检索结果-南通市图书馆

Studies on the Hypoglycemic and Hypolipidemic Effects of <i>Nelumbo nucifera</i>Leaf in Long-Evans Rats

Journal of Diabetes Mellitus 2017年第3期7卷 55-70页

作者： Dipa Islam Amdadul Huque Liton Chandra Mohanta Evena Parvin Lipy Md. Nazibur Rahman Abida Sultana sheuly U. K. Prodhan Department of Food Technology and Nutritional Science Mawlana Bhashani Science and Technology University Bangladesh Biomedical and Toxicological Research Institute Institute of Food Science and Technology Bangladesh Council of Scientific and Industrial Research Dhaka Bangladesh Department of Biochemistry and Molecular Biology Jahangirnagar University Savar Dhaka Bangladesh Department of Food Technology Kishoreganj Polytechnic Institute Kishoregan Bangladesh Science Secondary Education Quality and Access Enhancement Project (SEQAEP) Ministry ofEducation Dhaka Bangladesh

The study was carried out to evaluate the hypolipidemic and hypoglycemic effect of Nelumbo nucifera leaf powder. In rats, hyperlipidemia was induced by feeding High Fat Diet (Lab diet: Dalda: Coconut oil = 4:3:1) and type 2 diabetes was built inside by injecting Alloxan. The sample N. nucifera leaf powder was added in different percentages with the regular Lab Diet for 21 days feeding. In case of hyperlipidemia developed groups, feeding of Nelumbo nucifera leaf powder at, 30% (70% Lab diet + 30% Sample), 20% (80% Lab diet + 20% Sample) and 10% (90% Lab diet + 10% Sample) showed varied but in a nutshell significant (p Nelumbo nucifera leaf powder for 21 days resulted significant decrease in the blood glucose levels of alloxan-induced diabetic rats. Both the percentages of Nelumbo nucifera leaf powder having 20% with 80% Lab Diet and 10% with 90% Lab Diet significantly (p Nelumbo nucifera powder was found to be exerted to the more prominent effects in lowering the blood glucose level. Nelumbo nucifera leaf powder had 75% efficacy rate in lowering the blood glucose level in comparison to the drug control group treated with glibenclamide which was found with the decreasing capability up to 66%. Although not significant, it, based on the data, can be stated that the sample is endowed with the quality of decreasing capability of body weight. Thus, results of the experimental study reveal that the leaf of Nelumbo nucifera has potent hypoglycemic and hypolipidemic properties.

关键词： Diabetics Hypoglycemia Hypolipidemia Alloxan Monohydrate

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Liver Function Tests in Patients of Acute Leukemia before and after Induction Chemotherapy

引用

Journal of Biosciences and Medicines 2020年第2期8卷 110-121页

作者： Tahmidul Islam A. K. M. Shahidur Rahman Md. Kamrul Hasan Ferdous Jahan Manik Chandra Mondal sheuly Ferdoushi Sabrina Alam Mohammad Kamrul Ahsan Jannatut Tasnim Sharaban Tohura Department of Biochemistry Bangabandhu Sheikh Mujib Medical University (BSMMU) Dhaka Bangladesh Department of Nephrology Bangabandhu Sheikh Mujib Medical University (BSMMU) Dhaka Bangladesh Department of Haematology Colonel Malek Medical College Manikganj Bangladesh Department of Laboratory Medicine Bangabandhu Sheikh Mujib Medical University (BSMMU) Dhaka Bangladesh Department of Biochemistry TMSS Medical College Bogura Bangladesh Holy Family Red Crescent Medical College Hospital (HFRCMCH) Dhaka Bangladesh Department of Biochemistry Popular Medical College Dhaka Bangladesh Sadar Hospital Lalmonirhat Bangladesh

Background: Patients of acute leukemia require careful assessment of liver function prior to start chemotherapy to determine which drugs may be appropriate or to be modified. Post chemotherapy abnormalities of liver function tests may be due to drugs or due to disease process itself. Objective: To evaluate the status of liver function in acute leukemia patients before and after induction chemotherapy. Methodology: This was a prospective cross-sectional study conducted in the Department of Biochemistry, Dhaka Medical College, Dhaka, Bangladesh from January 2017 to December 2017 on fifty (50) newly diagnosed patients of acute leukemia who fulfilled the selection criteria. Blood samples for serum total bilirubin, alanine transaminase (ALT) and aspartate transaminase (AST) were collected before chemotherapy (Day 1) and after induction chemotherapy on 14th day and 30th day. Serum ALT and AST were measured by kinetic method and serum total bilirubin was measured by DMSO method. Data were analyzed and compared by statistical tests. Result: In this study, the mean level of serum total bilirubin before chemotherapy at day 1 was 0.89 ± 0.64 mg/dl. It was significantly (p Conclusion: It is concluded that serum total bilirubin, ALT and AST increase in response to chemotherapeutic drugs during treatment of acute leukemia.

关键词： Acute Leukaemia Alanine Transaminase (ALT) Aspartate Transaminase (AST) Bilirubin Chemotherapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Triglyceride and Glucose Index (TyG) is a Reliable Biomarker to Predict Non-Alcoholic Fatty Liver Disease

引用

Journal of Biosciences and Medicines 2020年第11期8卷 124-136页

作者： Sania Hossain Suraya Sultana Khan Md. Shahariar Zaman Sabrina Shafiq A. K. M. Shahidur Rahman Shah Md. Zakir Hossain Saiful Islam Mahammod Selim Uddin Md. Omar Faroque sheuly Ferdoushi Debatosh Paul Md. Quddusur Rahman Department of Cytopathology National Institute of Cancer Research and Hospital (NICRH) Dhaka Bangladesh Laboratory Services Division Sheikh Hasina National Institute of Burn and Plastic Surgery Dhaka Bangladesh Department of Laboratory Medicine Bangabandhu Sheikh Mujib Medical University (BSMMU) Dhaka Bangladesh Department of Nephrology Bangabandhu Sheikh Mujib Medical University (BSMMU) Dhaka Bangladesh Department of Hepatology Bangabandhu Sheikh Mujib Medical University (BSMMU) Dhaka Bangladesh Department of Medicine Mymensingh Medical College Hospital (MMCH) Mymensingh Bangladesh

Non-alcoholic fatty liver disease (NAFLD) is a common liver disease worldwide. There is no specific biomarker for the diagnosis of NAFLD. Trigly-ceride and glucose index (TyG) may predict the subsequent occurrence of NAFLD in later life. This cross sectional study was aimed to evaluate the effectiveness of triglyceride and glucose index (TyG) as a possible biomarker of NAFLD. The study was conducted at the Department of Laboratory Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh from March 2019 to February 2020. A total of 124 subjects were taken as study population following selection criteria. Among them 62 were diagnosed patients of NAFLD and 62 were healthy subjects as control group. Fasting plasma glucose was measured by glucose oxidase method and serum triglyceride was measured by enzymatic-colorimetric method, while TyG index was calculated accordingly. The mean age was 39.5 ± 11.27 years in NAFLD patients and 37.10 ± 12.28 years in control subjects with male female ratio 1:1.7 and 1:1.8 respectively. Major portion of NAFLD patients (62.9%) were overweight (BMI ≥ 25). The mean fasting plasma glucose level was 5.73 ± 1.47 mmol/L in NAFLD patients and 5.27 ± 0.69 mmol/L in control group (p < 0.027). The mean serum triglyceride level was 237.19 ± 96.47 mg/dl in NAFLD patients and 117.32 ± 53.07 mg/dl in control group (p < 0.001). The triglyceride and glucose index (TyG) was 9.36 ± 0.47 in NAFLD group and 8.53 ± 0.42 in control group. TyG index was significantly higher in NAFLD patients in comparison to control group (p < 0.001). In ROC analysis, cut off value of TyG index was 8.85 with sensitivity 93.5% and specificity 79%. As a fast and effective method, TyG index can be used as a diagnostic tool to predict NAFLD.

关键词： Non-Alcoholic Fatty Liver Disease (NAFLD) Plasma Glucose Serum Triglyceride Triglyceride and Glucose Index (TyG)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：