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Quantitative and qualitative subgenomic RNA profiles of SARS-CoV-2 in respiratory samples: A comparison between Omicron BA.2 and non-VOC-D614G

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Virologica Sinica 2024年第2期39卷 218-227页

作者： Zigui Chen Rita Way Yin ng Grace Lui Lowell Ling Agnes S.Y.Leung Chit Chow Siaw Shi Boon Wendy C.S.Ho Maggie Haitian Wang Renee Wan Yi Chan Albert Martin Li David Shu Cheong Hui Paul Kay Sheung Chan Department of Microbiology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anaesthesia and Intensive Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Paediatrics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anatomical and Cellular Pathology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Jockey Club School of Public Health and Primary Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Stanley Ho Centre for Emerging Infectious Diseases Faculty of MedicineThe Chinese University of Hong KongHong KongChina

The SARS-CoV-2 Omicron variants are notorious for their transmissibility,but little is known about their subgenomic RNA(sgRNA)*** study applied RNA-seq to delineate the quantitative and qualitative profiles of canonical sgRNA of 118 respiratory samples collected from patients infected with Omicron BA.2 and compared with 338 patients infected with non-variant of concern(non-VOC)-D614G.A unique characteristic profile depicted by the relative abundance of 9 canonical sgRNAs was reproduced by both BA.2 and non-VOCD614G regardless of host gender,age and presence of ***,such profile was lost in samples with low viral load,suggesting a potential application of sgRNA pattern to indicate viral activity of individual patient at a specific time point.A characteristic qualitative profile of canonical sgRNAs was also reproduced by both BA.2 and *** presence of a full set of canonical sgRNAs carried a coherent correlation with crude viral load(AUC¼0.91,95%CI 0.88–0.94),and sgRNA ORF7b was identified to be the best surrogate marker allowing feasible routine application in characterizing the infection status of individual *** potentials in using sgRNA as a target for vaccine and antiviral development are worth pursuing.

关键词： Coronavirus SARS-CoV-2 Omicron BA.2 Non-VOC-D614G RNA-seq Subgenomic RNA(sgRNA)

An update on hormonal regulation of early embryo-fallopian tube interactions: insights for improvements of assisted reproductive technology outcomes

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Reproductive and Developmental Medicine 2024年第1期8卷 39-49页

作者： Suranga P.Kodithuwakku Ernest H.Y.ng William S.B.Yeung Kai-Fai Lee Department of Obstetrics and Gynaecology LKS Faculty of MedicineThe University of Hong KongHong Kong SAR 999077China Department of Animal Science Faculty of AgricultureUniversity of PeradeniyaPeradeniya 20400Sri Lanka Shenzhen Key Laboratory of Fertility Regulation.The University of Hong Kong-Shenzhen Hospital Shenzhen 518053China

Human fallopian tubes(FTs)play important roles in the whole reproductive *** are the site for the final maturation of gametes,fertilization,transport of preimplantation embryos,and early embryonic development before entering the *** these functions are critical in the establishment of a successful *** the embryo is in transit through the FT,the FT microenvironment changes through endocrine,paracrine,autocrine,and juxtacrine mechanisms which involve various hormones and bioactive substances mainly from the neighboring ***,the interactions between the embryo and the FT may be the earliest embryo-maternal communications that are essential for the establishment of *** review critically discusses the evidence of various hormonal and bioactive mediated control of the microenvironment in the FTs during the earliest embryo-maternal ***,we highlight existing gaps in the knowledge and the importance of exploring more of the physiology of FTs which will hold the key to producing high-quality embryos for patients seekingin vitro fertilization(IVF)treatments.

关键词： Fallopian tube Embryo Maternal-embryo communication Hormonal control

Performance in the Fundamentals of Laparoscopic Surgery: Does it reflect global rating scales in the Objective Structured Assessment of Technical Skills in porcine laparoscopic surgery?

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Asian Journal of Urology 2024年第3期11卷 443-449页

作者： Ho Yee Tiong Wei Zheng So Jeremy Yuen-Chun Teoh Shuji Isotani Gang Zhu Teng Aik Ong Eddie Shu-Yin Chan Peggy Sau-Kwan Chu Kittinut Kijvikai Ming Liu Bannakji Lojanapiwat Michael Wong Anthony Chi-Fai ng Yong Loo Lin School of Medicine Department of SurgeryNational University of SingaporeSingapore S.H.Ho Urology Centre Department of SurgeryThe Chinese University of Hong KongHong KongChina Department of Urology Juntendo University Graduate School of MedicineTokyoJapan Department of Urology National University HospitalSingapore Department of Urology Beijing United Family HospitalBeijingChina Department of Surgery University of Malaya Specialist CentreKuala LumpurMalaysia Division of Urology Department of SurgeryTuen Mun HospitalHong Kong Department of Urology Ramathibodi HospitalMahidol UniversitySalayaThailand Department of Urology Beijing HospitalBeijingChina Department of Urology Chiangmai Ram HospitalChiang MaiThailand International Urology Fertility&Gynaecology CentreSingapore

Objective:To correlate the utility of the Fundamentals of Laparoscopic Surgery(FLS)manual skills program with the Objective Structured Assessment of Technical Skills(OSATS)global rating scale in evaluating operative ***:The Asian Urological Surgery Training and Educational Group(AUSTEG)Laparoscopic Upper Tract Surgery Course implemented and validated the FLS program for its usage in laparoscopic surgical ***’basic laparoscopic skills were assessed using three different training models(peg transfer,precision cutting,and intra-corporeal suturing).They also performed live porcine laparoscopic surgery at the same *** surgery skills were assessed by blinded faculty using the OSATS rating ***:From March 2016 to March 2019,a total of 81 certified urologists participated in the course,with a median of 5 years of post-residency *** differences in task time did not reach statistical significance,those with more surgical experience were visibly faster at completing the peg transfer and intra-corporeal suturing FLS ***,they took longer to complete the precision cutting task than participants with less *** OSATS scores correlated weakly with all three FLS tasks(peg transfer time:r=0.331,r^(2)=0.110;precision cutting time:r=0.240,r^(2)=0.058;suturing with intracorporeal knot time:r=0.451,r^(2)=0.203).Conclusion:FLS task parameters did not correlate strongly with OSATS globing rating scale *** FLS task models demonstrated strong validity,it is important to assimilate the inconsistencies when benchmarking technical proficiency against real-life operative competence,as evaluated by FLS and OSATS,respectively.

关键词： TheFundamentalsof Laparoscopic Surgery The Objective Structured Assessment of Technical Skills Laparoscopic training Surgical education Surgical training Urological laparoscopic surgery

失落的地理诗学:李劼人的中国革命时代的成都书写

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中国现代文学研究丛刊 2024年第5期 48-73页

作者：吴国坤() 胡安定(译) 香港浸会大学中国香港西南大学文学院 400715

李劼人作为一个地方性作家,在一系列小说中富有想象力地呈现了成都的微观历史,个中浓厚的地理历史兴趣和他的生活经历折射了成都独特的现代性转型,凸显了从清帝国到现代民族国家充满暴力和不确定性的转变历程。他通过对历史的微观“空... 详细信息

李劼人作为一个地方性作家,在一系列小说中富有想象力地呈现了成都的微观历史,个中浓厚的地理历史兴趣和他的生活经历折射了成都独特的现代性转型,凸显了从清帝国到现代民族国家充满暴力和不确定性的转变历程。他通过对历史的微观“空间化”来书写自己的家乡,这种微观的视角让作者将地方表述为拥有多元历史和当地日常生活片段之所在,从而挑战了“五四”以来进步的历史观,即单一、普遍的线性历史时间和目的。借助“大河小说”的广阔空间,他将晚清小说的多类代码重新改造为一种开放式的地方写作形式,完成了作为地方记忆载体的三部曲,从而形成了自己独特的风格。李劼人对地方主义和边缘之地的多重表述提供了一种超越精英和通俗二分的视角,从而管窥到地方性的诗学和小说写作的政治性以及地方、区域和国家层面的本土性与现代性之间的深层关联。

关键词：李劼人三部曲地理诗学地方性微观视角

生产性服务业与制造业融合发展的区域比较研究

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中国商论 2024年第13期33卷 130-133页

作者：刘玉丽 Vincent ng Kim Sheng 重庆第二师范学院旅游与服务管理学院重庆400065 SEGi University Malaysi

发展服务型制造、推动生产性服务和制造业融合是供给侧结构性改革的战略选择。从京津沪渝四个直辖市和粤鲁苏浙四个较为发达省份综合来看,制造业与生产性服务业之间存在着一定的关联效应和协同发展趋势,同时存在省市之间、行业之间的分... 详细信息

发展服务型制造、推动生产性服务和制造业融合是供给侧结构性改革的战略选择。从京津沪渝四个直辖市和粤鲁苏浙四个较为发达省份综合来看,制造业与生产性服务业之间存在着一定的关联效应和协同发展趋势,同时存在省市之间、行业之间的分异特征,且生产性服务业整体规模还与工业发展需求不相适应,表现在规模上其对工业的前向关联效应较弱。当然,近期呈现出生产性服务业在增长速度上与工业增速高度相关的发展态势。为更好实现生产性服务业与制造业融合协同发展,我国在服务业供给侧结构性改革进程中要转变制造业和服务业传统“二分法”思维,确立生产性服务业优先发展地位,着力推进研发性服务业高质量发展、坚守健康底线推进环保等高增长领域先行发展和坚持规模化导向推进商务服务业发展。

关键词：生产性服务业制造业融合发展灰色关联分析高质量发展

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基于TTC染色的水稻种子活力定量分析

种子 2024年第10期 135-141页

作者：乔菊香冯明春杨晓洪 Hoàng Minh Tú 王世敏刘艳芳云南省农业科学院质量标准与检测技术研究所农业农村部植物新品种测试(昆明)分中心昭通学院农学与生命科学学院越南国家植物种子和农产品检测中心

为了揭示种子活力与TTC染色之间的定量关系，本研究以水稻种子CY-150为试验材料，经人工加速老化处理和TTC染色后，利用体视镜获取种子胚部纵切面的RGB图像，并用农业农村部植物新品种测试（昆明）分中心建立的图像分析软件分析图像的CI... 详细信息

为了揭示种子活力与TTC染色之间的定量关系，本研究以水稻种子CY-150为试验材料，经人工加速老化处理和TTC染色后，利用体视镜获取种子胚部纵切面的RGB图像，并用农业农村部植物新品种测试（昆明）分中心建立的图像分析软件分析图像的CIELab值，计算单位面积染色强度。结果表明，发芽率、TTC染色率和活力指数之间呈显著正相关。其中，发芽率和活力指数、发芽率和染色率、染色率和活力指数之间的相关系数分别为0.997 6、0.971 8和0.963 1。此外，CIELab值与发芽率、染色率和活力指数之间显著相关，其中，L*和a*分别呈负相关和正相关，相关系数分别为-0.974 9、-0.976 1、-0.972 1、0.973 7、0.991 5和0.967 8。利用种子活力指数与CIELab值建立了种子活力方程。通过随机选取4个水稻品种对方程进行验证，结果显示，4个品种的活力指数真实值略高于预测值。研究表明，TTC染色不仅可用于水稻种子活力快速定性分析，而且通过种胚RGB图像可以实现种子活力的定量分析，为进一步普及水稻种子活力快速检测提供参考。

关键词：水稻种子活力 TTC染色定量分析

Fusobacterium is toxic for head and neck squamous cell carcinoma and its presence may determine a better prognosis

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Cancer Communications 2024年第8期44卷 879-883页

作者： Anjali Chander Jacopo Iacovacci Aize Pellon Radhika Kataria Anita Grigoriadis John Maher Cynthia Sears Gilad Bachrach Teresa Guerrero Urbano Mary Lei Imran Petkar Anthony Kong Tony ng Ester Orlandi Nicola Alessandro Iacovelli Loris De Cecco Mara Serena Serafini David Moyes Tiziana Rancati Miguel Reis Ferreira Centre for Host-Microbiome Interactions King’s College LondonLondonUK Comprehensive Cancer Centre King’s College LondonLondonUK Department of Oncology Guys and St Thomas NHS Foundation TrustLondonUK Data Science Unit Fondazione IRCCS Istituto Nazionale dei TumoriMilanItaly Medicine Department Johns Hopkins University School of MedicineBaltimoreMarylandUSA Institute of Biomedical and Oral Research The Hebrew University-Hadassah School of Dental MedicineHadassah Ein Kerem CampusJerusalemIsrael Dipartimento di scienze Clinico-Chirurgiche Diagnostiche e PediatricheUniversitàdegli studi di PaviaPaviaItaly Radiation Oncology Department Fondazione IRCCS Istituto Nazionale dei TumoriMilanItaly Department of Medicine Weill Cornell MedicineNew YorkUSA

Head and neck squamous cell carcinoma(HNSCC)is a devastating *** morbid treatment,5-year survival rates remain poor(28%-67%)[1].There is a significant knowledge gap regarding how the microbiota may impact HNSCC treatment efficacy[2].We used microbiome data from two independent cohorts to test and validate the hypothesis that oral bacteria are associated with HNSCC prognosis and in vitro models to investigate mechanistic *** are detailed in Supplementary Materials.

关键词： prognosis squamous carcinoma

Chalcogen heteroatoms doped nickel-nitrogen-carbon single-atom catalysts with asymmetric coordination for efficient electrochemical CO_(2)reduction

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Chinese Journal of Catalysis 2024年第9期64卷 54-65页

作者： Jialin Wang Kaini Zhang Ta Thi Thuy ng Yiqing Wang Yuchuan Shi Daixing Wei Chung-Li Dong Shaohua Shen International Research Center for Renewable Energy State Key Laboratory of Multiphase Flow in Power EngineeringXi'an Jiaotong UniversityXi'an 710049ShaanxiChina Department of Physics Tamkang UniversityNew Taipei City 25137TaiwanChina

The electronic configuration of central metal atoms in single-atom catalysts(SACs)is pivotal in electrochemical CO_(2)reduction reaction(eCO_(2)RR).Herein,chalcogen heteroatoms(e.g.,S,Se,and Te)were incorporated into the symmetric nickel-nitrogen-carbon(Ni-N4-C)configuration to obtain Ni-X-N3-C(X:S,Se,and Te)SACs with asymmetric coordination presented for central Ni *** these obtained Ni-X-N3-C(X:S,Se,and Te)SACs,Ni-Se-N3-C exhibited superior eCO_(2)RR activity,with CO selectivity reaching~98%at-0.70 V versus reversible hydrogen electrode(RHE).The Zn-CO_(2)battery integrated with Ni-Se-N3-C as cathode and Zn foil as anode achieved a peak power density of 1.82 mW cm-2 and maintained remarkable rechargeable stability over 20 ***-situ spectral investigations and theoretical calculations demonstrated that the chalcogen heteroatoms doped into the Ni-N4-C configuration would break coordination symmetry and trigger charge redistribution,and then regulate the intermediate behaviors and thermodynamic reaction pathways for eCO_(2)***,for Ni-Se-N3-C,the introduced Se atoms could significantly raise the d-band center of central Ni atoms and thus remarkably lower the energy barrier for the rate-determining step of*COOH formation,contributing to the promising eCO_(2)RR performance for high selectivity CO production by competing with hydrogen evolution reaction.

关键词： Electrochemical CO_(2)reduction reaction Chalcogen heteroatoms Single-atom catalysts Asymmetric coordination CO production

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加权加标网络的稳定与平衡

逻辑学研究 2024年第4期17卷 35-53页

作者：王轶董惠敏中山大学哲学系(珠海) 维也纳工业大学逻辑与计算研究所

经典结构平衡理论对不带权重的加标网络有较为完善的研究。Morrissette(1958)将结构平衡理论推广到加权加标网络并加以经验研究。近年来出现了基于时态逻辑CTL的结构平衡逻辑研究,但所探讨的社会网络局限于不带权重的加标网络。本文将... 详细信息

经典结构平衡理论对不带权重的加标网络有较为完善的研究。Morrissette(1958)将结构平衡理论推广到加权加标网络并加以经验研究。近年来出现了基于时态逻辑CTL的结构平衡逻辑研究,但所探讨的社会网络局限于不带权重的加标网络。本文将结构平衡逻辑推广到带权重的加标网络,引入几种适用的形式语言和语义,探讨由此得到的几个逻辑的表达能力,并给出证明系统。

关键词：加权加标网络结构平衡理论稳定性平衡性分支时间逻辑