例、低依从性3例,对照组分别为19、10、11例,观察组锻炼依从性优于对照组,差异有统计学意义(Z=1.997,P=0.046)。结论基于"互联网+"实施下肢力量训练康复管理可以有效缓解KOA患者的膝关节疼痛,改善膝关节功能,提高患者居家锻炼的依从性。

关键词：膝关节骨关节炎康复护理互联网+ 力量训练居家护理

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Comparative efficacy of traditional Chinese herbal injection for chronic renal failure:A systematic review and network meta-analysis of randomized controlled trials

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Journal of Traditional Chinese Medical Sciences 2023年第1期10卷 83-99页

作者： dongni shi Feng Liang Xihong Wang Nana Wang Lin Zhang Wanting Cui Jiashuai Deng Chung Tai Lau Luofan Zhang Xuan Zhang School of Chinese Medicine Hong Kong Baptist UniversityHong Kong 999077China Department of Nephropathy First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300193China Ministry of Education Tianjin University of Traditional Chinese MedicineTianjin 301617China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 102488China

Objective: To conduct a systematic review and network meta-analysis(NMA) for the comparison of the efficacy and safety of Chinese herbal injection(CHI) combined with Western medicine(WM) and WM monotherapy for chronic renal failure(CRF).Methods: Eight databases were searched from inception to August 30, 2022. Randomized controlled trials(RCTs) regarding the comparison of CHI-WM combination therapy and WM monotherapy were included. Literature search, risk-of-bias assessment, and data extraction were conducted by 2 reviewers independently. NMA was performed by Stata 14.0, R 4.0.4 software, and the latest risk of bias assessment tool 2(RoB 2).Results: A total of 53 RCTs were finally included, involving 4445 participants and 16 CHIs. RoB 2 showed that 2 of these studies had a high risk of bias. Tianqi injection(TQ) + WM was the most effective in reducing serum creatinine(Scr) level. Xingding injection(XD) + WM was the most effective in reducing blood urea nitrogen(BUN) and cystatin C(Cys C) levels. Guhong injection(GH) + WM had the highest endogenous creatinine clearance rate(Ccr). Shuxuetong injection(SXT) + WM was the most effective in improving the clinical effective rate. Danhong injection(DH) + WM resulted in the lowest 24-h urinary protein quantity(24 h-UPQ), while Danshen injection(DS) + WM led to the lowest blood uric acid(UA)level. Shenfu injection(SF) + WM was the most effective in increasing hemoglobin(Hb) ***: CHIs-WM combination therapy is more effective than WM monotherapy in treating *** all of the indicators, SK + WM may be the optimal treatment option for improving renal function in patients with CRF.

关键词： Chronic renal failure Chinese herbal injections Combination therapy Systematic review Network meta-analysis

Optimized generation of entanglement based on the f-STIRAP technique

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Communications in Theoretical Physics 2024年第7期76卷 37-43页

作者： dongni Chen Jiahui Li Stefano Chesi Ying-Dan Wang Department of Physics Korea UniversitySeoul 02841South Korea School of Quantum Information Future Technology Henan UniversityZhengzhou 450046China Beijing Computational Science Research Center Beijing 100193China Department of Physics Beijing Normal UniversityBeijing 100875China CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China

We consider generating maximally entangled states(Bell states)between two qubits coupled to a common bosonic mode,based on *** the systematic approach developed by Wang et al(2017 New ***.19093016),we quantify the effects of non-adiabatic leakage and system dissipation on the entanglement generation,and optimize the entanglement by balancing non-adiabatic leakage and system *** find the analytical expressions of the optimal coupling profile,the operation time,and the maximal *** findings have broad applications in quantum state engineering,especially in solid-state devices where dissipative effects cannot be neglected.

关键词： f-STIRAP entanglement optimization perturbation theory

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Reversal of tamoxifen resistance by artemisinin in ER+breast cancer:bioinformatics analysis and experimental validation

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Oncology Research 2024年第6期32卷 1093-1107页

作者： ZHILI ZHUO dongni ZHANG WENPING LU XIAOQING WU YONGJIA CUI WEIXUAN ZHANG MENGFAN ZHANG Department of Oncology China Academy of Chinese Medical Sciences Guang’anmen HospitalBeijingChina

Breast cancer is the leading cause of cancer-related deaths in women worldwide,with Hormone Receptor(HR)+being the predominant ***(TAM)serves as the primary treatment for HR+breast ***,drug resistance often leads to recurrence,underscoring the need to develop new therapies to enhance patient quality of life and reduce recurrence ***(ART)has demonstrated efficacy in inhibiting the growth of drug-resistant cells,positioning art as a viable option for counteracting endocrine *** study explored the interaction between artemisinin and tamoxifen through a combined approach of bioinformatics analysis and experimental *** characterized genes(ar,cdkn1a,erbb2,esr1,hsp90aa1)and seven drug-disease crossover genes(cyp2e1,rorc,mapk10,glp1r,egfr,pgr,mgll)were identified using WGCNA crossover *** functional enrichment analyses were *** findings confirm a significant correlation between key cluster gene expression and immune cell infiltration in tamoxifen-resistant and-sensitized ***-seq analysis revealed high expression of key cluster genes in epithelial cells,suggesting artemisinin’s specific impact on tumor cells in estrogen receptor(ER)-positive BC *** target docking and in vitro experiments with artemisinin on LCC9 cells demonstrated a reversal effect in reducing migratory and drug resistance of drug-resistant cells by modulating relevant drug resistance *** results indicate that artemisinin could potentially reverse tamoxifen resistance in ER-positive breast cancer.

关键词： Artemisinin Tamoxifen resistance Breast cancer

Boosting CO_(2)photoreduction by synergistic optimization of multiple processes through metal vacancy engineering

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Chinese Journal of Catalysis 2024年第8期63卷 202-212页

作者： Jinlong Wang dongni Liu Mingyang Li Xiaoyi Gu shiqun Wu Jinlong Zhang Key Laboratory for Advanced Materials Joint International Research Laboratory of Precision Chemistry and Molecular EngineeringFeringa Nobel Prize Scientist Joint Research CenterSchool of Chemistry and Molecular EngineeringEast China University of Science&TechnologyShanghai 200237China Shanghai Engineering Research Center for Multi-media Environmental Catalysis and Resource Utilization East China University of Science and TechnologyShanghai 200237China

The photoreduction of greenhouse gas CO_(2)using photocatalytic technologies not only benefits en-vironmental remediation but also facilitates the production of raw materials for ***-er,the efficiency of CO_(2)photoreduction remains generally low due to the challenging activation of CO_(2)and the limited light absorption and separation of *** engineering of catalysts rep-resents a pivotal strategy to enhance the photocatalytic activity for CO_(2),with most research on met-al oxide catalysts focusing on the creation of anionic *** exploration of metal vacancies and their effects,however,is still *** this study,we prepared an In2O3 catalyst with indium vacancies(VIn)through defect engineering for CO_(2)*** and theo-retical calculations results demonstrate that VIn not only facilitate light absorption and charge sepa-ration in the catalyst but also enhance CO_(2)adsorption and reduce the energy barrier for the for-mation of the key intermediate*COOH during CO_(2)*** metal vacancy engineering,the activity of the catalyst was 7.4 times,reaching an outstanding rate of 841.32μmol g(-1)h^(-1).This work unveils the mechanism of metal vacancies in CO_(2)photoreduction and provides theoretical guidance for the development of novel CO_(2)photoreduction catalysts.

关键词： Photocatalyst CO_(2)photoreduction Indium oxide Metal vacancy Defect

Adaptive Space Expansion for Fast Motion Planning

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IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1499-1514页

作者： Shenglei shi Jiankui Chen State Key Laboratory of Digital Manufacturing Equipment and Technology School of Mechanical Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

The sampling process is very inefficient for sam-pling-based motion planning algorithms that excess random sam-ples are generated in the planning *** this paper,we pro-pose an adaptive space expansion(ASE)approach which belongs to the informed sampling category to improve the sampling effi-ciency for quickly finding a feasible *** ASE method enlarges the search space gradually and restrains the sampling process in a sequence of small hyper-ellipsoid ring subsets to avoid exploring the unnecessary ***,for a con-structed small hyper-ellipsoid ring subset,if the algorithm cannot find a feasible path in it,then the subset is ***,the ASE method successively does space exploring and space expan-sion until the final path has been ***,we present a particular construction method of the hyper-ellipsoid ring that uniform random samples can be directly generated in *** last,we present a feasible motion planner BiASE and an asymptoti-cally optimal motion planner BiASE*using the bidirectional exploring method and the ASE *** demon-strate that the computation speed is much faster than that of the state-of-the-art *** source codes are available at https://***/shshlei/ompl.

关键词： Adaptive space expansion(ASE) hyper-ellipsoid ring informed sampling motion planning.